Article
Engineering, Biomedical
Esperanza Diaz, Marta Delafuente, Sara Delafuente, Sylvie Ribeiro, Senentxu Lanceros-Mendez
Summary: This paper studies the degradation behavior of poly(d,l-lactide-co-glycolide/reduced graphene oxide scaffolds obtained by thermally induced phase separation and lyophilization in phosphate buffered saline solution at 37°C for eight weeks. The addition of rGO particles increases the pore size and improves the morphological definition of the scaffolds. Higher rGO concentrations result in faster degradation and the restriction of movement of macromolecular chain segments. The addition of rGO also leads to a transition from insulating to conductive scaffolds with a percolation value of approximately 0.5 w/w. All PLGA samples with rGO content up to 1% show no cytotoxic behavior and are suitable for biomedical applications.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Nanoscience & Nanotechnology
Aline O. Pereira, Isabella M. I. Lopes, Thiago R. Silva, Thaila Q. Correa, Rafaella T. Paschoalin, Natalia M. Inada, Ievgeniia Iermak, Francisco van Riel Neto, Juliana C. Araujo-Chaves, Alexandre Marletta, Jose R. Tozoni, Luiz Henrique C. Mattoso, Vanderlei S. Bagnato, Iseli L. Nantes-Cardoso, Osvaldo N. Oliveira Jr, Patricia T. Campana
Summary: This research demonstrates that nanofibers can be utilized as an alternative method for bacterial inactivation, instead of UV and blue irradiation. The use of PLGA nanofiber scaffolds can effectively kill Staphylococcus aureus and Escherichia coli bacteria at lower light intensities. The enhanced effect of PLGA scaffolds is attributed to their nanofiber structures, which could pave the way for a more cost-effective and environmentally friendly surface sterilization method.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Egor Morokov, Nikita Yabbarov, Nikita Sedush, Alexey Bogachenkov, Alexander Malykhin, Varvara Demina, Pavel Azarkevich, Elena Nikolskaya, Margarita Chirkina, Maria Sokol
Summary: Biocompatible, biodegradable polymers are widely used in drug delivery systems and tissue engineering scaffolds. The hydrothermal aging of polymers, including microstructure degradation and changes in mechanical properties, depends on environmental conditions. In vitro studies cannot capture all the factors that affect polymer degradation in a living organism. It is promising to study the dynamic changes in microstructure and elastic properties of polymer implants in vivo. This study presents data from the application of new experimental equipment for high-resolution ultrasound imaging of polymer degradation in vivo, showing images of volumetric microstructure transformation and dynamic changes in elastic properties.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Physical
Antonio Montes, Diego Valor, Yaiza Penabad, Manuel Dominguez, Clara Pereyra, Enrique Martinez de la Ossa
Summary: The study aims to design a specific supercritical CO2 foaming process to produce porous polymeric devices with improved conductive properties for use as therapeutic scaffolds in tissue engineering and tissue regeneration. The effects of pressure, temperature, and contact time on foam properties were evaluated, and the resulting foams exhibited high porosity, uniform polymer distribution, and a wide range of conductivity and mechanical properties. These conductive and porous scaffolds hold potential for various biomedical applications.
Article
Biochemistry & Molecular Biology
Yuan Sun, Xiaona Jia, Qing Meng
Summary: This study investigated the fabrication of nanofibrous scaffolds by blending recombinant spider silk proteins (R1SR2 and NR1SR2C) with Poly(lactic-co-glycolic) Acid (PLGA). The presence of N- and C-termini of MiSp contributed to the reduction of nanofiber diameter, increased porosity and glass transition temperatures of the scaffolds, as well as improved hydrophilicity and ultimate strain. In cell culture assays, HBMSCs grown on NR1SR2C/PLGA (20/80) scaffolds showed enhanced proliferative and adhesive abilities compared to those on pure PLGA scaffolds. These findings suggest promising applications of recombinant MiSp/PLGA blend nanofibrous scaffolds, particularly NR1SR2C/PLGA (20/80), in bone tissue engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Morteza Bazgir, Wei Zhang, Ximu Zhang, Jacobo Elies, Morvarid Saeinasab, Phil Coates, Mansour Youseffi, Farshid Sefat
Summary: Electrospinning is an innovative technology for fabricating membranes suitable for tissue engineering applications. Coaxial porous scaffolds showed better mechanical properties compared to bilayer scaffolds, with improved quality and functionality for biomedical applications. The degradation process and mechanical properties play important roles in the suitability of the scaffolds for tissue engineering.
