Article
Oncology
Yoshitaka Saito, Kazuki Uchiyama, Yoh Takekuma, Yoshito Komatsu, Mitsuru Sugawara
Summary: A retrospective evaluation of mCRC patients receiving anti-EGFR monoclonal antibody treatment identified liver metastasis as an independent risk factor for skin toxicities and prophylactic administration of antibiotics as a preventive factor. The study suggests that preemptive antibiotic use can decrease the risk of skin toxicities during anti-EGFR treatment.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Dermatology
Rachel Bierbrier, Megan Lam, Kevin Pehr
Summary: This review summarizes the available data on the use of systemic retinoids for managing acneiform eruptions induced by EGFR inhibitors. The findings suggest that systemic retinoids are a safe and effective therapy, with the majority of patients experiencing moderate to significant improvement after treatment initiation.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Ji-Hye Park, YoungHwan Choi, Hyun Je Kim, Se Jin Oh, Dong-Youn Lee, Jong Hee Lee, Joo-Heung Lee
Summary: This research found that cetuximab-induced acneiform eruption can be effectively controlled with tetracycline-class antibiotics in about 3 months. It may last longer in male and younger patients, and the sooner and more severe it appears, the longer it can last.
Article
Oncology
Katsuko Kikuchi, Naoya Yamazaki, Keiko Nozawa, Haruhiko Fukuda, Taro Shibata, Ryunosuke Machida, Tetsuya Hamaguchi, Atsuo Takashima, Hirokazu Shoji, Narikazu Boku, Sumiko Takatsuka, Tatsuya Takenouchi, Tomohiro Nishina, Shusuke Yoshikawa, Masanobu Takahashi, Akiko Hasegawa, Akihito Kawazoe, Toshiki Masuishi, Hitoshi Mizutani, Yoshio Kiyohara
Summary: The study found no significant differences in the severity of facial acneiform eruption (FAfE) and adverse events caused by topical corticosteroids between the two groups over an 8-week period. However, the group starting with a strong corticosteroid showed lower incidence of grade 2 or higher FAfE during the first 2 weeks, suggesting that the regimen ranking up in potency may be more suitable for long-term management of FAfE due to EGFR inhibitor therapy.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Medicine, General & Internal
Canfeng He, Ruiting Lin, Jing Zhang, Lingling Sun, Jietao Lin, Lizhu Lin
Summary: This study aims to assess the treatment efficacy of acneiform eruptions caused by epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer patients. Bayesian network meta-analysis will be used, and it is hoped that the results will provide reliable evidence for the management of this condition.
Article
Biochemistry & Molecular Biology
Kyung-Jong Won, Rami Lee, Sun-Hye Choi, Ji-Hun Kim, Sung-Hee Hwang, Seung-Yeol Nah
Summary: This study aimed to elucidate the involvement of EGFRs in gintonin-induced wound repair in HaCaT keratinocytes. Results showed that gintonin increased EGF receptor activation, as well as promoted proliferation and migration in HaCaT cells. Additionally, gintonin stimulated the expression and release of HB-EGF. These findings suggest a close relationship between gintonin's wound-healing effects and the collaboration of EGF receptor activation and HB-EGF release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Twinkle Singh Thakur, Shreya Agrawal, Bhushan Madke, Sugat Jawade, Gauri Padmawar, Khushboo Verma
Summary: EGFR inhibitors are commonly used in the treatment of non-small cell carcinoma of the lung. Cutaneous toxicity, such as papulopustular eruption, is a known side effect and should be managed accordingly.
JOURNAL OF THE SCIENTIFIC SOCIETY
(2022)
Article
Dermatology
Keita Tsutsui, Katsuko Kikuchi, Keiko Nozawa, Atsuo Takashima, Kenichiro Tsuchiyama, Kenjiro Namikawa, Setsuya Aiba, Naoya Yamazaki
Summary: The study evaluated the efficacy and safety of topical benzoyl peroxide for treating epidermal growth factor receptor inhibitor-induced prolonged acneiform eruptions. Results showed potential in improving acneiform eruption severity and patients' quality of life.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Rachel Bierbrier, Kathleen D'Aguanno, Sarah Oliel, Yixiao Zeng, Khashayar Esfahani, Kevin Pehr
Summary: Acneiform eruptions are common adverse events of EGFRi therapy, occurring frequently and early. Combination cancer therapy with another chemotherapeutic agent is associated with a lower risk of acneiform eruptions, while other baseline characteristics are not statistically associated. Further research is needed to determine the risk factors for the development of acneiform eruptions.
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2023)
Article
Cell Biology
Xuan Wang, Shuyong Wang, Baolin Guo, Yuxin Su, Zuolong Tan, Mingyang Chang, Jinmei Diao, Yi Zhao, Yunfang Wang
Summary: The study presents a method for establishing and expanding human primary epidermal organoids under a chemically defined condition, which show tolerance to dermatophyte infections caused by Trichophyton Rubrum. This experimental model provides new insights into the pathogenesis of T. rubrum infections and serves as a potential tool for studying and testing antifungal drugs.
CELL DEATH & DISEASE
(2021)
Article
Medicine, General & Internal
Amir Amirabadi, Amirhosein Alami, Hamid Ahanchian, Nazila Ariaee, Nasrin Moazzen
Summary: Cetuximab is a potential treatment option for advanced basal cell carcinoma when conventional chemotherapy is not well-tolerated by the patient. Further studies are required to confirm its efficacy.
CLINICAL CASE REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Jing Zhao, Siying Li, Xuelei Pang, Yuping Shan
Summary: The therapeutic efficacy of nano-drugs targeting EGFR was evaluated in terms of cell entry efficiency and induced cell mechanical properties at the single particle/cell level in real time.
CHEMICAL COMMUNICATIONS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jasper Vonk, Jaron G. de Wit, Floris J. Voskuil, Yang Hang Tang, Wouter T. R. Hooghiemstra, Matthijs D. Linssen, Evert van den Broek, Jan J. Doff, Sebastiaan A. H. J. de Visscher, Kees-Pieter Schepman, Bert van der Vegt, Gooitzen M. van Dam, Max J. H. Witjes
Summary: This study investigated the use of fluorescence imaging to detect lymph node metastases in oral cancer patients. The results showed that fluorescence molecular imaging could accurately detect tumor-positive lymph nodes, reducing the need for microscopic assessment and identifying additional metastases missed by standard histopathologic analysis.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Ryuhei Okada, Takuya Kato, Aki Furusawa, Fuyuki Inagaki, Hiroaki Wakiyama, Daiki Fujimura, Shuhei Okuyama, Hideyuki Furumoto, Hiroshi Fukushima, Peter L. Choyke, Hisataka Kobayashi
Summary: This study compared the effects of Panitumumab and Cetuximab in APCs for NIR-PIT and the impact of different light exposure regimens on tumor growth in an immunocompetent mouse model. The results showed that APCs with longer half-life and double light exposure had superior outcomes in cancer cell-targeted NIR-PIT.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Mengkai Yang, Tao Zhang, Yangfeng Zhang, Xiaojun Ma, Jing Han, Ke Zeng, Yafei Jiang, Zongyi Wang, Zhuoying Wang, Jing Xu, Yingqi Hua, Zhengdong Cai, Wei Sun
Summary: The study revealed that MYLK4 promotes the growth and metastasis of osteosarcoma by activating the EGFR signaling pathway. Additionally, the combination of MYLK4 and EGFR inhibitors showed synergistic effects on the growth and metastasis of OS in vitro and in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)