Article
Neurosciences
Xiaomei Zhong, Ben Chen, Le Hou, Qiang Wang, Meiling Liu, Mingfeng Yang, Min Zhang, Huarong Zhou, Zhangying Wu, Si Zhang, Gaohong Lin, Yuping Ning
Summary: This study aimed to compare temporal variability in the spontaneous fluctuations of activity and connectivity between amnestic MCI (aMCI) and nonamnestic MCI (naMCI). The results showed that both aMCI and naMCI patients exhibited abnormal brain activity and connectivity. The variability in dALFF, dReHo, and hippocampal dFC was different between aMCI and naMCI patients and was associated with cognitive scores. The dReHo of the superior parietal lobule and dFC of the hippocampus-cerebellum contributed to the memory heterogeneity of MCI subtypes.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Cell Biology
Michael K. Yeung, Anson Kwok-yun Chau, Jason Yin-chuen Chiu, Jay Tsz-lok Shek, Jody Po-yi Leung, Toby Chun-ho Wong
Summary: The study found significant differences in neuroimaging abnormalities between amnestic mild cognitive impairment (aMCI) and nonamnestic mild cognitive impairment (naMCI), with aMCI showing more and more significant abnormalities, while naMCI showing more limited abnormalities, with shared features but unique neuroimaging abnormalities in aMCI.
AGEING RESEARCH REVIEWS
(2022)
Article
Geriatrics & Gerontology
Tammy T. Tran, Caroline L. Speck, Michela Gallagher, Arnold Bakker
Summary: The entorhinal cortex is affected by early pathological changes in Alzheimer's disease, resulting in neuronal, synaptic, and volumetric loss. Specifically, the lateral entorhinal cortex accumulates tau neurofibrillary tangles in the amnestic mild cognitive impairment (aMCI) phase. Structural and functional changes in the lateral entorhinal cortex are associated with impaired memory function in aMCI patients, while the medial entorhinal cortex appears to be less affected.
NEUROBIOLOGY OF AGING
(2022)
Article
Psychology, Clinical
Hillary J. Rouse, Brent J. Small, John A. Schinka, David A. Loewenstein, Ranjan Duara, Huntington Potter
Summary: The study found that older adults with mild behavioral impairment (MBI) performed worse on tasks of executive function, attention, and episodic memory than those without MBI. Additionally, individuals with both MCI and MBI showed significantly poorer performance on episodic memory tasks compared to those with only MCI.
INTERNATIONAL PSYCHOGERIATRICS
(2021)
Article
Neurosciences
Rahel Rabi, Ricky Chow, Shahier Paracha, Lynn Hasher, Sandra Gardner, Nicole D. Anderson, Claude Alain
Summary: This study found inhibition deficits in individuals with amnestic mild cognitive impairment (aMCI), with a more significant impact observed during non-optimal time of day.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Tamir Eisenstein, Galit Yogev-Seligmann, Elissa Ash, Nir Giladi, Haggai Sharon, Irit Shapira-Lichter, Shikma Nachman, Talma Hendler, Yulia Lerner
Summary: This study suggests that maximal aerobic capacity (MAC) may be associated with hippocampal-related cognitive reserve in aMCI patients by altering the relationship between hippocampal-related structural deterioration and cognitive function. Additionally, MAC is found to be associated with increased capacity to recruit neural resources during increased cognitive demands.
Article
Ophthalmology
C. A. S. O. N. B. ROBBINS, D. E. N. N. I. S. AKROBETU, J. U. S. T. I. N. P. MA, S. A. N. D. R. A. S. STINNETT, S. R. I. N. A. T. H. SOUNDARARAJAN, A. N. D. Y. J. LIU, K. I. M. G. JOHNSON, D. I. L. R. A. J. S. GREWAL, S. H. A. R. O. N. FEKRAT
Summary: This study found a significant reduction in perfusion density in individuals with amnestic MCI compared to those with nonamnestic MCI and controls with normal cognition.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Psychology, Developmental
K. Reiter, A. M. Butts, J. K. Janecek, A. N. Correro, A. Nencka, M. Agarwal, M. Franczak, L. Glass Umfleet
Summary: The study found an association between cognitive reserve and naMCI, with positive correlations between CR and whole brain volume, total gray matter, bifrontal, left parietal, left occipital, and bilateral cerebellum volumes in the naMCI group. Conversely, there were no significant correlations between CR and brain volumes in the aMCI group. Positive correlations with CR were observed in language, attention, and visual learning in both aMCI and naMCI groups.
