Article
Polymer Science
Zahra Fakhari, Saied Nouri Khorasani, Farzaneh Alihosseini, Mohamad Hossein Nasr Esfahani, Fereshteh Karamali, Shahla Khalili
Summary: In this research, biocompatible and biodegradable polymers PGS and POC were used to fabricate a core-shell structure, which showed increased fiber diameter, pore size, hydrophilicity, and degradation rate with the addition of POC. Mechanical testing and cell culture experiments indicated that the PGS/PCL-POC/PCL scaffold was suitable for retinal tissue engineering applications.
Article
Pharmacology & Pharmacy
Mohammad Foad Abazari, Shohreh Zare Karizi, Hadi Samadian, Navid Nasiri, Hassan Askari, Matin Asghari, Fateme Frootan, Hadi Bakhtiari, Hossein Mahboudi, Vahid Mansouri
Summary: This study demonstrated the potential application of fabricated PGS-PHB nanofibrous scaffold as a potential bone implant. Morphological study and cell experiments showed that the scaffold has a uniform surface and good biocompatibility. In the osteogenic differentiation process, the PGS-PHB scaffold exhibited promising supportive potential.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Engineering, Biomedical
Mengting Shi, Lang Bai, Meiguang Xu, Zhenlong Li, Tianli Hu, Juan Hu, Zixi Zhang, Zhanhai Yin, Baolin Guo
Summary: In this study, a micropatterned elastomer film that can simulate the mechanical properties, anisotropy, and electroactivity of natural myocardial tissues was developed. The film has sufficient mechanical strength, complies with the anisotropy of myocardium, and possesses conductivity and good cytocompatibility. In vivo experiments showed that the film with graphene can significantly promote myocardial function recovery. This electroactive micropatterned anisotropic elastomer film has potential applications in cardiac tissue engineering.
Article
Polymer Science
Shima Majidansari, Negin Vahedi, Mahmood Rekabgardan, Camellia Ganjoury, Najmeh Najmoddin, Mohammad Tabatabaei, Faraz Sigaroodi, Paniz Naraghi-Bagherpour, Seyed Amir Ali Taheri, Mohammad-Mehdi Khani
Summary: Cardiovascular diseases are a major cause of death worldwide, and tissue engineering offers promising strategies for their treatment. This study demonstrates that a nanofibrous scaffold produced through electrospinning can support and significantly promote endothelial differentiation of mesenchymal stem cells.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Polymer Science
Yi-Sheng Jiang, Ming-Hsien Hu, Jeng-Shiung Jan, Jin-Jia Hu
Summary: This study aimed to retard the degradation rate of Poly(glycerol sebacate) (PGS) by incorporating L-glutamic acid into its network. The results showed that the introduction of L-glutamic acid formed peptide bonds which led to altered mechanical properties and retarded degradation kinetics of the elastomer. It was found that PGSE displayed a lower degradation rate and different mechanical properties compared to PGS, making it a potential scaffold material for tissues with a low healing rate.
Article
Materials Science, Multidisciplinary
Mina Aleemardani, Louis Johnson, Michael Zivojin Trikic, Nicola Helen Green, Frederik Claeyssens
Summary: In this study, photocurable (PGS-co-PEG)-M copolymers were successfully prepared by methacrylation of PGS-co-PEG. The methacrylation process enhanced the mechanical strength of the copolymers while reducing their bioadhesive properties. These photocurable copolymers have great potential for biomedical applications.
MATERIALS TODAY ADVANCES
(2023)
Article
Engineering, Biomedical
Hooman Golbaten-Mofrad, Mohammad Hadi Salehi, Seyed Hassan Jafari, Vahabodin Goodarzi, Maliheh Entezari, Mehrdad Hashemi
Summary: This study systematically investigates the influence of nanoclay and graphene oxide on the thermal, mechanical, hydrophobic, and biological properties of poly(glycerol sebacate)/gelatin nanocomposites. The results show that the appropriate dispersion of nanofillers improves the properties of the composites, but has a slight effect on mechanical properties. Additionally, the presence of nanofillers positively affects the biological performance of the composites.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Engineering, Manufacturing
Mehdi Atari, Sheyda Labbaf, Shaghayegh Haghjooy Javanmard
Summary: Heart valve disease is a leading cause of cardiovascular complications and mortalities worldwide. This study successfully improves the durability and hemodynamic function of heart valves through the manufacturing strategy of a 3D biofunctional elastomeric biomimetic material. The crosslinked scaffold shows improved cellular response and hemo-compatibility.
