Article
Chemistry, Medicinal
Shumeng Ma, Longqing Zhu, Xiaohong Fan, Tian Luo, Dan Liu, Ziyi Liang, Xiaoling Hu, Tao Shi, Wen Tan, Zhen Wang
Summary: By modifying melatonin and salicylic acid, a new compound P-3 was created with the ability to inhibit the connection between inflammation and cancer, making it a promising chemical structure for developing novel anti-cancer agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Hongjin Lai, Yi Liu, Juan Wu, Jie Cai, Hui Jie, Yuyang Xu, Senyi Deng
Summary: Inflammatory processes play a crucial role in innate immunity and tumor development in various malignancies. Targeting inflammation with pharmacotherapies, such as non-steroidal anti-inflammatory drugs (NSAIDs), has the potential to reduce the risk of carcinogenesis and enhance the effectiveness of anti-cancer treatments. However, the pharmacogenomic variability of NSAIDs can greatly impact their pharmacokinetics and therapeutic outcomes in cancer patients. Thus, a comprehensive understanding of the pharmacogenomic characteristics of NSAIDs and cancer-related inflammation is important for developing new strategies in cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Kyler S. Crawford, Brian F. Volkman
Summary: The chemokine network comprises a family of signal proteins that encode messages for cells displaying chemokine G-protein coupled receptors (GPCRs). These proteins have diverse effects on cellular functions, particularly the directed migration of different cell types to sites of inflammation. The network is tightly regulated and can contribute to autoimmune diseases and cancer progression. Currently, there are three drugs targeting chemokine receptors approved for clinical use. However, the complexity of the network has limited their widespread implementation as anti-neoplastic and anti-metastatic agents.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Man Chu, Cheng Zheng, Cheng Chen, Gendi Song, Xiaoli Hu, Zhi-wei Wang
Summary: Accumulating evidence suggests that cancer stem cells (CSCs) play a crucial role in tumor progression and drug resistance. Numerous chemopreventive compounds, known as nutraceuticals, have been found to eliminate CSCs by regulating signaling pathways. These nutraceuticals, including soy isoflavone, curcumin, resveratrol, etc., may offer a promising strategy for treating cancer by targeting CSCs.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Alessandro Villa, Mariangela Garofalo, Daniela Crescenti, Nicoletta Rizzi, Electra Brunialti, Andrea Vingiani, Paolo Belotti, Carlo Sposito, Silvia Franze, Francesco Cilurzo, Giancarlo Pruneri, Camilla Recordati, Chiara Giudice, Alessia Giordano, Monica Tortoreto, Giangiacomo Beretta, Damiano Stefanello, Giacomo Manenti, Nadia Zaffaroni, Vincenzo Mazzaferro, Paolo Ciana
Summary: Research has shown that nano- and microsized extracellular vesicles (EVs) play a significant role in intercellular communication and can be used for targeted cancer therapy. By labeling EVs with indocyanine green (ICG) and tracking their distribution, it was found that nanoparticles with cancer tropism exist in the blood of colorectal cancer (CRC) patients. In mouse models, it was demonstrated that transplanted EVs were able to recognize tumors and deliver tumor-interfering molecules, indicating the therapeutic potential of autologous EVs for cancer treatment.
Review
Oncology
Kristina Andrijauskaite, Michael J. Wargovich
Summary: Breast cancer is a common cancer in women, and advancements in treatment have increased the number of surviving patients. However, the stress experienced by patients during diagnosis and treatment can affect their quality of life and disease outcome. This stress is often compared to post-traumatic stress disorder and may be related to chronic inflammation. Certain natural products in the diet may help alleviate symptoms and inflammation.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Chang Xu, Jinjie Chang, Yanhua Li, Kaiye Wang, Wei Pan, Hongyu Wang, Na Li, Bo Tang
Summary: This new active tumor-targeting organic photochemotherapy agent combines an organic photothermal material with a naproxen prodrug to precisely kill cancer cells and suppress inflammatory responses. In vitro and in vivo experiments have shown its low cytotoxicity and excellent tumor inhibitory effect.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Medicinal
Yang Li, Gaoxia Yang, Chengcan Yang, Pan Tang, Juncheng Chen, Jifa Zhang, Jie Liu, Liang Ouyang
Summary: Epigenetic modifications have been shown to regulate autophagy and the expression of tumor-associated genes, promoting tumor progression. Targeting autophagy with emerging epigenetic drugs is a promising therapeutic strategy for tumors.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Oncology
Zhenkun Fu, Zhoujun Lin, Mao Yang, Chenggang Li
Summary: Breast cancer is a common type of cancer, with surgery being the preferred treatment method. Various adjuvant therapies such as radiotherapy, chemotherapy, endocrine therapy, and targeted drug therapy can also be used.
