Article
Behavioral Sciences
Fernanda Gonzalez-Barriga, Vladimir Orduna
Summary: Both positive and aversive delayed consequences play a crucial role in decision making. While there is extensive research on temporal discounting of positive consequences, the study of aversive consequences is limited. This study evaluated impulsive behavior in spontaneously hypertensive rats (SHR), an animal model of ADHD, and found that choice impulsivity was similar between strains for both positive and aversive consequences. However, SHR exhibited a higher level of impulsive action compared to the control strain.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Psychology, Biological
Tyler S. Garman, Barry Setlow, Caitlin A. Orsini
Summary: Chronic exposure to a high-fat diet does not significantly affect impulsive choice, but it may increase motivation for a sucrose reward. Amphetamine has a similar effect on impulsive choice in both diet groups.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Toxicology
Barbara G. Schmitt, Joseph Tobin, Debra A. McNett, Jaeshin Kim, Jeremy Durham, Kathleen P. Plotzke
Summary: Octamethylcyclotetrasiloxane (D4) is a high production volume chemical that has been thoroughly studied for its toxicological properties. This study compared the pharmacokinetic behavior of D4 in Fischer and Sprague Dawley CD rats and identified strain-specific differences.
TOXICOLOGY LETTERS
(2023)
Article
Geriatrics & Gerontology
Alexander P. Young, Jiequan Zhu, Amina M. Bagher, Eileen M. Denovan-Wright, Susan E. Howlett, Melanie E. M. Kelly
Summary: The study revealed that aged rats have higher myogenic tone in cerebral arteries, a loss of ETB receptor activity, and an increase in ETA receptor expression, compared to young rats. This suggests that in aging vasculature, there is a shift towards ETA receptors in regulating cerebral blood flow, highlighting potential clinical implications for treating conditions with reduced cerebral perfusion in older adults.
Article
Neurosciences
Monica S. Carbajal, Asiah J. C. Bounmy, Olivia B. Harrison, Hunter G. Nolen, Samantha L. Regan, Michael T. Williams, Charles V. Vorhees, Helen J. K. Sable
Summary: Impulsive choice was examined in rats with Lphn3 deletion and spontaneously hypertensive rats (SHRs) using a delay-discounting task. Only SHRs showed a decrease in choosing the larger reward. There was no effect of Lphn3 deletion on impulsive choice.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Psychology, Biological
Sara Peck, Emma Preston, Kelsey B. Smith, Gregory J. Madden
Summary: This study examined the effects of delay exposure training on impulsive choice in rats of different genders. The findings showed that delay-exposure training reduced impulsive choice in male rats, but only had a temporary effect in female rats.
BEHAVIOURAL PROCESSES
(2022)
Article
Substance Abuse
Shadab Forouzan, Steven J. Nieto, Therese A. Kosten
Summary: Chronic cocaine exposure has differential neural effects in Fischer 344 (F344) vs Lewis inbred rats, with prior exposure leading to persistence of responding during extinction in F344 but not Lewis rats. This suggests that genetic factors may play a role in relapse-like behaviors.
AMERICAN JOURNAL ON ADDICTIONS
(2021)
Article
Psychology, Biological
Ryan J. Brackney, Raul Garcia, Federico Sanabria
Summary: The study revealed that as the required duration threshold increased, rats emitted fewer but longer bouts. This effect may reflect an effort-induced reduction in motivation and a duration-induced facilitation of a response-outcome association. Response durations were typically 0.5 s greater than the minimum duration threshold, with durations exceeding the threshold being approximately log-normally distributed.
LEARNING & BEHAVIOR
(2021)
Article
Developmental Biology
Allyssa Fahrenkopf, Grace Li, Ruth I. Wood, Christine K. Wagner
Summary: The study suggests that exposure to 17-OHPC during development may disrupt the development of the serotonergic pathway in the fetal brain and impact behavior in adulthood. Rats exposed to 17-OHPC during development showed less impulsive choices and higher omission rates in decision-making tasks. Further investigation is needed to better understand the potential effects of 17-OHPC on fetal brain development and behavior.
