Article
Critical Care Medicine
Jonas Stenberg, Live Eikenes, Kent Goran Moen, Anne Vik, Asta K. Haberg, Toril Skandsen
Summary: This prospective cohort study investigated the associations between acute diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) metrics and persistent post-concussion symptoms (PPCS) 3 months after mild traumatic brain injury (mTBI). Patients who developed PPCS had poorer white matter microstructural integrity acutely after the injury, compared with patients who recovered and healthy controls. Differences became less pronounced when cognitive reserve was controlled for, suggesting that pre-existing individual differences in axonal integrity accounted for some of the observed differences.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Medicine, General & Internal
Sophie Richter, Stefan Winzeck, Evgenios N. Kornaropoulos, Tilak Das, Thijs Vande Vyvere, Jan Verheyden, Guy B. Williams, Marta M. Correia, David K. Menon, Virginia F. J. Newcombe
Summary: The study found that white matter injury is associated with symptoms after mild traumatic brain injury (mTBI), and performing imaging within 72 hours of injury can better predict clinical recovery. This could help in identifying high-risk patients for clinical follow-up or interventional trials.
Article
Radiology, Nuclear Medicine & Medical Imaging
Pedro F. Ferreira, Arjun Banerjee, Andrew D. Scott, Zohya Khalique, Guang Yang, Ramyah Rajakulasingam, Maria Dwornik, Ranil De Silva, Dudley J. Pennell, David N. Firmin, Sonia Nielles-Vallespin
Summary: In this study, a fitting-free deep learning approach was used to reconstruct diffusion tensors for in vivo cardiac diffusion tensor imaging (cDTI) and reduce scan time. The results showed that both the conventional linear-least-square (LLS) and U-Net methods with reduced datasets had some bias compared to the reference results. However, when considering direct pixel-wise errors, the U-Net model outperformed the LLS tensor fit for reduced datasets that can be acquired in three or just one breath-hold. Therefore, the trained U-Net is a promising approach to minimize the number of breath-holds needed in clinical cDTI studies.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Medicine, General & Internal
Sung-Ho Jang, Min-Jye Cho
Summary: This review paper discusses the application of diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) in the diagnosis of traumatic axonal injury (TAI) in individuals with concussion or mild traumatic brain injury (mTBI). While several hundred DTI-based studies have reported TAI in concussion or mTBI, there are fewer case studies focusing on individual patients. The summary of these studies suggests that DTI can be used as a non-invasive tool for determining the presence and severity of TAI in individual patients with concussion or mTBI. However, certain conditions need to be met for an accurate diagnosis, and further studies are required to improve the precision of TAI diagnosis in individual patients.
Article
Clinical Neurology
Angelica C. Gonzalez, Minseon Kim, Zafer Keser, Lamya Ibrahim, Sonia K. Singh, Mohammed J. Ahmad, Omar Hasan, Arash Kamali, Khader M. Hasan, Paul E. Schulz
Summary: This study found a correlation between DTI variables and MoCA scores in patients with a history of concussion and persistent cognitive impairment. Specifically, MD and FA values in certain brain regions were closely related to MoCA scores.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Erhard Trillingsgaard Naess-Schmidt, Jakob Udby Blicher, Mille Moller Thastum, Charlotte Ulrikka Rask, Susanne Wulff Svendsen, Andreas Schroder, Astrid Hogh Tuborgh, Leif ostergaard, Ryan Sangill, Torben Lund, Sune Norhoj Jespersen, Asger Roer Pedersen, Brian Hansen, Simon Fristed Eskildsen, Jorgen Feldbaek Nielsen
Summary: A recent study found that a novel behavioral intervention is more effective in reducing symptoms in young patients with long-term post-concussion symptoms compared to enhanced usual care. However, diffusion-weighted MRI indices responded differently to the interventions, and their correlation with the improvement of post-concussion symptoms remains unclear.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Critical Care Medicine
Jonas Stenberg, Toril Skandsen, Kent Goran Moen, Anne Vik, Live Eikenes, Asta K. Haberg
Summary: This prospective cohort study aimed to characterize diffusion changes in white matter the first year after mild traumatic brain injury (MTBI). The results showed that there were significant differences in white matter diffusion between MTBI patients and controls at 72 h, 3 months, and 12 months. These findings suggest that there are differences in white matter integrity between MTBI patients and healthy individuals.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Neurosciences
E. R. Sabidussi, S. Klein, B. Jeurissen, D. H. J. Poot
Summary: Diffusion weighted MRI is essential for patient screening and diagnosis. However, current deep learning methods for quantifying diffusion parameters lack generalization, requiring retraining for each new scan. In this study, we propose dtiRIM, a deep learning method for Diffusion Tensor Imaging with superior generalization due to its ability to solve inverse problems and promote data consistency using the diffusion tensor model. Results show that dtiRIM produces high-quality tensor estimates, comparable or better than existing methods, with low dependency on tissue properties and scanning parameters. Furthermore, a single dtiRIM model can be used for diverse datasets without significant loss in quality, making it a groundbreaking solution for DTI analysis.
