Article
Geriatrics & Gerontology
Woori Moon, Ji Won Han, Jong Bin Bae, Seung Wan Suh, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim
Summary: This study investigated the disease burden of various dementias and mild cognitive impairment in a representative South Korean population, predicting a significant increase in disability-adjusted life-years and years lived with disability due to these conditions by 2065.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Article
Neurosciences
Anna E. Bruus, Gunhild Waldemar, Asmus Vogel
Summary: Autobiographical memory may be impaired in the early stages of Alzheimer's disease, even when standardized tests show no decline, suggesting that subjective cognitive decline may be an indicator of early AD-related memory deficits.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Deepika Dinesh, Qing Shao, Madhuri Palnati, Sarah McDannold, Quanwu Zhang, Amir Abbas Tahami Monfared, Guneet K. Jasuja, Heather Davila, Weiming Xia, Lauren R. Moo, Donald R. Miller, Natalia Palacios
Summary: Based on electronic health records data, a study found that US veterans have a unique dementia risk profile that may be changing over time. From 2000 to 2019, the incidence and prevalence of Alzheimer's disease (AD) and related dementias (ADRD) decreased, while ADRD prevalence increased primarily due to an increase in dementia not otherwise specified. The prevalence and incidence of mild cognitive impairment (MCI) sharply increased, especially after 2010. The highest prevalence and incidence of AD, ADRD, and MCI were observed in the oldest veterans, female veterans, and African American and Hispanic veterans.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Andrea M. Weinstein, Swathi Gujral, Meryl A. Butters, Christopher R. Bowie, Corinne E. Fischer, Alastair J. Flint, Nathan Herrmann, James L. Kennedy, Linda Mah, Shima Ovaysikia, Bruce G. Pollock, Tarek K. Rajji, Benoit H. Mulsant
Summary: This study compared diagnostic rates and clinical predictors between NIA-AA criteria and DSM-5 criteria, finding that discrepancies were more likely in individuals with a history of MDD or carrying at least one ApoE4 allele. Detailed neuropsychological testing and NIA-AA criteria identified a greater prevalence of cognitive impairment compared to DSM-5 criteria and the Montreal Cognitive Assessment.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Neurosciences
Jasmin E. Guevara, Natalie E. Kurniadi, Kevin Duff
Summary: This study quantifies cognitive change in patients with mild cognitive impairment (MCI) using standardized regression-based (SRB) z-scores. The findings show a significant decline in cognitive function over time, especially in learning and memory. Patients who progressed to dementia (MCI-Decline) showed more decline compared to those who remained stable (MCI-Stable). The study highlights the value of SRB in quantifying cognitive decline and identifying individuals at higher risk for MCI progression.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Marco Filardi, Roberta Barone, Giulia Bramato, Salvatore Nigro, Benedetta Tafuri, Maria Elisa Frisullo, Chiara Zecca, Rosanna Tortelli, Giancarlo Logroscino
Summary: This study investigated the relationship between muscle strength and cognition in patients with AD and mild cognitive impairment (MCI). It found that handgrip strength was associated with overall cognitive functioning, attentional, and memory performance in MCI and AD dementia, suggesting that it could potentially be a simple method to monitor functional and cognitive decline in these patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Egle Audronyte, Vaiva Sutnikiene, Gyte Pakulaite-Kazliene, Gintaras Kaubrys
Summary: This study investigated olfactory memory and its relationship with verbal memory and other clinical features in patients with early-stage Alzheimer's disease (AD). The results showed that olfactory memory was significantly impaired in patients with AD compared to individuals with mild cognitive impairment due to AD and cognitively normal older participants. Furthermore, the duration of AD symptoms was a strong predictor of olfactory recognition memory scores.
FRONTIERS IN NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Sunee Bovonsunthonchai, Roongtiwa Vachalathiti, Vimonwan Hiengkaew, Mon S. Bryant, Jim Richards, Vorapun Senanarong
Summary: This study found that spatiotemporal gait variables can effectively differentiate between dementia and cognitively intact groups. This suggests that gait could potentially be used as a clinical marker for diagnosing cognitive problems.
