Article
Clinical Neurology
Patrick Oeckl, Sarah Anderl-Straub, Christine A. F. Von Arnim, Ines Baldeiras, Janine Diehl-Schmid, Timo Grimmer, Steffen Halbgebauer, Anna M. Kort, Marisa Lima, Taina M. Marques, Marion Ortner, Isabel Santana, Petra Steinacker, Marcel M. Verbeek, Alexander E. Volk, Albert C. Ludolph, Markus Otto
Summary: This study reveals differences in serum levels of GFAP in AD and bvFTD, showing an early increase in MCI-AD and superior diagnostic performance for AD compared to NfL.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Health Care Sciences & Services
Cheng-Li Liu, Che-Jen Chuang, Chin-Mei Chou
Summary: Mild cognitive impairment (MCI) refers to the decline in brain function between normal aging and the AD stage. This study developed a MCI assessment system using 3D virtual reality and fuzzy logic control technology, which showed a high correlation with traditional screening tests. The assessment system received positive feedback and provided an integrated reference score for clinic workers.
Article
Clinical Neurology
Daniele Altomare, Sara Stampacchia, Federica Ribaldi, Szymon Tomczyk, Claire Chevalier, Geraldine Poulain, Saina Asadi, Bianca Bancila, Moira Marizzoni, Marta Martins, Aurelien Lathuiliere, Max Scheffler, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Ilse Kern, Miguel Frias, Valentina Garibotto, Giovanni B. Frisoni
Summary: This study aimed to confirm the correlations between plasma and traditional Alzheimer's disease (AD) biomarkers, assess the diagnostic accuracy of plasma biomarkers compared to traditional biomarkers, and estimate the potential savings in traditional exams by using plasma biomarkers. The results showed significant correlations between plasma biomarkers and traditional biomarkers, and high accuracy in discriminating biomarker status. The implementation of plasma biomarkers could save a significant proportion of expensive traditional exams, making the diagnostic workup more cost-effective and improving patient care.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Stephanie Perin, Janice Lai, Matthew Pase, Lisa Bransby, Rachel Buckley, Nawaf Yassi, Robert H. Pietrzak, Paul Maruff, Yen Ying Lim
Summary: Depressive and anxiety symptoms in midlife are associated with cognitive decline, particularly anxiety symptoms are significantly correlated with attention and memory deficits. Clinically meaningful anxiety or depressive symptoms are linked to increased subjective cognitive concerns, with a more pronounced effect when both anxiety and depressive symptoms are present.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemical Research Methods
Manikandan Selvaraj, Karthik Sadasivam, Muralidharan Jothimani, Karthikeyan Muthusamy
Summary: Alzheimer's Disease (AD), the most common and major disability issue in our society, has a substantial economic impact. Despite substantial advances in aetiology, diagnosis, and therapy, the fundamental causes of the disease remain unknown, accurate biomarkers are not well characterized, and current pharmaceutical medications are not cost-effective.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Article
Geriatrics & Gerontology
Christine W. Lary, Samuel Ghatan, Meghan Gerety, Alexandra Hinton, Archana Nagarajan, Clifford Rosen, Ryan D. Ross, David A. Bennett, Anita L. Destefano, Mohammad A. Ikram, Fernando Rivadeneira, Douglas P. Kiel, Sudha Seshadri, Alexa Beiser
Summary: This study found that baseline bone mineral density (BMD) is associated with incident dementia, while prior bone loss is not.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Editorial Material
Neurosciences
David G. Loughrey, Iracema Leroi
Summary: Recent epidemiological research has found a link between a decline in multiple sensory functions and an increased risk of dementia. However, the exact pathways connecting these factors with neurodegenerative disorders are still unclear. Studying this area is important for guiding the allocation of public health resources and the development of clinical trials aimed at delaying or preventing dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Xulin Liu, Maria-Eleni Dounavi, Karen Ritchie, Katie Wells, Craig W. Ritchie, Li Su, Graciela Muniz-Terrera, John T. O'Brien
Summary: This study revealed accelerated gray matter atrophy in several AD signature cortical regions in the middle-aged population with high CAIDE scores.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Tom Ala, Danah Bakir, Srishti Goel, Nida Feller, Albert Botchway, Cindy Womack
Summary: This study aims to improve the ability to differentiate between AD and DLB by studying MMSE scores and including other dementia patients for perspective. The results suggest that the equation P minus M can effectively distinguish between AD and DLB, and it can also differentiate AD from Parkinson's disease dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Health Care Sciences & Services
Shirlene Vianna Moreira, Francis Ricardo dos Reis Justi, Carlos Falcao de Azevedo Gomes, Marcos Moreira
Summary: This study suggests that a music therapy intervention can be promising for improving episodic memory in older adults, especially those with dementia.
