期刊
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
卷 16, 期 2, 页码 233-243出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1355617709991160
关键词
Dementia; Latent class analysis; Cognition; Mattis Dementia Rating Scale-2; Mini-Mental State Examination; Apolipoprotein E
资金
- GlaxoSmithKline RD
- National Institute on Drug Abuse [P50-DA-010075]
Heterogeneity is observed in the patterns of cognition in Alzheimer's disease (AD). Such heterogeneity might suggest the involvement of different etiological pathways or different host responses to pathology. A total of 627 subjects with mild/moderate AD underwent cognitive assessment with the Mini-Mental State Examination (MMSE) and the Dementia Rating Scale-2 (DRS-2). Latent class analysis (LCA) was performed on cognition subscale data to identify and characterize cognitive Subgroups. Clinical, demographic, and genetic factors were explored for association with class membership. LCA suggested the existence of four subgroups; one group with mild and another with severe global impairment across the cognitive domains, one group with primary impairments in attention and Construction, and another group with primary deficits in memory and orientation. Education, disease duration, age, Apolipoprotein E-epsilon 4 (APOE 0) status, gender, presence of grasp reflex, white matter changes, and early or prominent visuospatial impairment were all associated with class membership. Our results support the existence of heterogeneity in patterns of cognitive impairment in AD. Our observation of classes characterized by predominant deficits in attention/construction and memory respectively deserves further exploration its does the association between membership in the attention/construction class and APOE epsilon 4 negative status. (JINS, 2010, 16, 233-243.)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据