Article
Dermatology
Lydia Costello, Kirsty Goncalves, Paola De Los Santos Gomez, Amy Simpson, Victoria Maltman, Pamela Ritchie, Ryan Tasseff, Robert Isfort, Teresa Dicolandrea, Xingtao Wei, Arto Maatta, Iakowos Karakesisoglou, Ewa Markiewicz, Charles C. Bascom, Stefan Przyborski
Summary: Skin ageing is a complex process influenced by internal and external factors. This study analyzed skin parameters in individuals with Fitzpatrick skin types II-III to understand the effects of age and photoexposure. Differences in epidermal thickness were attributed to changes in the dermal-epidermal junction (DEJ). Basal keratinocytes showed increased cell size and a more columnar phenotype in photoexposed sites, suggesting accelerated photoageing. The study highlights the importance of early skin care education and photoprotection.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Rita Favas, Janaina Morone, Rosario Martins, Vitor Vasconcelos, Graciliana Lopes
Summary: Skin, as the largest organ in the human body, acts as a physicochemical barrier protecting against environmental stressors and plays a significant psychosocial role in the aging population. The cosmetic industry is developing new formulas to reduce visible signs of aging prompted by consumer demands for skincare. Increasing importance is placed on natural products, with cyanobacteria and microalgae gaining importance for their anti-aging potential and effects on enzymes involved in pigmentation processes.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Bethany K. Hughes, Cleo L. Bishop
Summary: Melanocytes protect the skin from UV damage by producing melanin, but prolonged exposure to UV light can lead to the formation of senescent cells, which may contribute to skin aging.
Article
Cell Biology
Matiss Ozols, Alexander Eckersley, Kieran T. Mellody, Venkatesh Mallikarjun, Stacey Warwood, Ronan O'Cualain, David Knight, Rachel E. B. Watson, Christopher E. M. Griffiths, Joe Swift, Michael J. Sherratt
Summary: Peptide location fingerprinting is a proteomic analysis technique that can identify structural modification-associated differences in complex biological samples, such as photoaged and intrinsically aged skin proteomes. This technique has the potential for discovering new biomarker candidates in various pathways, and has been demonstrated to be effective in identifying biomarkers in ageing tendon using published MS data sets.
Review
Cell Biology
Angelika Bielach-Bazyluk, Edyta Zbroch, Hanna Mysliwiec, Alicja Rydzewska-Rosolowska, Katarzyna Kakareko, Iwona Flisiak, Tomasz Hryszko
Summary: Skin aging is influenced by both intrinsic and extrinsic factors, with UV radiation being a major extrinsic factor. Sirtuin 1 plays a key role in regulating protein, histone, and chromatin expression, demonstrating beneficial effects on skin aging but with controversial role in carcinogenesis.
Review
Microbiology
Krzysztof Skowron, Justyna Bauza-Kaszewska, Zuzanna Kraszewska, Natalia Wiktorczyk-Kapischke, Katarzyna Grudlewska-Buda, Joanna Kwiecinska-Pirog, Ewa Walecka-Zacharska, Laura Radtke, Eugenia Gospodarek-Komkowska
Summary: This article explores the impact of skin microbiota on health and disease, as well as the relationship between microbial communities and the human immune system, providing new insights into the study of the human skin microbiome.
Article
Chemistry, Multidisciplinary
Nicola Zerbinati, Sabrina Sommatis, Cristina Maccario, Maria Chiara Capillo, Serena Di Francesco, Elsa Liga, Raffaele Rauso, Edoardo D'Este, Daniela Dalla Gasperina, Stefania Guida, Roberto Mocchi
Summary: The study shows that a new dermocosmetic formulation enriched with retinoids can improve collagen and elastin synthesis, leading to a reduction in aging signs, and decrease the secretion of a proteinase associated with skin aging.
APPLIED SCIENCES-BASEL
(2021)
Article
Multidisciplinary Sciences
Kouji Narita, Krisana Asano, Kyosuke Yamane, Hiroyuki Ohashi, Tatsushi Igarashi, Akio Nakane
Summary: This study reported the germicidal effect of 222 nm UVC and the critical role of bandpass filters in reducing the harmful effects of wavelengths outside of 222 nm on mammalian cells. Mice exposed to UVC emitted from a filtered lamp showed significantly lower levels of DNA damage compared to those exposed to UVC emitted from an unfiltered lamp.
