Article
Biochemistry & Molecular Biology
Maria S. Gavrish, Mark D. Urazov, Tatiana A. Mishchenko, Victoria D. Turubanova, Ekaterina A. Epifanova, Victoria G. Krut', Alexey A. Babaev, Maria V. Vedunova, Elena Mitroshina
Summary: The role of neurotrophic factors BDNF and GDNF in maintaining brain resistance to hypoxia and promoting recovery of neural networks is being actively studied. This study aimed to evaluate the effects of overexpressing BDNF and GDNF using viral vectors in modeling hypoxia. The results showed increased survival rate of mice under hypoxic conditions, indicating that overexpression of neurotrophic factors may be a potential neuroprotection method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Luyu Ding, Yifan Wu, Lingtao Kong, Jiaze Sun, Fangru Qu, Kaiqi Xin, Anqi Yang, Xintong Yan, Yihui Lu, Xiaowei Jiang, Yanqing Tang, Feng Wu
Summary: This study investigates whether the glial cell line-derived neurotrophic factor (GDNF) levels differ in terms of gender in patients with bipolar disorder (BD). The results show that in the healthy control group, males have significantly higher GDNF levels compared to females, while in the BD group, males have significantly lower GDNF levels compared to males in the healthy control group.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Ophthalmology
Abhigna Akurathi, Erin A. Boese, Randy H. Kardon, Johannes Ledolter, Markus H. Kuehn, Matthew M. Harper
Summary: This study aimed to investigate the expression of glial-derived neurotrophic factor (GDNF) and its receptors, GFR alpha 1 and GFR alpha 2, ciliary neurotrophic factor (CNTF), and its receptor CNTFR alpha, in both normal and glaucomatous human tissue. The results showed that the expression of GFR alpha 2 was significantly decreased in glaucomatous eyes, while the expression of GFR alpha 1 was decreased in the peripapillary region. The findings suggest that the decreased expression of GDNF receptors in glaucomatous tissue may limit the potential for neuroprotective therapy using GDNF supplementation.
CURRENT EYE RESEARCH
(2022)
Review
Neurosciences
Anastasiia Kotliarova, Yulia A. Sidorova
Summary: This article summarizes the effects of GDNF family ligands on neuropathic pain and neuroinflammation, as well as the potential therapeutic implications of targeting GFL receptors in neurodegenerative disorders and neuropathic pain.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Immunology
Kouminin Kanwore, Konimpo Kanwore, Xiaoxiao Guo, Ying Xia, Han Zhou, Lin Zhang, Gabriel Komla Adzika, Adu-Amankwaah Joseph, Ayanlaja Abdulrahman Abiola, Peipei Mu, Piniel Alphayo Kambey, Marie Louis N'dzie Noah, DianShuai Gao
Summary: The study found that testosterone upregulates GDNF in glioma cells and astrocytes, promoting their proliferation, migration, and invasion. Testosterone also contributes to brain neuron and astrocyte inflammation by upregulating NRF2, GFAP, and SIRT5, leading to recruitment of pro-inflammatory macrophages. Additionally, testosterone treatment regulates GDNF translocation from cell nuclei to the cytoplasm.
INFLAMMATION AND REGENERATION
(2023)
Review
Endocrinology & Metabolism
William W. Wright
Summary: This review focuses on the in vivo regulation of spermatogonial stem cells (SSCs) in adult testes by glial cell line-derived neurotrophic factor (GDNF). Through chemical-genetic approach, the inhibition of GDNF stimulation of SSCs was found to decrease replication and increase differentiation of SSCs, ultimately leading to the loss of all SSCs and resembling the condition of Sertoli cell-only (SCO) syndrome. Abnormally low expression of GDNF, FGF2, and FGF8 was observed in infertile human testes, although some SCO testes still contain SSCs. Restoration of GDNF signaling showed partial rebuilding of depleted SSC pool, suggesting GDNF as a potential therapy for men with SCO syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Muhammad S. Aldhshan, Gursagar Jhanji, Nicole J. Poritsanos, Tooru M. Mizuno
Summary: This study found that increased local glucose concentration stimulates GDNF expression and inhibits MANF expression in microglia, leading to suppressed appetite. Furthermore, this regulation is associated with GLUT5.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Madeha Adam, Ling Lin, Amir Makin, Xiao-Fen Zhang, Lu-Xi Zhou, Xin-Yue Liao, Li Zhao, Feng Wang, Dao-Shu Luo
Summary: This study aimed to develop an efficient in vitro model mimicking the glial environment of trigeminal root entry zone. The results showed that glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor are involved in the regulation of astrocyte-Schwann cell interaction in the co-culture system derived from the trigeminal root entry zone.
