Review
Biotechnology & Applied Microbiology
Astgik Petrosyan, Filippo Montali, Andrea Peloso, Antonio Citro, Lori N. Byers, Catherine La Pointe, Mara Suleiman, Alice Marchetti, Eoin P. Mcneill, Allison L. Speer, Wai Hoe Ng, Xi Ren, Benedetta Bussolati, Laura Perin, Paolo Di Nardo, Vincenzo Cardinale, Jerome Duisit, Alexandra Rose Monetti, John Richard Savino, Amish Asthana, Giuseppe Orlando
Summary: Regenerative medicine is a field that is changing the practice of transplant medicine by developing methods to regenerate or replace damaged organs and tissues. This review highlights advancements in regenerative medicine specifically relating to transplant medicine, focusing on tools and techniques designed for different organs such as the kidney, heart, liver, and lungs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Alex Ross, Mildred A. A. Sauce-Guevara, Emilio I. I. Alarcon, Miguel A. A. Mendez-Rojas
Summary: This mini review discusses recent advances in the design and application of peptide-based biomaterials and explores the challenges and opportunities presented by peptide-based structures in the field of tissue engineering and regenerative medicine.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cell Biology
Bruna Andrade Aguiar Koga, Leticia Alves Fernandes, Paula Fratini, Mari Cleide Sogayar, Ana Claudia Oliveira Carreira
Summary: Mesenchymal stem cells (MSCs) secrete vesicles known as extracellular vesicles (EVs), which play a crucial role in tissue homeostasis, repair, and therapeutic applications. MSC-derived EVs have advantages such as low immunogenicity and the ability to pass through barriers, making them potential drug delivery agents for various diseases. Extensive in vitro studies have been conducted to understand the mechanisms and signaling pathways of EVs. Clinical trials are underway to explore the therapeutic potential of EVs in Alzheimer's disease, retina degeneration, and COVID-19. This review provides an overview of different EV isolation methods and highlights their therapeutic applications in tissue repair and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Food Science & Technology
Seyed Zachariah Moradi, Faramarz Jalili, Negin Farhadian, Tanuj Joshi, Mingfu Wang, Liang Zou, Hui Cao, Mohammad Hosein Farzaei, Jianbo Xiao
Summary: Neurodegenerative diseases remain a challenge for modern therapeutics, with organ transplantation, stem cell therapy, and other regenerative approaches offering limited solutions. While significant advancements have been made in medical science, the field of neuronal regeneration faces obstacles in fully addressing damaged tissues and neurodegenerative diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Heidrun Steinle, Josefin Weber, Sandra Stoppelkamp, Katharina Grosse-Berkenbusch, Sonia Golombek, Marbod Weber, Tuba Canak-Ipek, Sarah-Maria Trenz, Christian Schlensak, Meltem Avci-Adali
Summary: Nucleic acid-based therapeutics, particularly synthetic mRNA, have emerged as promising drugs for disease prevention and treatment. Recent advances in using synthetic mRNA-based vaccines against COVID-19 have shown significant potential. The introduction of novel chemical modifications and different delivery vehicles have enhanced the efficiency and uptake of mRNA molecules for therapeutic applications.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Juan Mitchell, Kevin W. -H. Lo
Summary: Cell adhesion is crucial for cell survival, communication, and regulation, as well as the development and maintenance of tissues. Controlling biomaterial surfaces and using bioadhesives have been extensively studied in tissue regeneration and cell biology research. However, there are limitations and drawbacks in traditional bioadhesives and animal-derived materials, which calls for alternative strategies such as the use of cell-adhesive small molecules.
Article
Chemistry, Multidisciplinary
Ju An Park, Yejin Youm, Hwa-Rim Lee, Yongwoo Lee, Sarah L. Barron, Taejeong Kwak, Gyu Tae Park, Young-Cheol Song, Roisin M. Owens, Jae Ho Kim, Sungjune Jung
Summary: A cell sheet transfer method from a culture surface to a target tissue is introduced in this study. UV-treated parylene, a commercially available flexible material, is used as the culture surface to provide adequate cell adhesiveness for both cell attachment during culture and efficient transfer. Various cell types are successfully transferred using this versatile cell-transfer process. The mechanism of interfacial cell migration between surfaces with different adhesion preferences is observed, and the re-establishment and reversal of cell polarity after transfer are identified. The unique capabilities of 3D multilayer stacking, freeform design, and curved surface application are demonstrated. The therapeutic potential of the cell-sheet delivery system is demonstrated through experiments on cutaneous wound healing and skin-tissue regeneration in mice models.