Review
Biochemistry & Molecular Biology
Fengbo Sun, Xiaodan Sun, Hetong Wang, Chunxu Li, Yu Zhao, Jingjing Tian, Yuanhua Lin
Summary: This review systematically summarizes the research progress of 3D-printed, PLGA-based scaffolds, introduces the properties of the modified components, analyzes the influence of structure and printing method change in the printing process, illustrates the advantages and disadvantages of their applications with examples, and finally discusses the limitations and future development direction of current 3D-printed, PLGA-based materials for bone tissue repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Panjian Lu, Gang Wang, Tianmei Qian, Xiaodong Cai, Ping Zhang, Meiyuan Li, Yinying Shen, Chengbin Xue, Hongkui Wang
Summary: Research suggests that an appropriate amount of PLGA scaffolds can promote successful nerve regeneration, contributing to aspects such as the structure of the regenerated nerve, reinnervation of the target muscle, and Schwann cell migration and maturation. Additionally, the correct ratio of PLGA and chitosan degradation products helps reduce inflammatory response and enhance the regeneration microenvironment.
MATERIALS TODAY BIO
(2021)
Article
Engineering, Biomedical
Hu Qian, Ting Lei, Long Hua, Yu Zhang, Dongyu Wang, Jiangyu Nan, Wenbin Liu, Yan Sun, Yihe Hu, Pengfei Lei
Summary: In this study, a novel scaffold composed of gelatin methacryloyl (GelMA) hydrogel and poly(lactic co-glycolic acid) (PLGA) microspheres encapsulating vancomycin (Van) was developed for one-stage repair of infected bone defects (IBDs). The scaffold exhibited sustained release of Van for over 2 weeks and demonstrated good biocompatibility, bacteriostasis, and osteointegration properties, showing great potential for clinical application. The construction of this scaffold provides new insights into the development of orthopaedic implants and offers a novel approach for the treatment of IBDs.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Sheng-Ju Lin, Chieh-Cheng Huang
Summary: A strontium peroxide (SrO2)-loaded composite scaffold has been developed as a multifunctional bioactive bone graft for bone tissue engineering. The scaffold can release strontium ions in a sustained manner, stimulating the proliferation of osteoblasts and suppressing the formation of osteoclasts. It can also generate hydrogen peroxide and oxygen molecules, increasing local oxygen tension for osteogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Sitansu Sekhar Nanda, Tuntun Wang, Md Imran Hossain, Hong Yeol Yoon, Subramanian Tamil Selvan, Kwangmeyung Kim, Dong Kee Yi
Summary: This study developed a gold nanorod-incorporated scaffold that controlled heat shock protein and improved wound healing through external light stimulation. In vitro experiments showed that the scaffold had no harmful effects on cells and promoted cell proliferation. In mouse experiments, the scaffold increased local temperature, effectively promoted HSP70 expression, and enhanced the wound healing process.
