期刊
POLYMER CHEMISTRY
卷 6, 期 1, 页码 64-69出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4py01087f
关键词
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资金
- Wallonia Region
- European Commission (FSE, FEDER)
- National Fund for Scientific Research (F.R.S.-FNRS)
- Belgian Federal Science Policy Office [PAI 6/27]
- F.R.I.A.
- University of Brest
- Region de Bretagne
A tandem mass spectrometry-based method is developed to determine the degree of purity achieved in the cyclization of a linear poly(L-lactide) prepared by copper-catalyzed alkyne-azide cycloaddition. When proton nuclear magnetic resonance, size-exclusion chromatography, and single-stage mass spectrometry are unable to demonstrate the presence of a residual linear polymer, the proposed ESI-tandem mass spectrometry methodology allows detection of starting material traces (<5%) based on radically different collision-induced dissociation (CID) behaviours. The technique is believed to be readily adaptable to numerous isomeric pairs of macromolecules presenting different CID characteristics.
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