Article
Neurosciences
Jasmine Carcamo, Anton J. Kociolek, Kayri K. Fernandez, Yian Gu, Carolyn W. Zhu, Yaakov Stern, Stephanie Cosentino
Summary: This study assessed the predictive value of neuropsychological tests for severe dependency in Alzheimer's disease. Findings indicated that higher semantic processing and memory test scores at baseline were associated with lower risk of severe dependency. This suggests that the integrity of semantic processing and memory abilities in dementia can predict time to severe functional dependency.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Hui Wen Meng, Ji-Hyun Kim, Hyun Young Kim, Ah Young Lee, Eun Ju Cho
Summary: This study found that paeoniflorin has protective effects against memory loss and cognitive decline in lipopolysaccharide-induced mice. Behavioral tests confirmed the alleviation of neurobehavioral dysfunction by paeoniflorin. Paeoniflorin also inhibited the amyloidogenic pathway-related proteins expression, suggesting its potential in preventing neuroinflammation related to Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Mehmet Bostanciklioglu
Summary: Studies suggest that memory performance in dementia patients near death unexpectedly improves due to fluctuations in neuromodulators. The new lucidity hypothesis proposes that significant changes in neurotransmitter release around death trigger episodes of lucidity in demented individuals.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Juan Carlos Cejudo, Melissa Samaniego, Marta Almeria, Susana Castrillo, Lidia Medina, Domenec Gil
Summary: This study aimed to create, validate, and normalize a new test called the Ikos test for assessing semantic memory (SM) in Alzheimer's disease (AD) and early AD. The test showed high correlation indexes and met the criteria of validity and reliability. It can be considered a valid and reliable tool for SM assessment in diagnosing AD and the early stages of clinical disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Laura Ferre-Gonzalez, Carmen Pena-Bautista, Miguel Baquero, Consuelo Chafer-Pericas
Summary: The prevalence of Alzheimer's disease (AD) and other dementias is increasing in the older population, and there is a need for affordable and non-invasive biomarkers for early diagnosis. This study found that peroxidation by-products derived from the oxidation of brain lipids could be potential biomarkers for AD, as they are involved in inflammation, neurotoxicity, and cell death mechanisms in AD pathology. Analysis of these lipid peroxidation compounds in plasma samples showed significant differences between different groups, indicating their potential diagnostic value. Additionally, certain compounds and total parameters showed prognostic value for AD disease progression. These findings suggest that lipid peroxidation compounds could be promising biomarkers for differential diagnosis and prognosis of AD.