ACS APPLIED NANO MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Zhe Wang, Shuai Hou, Shiyu Yao, Yuli Shang, Shu Deng, Yang Peng, Weiwei Zhou, Xiaofei Lv, Bo Ren, Cheng Peng, Jie Yang, Zhaohui Huang
Summary: This article reports the fabrication of a novel Tilapia Collagen/Hydroxyapatite-based tissue engineering scaffold that imitates functional extracellular matrix. By embedding Aspirin-PLGA microspheres in the scaffold, the osteoinductive activity was improved. The scaffold demonstrated ideal pore structure, mechanical strength, chemical stability, and controlled release of aspirin. The enhanced cell proliferation and mineralization capacity make it an ideal biomaterial for bone tissue engineering.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Physics, Multidisciplinary
Mohsen Norouzi, Mohammad Rafienia, Seyedmajid Hosseini
Summary: In this study, electrospun scaffolds made from different ratios of pure PLGA solution, PLGA/Fibrin, PLGA/Lignin, and PLGA/Fibrin/Lignin were characterized physiochemically and biologically. The scaffolds exhibited homogeneous nanostructures and changing the composition led to differences in fiber diameter and color. The incorporation of fibrin, lignin, or fibrin/lignin improved the absorption capacity and degradation rate of the scaffolds. The addition of natural components gradually decreased the scaffolds' tensile strength and enhanced cell viability. Among the options, PLGA/20%Fibrin/10%Lignin showed superior physical features and enhanced biological responses, making it suitable for various biomedical applications.
Article
Chemistry, Physical
Morteza Bazgir, Wei Zhang, Ximu Zhang, Jacobo Elies, Morvarid Saeinasab, Phil Coates, Mansour Youseffi, Farshid Sefat
Summary: The study evaluated the characteristics and degradation effects of PLGA- and PCL-based nanofibrous scaffolds, finding that longer electrospinning times resulted in stronger mechanical properties and maintained fiber structure. Both PCL and PLGA scaffolds demonstrated adequate degradation over time, with slight increase in fiber diameter and substantial decrease in pore size and porosity percentage. This experiment suggests promise for PCL and PLGA in tissue engineering and regenerative medicine applications.
Article
Biochemistry & Molecular Biology
Runcai Yang, Sijing Yang, Kaijing Li, Ziming Luo, Bikun Xian, Jiaqi Tang, Meifang Ye, Shoutao Lu, Haijun Zhang, Jian Ge
Summary: The novel retinal sheet composed of carbon nanotubes and PLGA can enhance retinal cell therapy, offering new insights into retinal injury, repair, and regeneration. This biomaterial shows excellent electrical conductivity, biocompatibility, and biodegradation compared to PLGA scaffolds.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Polymer Science
Yuanzhang Jiang, Xuyi Wang, Yanting Han, Dakai Gong, Yingchun Gu, Lin Tan
Summary: In this study, FeCl3 and poly(acrylic acid) (PAA) were doped into waterborne polyurethanes (WPUs) to create multifunctional materials with self-healing and antimicrobial properties. WPU/Fe/PAA-5.5, containing 5.5 wt % PAA, exhibited excellent mechanical properties, strong self-healing capabilities, and an impressive antimicrobial rate of over 90%. These supramolecular films were also highly recyclable through hot-pressing.
Article
Polymer Science
Longyu Tian, Min Wang, Guangming Liao, Baoliang Liu, Sujuan Zhang, Yucheng Sun, Zhen Meng, Jintao Zhang, Zaijun Lu
Summary: Two kinds of benzoxazine monomers were synthesized and used to prepare polybenzoxazine anion exchange membranes (AEMs) with quaternary ammonium functionalization. The LQPBZ AEM exhibited better ion conductivity and alkaline stability.
Article
Polymer Science
Claire A. Lemarchand
Summary: This study investigates the shock behavior of three different polymers through molecular dynamics simulations. The results reveal specificities in the shock behavior of polymers, including deviations from the linear relation between shock velocity and particle velocity, as well as differences in shear stress relaxation behind the shock front. It is found that the deviation of the Hugoniot locus is related to the change in the relative contribution of bonding and non-bonding potential energies, while polymers with higher glass transition temperatures exhibit slower shear stress relaxation.
Article
Polymer Science
Zengquan Liu, Xiaochun Yin, He Zhang, Shuo Gao, Qinglin Kuang, Yanhong Feng
Summary: A powder solid-state extension (PSSE) technology was proposed to address the high melt viscosity issue of UHMWPE. By uniaxial extension and sintering in the solid state, a highly self-reinforced material was prepared. X-ray diffraction and scattering techniques were used to study the structural evolution during the PSSE process, and a solid-phase induced transformation model was established.
