Article
Immunology
Ying Li, Han Ma, Liang Xue, Huizhen Chen, Rui Pang, Yanyan Shang, Juan Luo, Xinqiang Xie, Jumei Zhang, Yu Ding, Moutong Chen, Juan Wang, Qingping Wu
Summary: The study found that severe paronychia is associated with a higher abundance of anaerobic microorganisms such as Parvimona, Prevotella, and Peptoniphilus, while Lactobacillus decreases as the disease progresses. Co-occurring network analysis suggested that disturbance of dermic microbiome and reduction of antagonism by Lactobacillus against anaerobic pathogens may worsen inflammation in paronychia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Felix Marcos-Tejedor, Raquel Mayordomo, Ana Maria Perez Pico, Pablo A. Cantero-Garlito, Maria Jose Iglesias-Sanchez
Summary: Nail disorders, while not severe, have a psychological and social impact on patients, leading to self-isolation and potential anxiety and depression. Laser therapy is seen as a potential treatment for nail disorders, but there is a lack of conclusive scientific evidence regarding its efficacy in treating traumatic onycholysis.
APPLIED SCIENCES-BASEL
(2021)
Article
Computer Science, Artificial Intelligence
Chakkarai Sathyaseelan, L. Ponoop Prasad Patro, Thenmalarchelvi Rathinavelan
Summary: Zinc finger (ZnF) is an important class of nucleic acid and protein recognition domain with diverse structures and biological functions. In order to accurately predict ZnF motifs, researchers collected 74 ZnF sequence patterns and used Pfam HMM profiles for prediction. They developed a web server called ZnF-Prot that can predict 31 ZnF domains in protein sequences of any organism.
PATTERN RECOGNITION
(2023)
Article
Dermatology
Minsu Kim, Seungkeol Yang, Bo Ri Kim, Sang Woong Youn
Summary: The study found that 66.3% of PPP patients had nail involvement, with the severity of nail involvement correlated with the severity of cutaneous lesions. Compared to PsO, onycholysis and crumbling were more common in PPP, but nail changes in the first digits were less prominent. Risk factors for nail involvement in PPP included female sex, younger age at diagnosis, and higher severity of the disease.
JOURNAL OF DERMATOLOGY
(2021)
Article
Environmental Sciences
Cuicui Wang, Zongli Xu, Xinye Qiu, Yaguang Wei, Adjani A. Peralta, Mahdieh Danesh Yazdi, Tingfan Jin, Wenyuan Li, Allan Just, Jonathan Heiss, Lifang Hou, Yinan Zheng, Brent A. Coull, Anna Kosheleva, David Sparrow, Chitra Amarasiriwardena, Robert O. Wright, Andrea A. Baccarelli, Joel D. Schwartz
Summary: This study investigated the relationship between toenail metals and adverse health outcomes, such as cancer and cardiovascular disease, in elderly men. The researchers analyzed DNA methylation and found significant associations with metal mixtures and CpG sites related to cancer and cardiovascular disease.
ENVIRONMENTAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Ranjeet Maurya, Aparna Swaminathan, Uzma Shamim, Smriti Arora, Pallavi Mishra, Aakarshan Raina, Varsha Ravi, Bansidhar Tarai, Sandeep Budhiraja, Rajesh Pandey
Summary: The emergence of multiple SAR-CoV-2 variants during the COVID-19 pandemic has led to an increased understanding of the host-immune kinetics associated with these variants. A longitudinal investigation revealed a robust antiviral response in Omicron infection, which was largely absent in the Pre-VOC and Delta waves. The study also highlighted differential protein-protein interactions and gene expression patterns, particularly in relation to zinc finger proteins, that contribute to the immune response.
Article
Public, Environmental & Occupational Health
Nicole M. Niehoff, Katie M. O'Brien, Alexander P. Keil, Keith E. Levine, Chamindu Liyanapatirana, Laura G. Haines, Suramya Waidyanatha, Clarice R. Weinberg, Alexandra J. White
Summary: This study found little evidence supporting an association between individual metals and breast cancer, with an exception for molybdenum which may be associated with reduced incidence of overall breast cancer risk. Metal mixtures were also not strongly associated with breast cancer risk. Further study is warranted to explore mechanisms for the inverse associations with some metals.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Microbiology
Steven Hainsworth, Ann C. Lawrie, Thiru Vanniasinkam, Danilla Grando
Summary: This study used metagenomics to analyze the microbiology of 18 clinically diagnosed mycotic nails and 2 normal nails, and found that T. rubrum and T. interdigitale/mentagrophytes were the main fungi causing the infections, while Staphylococcus epidermidis was the most abundant bacteria.