NEURAL REGENERATION RESEARCH
(2023)
Article
Oncology
Xiaoyan Wang, Yuehan Wang, Xuelian Chen, Tinglei Li, Shu Zhang, Rong Dong, Zhe Chen
Summary: The expression of glial cell line-derived neurotrophic factor (GDNF) is increased in the lung and brain of asthmatic rats. During an asthma attack, the increased GDNF expressions in the rat brain remarkably aggravate the asthmatic symptoms.
ANNALS OF TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Ane Escobar, Mariana R. Carvalho, F. Raquel Maia, Rui L. Reis, Tiago H. Silva, Joaquim M. Oliveira
Summary: This study demonstrates the effectiveness of using CMCht/PAMAM NPs as a GDNF release system for peripheral nerve regeneration, providing stable GDNF release under physiological conditions and improving cell viability as well as enhancing the uptake rate of neural cells.
Review
Biochemistry & Molecular Biology
Serena Stanga, Marina Boido, Pascal Kienlen-Campard
Summary: The neuromuscular junction (NMJ) is a crucial interface between the nervous system and muscles, where the Glial cell line-Derived Neurotrophic Factor (GDNF) plays a key role in synaptic formation, stabilization, and function, as well as in protecting the NMJ during neurodegeneration. GDNF also has unique properties that make it essential in neurodegenerative disorders. Research highlights the importance of GDNF in the NMJ-muscle interaction, and its therapeutic potential in diseases like Alzheimer's, ALS, and SMA. Additionally, 3D neuromuscular co-culture systems are being developed as models to study NMJ formation and involvement in neuromuscular disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Shiori Murase, Kimiko Kobayashi, Teruaki Nasu, Chiaki Kihara, Toru Taguchi, Kazue Mizumura
Summary: Nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) are essential for neuronal development and survival, but can induce hyperalgesia in painful conditions. There is a synergistic interaction between NGF and GDNF, mainly in primary afferent neurons where some neurons coexpress NGF and GDNF receptors.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biochemistry & Molecular Biology
Tatsuya Iwasaki, Koji Akeda, Koki Kawaguchi, Junichi Yamada, Takahiro Hasegawa, Norihiko Takegami, Tatsuhiko Fujiwara, Akihiro Sudo
Summary: NRTN, ARTN, PSPN, and their receptors are expressed in human IVD cells and their expression is enhanced in advanced degeneration, suggesting their involvement in the pathogenesis of discogenic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Wesley Stansberry, Brian Pierchala
Summary: The discovery of neurotrophins and their potential to save dying neurons in neurodegenerative diseases caused great excitement. Subsequent findings of the survival-promoting activity of BDNF, CNTF, and GDNF on motor neurons led to their proposed use in ALS. This review summarizes the literature on the role of NGF, BDNF, CNTF, and GDNF on spinal motor neuron development and physiology, as well as the preclinical studies and clinical trials evaluating their potential for ALS treatment.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Daniel Hellenbrand, Clayton L. Haldeman, Jae-Sung Lee, Angela G. Gableman, Elena K. Dai, Stephen D. Ortmann, Jerrod C. Gotchy, Kierra K. Miller, Adrianna M. Doucas, Nicole C. Nowak, William L. Murphy, Amgad S. Hanna
Summary: The gold standard for treating peripheral nerve injuries with large nerve gaps is autologous nerve grafts. However, incorporating mineral coated microparticles (MCMs) to release growth factors like NGF and GDNF can significantly enhance axon growth and improve limb function in rats with nerve grafts.
NEURAL REGENERATION RESEARCH
(2021)