Letter
Oncology
Carla Isabelly Rodrigues-Fernandes, Lady Paola Aristizabal Arboleda, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Alan Roger Santos-Silva
Summary: This report describes an uncommon case of verrucous carcinoma in the oral cavity with a unique presentation of proliferative verrucous leukoplakia. It highlights the importance of considering verrucous carcinoma in the differential diagnosis of multiple leukoplakias, especially in elderly patients.
Article
Oncology
Yujie Yan, Zhenglei Li, Xin Tian, Xin Zeng, Qianming Chen, Jiongke Wang
Summary: Non-invasive photodynamic therapy (PDT) is an effective method for selectively treating proliferative verrucous leukoplakia (PVL), but the hyperkeratosis of lesions limits the penetration of photosensitizers. Laser-assisted PDT can improve the delivery of photosensitizers and their accumulation in tissues, achieving satisfactory clinical results.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Review
Oncology
Gaspare Palaia, Amelia Bellisario, Riccardo Pampena, Roberto Pippi, Umberto Romeo
Summary: PVL, a rare subtype of oral leukoplakia, has a high risk of malignant transformation, with almost 50% progressing to OSCC. Female patients, especially elderly non-smokers and non-drinkers, are at higher risk for this transformation.
Article
Dentistry, Oral Surgery & Medicine
Jasbir D. Upadhyaya, Sarah G. Fitzpatrick, Mohammed N. Islam, Indraneel Bhattacharyya, Nagamani Narayana, Donald M. Cohen
Summary: This study highlights 30 cases of marginal gingival leukoplakia, showing characteristics of benign lesions, premalignant lesions, and malignant tumors. Most patients presented with well-demarcated white lesions on the gingival margin, some forming a ring around the tooth collar, with recurrent or multifocal involvement.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
U. Alkan, G. Bachar, Y. Nachalon, A. Zlotogorsky, E. G. Levin, I. Kaplan
Summary: This retrospective study compares the clinicopathological features of proliferative verrucous leukoplakia, leukoplakia without dysplasia, oral lichen planus/oral lichenoid lesions, and verrucous carcinoma. The findings suggest that proliferative verrucous leukoplakia has persistent aggressive behavior and a high malignant transformation rate, emphasizing the need for detailed definition and long-term close monitoring.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Alexandro Barbosa de Azevedo, Teresa Cristina Ribeiro Bartholomeu dos Santos, Marcio Ajudarte Lopes, Fabio Ramoa Pires
Summary: The study analyzed the clinical and histological characteristics of a series of oral mucosal lesions, finding that most cases occurred in middle-aged females, with the tongue, lower lip, and buccal mucosa being the most commonly affected sites, and the majority of lesions were leukoplakias with histological findings predominantly showing mild dysplasia.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Article
Oncology
Xinyi Zhang, Frederico O. Gleber-Netto, Shidan Wang, Roberta Rayra Martins-Chaves, Ricardo Santiago Gomez, Nadarajah Vigneswaran, Arunangshu Sarkar, William N. N. William Jr, Vassiliki Papadimitrakopoulou, Michelle Williams, Diana Bell, Doreen Palsgrove, Justin Bishop, John V. V. Heymach, Ann M. M. Gillenwater, Jeffrey N. N. Myers, Renata Ferrarotto, Scott M. M. Lippman, Curtis Rg Pickering, Guanghua Xiao
Summary: Convolutional neural networks-based histology image analysis can accelerate the discovery of better oral cancer progression risk models by predicting the development of oral leukoplakia. This can contribute to early intervention and decrease morbidity and mortality of oral cancer.
Article
Dentistry, Oral Surgery & Medicine
Helen McParland, Saman Warnakulasuriya
Summary: A retrospective study was conducted on 51 cases of PVL initially diagnosed as frictional keratosis, oral leukoplakia or oral lichen planus. It was found that lichen planus or lichenoid lesions could be the initial presentation of many PVL cases, which later developed into PVL with some cases experiencing malignant transformation.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Review
Dentistry, Oral Surgery & Medicine
Pablo Ramos-Garcia, Miguel angel Gonzalez-Moles, Fernanda Weber Mello, Jose V. Bagan, Saman Warnakulasuriya
Summary: This study investigated the malignant transformation of oral proliferative verrucous leukoplakia, finding that females and gingiva were more commonly affected. The pooled proportion of malignant transformation was 43.87%, with conventional squamous cell carcinoma being the most frequent histopathological subtype. No conclusive results were found between malignant transformation and sex, age, tobacco, or alcohol consumption.