Article
Clinical Neurology
Sarah P. Coundouris, Julie D. Henry, Peter G. Rendell, Alexander C. Lehn
Summary: This study provides the first examination of the impairments in episodic foresight in individuals with Parkinson's disease. The findings suggest that the ability to initiate and apply episodic foresight is compromised in Parkinson's disease, independent of other cognitive measures and clinical characteristics. Understanding the reasons behind these difficulties and their impact on real-life functional capacity is crucial.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Geriatrics & Gerontology
Julie D. Henry, Sarah P. Coundouris, Jessica Mead, Brielle Thompson, Ruth E. Hubbard, Sarah A. Grainger
Summary: This study examines the relationship between social cognitive difficulties and social frailty, as well as the correlation between social frailty and psychological well-being. The findings show that social cognitive difficulties and social behavior can predict increased social frailty, with social behavior being the only significant predictor. Furthermore, social frailty is also associated with various aspects of psychological well-being, with significant effects on demoralization, resilience, and life satisfaction even after adjusting for covariates.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Psychology, Clinical
Sarah A. Grainger, Kate T. McKay, Julia C. Riches, Russell J. Chander, Rhiagh Cleary, Karen A. Mather, Nicole A. Kochan, Perminder S. Sachdev, Julie D. Henry
Summary: This study compared three assessment methods for cognitive and affective empathy and found that there was a lack of convergence among the assessment methods for cognitive empathy. In contrast, self-report was significantly associated with both behavioral and informant-report assessments for affective empathy. However, both cognitive and affective empathy measures showed poor discriminant validity. Only informant-report measures consistently correlated with social functioning.
Article
Psychology, Clinical
Sarah P. Coundouris, Courtney von Hippel, Alexander C. Lehn, Julie D. Henry
Summary: This study found that younger age and greater communication difficulties make people with Parkinson's disease more susceptible to stereotype threat, and higher stereotype threat is associated with increased emotional distress. These findings are important for understanding the factors and consequences of stereotype threat in Parkinson's disease.
BRITISH JOURNAL OF CLINICAL PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Thanwarat Chantanachai, Daina L. Sturnieks, Stephen R. Lord, Jasmine Menant, Kim Delbaere, Perminder S. Sachdev, Henry Brodaty, Peter Humburg, Morag E. Taylor
Summary: This study examined longitudinal changes in cognitive and physical function, as well as the associations between these changes and falls in people with and without mild cognitive impairment (MCI). The results showed that the MCI and cognitively fluctuating groups experienced declines in cognitive function, while the cognitively normal group did not. The MCI group had worse physical function at baseline but similar decline over time compared to other groups. Decline in global cognitive function and sensorimotor performance were associated with multiple falls in the cognitively normal group, and decline in mobility was associated with falls in the entire sample. Therefore, exercise should be recommended for maintaining physical function in older adults, and interventions aimed at mitigating cognitive decline should be encouraged for people with MCI.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Psychology, Clinical
Shafi Kalam, Katya Numbers, Darren M. Lipnicki, Ben C. P. Lam, Henry Brodaty, Simone Reppermund
Summary: This study investigated the associations between olfactory dysfunction and depression with dementia risk in older adults. The results showed that both factors independently predicted incident dementia over 12 years, and using both olfactory function testing and depression screening improved the ability to predict dementia.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Clinical Neurology
Cailen J. Calkin, Katya Numbers, Henry Brodaty, Perminder S. Sachdev, Oleg N. Medvedev
Summary: This study examined the psychometric properties of the K-10 scale in older populations using Rasch methodology. After minor modifications, the K-10 demonstrated good measurement properties and allowed for the transformation of raw scores into interval-level data, increasing its reliability.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Heidi J. Welberry, Tiffany Chau, Megan Heffernan, Juan Carlo San Jose, Louisa R. Jorm, Maria Fiatarone Singh, Perminder S. Sachdev, Kaarin J. Anstey, Nicola T. Lautenschlager, Michael Valenzuela, John J. McNeil, Henry Brodaty