Review
Biochemistry & Molecular Biology
Kyoungjoo Cho
Summary: Cognitive impairment is a serious condition associated with aging and disruption of inflammation and innate immunity. Recent studies have shown that the innate immune system is prevalent in patients with Alzheimer's disease, and peripheral neutrophil markers can predict a decline in cognitive function in patients with mild cognitive impairment. Furthermore, altered levels of pro-inflammatory interleukins have been reported in patients with mild cognitive impairment, potentially playing a role in the progression from early cognitive impairment to dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
John Preetham Kumar Gurja, Suriya Prakash Muthukrishnan, Manjari Tripathi, Nalin Mehta, Ratna Sharma
Summary: This study aimed to identify a biomarker for classifying mild cognitive impairment (MCI) and Alzheimer's disease (AD) using multi-domain cognitive testing. The results showed that global cognitive tools were less specific in differentiating MCI from the control group, while tasks involving picture and word memory had high sensitivity and specificity. Therefore, the researchers suggested including these tasks in the existing diagnostic protocol.
Article
Clinical Neurology
Pavel Katsel, Peter Fam, Weilun Tan, Sonia Khan, Miguel Gama-Sosa, Rita De Gasperi, Panos Roussos, Ari Robinson, Itzik Cooper, Michal Schnaider-Beeri, Vahram Haroutunian
Summary: The study found that subsets of vascular genes related to early response to hypoxia were upregulated in MCI patients before the accumulation of AD neuropathology, suggesting that cerebrovascular remodeling is an important antecedent to the development of dementia and a component of the homeostatic response to reduced oxygen tension in aging prior to the onset of AD. The early activation of pro-angiogenic hypoxia-inducible factor signaling in response to mild hypoxia was also detected in mouse brains similar to those that were altered in MCI. Protracted responses to hypoxia were characterized by activation of phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt)-the mammalian target of rapamycin (mTOR) pathways in brain microvessel isolates.
ALZHEIMERS & DEMENTIA
(2022)
Article
Geriatrics & Gerontology
Yotam Lavy, Tzvi Dwolatzky, Zeev Kaplan, Jonathan Guez, Doron Todder
Summary: The study found that using an EEG-based neurofeedback system can significantly improve memory performance in patients with mild cognitive impairment (MCI), with this improvement lasting for at least one month.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Kym McNicholas, Maxime Francois, Jian-Wei Liu, James D. Doecke, Jane Hecker, Jeff Faunt, John Maddison, Sally Johns, Tara L. Pukala, Robert A. Rush, Wayne R. Leifert
Summary: This study identified biomarkers in saliva that can be used for early detection of cognitive impairment and Alzheimer's disease. The findings suggest that combinations of specific proteins can effectively distinguish patients with cognitive impairment and Alzheimer's disease from cognitively normal individuals.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Psychology, Clinical
Erin Trifilio, Jared J. Tanner, London Butterfield, Paul Mangal, Jacqueline E. Maye, Michael Marsiske, Catherine C. Price, Dawn Bowers
CLINICAL NEUROPSYCHOLOGIST
(2020)
Article
Anesthesiology
Bailey W. Frei, Kristen T. Woodward, Mitchell Y. Zhang, Shawna Amini, Patrick Tighe, Cynthia W. Garvan, Chris Giordano, Catherine C. Price
ANESTHESIA AND ANALGESIA
(2019)
Article
Clinical Neurology
Sarah Tomaszewski Farias, Jason Gravano, Alyssa Weakley, Maureen Schmitter-Edgecombe, Danielle Harvey, Dan Mungas, Michelle Chan, Tania Giovannetti
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2020)
Article
Clinical Neurology
Katherine Hackett, Rachel Mis, Deborah A. G. Drabick, Tania Giovannetti
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2020)
Article
Neurosciences
Katherine Hackett, Sarah Lehman, Ross Divers, Matthew Ambrogi, Likhon Gomes, Chiu C. Tan, Tania Giovannetti
Summary: This pilot study examined the feasibility and efficacy of the smartphone-based reminder application SmartPrompt in reducing functional disability in older adults with cognitive difficulties. The results showed promise for the use of SmartPrompt in at-home contexts.
NEUROPSYCHOLOGICAL REHABILITATION
(2022)
Article
Psychology, Clinical
Tania Giovannetti, Rachel Mis, Katherine Hackett, Stephanie M. Simone, Molly B. Ungrady
Summary: This review summarizes the relatively small body of neuropsychological and cognitive research conducted over the past 100 years focusing on theoretical models explaining the neurocognitive processes supporting everyday functioning and the breakdown of functional abilities in the face of neurological damage or disease. The goal-control model integrates the most recent empirical findings in neuropsychology with mechanisms proposed by cognitive models, providing empirically supported solutions for understanding and predicting functioning in the real world. This new model generates testable predictions for future research and provides guidance for clinical assessment and interventions.