FRONTIERS IN ONCOLOGY
(2022)
Article
Plant Sciences
Praveen Kumar, Rohit Sharma, Neha Garg
Summary: Dysregulated inflammatory responses play a significant role in cancer initiation and progression. Withania somnifera has been shown to inhibit cancer cell proliferation and reduce inflammation. However, the underlying molecular mechanisms of its anti-inflammatory effects in cancer need further investigation.
Article
Medicine, Research & Experimental
Yvonne H. W. Derks, Mark Rijpkema, Helene I. Amatdjais-Groenen, Annemarie Kip, Gerben M. Franssen, J. P. Michiel Sedelaar, Diederik M. Somford, Michiel Simons, Peter Laverman, Martin Gotthardt, Dennis W. P. M. Lowik, Susanne Luetje, Sandra Heskamp
Summary: A novel PSMA-targeting ligand was developed and optimized for multimodal image-guided prostate cancer surgery combined with targeted photodynamic therapy, showing increased uptake in PSMA-expressing tumors and specificity in human samples.
Review
Biochemistry & Molecular Biology
Tingting Liang, Lu Lu, Xueting Song, Jianguo Qi, Jianhong Wang
Summary: This article reviews the combinations of microtubule targeting agents (MTAs) with other anticancer drugs to overcome toxicities, resistance, and improve treatment efficacy for cancer. It provides helpful information for combination therapy based on MTAs.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Oncology
Zhilan Xiao, Shubhra Singh, Manisha Singh
Summary: IL-1 in tumors can induce immune suppression and resistance to immunotherapy, thus targeting the IL-1 pathway may enhance the efficacy of immunotherapy.
Article
Oncology
Carlota Castro-Espin, Catalina Bonet, Marta Crous-Bou, Verena Katzke, Charlotte Le Cornet, Franziska Jannasch, Matthias B. Schulze, Anja Olsen, Anne Tjonneland, Christina C. Dahm, Christian S. Antoniussen, Maria Jose Sanchez, Pilar Amiano, Maria Dolores Chirlaque, Marcela Guevara, Claudia Agnoli, Rosario Tumino, Carlotta Sacerdote, Maria Santucci De Magistris, Malin Sund, Stina Boden, Torill Enget Jensen, Karina Standahl Olsen, Guri Skeie, Marc J. Gunter, Sabina Rinaldi, Esther M. Gonzalez-Gil, Elisabete Weiderpass, Sofia Christakoudi, Alicia K. Heath, Laure Dossus, Antonio Agudo
Summary: This study aimed to investigate the relationship between pre-diagnostic dietary patterns related to inflammatory, insulin, and estrogenic pathways and breast cancer (BC) survival. The results showed that adherence to an anti-diabetic and anti-inflammatory diet was associated with lower overall mortality among BC survivors, while no significant association was found with the estrogen-related dietary pattern. Therefore, following these dietary patterns could potentially improve the prognosis of BC survivors.
BRITISH JOURNAL OF CANCER
(2023)
Article
Pharmacology & Pharmacy
Stav Brown, Joseph H. Dayan, Michelle Coriddi, Leslie McGrath, Raghu P. Kataru, Babak J. Mehrara
Summary: This retrospective study analyzed the efficacy of using doxycycline to treat breast cancer-related lymphedema. The results showed no significant improvements in limb volume or L-Dex scores, but patients reported significant improvements in quality of life measures. This suggests that doxycycline may have a role in improving quality of life for patients with breast cancer-related lymphedema, although further larger studies are needed.
FRONTIERS IN PHARMACOLOGY
(2022)