Article
Clinical Neurology
Robin B. Brown, Daniel J. Tozer, Marco Egle, Anil M. Tuladhar, Frank-Erik de Leeuw, Hugh S. Markus
Summary: This study investigated the regression of white matter hyperintensity lesions (WMHs) in patients with cerebral small vessel disease (SVD). It found that only a small proportion of patients showed regression, and this regression was associated with smaller initial lesion volume and better white matter microstructural integrity.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Biochemistry & Molecular Biology
Annemarie Luise Kuehn, Stefan Frenzel, Alexander Teumer, Katharina Wittfeld, Linda Garvert, Antoine Weihs, Georg Homuth, Holger Prokisch, Robin Buelow, Matthias Nauck, Uwe Voelker, Henry Voelzke, Hans Jorgen Grabe, Sandra Van der Auwera
Summary: The gene TREML2 has been found to be associated with both Alzheimer's disease and white matter hyperintensities, but the APOE status does not affect these associations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neuroimaging
Angela C. C. Jochems, Susana Munoz Maniega, Maria del C. Valdes Hernandez, Gayle Barclay, Devasuda Anblagan, Lucia Ballerini, Rozanna Meijboom, Stewart Wiseman, Adele M. Taylor, Janie Corley, Francesca M. Chappell, Ellen V. Backhouse, Michael S. Stringer, David Alexander Dickie, Mark E. Bastin, Ian J. Deary, Simon R. Cox, Joanna M. Wardlaw
Summary: Based on the data from the Lothian Birth Cohort 1936, the study found that there are longitudinal associations between lateral ventricle and white matter hyperintensities (WMH) volumes, which are influenced by factors such as age, blood pressure, total brain volume, and gender. The changes in ventricular and WMH volumes are moderately correlated, but their underlying processes are not fully overlapping.
NEUROIMAGE-CLINICAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Laura W. M. Vergoossen, Jacobus F. A. Jansen, Thomas T. van Sloten, Coen D. A. Stehouwer, Nicolaas C. Schaper, Anke Wesselius, Pieter C. Dagnelie, Sebastiaan Kohler, Martin P. J. van Boxtel, Abraham A. Kroon, Joost J. A. de Jong, Miranda T. Schram, Walter H. Backes
Summary: The study found that white matter hyperintensity volume, local network efficiency, and information processing speed scores are interrelated, and local network properties explain lower cognitive performance due to white matter network alterations. Part of the relationship between WMH and information processing speed is mediated by local network efficiency.
Article
Geriatrics & Gerontology
Andrei Irimia, Van Ngo, Nikhil N. Chaudhari, Fan Zhang, Shantanu H. Joshi, Anita N. Penkova, Lauren J. O'Donnell, Nasim Sheikh-Bahaei, Xiaoyu Zheng, Helena C. Chui
Summary: This study found that cerebral microbleeds in mTBI patients are associated with white matter degradation and cognitive decline, with male sex and older age as significant risk factors for larger reductions. The findings indicate a significant positive correlation between CMBs and changes in cognitive functions, suggesting the need for long-term cognitive assessment in mTBI patients.
NEUROBIOLOGY OF AGING
(2022)
Article
Neurosciences
Zhiyu Cao, Yingren Mai, Wenli Fang, Ming Lei, Yishan Luo, Lei Zhao, Wang Liao, Qun Yu, Jiaxin Xu, Yuting Ruan, Songhua Xiao, Vincent C. T. Mok, Lin Shi, Jun Liu
Summary: This study explored the association between white matter hyperintensities (WMHs) and regional brain lobe atrophy in patients with Alzheimer's disease (AD). The results showed that the severity of WMHs tends to be associated with atrophy in specific brain regions, especially in the medial temporal lobe, temporal lobe, and insular lobe. Periventricular WMHs contributed to these correlations.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Yousef Hannawi, Dhananjay Vaidya, Lisa R. Yanek, Michelle C. Johansen, Brian G. Kral, Lewis C. Becker, Diane M. Becker, Paul A. Nyquist
Summary: Our study shows that periventricular white matter hyperintensity volume is more strongly associated with arterial stiffness and cardiovascular remodeling measurements, independent of age and other cardiovascular risk factors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Clinical Neurology
Sigurdur Sigurdsson, Thor Aspelund, Olafur Kjartansson, Elias Gudmundsson, Palmi Jonsson, Mark A. van Buchem, Vilmundur Gudnason, Lenore J. Launer
Summary: This study found that the risk factors for different types of brain infarcts vary depending on the location in the brain. Small vessel disease risk factors such as hypertension and diabetes were associated with subcortical infarcts, while atherosclerotic/coronary processes were associated with cortical infarcts, and a mixed profile of factors was associated with cerebellar infarcts. Assessing risk factors based on the location of asymptomatic infarcts detected on magnetic resonance imaging may help improve preventive therapeutic approaches for stroke.
