Review
Clinical Neurology
Yuhan Wang, Chencheng Zhang, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: This study aimed to evaluate optimal stimulation parameters for treating dystonia with STN-DBS. Results showed that the optimal parameters vary among patients, with improvement rate being linearly dependent on stimulation parameters. Adverse effects include dyskinesia and depression.
JOURNAL OF NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Charles W. Lu, Daniel E. Harper, Asra Askari, Matthew S. Willsey, Philip P. Vu, Andrew D. Schrepf, Steven E. Harte, Parag G. Patil
Summary: Stimulation of the zona incerta can reduce heat pain perception, but does not affect warmth perception or pressure pain. These findings provide a mechanistic explanation for sensory changes observed in Parkinsonian patients undergoing subthalamic deep brain stimulation and identify the zona incerta as a potential target for neuromodulation of pain.
SCIENTIFIC REPORTS
(2021)
Letter
Clinical Neurology
T. J. C. Zoon, V. Mathiopoulou, G. van Rooijen, P. van den Munckhof, D. A. J. P. Denys, P. R. Schuurman, R. M. A. de Bie, M. Bot
Summary: This study used subthalamic nucleus deep brain stimulation (STN DBS) and network analysis to investigate the relationship between the location of active DBS contact points and apathy in Parkinson's disease (PD) patients. The results showed that active contacts in apathy patients were more often positioned in the area with a high density of surrounding projections to associative cortex areas. The study provides insight into the anatomical connectivity substrate for apathy in DBS.
Article
Neurosciences
Yingchuan Chen, Guanyu Zhu, Yuye Liu, Defeng Liu, Tianshuo Yuan, Xin Zhang, Yin Jiang, Tingting Du, Jianguo Zhang
Summary: The study found that changes in brain morphology are associated with the initial motor response to subthalamic nucleus deep brain stimulation in Parkinson's disease patients, and can be used to predict individual initial stimulation-related motor responses.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Clinical Neurology
Thomas J. C. Zoon, Geeske van Rooijen, Georgina M. F. C. Balm, Isidoor O. Bergfeld, Joost G. Daams, Paul Krack, Damiaan A. J. P. Denys, Rob M. A. de Bie
Summary: This meta-analysis found that apathy is increased after STN DBS compared to the pre-operative state and medication only. The difference in severity of apathy remained significant after multiple analyses.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Article
Neurosciences
Roxanne Lofredi, Cem-Georg Auernig, Siobhan Ewert, Friederike Irmen, Leon A. Steiner, Ute Scheller, Bernadette C. M. van Wijk, Simon Oxenford, Andrea A. Kuhn, Andreas Horn
Summary: Lead-DBS is a reliable and easy-to-use software tool for precise localization of deep brain stimulation electrodes. This study investigates the differences introduced by different raters and imaging types in the manual refinement process of electrode localization using Lead-DBS. The results show similar outcomes for all users, with an increase in variability when using postoperative MRI and standard space normalization. These findings contribute to the understanding of Lead-DBS and its potential use in formal training and imaging research in the field of deep brain stimulation.
Article
Medicine, General & Internal
Tianqi Hu, Hutao Xie, Yu Diao, Houyou Fan, Delong Wu, Yifei Gan, Fangang Meng, Yutong Bai, Jianguo Zhang
Summary: This study aimed to investigate the effects of STN-DBS on PD patients with different levels of depression and identify predictors of these effects. The results showed that patients with moderate depression had better improvement, and gender (female) and preoperative HAMA scores were predictors of the effects of STN-DBS on PD depression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Behavioral Sciences
Chun-Hwei Tai
Summary: Understanding the pathophysiological mechanism of Parkinson's disease in the subthalamic nucleus is crucial for effective treatment through deep brain stimulation. STN burst firing is considered an electrophysiological signature of the cortico-basal ganglia circuit in PD patients, and plays a significant role in the motor symptoms of PD as well. This review explores the origins of STN bursts, factors influencing their formation, and the potential for interventions to alleviate PD symptoms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Lulu Jiang, Wanru Chen, Qiyu Guo, Chao Yang, Jing Gu, Wenbiao Xian, Yanmei Liu, Yifan Zheng, Jing Ye, Shaohua Xu, Yu Hu, Lei Wu, Jie Chen, Hao Qian, Xiaoli Fu, Jinlong Liu, Ling Chen
Summary: The long-term therapeutic efficacy of STN-DBS can be achieved in southern China with relatively low stimulation intensity and medication dosage, maintaining motor improvement and medication reduction through an 8-year follow-up, while improvement in quality of life lasts for only 3 years. No definite changes in nonmotor symptoms were found after STN-DBS.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Clinical Neurology
Inken Toedt, Bassam Al-Fatly, Oliver Granert, Andrea A. Kuehn, Paul Krack, Joern Rau, Lars Timmermann, Alfons Schnitzler, Steffen Paschen, Ann-Kristin Helmers, Andreas Hartmann, Eric Bardinet, Michael Schuepbach, Michael T. Barbe, Till A. Dembek, Valerie Fraix, Dorothee Kuebler, Christine Brefel-Courbon, Alireza Gharabaghi, Lars Wojtecki, Marcus O. Pinsker, Stephane Thobois, Philippe Damier, Tatiana Witjas, Jean-Luc Houeto, Carmen Schade-Brittinger, Marie Vidailhet, Andreas Horn, Guenther Deuschl
Summary: This study assessed the impact of subthalamic nucleus deep brain stimulation (STN-DBS) on clinical outcomes and quality of life in patients with Parkinson's disease, finding a correlation between the stimulated part of the STN and improvements in symptom control and quality of life.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Roxanne Lofredi, Georg Cem Auernig, Friederike Irmen, Johanna Nieweler, Wolf-Julian Neumann, Andreas Horn, Gerd-Helge Schneider, Andrea A. Kuehn
Summary: In Parkinson's disease patients, subthalamic deep brain stimulation significantly increases stop times, which are closely related to the connectivity of the stimulation volume to the stopping network. This finding may advance understanding of stopping ongoing movements and inspire circuit-based adaptive stimulation strategies for control of stopping impairment.
