期刊
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
卷 52, 期 4, 页码 327-330出版社
KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
DOI: 10.3839/jksabc.2009.058
关键词
anthracene; anthracene-9-carboxylic acid; antimicrobial activity; intestinal bacteria
The growth-inhibitory effects of anthracene were determined against intestinal bacteria, and compared with those of its derivatives for a better understanding of structure-activity relationships. The Growth inhibiting activity was shown to vary the chemical, dose, and bacterial strain tested. In tests with Clostridium perfringens, anthracence evidenced strong (+++) and moderate (++) growth inhibition at 1.0 and 0.25 mg/disc, respectively, but exhibited no growth inhibition effects against lactic-acid producing bacteria and E. coli. In our study of structure-activity relationships, anthracene-9-carboxylic acid evidenced strong (+++) and moderate (++) growth inhibition at 1.0 and 0.25 mg/disc, respectively, but anthracence-9-carboxaldehyde, anthrone, and 9-(hydroxymethyl)-anthracene exhibited no growth-inhibitory effects against six intestinal bacteria. In conclusion, the growth-inhibitory activities of anthracene and anthracene-9-carboxylic acid against C perfringens may be indicative of at least one of these pharmacological actions. Furthermore, anthracene and anthracene-9-carboxylic acid may prove useful as prospective therapeutics for the treatment of gastrointestinal diseases caused by C perfringens.
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