Article
Otorhinolaryngology
Monica Pentenero, Patrizio Castagnola, Faride Victoria Castillo, Elena Isaevska, Samuele Sutera, Sergio Gandolfo
Summary: This prospective observational study examined the factors associated with malignant transformation in localized oral leukoplakia (OL) and proliferative verrucous leukoplakia (PVL). Data on demographics, clinical characteristics, histology, and DNA ploidy status were collected. The presence of OED, DNA ploidy, clinical presentation, and lesion site were found to be associated with malignant transformation in patients with OL, while none of these predictors were associated with PVL. The study suggests that DNA ploidy may be able to identify a subset of OL with low or minimal risk of malignant transformation, but it is not a reliable predictor in PVL patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Medicine, General & Internal
Vipin Thampi, Roopa Hariprasad, Amrita John, Suzanne Nethan, Kavitha Dhanasekaran, Vipin Kumar, Praveen Birur, J. S. Thakur, Richard Lilford, Nasir M. Rajpoot, Paramjit Gill
Summary: Visual screening for oral cancer showed a substantial reduction in mortality in a trial in Kerala, India, while utilizing community health workers has been proposed as a strategy to address the shortage of medical personnel in resource-deficient regions. A cross-sectional study in Uttar Pradesh, India, found that trained community health workers, after initial supervision by qualified dentists, were able to perform oral cancer screening programs effectively, suggesting their feasibility in resource-constrained settings.
Article
Oncology
Fei Wang, Yujie Shi, Yunmei Dong, Tiannan Liu, Hongxia Dan, Jiongke Wang, Xin Zeng
Summary: Oral proliferative verrucous leukoplakia is a potentially malignant disorder that is often difficult to treat. Topical 5-aminolevulinic acid-mediated photodynamic therapy combined with diode laser drilling pre-treatment can effectively treat this disease.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Review
Oncology
Miguel Angel Gonzalez-Moles, Saman Warnakulasuriya, Pablo Ramos-Garcia
Summary: Proliferative verrucous leukoplakia patients with oral carcinoma (PVL-OC) have a lower mortality rate compared to conventional oral cancer, indicating favorable prognostic parameters.
Review
Pharmacology & Pharmacy
Pratima Kumari, Priyanka Debta, Anshuman Dixit
Summary: Oral cancer is a critical health issue, with the majority of new cases occurring in Asia. Various factors, such as genetics and lifestyle, are closely associated with its occurrence and progression. Early signs of oral cancer include oral lesions, genetic mutations, and viral infections. Lesions with dysplastic features have a high risk of malignancy, and OPMDs have a high prevalence in South Asian countries. Early detection, prevention, and treatment of OPMDs are crucial.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Isabel Schausltz Pereira Faustino, Mariana de Pauli Paglioni, Bruno Augusto Linhares de Almeida Mariz, Ana Gabriela Costa Normando, Maria Eduarda Perez-de-Oliveira, Maria Georgaki, Nikolaos G. Nikitakis, Pablo Agustin Vargas, Alan Roger Santos-Silva, Marcio Ajudarte Lopes
Summary: This study evaluated the prognostic outcomes of PVL-derived oral squamous cell carcinomas (P-OSCC) and found that P-OSCC has better clinical prognostic characteristics compared to conventional OSCC. The common prognostic outcomes are recurrence and new primary tumors, while metastasis is rare. Most patients have an average survival period of 5 years.
Article
Otorhinolaryngology
Shih-Jung Cheng, Chi-Feng Chang, Hui-Hsin Ko, Jang-Jaer Lee, Hsin-Ming Chen, Huei-Jen Wang, Hsiao-Shan Lin, Chun-Pin Chiang
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2018)
Article
Medicine, General & Internal
Yu-Hsueh Wu, Yang-Che Wu, Fang-Yeh Chu, Shih-Jung Cheng, Andy Sun, Hsin-Ming Chen
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2019)
Article
Medicine, General & Internal
Yu-Hsueh Wu, Yang-Che Wu, Shih-Jung Cheng, Ying-Shiung Kuo, Andy Sun, Hsin-Ming Chen
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2019)
Article
Medicine, General & Internal
Hou-Chiang Chou, Han-Wei Lin, Ju-Hsuan Yang, Ping-Yi Lin, Shih-Jung Cheng, Yu-Hsueh Wu, Ying-Shiung Kuo
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2019)
Article
Otorhinolaryngology
Hsin-Hui Peng, Hui-Hsin Ko, Nai-Chi Chi, Yi-Ping Wang, Hsiang-Chieh Lee, Pei-Yao Pan, Mark Yen-Ping Kuo, Shih-Jung Cheng
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2020)
Article
Dentistry, Oral Surgery & Medicine
H-W Wang, S-H Kok, C-N Yang, C-Y Hong, C-W Chi, M-H Chen, S-J Cheng, C-T Shun, H. Yang, S-K Lin
Summary: The study revealed that LPS could stimulate the expression of SREBP-1c and FASN in macrophages, enhance palmitic acid synthesis, and promote CCL2 secretion and cellular chemotaxis. Inhibition of fatty acid signaling could alleviate tissue damage and macrophage recruitment in apical periodontitis.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Medicine, General & Internal
Ling-Ying Wei, Sang-Heng Kok, Yen-Ching Lee, Wei-Yih Chiu, Jai-Jen Wang, Shih-Jung Cheng, Hao-Hueng Chang, Jang-Jaer Lee
Summary: The study investigated the treatment outcomes and prognostic indicators of MRONJ in 133 cancer patients receiving zoledronic acid, revealing that patients with multiple myeloma had a worse treatment outcome.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ling-Ying Wei, Sang-Heng Kok, Yen-Ching Lee, Wei-Yih Chiu, Jai-Jen Wang, Shih-Jung Cheng, Hao-Hueng Chang, Jang-Jaer Lee
Summary: This study aimed to investigate the prognosis of medication-related osteonecrosis of the jaws (MRONJ) in prostate cancer patients who received different types of antiresorptive agents for bone metastasis. The results showed that patients treated with denosumab as the antiresorptive agent, with higher pretreatment levels of CTX and without anemia, had a better treatment outcome for MRONJ.