Article
Neurosciences
Qiang Wang, Harith Akram, Muthuraman Muthuraman, Gabriel Gonzalez-Escamilla, Sameer A. Sheth, Simon Oxenford, Fang-Cheng Yeh, Sergiu Groppa, Nora Vanegas-Arroyave, Ludvic Zrinzo, Ningfei Li, Andrea Kuhn, Andreas Horn
Summary: This study compared the abilities of patient-specific, disease-matched, and normative structural connectivity data in predicting clinical improvement in DBS patients. The results indicated that patient-specific connectivity information and normative connectomes showed similar effectiveness in predicting clinical improvement.
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Letter
Clinical Neurology
Yunhao Wu, Yixin Pan, Peng Huang, Tao Wang, Chencheng Zhang, Bomin Sun, Dianyou Li, Hongxia Li, Yiwen Wu
Summary: Lingual dystonia is a rare disease that severely affects daily activities. Previous studies have shown the efficacy of GPi-DBS on patients with refractory lingual symptoms, but high-level evidence is lacking. Our retrospective study on six lingual dystonia patients treated with subthalamic DBS demonstrates its immediate and long-lasting efficacy.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Psychiatry
Delphine Raucher-Chene, Michael Bodnar, Katie M. Lavigne, Ashok Malla, Ridha Joober, Martin Lepage
Summary: Persistent negative symptoms have a significant impact on clinical insight in first episode psychosis patients, affecting long-term functional outcomes. Patients with PNS or sPNS showed poorer insight over a 24-month period compared to those without negative symptoms, highlighting the strong relationship between poor insight and negative symptoms early in the course of the disorder.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Behavioral Sciences
Marianne Khalil, Philippine Hollander, Delphine Raucher-Chene, Martin Lepage, Katie M. Lavigne
Summary: Schizophrenia is characterized by cognitive impairments and structural brain abnormalities. Research suggests significant associations between brain structure and cognition, potentially following a functional network architecture.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Clinical Neurology
Lea Decombe, Audrey Henry, Rene Decombe, Melissa Tir, Anne Doe de Maindreville, Lou Galland Hairabedian, Arthur Kaladjian, Delphine Raucher-Chene
Summary: This study compared the attributional bias of patients with Parkinson's disease (PD) to controls and found that patients exhibited more hostile and aggressive biases, especially in ambiguous situations. Stimulated patients showed greater hostility and aggression biases, as well as a higher blame score in accidental situations. This is the first study to assess attributional bias in PD patients and suggests that deep-brain stimulation may exacerbate this impairment.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Psychiatry
Katie M. Lavigne, Genevieve Sauve, Delphine Raucher-Chene, Synthia Guimond, Tania Lecomte, Christopher R. Bowie, Mahesh Menon, Shalini Lal, Todd S. Woodward, Michael D. Bodnar, Martin Lepage
Summary: This study conducted a review on remote cognitive assessment in severe mental illness and found that it has the potential to advance research and treatment, but is not widely used in psychiatric populations. The review identified 82 measures assessing cognition in severe mental illness, but more rigorous validation and consideration of influential factors are needed.