Article
Computer Science, Artificial Intelligence
Javad Khodadoust, Miguel Angel Medina-Perez, Raill Monroy, Ali Mohammad Khodadoust, Seyed Saeid Mirkamali
Summary: Authentication systems are crucial in modern life, and multibiometric systems offer enhanced security and recognition accuracy by combining biometric features. Before designing a multibiometric system, factors such as the number of biometric modalities, system accuracy, and budget allocation need to be carefully considered.
EXPERT SYSTEMS WITH APPLICATIONS
(2021)
Article
Oncology
Malene Outzen, Anne Tjonneland, David J. Hughes, Mazda Jenab, Kirsten Frederiksen, Lutz Schomburg, Steve Morris, Kim Overvad, Anja Olsen
Summary: The study did not find any association between toenail selenium or plasma SELENOP concentrations with advanced, high-grade or advanced-stage prostate cancer. Additionally, variations in selenoprotein genes were not found to be associated with PC risk.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Kaushalya Kumarasinghe, Nikola Kasabov, Denise Taylor
Summary: The study introduces a novel Brain-Inspired Spiking Neural Network (BI-SNN) model for incremental learning of spike sequences, successfully predicting muscle activity and kinematics. By mapping spiking activity from input channels into a high-dimensional source-space, the BI-SNN extends a previously proposed computational model, integrating it with a brain-inspired SNN architecture.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Axel P. Villani, Stephanie Boutroy, Celine Coutisson, Marie-Christine Carlier, Lois Barets, Hubert Marotte, Bertrand Richert, Roland D. Chapurlat, Denis Jullien, Cyrille B. Confavreux
Summary: This study found that onycholysis may be associated with early bone erosions of the DIP joint, which can impact the development of PsA. In the ONY group, there were significantly more bone erosions compared to the PSO group.
Review
Biology
Abdurrahman Pharmacy Yusuf, Murtala Bello Abubakar, Ibrahim Malami, Kasimu Ghandi Ibrahim, Bilyaminu Abubakar, Muhammad Bashir Bello, Naeem Qusty, Sara T. Elazab, Mustapha Umar Imam, Athanasios Alexiou, Gaber El-Saber Batiha
Summary: Zinc was established more than half a century ago as an essential micronutrient for normal human physiology, with around 10% of the human proteome potentially binding zinc. Proteins with zinc-binding domains play key roles in epigenetic modifications, such as DNA methylation and histone modifications, regulating transcription under physiological and pathological conditions. Zinc metalloproteins in epigenetics, mainly zinc metalloenzymes and zinc finger proteins, interact as writers, erasers, readers, editors, and feeders to maintain the epigenome's functioning.
Article
Chemistry, Multidisciplinary
Muhammad Nasir, Ryuhei Yamaguchi, Yun She, Anindityo Patmonoaji, Mohammad Azis Mahardika, Weicen Wang, Zijing Li, Shintaro Matsushita, Tetsuya Suekane
Summary: Hydrodynamic fingering induced by gel formation shares common features with growing biofilms, bacterial colonies, and the instability of a confined chemical garden. This study conducted displacement experiments and developed a mathematical model to investigate the effects of gel film formation on the fingering instability of a miscible fluid system.
APPLIED SCIENCES-BASEL
(2022)
Review
Dermatology
Maria L. D. Favero, Aline F. Bonetti, Eric L. Domingos, Fernanda S. Tonin, Roberto Pontarolo
Summary: This study compared the efficacy and safety of commercially available oral antifungals for the treatment of onychomycosis. The results showed that albaconazole 400 mg, posaconazole 200-400 mg, and terbinafine 250-350 mg were the most effective therapies, while itraconazole 400 mg was the safest drug. Further research is needed to investigate the advantages of albaconazole and posaconazole compared to current first-line therapies.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)