Article
Neurosciences
M. A. Infante, S. C. Eberson, Y. Zhang, T. Brumback, S. A. Brown, I. M. Colrain, F. C. Baker, D. B. Clark, M. D. De Bellis, D. Goldston, B. J. Nagel, K. B. Nooner, Q. Zhao, K. M. Pohl, E. Sullivan, A. Pfefferbaum, S. F. Tapert, W. K. Thompson
Summary: This study utilized longitudinal data and found that binge drinking has negative effects on adolescent brain development, especially in the frontal regions. The study also revealed a dose-response relationship between the number of binge drinking episodes and the proximity of decreased brain volume.
Article
Neurosciences
Preeti Kar, Jess E. Reynolds, William Ben Gibbard, Carly McMorris, Christina Tortorelli, Catherine Lebel
Summary: Prenatal alcohol exposure is associated with alterations in brain white matter microstructure. Children with prenatal alcohol exposure show slower white matter development in certain brain regions, which may have implications for cognitive and behavioral learning.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Wookjin Yang, Dong-Wan Kang, Sue Young Ha, Seung-Hoon Lee
Summary: This study found that middle-aged participants with specific drinking patterns had a reduced risk of ischemic stroke, but this effect was limited to the earlier period.
Article
Clinical Neurology
Jingqin Luo, Yinjiao Ma, Folasade Jane Agboola, Elizabeth C. Grant, John Morris, Eric M. McDade, Anne Fagan, Tammie L. S. Benzinger, Jason J. Hassenstab, Randall J. Bateman, Richard A. Perrin, Brian Gordon, Manu F. Goyal, Jeremy Strain, Igor S. Yakushev, Gregory Day, Chengjie Xiong
Summary: White matter hyperintensities (WMH) are correlated with Alzheimer disease (AD) biomarkers and modulate AD pathogenesis. This study analyzed the longitudinal data of WMH volume and established AD biomarkers in cognitively normal individuals. The results showed that longitudinal increases in WMH volume were associated with changes in PET amyloid uptake, MRI structural outcomes, and cognition. The inflection point of baseline age in WMH volume was identified at 60.46 years.
Article
Multidisciplinary Sciences
Cheuk Y. Tang, Victoria X. Wang, Min Yin Lun, Joshua S. Mincer, Johnny C. Ng, Jess W. Brallier, Arthur E. Schwartz, Helen Ahn, Patrick J. McCormick, Tommer Nir, Bradley Delman, Mary Sano, Stacie G. Deiner, Mark G. Baxter
Summary: Cognitive dysfunction after surgery under general anesthesia, specifically with sevoflurane, can lead to transient changes in white matter microstructure, as seen through Diffusion Tensor Imaging. These changes in white matter integrity and volume during anesthesia are independent of age and sex, but do not have long-lasting effects. Further research is needed to understand the role of white matter in unconsciousness under anesthesia and to consider these results in future MRI studies involving anesthesia.
Article
Clinical Neurology
Sara Schramm, Lea Schliephake, Heiko Himpfen, Svenja Caspers, Raimund Erbel, Karl-Heinz Joeckel, Susanne Moebus
Summary: This study found an inverse association between serum 25-hydroxyvitamin D (25OHD) levels and white matter hyperintensities (WMHs), suggesting that low 25OHD levels may be a risk factor for the occurrence of WMHs.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Jianqiao Tian, Sheelakumari Raghavan, Robert I. Reid, Scott A. Przybelski, Timothy G. Lesnick, Robel K. Gebre, Jonathan Graff-Radford, Christopher G. Schwarz, Val J. Lowe, Kejal Kantarci, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Prashanthi Vemuri
Summary: This study used neurite orientation dispersion and density imaging (NODDI) to investigate the association between white matter (WM) changes and Alzheimer disease (AD), and evaluated its relationship with cognitive performance. The results showed that the neurodegeneration of WM is spatially dependent and correlated with regional tau deposition in different stages of AD. Additionally, the WM changes explained a similar amount of cognitive performance variation as regional tau deposition and provided complementary information about disease staging and progression.