Article
Clinical Neurology
Margaux Chene, Marina Sanchez-Rico, Carlos Blanco, Rachel Pascal De Raykeer, Cecile Hanon, Pierre Vandel, Frederic Limosin, Nicolas Hoertel
Summary: In older adults with major psychiatric disorders, all psychiatric symptoms are associated with increased mortality, mainly through a general psychopathology dimension. No BPRS item or lower order factor has a significant effect on mortality beyond the general psychopathology factor. Greater number of medical conditions, older age, male sex, and being hospitalized or institutionalized at baseline are significantly associated with this increased risk, independently from the general psychopathology factor.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Katie M. Lavigne, Delphine Raucher-Chene, Michael D. Bodnar, Carolina Makowski, Ridha Joober, Ashok Malla, Alan C. Evans, Martin Lepage
Summary: This study found distinct structural brain changes associated with persistent negative symptoms (PNS) in the left medial temporal lobe (MTL) and suggests that basal ganglia alterations may contribute to PNS regardless of their etiology. Reductions in left MTL volume were most evident after 1 year of treatment, highlighting the importance of targeted early interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychiatry
Delphine Raucher-Chene, Gabrielle Pochiet, Katie M. Lavigne, R. Walter Heinrichs, Ashok Malla, Ridha Joober, Martin Lepage
Summary: In first-episode psychosis (FEP) patients, 57.9% have normal-range (NR) verbal memory (VM) which appears to be functionally advantageous, but this NR VM is nuanced by the presence or absence of a potential decrement.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Elisabeth Thibaudeau, Jesse Rae, Delphine Raucher-Chene, Alan Bougeard, Martin Lepage
Summary: This study aimed to investigate the associations between theory of mind (ToM) impairments and clinical symptoms in patients with schizophrenia spectrum disorders (SSD). The results revealed that cognitive/disorganization and negative symptoms showed stronger associations with ToM compared to other dimensions such as depression/anxiety.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Joshua Unrau, Olivier Percie du Sert, Ridha Joober, Ashok Malla, Martin Lepage, Delphine Raucher-Chene
Summary: The combination of persistent negative symptoms and symptom-based trajectory can predict functional outcomes more accurately, providing significant advances in developing targeted interventions for patients at risk for poor functional outcomes.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Neurosciences
Ksenija Vucurovic, Delphine Raucher-Chene, Alexandre Obert, Pamela Gobin, Audrey Henry, Sarah Barriere, Martina Traykova, Fabien Gierski, Christophe Portefaix, Stephanie Caillies, Arthur Kaladjian
Summary: This study investigated the correlations between schizotypal personality traits and brain activation during affective ToM and cognitive ToM tasks in healthy individuals. The results revealed that schizotypal personality traits were positively correlated with brain activation in certain regions during affective ToM, but negatively correlated with emotional disconnection and self-reported empathy scores.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2023)
Review
Clinical Neurology
Olivier Percie du Sert, Joshua Unrau, Claudine J. Gauthier, Mallar Chakravarty, Ashok Malla, Martin Lepage, Delphine Raucher-Chene
Summary: Schizophrenia-spectrum disorders (SSD) are a major cause of global disability and are often associated with neurodevelopmental brain abnormalities. Nuclear medicine imaging studies and recent advancements in MRI techniques have provided insights into the pathophysiology of these disorders. This literature review and meta-analysis of perfusion studies support the involvement of hemodynamic correlates in the symptoms and disorders of psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychology, Biological
Apolline Durtette, Franca Schmid, Sarah Barriere, Alexandre Obert, Julie Lang, Delphine Raucher-Chene, Fabien Gierski, Arthur Kaladjian, Audrey Henry
Summary: This study investigated the relationship between eye movements and facial emotion recognition among nonclinical individuals with schizotypal personality traits. The results showed that higher schizotypal personality trait scores were associated with shorter dwell time on relevant facial features during sadness recognition, and lower surprise recognition accuracy scores. Schizotypal personality traits may lead to decreased attentional engagement and slower processing during the recognition of sad faces.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2023)
Meeting Abstract
Neurosciences
Olivier Percie du Sert, Delphine Raucher-Chene, Joshua Unrau, Claudine Gauthier, M. Mallar Chakravarty, Martin Lepage
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)
Article
Psychiatry
Daniel Mendelson, Elisabeth Thibaudeau, Genevieve Sauve, Katie M. Lavigne, Christopher R. Bowie, Mahesh Menon, Todd S. Woodward, Martin Lepage, Delphine Raucher-Chene
Summary: This study aimed to assess the feasibility and acceptability of delivering remote group psychosocial therapies for cognitive health in schizophrenia-spectrum disorders (SSDs) from the perspectives of participants and therapists. The results of the study showed that participants had a positive experience with therapy, technology did not significantly hinder participation, and therapists were satisfied with the levels of attention and participation. However, participants indicated a desire for more social interactions during the therapy.
SCHIZOPHRENIA RESEARCH-COGNITION
(2022)
Article
Psychology, Clinical
Franca Schmid, Franklin Moreau, Farid Benzerouk, Delphine Raucher-Chene, Arthur Kaladjian, Fabien Gierski, Audrey Henry
Summary: The impairment of executive functions and theory of mind in patients with alcohol use disorders has been found to be interrelated. Based on these findings, tailored cognitive rehabilitation programs that simultaneously target both impairments could be developed to improve social inclusion and reduce the risk of relapse.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2022)