Article
Geriatrics & Gerontology
Emma Rhodes, Tania Giovannetti
Summary: The study revealed that grit remains stable throughout older adulthood and is positively associated with successful aging. Consistency of interests plays an adaptive role in all facets of successful aging, while perseverance of effort may have a circumscribed positive effect on physical and emotional well-being in older adults.
AGING & MENTAL HEALTH
(2022)
Article
Geriatrics & Gerontology
Katherine Hackett, Steven R. Sabat, Tania Giovannetti
Summary: This article critically reviews the effectiveness of music-based interventions for people with dementia, highlighting the lack of conclusive evidence and proposing a person-centered framework integrating precision-medicine methodology. The aim is to inform precise and tailored interventions that will bring clarity to this growing body of research and to foster a more humane, person-centered approach to care culture.
AGING & MENTAL HEALTH
(2022)
Article
Psychology, Experimental
Rachel Mis, Tania Giovannetti
Summary: The loss of daily living skills is a defining characteristic of dementia, while even healthy older adults may experience subtle functional difficulties compared to younger adults. These difficulties are associated with negative outcomes and there is a lack of theoretically motivated interventions for everyday functioning issues.
TOPICS IN COGNITIVE SCIENCE
(2022)
Review
Clinical Neurology
Catherine C. Price
Summary: This article discusses the importance of preoperative cognitive assessment and perioperative cognitive medicine for older adults at risk for Alzheimer's disease and related dementias. It highlights the need for medical professionals in perioperative settings to receive training in cognitive-behavioral principles and understanding of neurodegenerative diseases of aging to provide appropriate care for these patients undergoing anesthesia.
Article
Neurosciences
Dominic S. Fareri, Katherine Hackett, Lindsey J. Tepfer, Victoria Kelly, Nicole Henninger, Crystal Reeck, Tania Giovannetti, David Smith
Summary: Social relationships change across the lifespan, with social networks narrowing and motivational priorities shifting. Aging is associated with changes in executive function, including decision-making abilities. By studying an economic trust game, researchers found age-related differences in brain responses and connectivity during reciprocal trust, indicating that older adults may exhibit diminished striatal responses to social closeness compared to younger adults. These findings enhance our understanding of age-related differences in sensitivity to social closeness.
Article
Psychology, Clinical
Molly B. Tassoni, Deborah A. G. Drabick, Tania Giovannetti
Summary: This study aimed to investigate the influence of contextual factors on self-reports of cognitive abilities. The results showed that age, daily busyness, and daily routines were significant predictors of the frequency of self-reported memory failures. Younger individuals and those with busier and less routine activities reported more frequent memory failures. Additionally, the COVID-19 pandemic had an impact on self-reported memory failures.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Psychology, Clinical
Stephanie M. Simone, Catherine C. Price, Thomas F. Floyd, Molly Fanning, Steven R. Messe, Deborah A. G. Drabick, Tania Giovannetti
Summary: This study aimed to investigate whether preoperative cognitive measures predicted postoperative clinical stroke/TIA and mortality in older adults undergoing SAVR, and to identify the best predictors within a comprehensive cognitive protocol. The findings showed that preoperative cognitive measures reflecting temporal and parietal lobe functions predicted postoperative clinical stroke/TIA within 1 week of surgery and mortality within 1 year of surgery.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2022)
Article
Psychology, Developmental
Ross Divers, Lillian Ham, Anastasia Matchanova, Katherine Hackett, Rachel Mis, Kia Howard, Sarah Seligman Rycroft, Emily Roll, Tania Giovannetti
Summary: The study found that micro-errors in older adults during everyday tasks are mainly influenced by poor error monitoring and goal decay. Additionally, micro-errors also occur when switching to new tasks and when dealing with distractor objects.
AGING NEUROPSYCHOLOGY AND COGNITION
(2021)
Article
Neuroimaging
Eunice Y. Chen, Simon B. Eickhoff, Tania Giovannetti, David V. Smith
NEUROIMAGE-CLINICAL
(2020)