DEVELOPMENTAL NEUROBIOLOGY
(2021)
Article
Immunology
Maria Amparo Assis, David Diaz, Rosa Ferrado, Carmelo Antonio Avila-Zarza, Eduardo Weruaga, Emilio Ambrosio
Summary: Peripheral immune system, particularly CD4(+) T cells, play a significant role in drug addiction and relapse, impacting vulnerability and resilience mechanisms. Understanding individual susceptibility and resistance can lead to personalized treatment strategies to prevent relapse.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
V. A. Gruzdeva, A. Sharkova, M. Zaichenko, G. A. Grigoryan
Summary: Female rats demonstrated more impulsive behavior than males in their youth, but no significant difference was found in maturity. The LPS group exhibited higher impulsivity levels compared to the control group in matured age, with male rats not showing age-related differences in impulsivity.
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA
(2021)
Article
Psychology, Biological
Roberta Freitas-Lemos, Jeffrey S. Stein, Derek A. Pope, Jeremiah Brown, Marc Feinstein, Kelsey M. Stamborski, Allison N. Tegge, Bryan W. Heckman, Warren K. Bickel
Summary: This study used the Experimental Tobacco Marketplace to examine the effect of workplace policies and nicotine concentrations on tobacco product consumption. The results showed that allowing e-cigarette use in the workplace increased demand for e-liquid, regardless of nicotine strength, while conventional cigarette demand remained unchanged. The study suggests that e-cigarette policies have a stimulus control effect on purchasing behavior, but are not substitutive for traditional cigarettes.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Psychology, Biological
Liqa N. Athamneh, Jeremiah Brown, Jeffrey S. Stein, Kirstin M. Gatchalian, Stephen M. LaConte, Warren K. Bickel
Summary: The study conducted a field trial using remotely delivered EFT to reduce alcohol consumption among individuals with AUD. Results showed a significant decrease in alcohol consumption, and the remote approach was considered feasible and acceptable.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Psychology, Multidisciplinary
Jeremiah Brown, Wendy Donlin Washington, Jeffrey S. Stein, Brent A. Kaplan
Summary: By examining the demand indices and the rates of systematic and nonsystematic responding related to physical activity, initial evidence of construct validity for each task was found. Additionally, the probability of purchase task generated significantly lower rates of nonsystematic responding compared to the quantity of purchase task.
PSYCHOLOGICAL RECORD
(2022)
Article
Psychology, Clinical
Roberta Freitas-Lemos, Allison N. Tegge, Jeffrey S. Stein, William Brady DeHart, Sarah A. Reisinger, Peter G. Shields, Dorothy K. Hatsukami, Warren K. Bickel
Summary: Regulating filter ventilation changes the value of tobacco products, leading smokers to face the explore/exploit dilemma. This study found that higher prices for ventilated cigarettes decrease their purchase likelihood and increase the likelihood of purchasing lower-ventilated cigarettes. Initial exposure to lower-ventilated cigarettes reduces the number of high-priced cigarettes purchased and increases exploration of alternative tobacco products. Successive exposure to lower-ventilated cigarettes decreases the likelihood of purchasing high-ventilated cigarettes and alternative products, and increases the likelihood of purchasing lower-ventilated cigarettes.
ADDICTIVE BEHAVIORS
(2022)
Article
Behavioral Sciences
Jeffrey S. Stein, Jeremiah M. Brown, Allison N. Tegge, Roberta Freitas-Lemos, Mikhail N. Koffarnus, Warren K. Bickel, Gregory J. Madden
Summary: Choice bundling is an effective method for increasing the valuation of delayed gains and losses, specifically for cigarette smokers. This study found that choice bundling significantly increased the valuation of both gains and losses, with a greater effect on losses.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Environmental Sciences
Ron Borland, Michael Le Grande, Bryan W. Heckman, Geoffrey T. Fong, Warren K. Bickel, Jeff S. Stein, Katherine A. East, Peter A. Hall, Kenneth Michael Cummings
Summary: This study explores the predictive relationships of delay discounting and time perspective for smoking cessation. The results suggest that time perspective predicts making quit attempts but is negatively associated with quit success, while delay discounting is not related to making quit attempts but predicts relapse.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Jasmine S. Sukumar, Jennifer E. Vaughn, Allison Tegge, Sagar Sardesai, Maryam Lustberg, Jeffrey Stein
Summary: This study examined the relationship between delay discounting (DD) and obesity in breast cancer survivors. The results showed that lower DD was associated with lower BMI and higher vegetable consumption. This finding suggests that DD may serve as a therapeutic target for behavioral interventions to promote weight loss and improve overall health in breast cancer survivors.