Article
Medicine, General & Internal
Luca Liberale, Nicole R. Bonetti, Yustina M. Puspitasari, Ana Vukolic, Alexander Akhmedov, Candela Diaz-Canestro, Stephan Keller, Fabrizio Montecucco, Mario Merlini, Aurora Semerano, Giacomo Giacalone, Marco Bacigaluppi, Maria Sessa, Frank Ruschitzka, Thomas F. Luscher, Peter Libby, Jurg H. Beer, Giovanni G. Camici
Summary: Older mice showed larger stroke size and increased neuromotor deficit compared to young ones. Inhibition of TNF-alpha restored stroke volume, neuromotor performance, and survival rates in older mice, suggesting TNF-alpha as a causative contributor to the deleterious effect of aging on stroke outcomes. Increased TNF-alpha plasma levels in patients with ischemic stroke correlated with worsened short-term neurological outcome and age.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Robotics
Jiajun Lv, Xingxing Zuo, Kewei Hu, Jinhong Xu, Guoquan Huang, Yong Liu
Summary: Accurate and reliable sensor calibration is crucial for fusing LiDAR and IMU measurements. This article proposes a novel LiDAR-IMU calibration method within a continuous-time batch-optimization framework, which calibrates the intrinsics and spatial-temporal extrinsics of both sensors without using calibration infrastructure. Two observability-aware modules are leveraged to improve efficiency and address degenerate motions. The proposed method has been extensively validated in simulated and real-world experiments, demonstrating high accuracy and repeatability.
IEEE TRANSACTIONS ON ROBOTICS
(2022)
Article
Nanoscience & Nanotechnology
Hailong Shi, Xiaojun Wang, Yeyang Xiang, Chunlei Zhang, Xuejian Li, Chao Xu, Xiaoshi Hu, Weimin Gan
Summary: Constructing a layered structure is an effective approach to achieve a balance between strength and toughness. The toughening mechanisms for metal matrix composites include crack deflection and stress concentration mitigation. The study found that GNS layers can promote dislocation emission and alleviate stress concentration, enhancing the toughness of the composite.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2023)
Review
Cell Biology
Ren Jie Tuieng, Sarah H. Cartmell, Cliona C. Kirwan, Michael J. Sherratt
Summary: Exposure to ionising and non-ionising radiation can impact human health, particularly through damage to extracellular matrix proteins, but the exact consequences of this type of radiation exposure on tissue function and structure remain poorly defined compared to the well-characterised impact on cell biology.
Review
Medicine, General & Internal
Rafaela-Maria Kavasi, Monica Neagu, Carolina Constantin, Adriana Munteanu, Mihaela Surcel, Aristidis Tsatsakis, George N. Tzanakakis, Dragana Nikitovic
Summary: This article discusses the structural and functional modulations of the keratinocyte carcinoma microenvironment, focusing on the extracellular matrix (ECM) and its role in the pathogenesis of skin cancer.
FRONTIERS IN MEDICINE
(2022)
Article
Construction & Building Technology
Muhammad Jamal, Gilberto Martinez-Arguelles, Filippo Giustozzi
Summary: This study found that using coarser crumb rubber (CR) particles in asphalt can improve elastic response and storage stability, as well as enhance resistance to UV aging.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Environmental Sciences
Marcelo de Paula Correa, Alexandre Germano Marciano, Vanessa Silveira Barreto Carvalho, Plinio Marcos Bernardo de Souza, Julia da Silveira Carvalho Ripper, Daniel Roy, Lionel Breton, Rodrigo De Vecchi
Summary: This study aimed to quantify human exposure to environmental factors during routine daily activities and investigate the relationship between environmental factors and skin health. The study found that in most areas of Brazilian cities, people may be exposed to environmental factors such as UV radiation, temperature, and humidity, which could lead to skin damage.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