JOURNAL OF MANUFACTURING PROCESSES
(2023)
Article
Chemistry, Multidisciplinary
Bruno Godinho, Rosana Nogueira, Nuno Gama, Artur Ferreira
Summary: In this study, poly-(glycerol-co-diacids) prepolymers were synthesized with different ratios of glycerol, sebacic acid, and succinic acid. The reaction time was found to be correlated with the ratio of diacids, with an increase in succinic acid leading to a decrease in reaction duration. Analysis using mass spectrometry and nuclear magnetic resonance revealed that the presence of succinic acid not only catalyzes the formation of poly-(glycerol)/ether bonds but also results in the growth of ester oligomers, the formation of cyclic structures, an increase in the number of oligomers detected, and a difference in mass distribution.
Article
Materials Science, Multidisciplinary
Ahmad Saudi, Seyed Mojtaba Zebarjad, Hamed Alipour, Elham Katoueizadeh, Aliakbar Alizadeh, Mohammad Rafienia
Summary: Nerve tissue engineering is a promising interdisciplinary strategy that combines life science and engineering to regenerate damaged nerves. In this study, aligned PCL/PGS fibers containing different weight percentages of multi-walled carbon nanotubes (MWCNTs) were fabricated using electrospinning. The effect of MWCNTs on the morphology and diameter of the fibers was investigated, and the physicochemical properties of the scaffolds were evaluated using various techniques. Cell viability and adhesion experiments confirmed the positive effect of MWCNTs on cell-scaffold interaction. The results suggest that PCL/PGS/MWCNTs scaffolds are a promising biodegradable biomaterial for nerve tissue engineering.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Review
Biotechnology & Applied Microbiology
Bruno Godinho, Nuno Gama, Artur Ferreira
Summary: Poly(glycerol sebacate) (PGS) is a biodegradable elastomer attracting attention in tissue engineering. New synthesis methods have been reported to reduce time and energy, and adjust properties for specific applications. This review compiles 20+ years of reports and proposes alternatives for faster production of PGS structures with desired properties.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Dongyong Sha, Zihan Wu, Jingjing Zhang, Yifan Ma, Zhaogang Yang, Yuan Yuan
Summary: In the past decade, PGS has gained significant attention in various biomedical fields due to its superior elasticity, biocompatibility, and biodegradability. To meet the increasing demands, different modification strategies and construction methods have been developed to expand the properties of PGS. Currently, PGS has been applied in areas such as hard tissue engineering, soft tissue engineering, drug delivery, and device design.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Engineering, Biomedical
Mahmood Rekabgardan, Mahya Rahmani, Masoud Soleimani, Simzar HosSein Zadeh, Reza Roozafzoon, Azim Parandakh, Mohammad-Mehdi Khani
Summary: A novel scaffold composed of poly(glycerol-sebacate) (PGS) and polyurethane (PU) was introduced in this study, showing mechanical competence, biocompatibility, and ability to support stem cell growth and differentiation. The scaffold demonstrated cell viability and proliferation in vitro, as well as supported endothelial differentiation of mesenchymal stem cells upon VEGF stimulation.
Review
Engineering, Biomedical
Lena Vogt, Florian Ruther, Sahar Salehi, Aldo R. Boccaccini
Summary: PGS is a promising material for biomedical applications due to its tunable properties through synthesis parameters and specific chemical modifications, allowing for a wide range of applications. Recent developments in PGS-based biomaterials have shown significant progress in tissue engineering, drug delivery, and wound healing.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Ruben Martin-Cabezuelo, Alicia Naderpour-Penalver, A. Sigen, Wenxin Wang, Guillermo Vilarino-Feltrer, Ana Valles-Lluch
Summary: Poly(glycerol sebacate) (PGS) is a hyperbranched polyester with tunable chemical and mechanical properties, along with biocompatibility and biodegradability. Understanding the synthesis parameters of PGS is crucial for controlling its synthesis and obtaining a scalable and reproducible final product. This study reveals the importance of hydroxyl affinity, water presence, and glycerol loss in determining the properties of the final PGS product.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Engineering, Biomedical
Xinyao Zhu, Yifan Liu, Jing Ye, Wei Xu, Xuexia Zhao, Tianyan Liu
Summary: This study reveals the adverse effect of acid on dentin in terms of degradation of its fracture toughness. The peritubular dentin plays a significant role in enhancing the dentin's fracture resistance capability. The findings highlight the importance of structural integrity for dentin.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Priya Ranganathan, Vijayakumari Sugumaran, Bargavi Purushothaman, Ajay Rakkesh Rajendran, Balakumar Subramanian
Summary: The study aims to design and fabricate an ultra-easier multi-functional biomedical polymeric scaffold loaded with unique equimolar Ca:P phasic bioactive glass material. The results showed that the G:BG (1:2) ratio is the more appropriate composition for enhanced bio-mineralization and higher surface area. The scaffold can induce mitogenesis in osteoblast cells for hard tissue regeneration and rapid collagen secretion in fibroblast cells for soft tissue regeneration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ziad Guerfi, Oum keltoum Kribaa, Hanane Djouama
Summary: Hydroxyapatite, a biocompatible and bioactive ceramic material, has been widely studied in fields such as orthopedics and plastic surgery. The use of computational tools, especially density functional theory, has become increasingly important in research. In this study, Hydroxyapatite was synthesized using the double decomposition method and quantum mechanical computations were performed using density functional theory. The experimental and computational results confirmed the successful synthesis of Hydroxyapatite and showed good agreement in spectroscopic characterizations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Sally AbdulHussain Kadhum, Nassier A. Nassir
Summary: In this research, porous composites were successfully prepared and reinforced for bone scaffold applications. The functional groups, pore structure, and composition distribution of the materials were characterized using techniques such as FTIR, Atomic Force Microscopy (AFM), and Scanning Electron Microscopy (SEM).