AGING NEUROPSYCHOLOGY AND COGNITION
(2022)
Article
Clinical Neurology
Florence Gaillardin, Jean-Christophe Bier, Sandra De Breucker, Stephane Baudry
Summary: This study found that increasing the contribution of executive functions worsens the cognitive-motor interaction in individuals with amnestic mild cognitive impairment (aMCI). In dual-task situations that require working memory or during complex locomotor tasks, individuals with aMCI had a higher dual-task cost compared to controls. Furthermore, this increase in dual-task cost is associated with cognitive decline as assessed by the Montreal Cognitive Assessment score.
JOURNAL OF NEUROLOGIC PHYSICAL THERAPY
(2022)
Article
Clinical Neurology
Margo W. Menkes, Carolyn M. Andrews, Helen J. Burgess, Isabel Carley, David F. Marshall, Scott A. Langenecker, Melvin G. McInnis, Patricia J. Deldin, Kelly A. Ryan
Summary: Individuals with bipolar I disorder (BD-I) have poorer sleep quality and neuropsychological functioning compared to healthy controls, and poor sleep quality is associated with learning, memory, and executive functioning impairments, with similar effects across groups.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Geriatrics & Gerontology
Ricky Chow, Rahel Rabi, Shahier Paracha, Brandon P. Vasquez, Lynn Hasher, Claude Alain, Nicole D. Anderson
Summary: This study compared response inhibition and interference control between single-domain and multiple-domain aMCI subtypes, finding that individuals with multiple-domain aMCI exhibited higher RT IIV on both tasks. RT IIV may detect subtle differences in inhibition deficits between aMCI subtypes not evident with conventional behavioral measures, supporting its supplementary use in assessing early executive function deficits.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Alejandro Gonzalez-Andrade, Amalia Garcia-Torres, Miguel Perez-Garcia, Esperanza Vergara-Moragues
Summary: The study found a significant relationship between executive functioning and instrumental skills in persons with HIV, with set-shifting being the strongest predictor. Executive functions, particularly set-shifting, are related to community living skills but not household living skills.
PSYCHOLOGY HEALTH & MEDICINE
(2022)
Article
Behavioral Sciences
Yu-Ruei Lin, Chia-Hsing Chi, Yu -Ling Chang
Summary: Amnestic mild cognitive impairment (aMCI) is a risk factor for dementia due to Alzheimer's disease. Patients with aMCI perform poorly on both detail and gist memory tests compared to cognitively normal older adults, and this performance gap persists over time. Additionally, multisensory encoding improves memory performance in patients with aMCI. Overall, the findings suggest that detail and gist memory decay differently, with a longer lasting group gap in gist memory. Multisensory encoding effectively reduces or overcomes the gaps between time intervals and within groups, especially for gist memory.
Article
Immunology
Erin E. Sundermann, Mark W. Bondi, Laura M. Campbell, Ben Gouaux, Raeanne C. Moore, Virawudh Soontornniyomkij, David J. Moore
Summary: This study aimed to distinguish aMCI from HAND in PWH using a neuropsychological method, finding a higher prevalence of high aMCI risk in the HAND group, with beta-amyloid pathology being associated with high aMCI risk, while phospho-Tau pathology did not differ by aMCI classification.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Hiroyuki Umegaki, Yusuke Suzuki, Hitoshi Komiya, Kazuhisa Watanabe, Masaaki Nagae, Yosuke Yamada, Masafumi Kuzuya
Summary: This study investigated the association between gait speed and qualitative errors on the Clock Drawing Test (CDT) in individuals with mild cognitive impairment (MCI). The results showed that conceptual deficit (CD) type errors were negatively associated with maximum gait speed. This study further supports the clinical importance of qualitative assessments of the CDT.
SCIENTIFIC REPORTS
(2022)