Article
Psychology, Clinical
Leonard H. Epstein, Rocco A. Paluch, Mathew J. Biondolillo, Jeff S. Stein, Teresa Quattrin, Lucy D. Mastrandrea, Kirstin Gatchalian, Mark H. Greenawald, Warren K. Bickel
Summary: This study examined the effects of episodic future thinking (EFT) training on individuals with prediabetes and found that EFT can reduce delay discounting and have long-term effects, even without cues. The study also showed that telehealth is a scalable approach for treating prediabetes.
JOURNAL OF BEHAVIORAL MEDICINE
(2022)
Article
Substance Abuse
William H. Craft, Allison N. Tegge, Diana R. Keith, Hwasoo Shin, Jacob Williams, Liqa N. Athamneh, Jeffrey S. Stein, Howard D. Chilcoat, Anne Le Moigne, Angela DeVeaugh-Geiss, Warren K. Bickel
Summary: This study investigated the long-term outcomes of individuals with opioid use disorder (OUD) and found high levels of abstinence from opioids and positive psychosocial functioning. These results highlight the multidimensional nature of OUD recovery and support the effectiveness of buprenorphine as a treatment for OUD.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Psychology, Biological
Roberta Freitas-Lemos, Allison N. Tegge, Liqa N. Athamneh, Devin C. Tomlinson, Jeffrey S. Stein, Warren K. Bickel
Summary: Reading narratives about penalties for illegal tobacco purchases significantly increases psychological distress among cigarette smokers. Further research is needed to assess the ability of narratives to imitate real-world psychological effects and determine their utility.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2023)
Letter
Psychology, Clinical
Jeffrey S. Stein, James MacKillop, Samuel M. McClure, Warren K. Bickel
Summary: It is widely recognized that understanding the limitations of the delay discounting paradigm is important for research on intertemporal choice in clinical disorders. However, a systematic review and meta-analysis should be conducted to accurately assess the significance of these limitations, and the strengths of the paradigm should be acknowledged to avoid weakening the measures.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Biological
Roberta Freitas-Lemos, Allison N. Tegge, William H. Craft, Devin C. Tomlinson, Jeffrey S. Stein, Warren K. Bickel
Summary: This study found that conducting an instruction quiz before a cigarette purchase task can improve the data quality and the consistency of responses regarding daily cigarette consumption and purchasing behavior among smokers.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Perisa Ruhi-Williams, Mary J. King, Jeffrey S. Stein, Warren K. Bickel
Summary: Cigarette smokers who have excessive delay discounting show reduced discounting and craving for cigarettes when engaging in episodic future thinking (EFT), specifically about smoking-related illness (SRI). These findings suggest that EFT, particularly focused on SRI, may be beneficial for smoking cessation interventions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Correction
Substance Abuse
William H. Craft, Allison N. Tegge, Diana R. Keith, Hwasoo Shin, Jacob Williams, Liqa N. Athamneh, Jeffrey S. Stein, Howard D. Chilcoat, Anne Le Moigne, Angela DeVeaugh-Geiss, Warren K. Bickel
DRUG AND ALCOHOL DEPENDENCE
(2022)
Review
Public, Environmental & Occupational Health
Jeremiah Michael Brown, Jeffrey Scott Stein
Summary: Episodic future thinking (EFT) has emerged as a promising behavioral intervention to reduce delay discounting or maladaptive health behaviors. However, there is considerable methodological heterogeneity in methods for eliciting engagement in EFT in prior research. This narrative review summarizes the methods for generating EFT cues, the content of EFT cues, common control conditions, and considerations for cue delivery and implementation, and provides suggestions for best practices and future research.
FRONTIERS IN PUBLIC HEALTH
(2022)