Article
Medicine, General & Internal
Jing Yan, Yuanshen Zhaoc, Yinsheng Chend, Weiwei Wangb, Wenchao Duanf, Li Wange, Shenghai Zhangc, Tianqing Dingc, Lei Liuc, Qiuchang Sunc, Dongling Peif, Yunbo Zhanf, Haibiao Zhaof, Tao Sunf, Chen Sunf, Wenqing Wangf, Zhen Liuf, Xuanke Hongf, Xiangxiang Wangf, Yu Guof, Wencai Li, Jingliang Chenga, Xianzhi Liuf, Xiaofei Lvg, Zhi-Cheng Li, Zhenyu Zhangb
Summary: A deep learning signature (DLS) from diffusion tensor imaging (DTI) was developed for predicting overall survival in patients with infiltrative gliomas, with five key biological pathways identified. The DLS was associated with survival, independent predictor, and improved survival prediction when incorporated into existing risk system. Therapies targeting neuron-to-brain tumor synaptic communication may be more effective in high-risk glioma defined by DTI-derived DLS.
Article
Engineering, Biomedical
Mehdi Sadighi, Mert Sisman, Berk C. Acikgoz, Hasan H. Eroglu, B. Murat Eyuboglu
Summary: DT-MREIT is an imaging modality based on diffusion tensor imaging and MREIT techniques, allowing for the reconstruction of low-frequency anisotropic conductivity distribution. A novel reconstruction algorithm is proposed in this study to reconstruct conductivity tensor images using a single current injection, increasing clinical applicability. The method is evaluated using simulated measurements and physical experiments, demonstrating successful reconstruction of anisotropic conductivity distribution.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Critical Care Medicine
Stephanie Turner, Rachel Lazarus, Donald Marion, Keith L. Main
Summary: In the past 20 years, new technologies have significantly improved the diagnosis and prognosis of traumatic brain injury (TBI). Researchers are now focusing on identifying biomarkers to detect and monitor the condition, with particular attention on advancements in biomolecular and neuroimaging domains. Integration of these technologies could lead to improved disease prognostication and patient care.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Critical Care Medicine
Briana Lees, Nicola E. Earls, Susanne Meares, Jennifer Batchelor, Vincent Oxenham, Caroline D. Rae, Lauriane Juge, Lucette A. Cysique
Summary: This systematic review examined DTI-WM changes post-SRC and found widespread moderate-to-large differences in white matter, which remained stable in the chronic stage. These differences were commonly associated with SRC symptom severity.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Neurosciences
Olivier Brown, Katherine Healey, Zhuo Fang, Roger Zemek, Andra Smith, Andree-Anne Ledoux
Summary: This study explored the relationship between psychological resilience and white matter microstructure in pediatric concussion. The researchers found that there was a correlation between resilience at 72 hours post-injury and certain measures of white matter integrity. These findings suggest that resilience may play a role in the acute phase of concussion and should be considered in concussion research.
HUMAN BRAIN MAPPING
(2023)
Review
Health Care Sciences & Services
Sung Ho Jang, Dong Hyun Byun
Summary: This study reviewed traumatic axonal injury (TAI) in patients with concussion. DTI provides valuable data for the diagnosis of TAI in patients with concussion, but further research is needed to find a diagnostic method that does not require a brain biopsy for live confirmation of TAI.
Article
Neurosciences
Zilong Wang, Fangzhan Guan, Wenchao Duan, Yu Guo, Dongling Pei, Yuning Qiu, Minkai Wang, Aoqi Xing, Zhongyi Liu, Bin Yu, Hongwei Zheng, Xianzhi Liu, Dongming Yan, Yuchen Ji, Jingliang Cheng, Jing Yan, Zhenyu Zhang
Summary: This study investigates the prognostic value of hand-crafted radiomic features derived from DTI in IDH wild-type GBM, and the biological interpretation of individual DTI radiomic features and metrics. The DTI-based radiomic signature is an independent prognostic factor. Incorporating the radiomic signature into a clinical model improves survival prediction and reveals the involvement of distinct pathways in GBM.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)