ADVANCED MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Giuseppe Alonci, Roberto Mocchi, Sabrina Sommatis, Maria Chiara Capillo, Elsa Liga, Agata Janowska, Lidia Nachbaur, Nicola Zerbinati
Summary: The study introduces a technology using amino acid L-Lysine as a biocrosslinker to stabilize hyaluronic acid (HA) and produce bionic hydrogels for regenerative medicine applications. These hydrogels exhibit a 3D network structure and mimic biological matrixes, making them a promising candidate for cell proliferation, regeneration, wound healing, and other medical applications.
Review
Cell & Tissue Engineering
Yu-Ting Song, Peng-Cheng Liu, Jie Tan, Chen-Yu Zou, Qian-Jin Li, Jesse Li-Ling, Hui-Qi Xie
Summary: Intrauterine adhesion is a condition caused by uterine injury leading to endometrial repair disorders, with limited treatment options prompting the need for new prevention methods. The loss of stem cells in severely damaged endometrium may hinder regeneration processes.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Engineering, Biomedical
Lu Chen, Liying Cheng, Zhen Wang, Jianming Zhang, Xiyuan Mao, Zhimo Liu, Yuguang Zhang, Wenguo Cui, Xiaoming Sun
Summary: The study introduced a novel regenerative therapy utilizing biodegradable micro-nano electrospun fibers loaded with highly active conditioned medium of adipose-derived stem cells (ADSC-CM). The results showed that this innovative biomaterial can accelerate fibroblast migration, inhibit over proliferation, and prevent fibroblast transformation, leading to improved wound closure and regeneration outcomes. This research pioneers the application of CM-biomaterials in regenerative medicine, demonstrating its practicality and significant biological effects.
BIOACTIVE MATERIALS
(2021)
Review
Orthopedics
Mesalie Feleke, Samuel Bennett, Jiazhi Chen, Xiaoyong Hu, Desmond Williams, Jiake Xu
Summary: The deer antler serves as a unique model for studying organ regeneration in mammals, with potential applications in regenerative medicine and bone remodeling. Understanding the process and defining the antler stem cells could lead to improved clinical outcomes in the field of regenerative medicine.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Review
Biotechnology & Applied Microbiology
Genglei Chu, Weidong Zhang, Feng Han, Kexin Li, Chengyuan Liu, Qiang Wei, Huan Wang, Yijie Liu, Fengxuan Han, Bin Li
Summary: Regenerative medicine for intervertebral disc (IVD) disease, using chondrocytes, IVD cells, and stem cells, has reached clinical trials for back pain treatment. The survival and function of mesenchymal stem cells (MSCs) depend on the microenvironment in which they are transplanted, which is influenced by the complex microenvironment in the degenerative disc. Understanding how MSCs and endogenous disc cells survive and thrive in the harsh microenvironment is important. The use of materials containing stem cells and their natural microenvironment has shown good clinical effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biology
Lorenzo Alibardi
Summary: This study proposes a new hypothesis to explain why only some animals can regenerate their organs. Water-dwelling animals and animals that undergo metamorphosis can regenerate due to the re-utilization of genes previously used for metamorphosis. Humans and terrestrial animals have lost or modified these genes during evolution, resulting in the inability to regenerate. The ability to regenerate in different animals comes from their specific life cycles, and attempts to introduce regenerative genes in non-regenerative species may disrupt genetic networks and result in negative consequences.
Review
Cell & Tissue Engineering
Amber F. MacDonald, Andrew J. Gross, Brady J. Jones, Madhu S. Dhar
Summary: Various abnormalities of the tongue often require surgical removal, but this can have negative impacts on speech and swallowing. Reconstructing the tongue is crucial, and the current standard method has limitations. Regenerative medicine and stem cell technology could provide innovative strategies for tongue reconstruction.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
Review
Chemistry, Multidisciplinary
Faranak Mankavi, Rana Ibrahim, Hongjun Wang
Summary: This article summarizes the recent advances in nerve guidance conduits (NGCs) for peripheral nerve regeneration and repair, including biomaterial innovations, structural design, advanced fabrication technologies, and cellular responses to biomimetic cues.