Article
Oncology
An Ning Cheng, Li-Chun Cheng, Cheng-Liang Kuo, Yu Kang Lo, Han-Yu Chou, Chung-Hsing Chen, Yi-Hao Wang, Tsung-Hsien Chuang, Shih-Jung Cheng, Alan Yueh-Luen Lee
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Dentistry, Oral Surgery & Medicine
Ya-Wen Lo, Alan Yueh-Luen Lee, Yi-Ching Liu, Hui-Hsin Ko, Hsin-Hui Peng, Hsiang-Chieh Lee, Pei-Yao Pan, Chun-Pin Chiang, Shih-Jung Cheng
Summary: The study revealed a significant increase in MDSC levels in OSCC patients, which decreased significantly after beta-glucan treatment. Patients receiving beta-glucan treatment showed higher recurrence-free survival rates.
Article
Dentistry, Oral Surgery & Medicine
Yi-Chen Juan, Yee-Fun Su, Chyi-Huey Bai, Yen-Chun Fan, Tzu-Tung Kuo, Hui-Hsin Ko, Hsin-Hui Peng, Chun-Pin Chiang, Chyng-Wen Fwu, Shih-Jung Cheng
Summary: This hospital-based cohort study found that high levels of ZNF582 methylation can serve as a noninvasive biomarker for identifying oral lesions with a high potential for malignant transformation.
Article
Dentistry, Oral Surgery & Medicine
Hsiu-Yang Tseng, Yi-Wen Chen, Bor-Shiunn Lee, Po-Chun Chang, Yi-Ping Wang, Chun-Pin Lin, Shih-Jung Cheng, Mark Yen-Ping Kuo, Hsin-Han Hou
Summary: This study found that excessive neutrophil-secreted neutrophil elastase (NE) upregulates the expression of placenta growth factor (PGF) and is involved in the pathogenesis and progression of periodontal disease.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Oncology
Ling-Ying Wei, Hsuan-Chao Lin, Feng-Chiao Tsai, Jenq-Yuh Ko, Sang-Heng Kok, Shih-Jung Cheng, Jang-Jaer Lee, Jean-San Chia
Summary: The study revealed that high levels of IL-6 or STAT3 in oral squamous cell carcinoma (OSCC) patients were associated with an unfavorable prognosis. IL-6 promoted tumor cell survival and growth through the STAT3 signaling pathway, which could be inhibited by Siltuximab or Tocilizumab.
Article
Dentistry, Oral Surgery & Medicine
Yi-Wen Chen, Guan-Hua Wu, Bor-Shiunn Lee, Chung-Te Liu, Huei-Ying Li, Shih-Jung Cheng, Wei-Ting Kuo, Jiiang-Huei Jeng, Po-Chun Chang, Chun-Pin Lin, Han-Yi E. Chou, Hsin-Han Hou
Summary: This study used the ONT third-generation sequencing system to identify pathogens from subgingival dental plaque in patients with periodontitis and validated the impact of a selected pathogen in periodontitis progression using a mouse model. The results showed that Scardovia wiggsiae (S. wiggsiae) was dominant in the subgingival plaque of the patients and significantly worsened the symptoms of periodontitis in the mouse model.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Oncology
Yi-Jie Lu, Yi-Ting Deng, Hui-Hsin Ko, Hsin-Hui Peng, Hsiang-Chieh Lee, Mark Yen-Ping Kuo, Shih-Jung Cheng
Summary: LOXL2 expression is significantly associated with clinical stage, lymph node metastasis, and overall survival time in oral squamous cell carcinoma (OSCC). Overexpression of LOXL2 enhances migration, invasion, epithelial-mesenchymal transition (EMT), and cancer stem cell (CSC) phenotypes, independent of its enzymatic activity. LOXL2 also increases the levels of IFIT1 and IFIT3, which are key downstream components of LOXL2 action in migration, invasion, EMT, and CSC phenotypes.