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Veronika Geiger, Felicitas Mayinger, Moritz Hoffmann, Marcel Reymus, Bogna Stawarczyk
Summary: The study investigated the mechanical properties of four additively manufactured denture base resins in different measurement environments, and found that the measurement environment impacts the strength and fracture toughness of the materials.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Junxiao Wang, Amatjan Sawut, Rena Simayi, Huijun Song, Xueying Jiao
Summary: The development of cost-effective and eco-friendly conductive hydrogels with excellent mechanical properties, self-healing capabilities, and non-toxicity is of great significance in the field of biosensors.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Yijun Zhou, Lisa Ho, Ayan Samanta, Philip Procter, Cecilia Persson
Summary: In this study, soft, non-setting biomaterials based on Hyalectin gels and different morphological parameters of hydroxyapatite (HA) particles were evaluated as potential augmentation materials for orthopaedic implant fixation. The results showed that constructs reinforced with irregularly shaped nano-HA particles and spherically shaped micro-HA particles had significantly higher pull-out force compared to the control group.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Mehdi Jahandardoost, Donald Ricci, Abbas S. Milani, Mohsen Jahandardoost, Dana Grecov
Summary: Tubular flow diverters are important for treating cerebral aneurysms. A new design called VR-eCLIPs has been developed to cover the neck of challenging bifurcation aneurysms. A finite element model has been used to simulate the implantation processes of VR-eCLIPs and assess potential plastic deformation.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marek Traczynski, Adam Patalas, Katarzyna Roslan, Marcin Suszynski, Rafa l Talar
Summary: This article evaluates the forces acting on intravenous needles during insertion into the skin and selects the most suitable model for future research. The experimental results show that needle size, insertion angle, and insertion speed have an influence on the measured force values.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chester Jar, Andrew Archibald, Monica Gibson, Lindsey Westover
Summary: This study evaluates the ASIST technique for assessing the stability of dental implants. The results show that the ASIST technique can reliably measure the interfacial stiffness of dental implants, which is not significantly influenced by different abutment types. This method may provide an improved non-invasive way to measure the stability of dental implants.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ali Kamali, Kaveh Laksari
Summary: In this paper, a UNet-based neural network model (El-UNet) is developed to infer the spatial distributions of mechanical parameters. The El-UNet shows superior performance in terms of accuracy and computational cost compared to other neural network models. A self-adaptive spatial loss weighting approach is proposed, which achieves the most accurate reconstructions in equal computation times.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chunyan Yu, Yanju Lu, Jinhui Pang, Lu Li
Summary: In this study, a safe and effective hemostatic composite sponge was developed by combining chitosan and hydroxypropylmethylcellulose (HPMC). The sponge exhibited excellent flexibility and rapid hemostatic ability in vitro. In vivo assessments showed that the sponge had the shortest clotting time and minimal blood loss.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Zhongliang Yu, Lin Yu, Junjie Liu
Summary: The study proposes incorporating functionally graded tablets into nacreous composites to enhance both stiffness and damping properties. Analytical formulae and numerical experiments demonstrate the effectiveness of this design, surpassing existing homogeneous composites in performance.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marc Graham, Sandra Klinge
Summary: This study investigates the macroscopic diffusion behavior of heterogeneous gels using a homogenization method in a finite element framework. Two materials, calcifying PDMA and PAAm, were studied, and the results show that the diffusivity of PDMA has a strong nonlinear dependence on the solute molecule radius.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Abdur-Rasheed Alao
Summary: This study aimed to find the optimal sandblasting parameters for roughening YTZP surfaces. Through experimental and statistical analysis, the best setting was found to be IA = 45 degrees, AP = 110 μm, ST = 20 s, and P = 400 kPa, which resulted in the maximum surface roughness, phase transformation, and shear bond strength.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)