Summary: The MYB trial aims to prevent cognitive decline and dementia through multidomain, web-based risk-reduction interventions. A study was conducted to explore the characteristics associated with participation in this trial. The results showed that higher educational attainment and lower self-rated quality of life were related to increased and reduced participation, respectively. Family history of Alzheimer's disease was related to increased participation, while other dementia risk factors were associated with reduced participation.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Morgan Elliott, Gill Terrett, H. Valerie Curran, Peter G. Rendell, Julie D. Henry
Summary: Alcohol intoxication impairs the generation of phenomenological characteristics of future events and the execution of directed preparatory behaviours. This study aimed to test how alcohol intoxication influences the functional application of episodic foresight and investigate if these difficulties are related to problems in retrospective memory and executive control. Results showed that alcohol consumption impaired episodic foresight, which was associated with poorer retrospective memory but not executive control. The findings suggest that even moderate intoxication affects the ability to use episodic foresight in a functionally adaptive way.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Catherine A. Browning, Claire L. Thompson, Nicole A. Kochan, Henry Brodaty, Perminder S. Sachdev, Julie D. Henry
Summary: This study examined whether prospective memory (PM) could serve as an early cognitive marker of future cognitive decline and incident dementia. The results showed that decreased PM accuracy and missed PM responses were associated with cognitive decline over 8 years and risk of incident dementia over 4 years. The effects remained significant even after controlling for baseline cognition and were strongest for event-based and regular PM tasks. These findings suggest that PM tasks could be useful in clinical assessments.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Gerontology
Issra Allam, Meredith Gresham, Lyn Phillipson, Henry Brodaty, Lee-Fay Low
Summary: This study aims to understand the perceptions of dementia symptoms, help-seeking and support in the Australian Arabic-speaking community. By conducting qualitative interviews, seven themes were identified. Dementia was described as confusion and memory loss symptoms. Barriers to help-seeking and support included cultural norms, lack of knowledge on where to seek help, and fear of community judgement. Building trust through culturally appropriate support and educating the community are two ways to facilitate help-seeking and support.
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2023)
Article
Rehabilitation
Jacky Zheng, Meredith Gresham, Lyn Phillipson, Danika Hall, Yun-Hee Jeon, Henry Brodaty, Lee-Fay Low
Summary: This study examines the usability, usefulness, and user experience of the Forward with Dementia website for individuals with dementia and family caregivers. It also identifies strategies to improve web design for this population. The website was tested by 12 participants, and data collection involved observations, interviews, and questionnaires. Findings suggest that simplifying functions, streamlining navigation, and decluttering page layouts were effective strategies to improve the website's usability and user experience. The study highlights the importance of dementia-related websites in providing information and assistance to individuals managing dementia.
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
(2023)
Article
Psychology, Developmental
Princess Neila Litkouhi, Katya Numbers, Michael Valenzuela, John D. Crawford, Ben C. P. Lam, Princess Noosha Litkouhi, Perminder S. Sachdev, Nicole A. Kochan, Henry Brodaty
Summary: Cognitive, social, and physical activities, especially during young adulthood, are associated with better late-life cognitive outcomes. Formal education plays a significant role in the relationship between young adulthood cognitive activity and late-life global cognition.
AGING NEUROPSYCHOLOGY AND COGNITION
(2023)
Article
Gerontology
Leona Kosowicz, Kham Van Tran, Henry Brodaty, Elizabeth Roughead, Adrian Esterman, Ladson Hinton, Giang Bao Kim, Susan Kurrle, Thu Ha Dang, Maria Crotty, Andrew Gilbert, Esther Tan, Tuan Anh Nguyen
Summary: This study assessed Vietnam's dementia service delivery and found that the workforce lacks sufficient skills to address the needs of people with dementia. There is a lack of dementia-specific services, and diagnosis and treatment services are mainly available in hospitals and metropolitan areas. Home-based care is provided by family carers without dementia care training and there is no active dementia prevention or public awareness campaign.
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2023)
Review
Public, Environmental & Occupational Health
Lee-Fay Low, Tanya J. Duckworth, Lauren King, Meredith Gresham, Lyn Phillipson, Yun-Hee Jeon, Henry Brodaty
Summary: People with dementia and their care partners lack support and information, and are often excluded from decision-making. The literature on care planning for community-dwelling people with dementia is scarce, and there is limited evidence that care planning alone improves outcomes.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2023)