Article
Polymer Science
Zhike Li, Anyu Luo, Rui Zhou, Xin Li, Haiyan Li
Summary: A novel high temperature resistance IL@SiO2 nanocapsules were successfully prepared and their friction and wear properties in PA6 composites were studied. The addition of IL@SiO2 nanocapsules reduced the friction coefficient and wear rate without affecting the mechanical properties of PA6. The synergy between the IL core and SiO2 wall in the nanocapsules improved the self-lubricating performance of the PA6 composites.
Article
Polymer Science
Xin Liu, Xuhong Guo, Qi Liao
Summary: In this study, an algorithm for accurately estimating viscosity is developed using molecular dynamics simulations and the Green-Kubo formula. This algorithm can be applied to complex systems with long correlations, such as macromolecular and biological simulation systems.
Article
Polymer Science
Hao Pu, Yun-Lei Hou, Jing -Zhou Chen, Dong -Lin Zhao
Summary: The use of modified graphene improves the interfacial adherence of carbon fibers to epoxy resin, resulting in enhanced interfacial and bending properties of CF and matrix in CF/EP composites, as well as increased interlaminar shear strength and flexural strength.
Article
Polymer Science
Wei-Chung Ke, Jin-Wei Lin, Manohar Reddy Busireddy, Yueh-Hsing Lee, Jiun-Tai Chen, Chain-Shu Hsu
Summary: This study introduces a crosslinkable monomer, TAIC, to synthesize three crosslinked polyimide films, which exhibit improved thermal, mechanical, and dielectric properties. The introduction of TAIC enhances the tensile strength, reduces the dielectric constant and dielectric loss, and decreases the coefficient of thermal expansion of the polyimide films.
Article
Polymer Science
Alex Kwasi Kumi, Ruiling Fan, Ye Chen, Yumei Zhang
Summary: The difference in leaching of amylopectin from cellulose/amylopectin/1-butyl-3-methylimidazolium chloride ([Bmim][Cl]) blends during regeneration in water and aqueous ethanol has been studied. Molecular dynamics simulations showed that the dissolution and regeneration mechanisms of amylopectin in [Bmim][Cl] are similar to cellulose in ionic liquids. Water regeneration leads to weak electrostatic interactions, resulting in high leaching of amylopectin. In contrast, ethanol-water interactions enhance electrostatic interactions among amylopectin chains, limiting amylopectin leaching in aqueous ethanol.
Article
Polymer Science
Xi Zeng, Junwei Zhou, Junbiao Peng, Chunsheng Zhang, Danling Wang, Yihu Song, Qiang Zheng
Summary: This study utilizes an oligomer deep eutectic solvent (DES) based on polyethylene glycol to regulate the vulcanization kinetics of rubber. The results show that the DES can accelerate vulcanization at low temperatures without affecting the crosslinking density and Mullins effect.
Article
Polymer Science
Qianqian Yue, Yongfei Peng, Xingjian Liu, Aihua He, Huarong Nie
Summary: The addition of metal deactivators can effectively suppress the aging of TBIR, prolong its lifespan, and have no negative effects on its physical and processing properties. These research findings are of great importance for improving the stability and aging resistance of polymers.
Article
Polymer Science
J. Gomez-Caturla, J. Ivorra-Martinez, R. Tejada-Oliveros, V Moreno, D. Garcia-Garcia, R. Balart
Summary: This work focuses on the development of environmentally friendly PLA formulations by using different esters derived from geraniol as plasticizers. The results show that these esters have good compatibility with PLA, and they can effectively enhance the elongation and plasticity of PLA, reduce its glass transition temperature, and slightly improve its water absorption capabilities.
Article
Polymer Science
Dandan Li, Zhaohui Lu, Zhao Ke, Ke Xu, Fengna Dai, Youhai Yu, Guangtao Qian, Chunhai Chen
Summary: In this study, cross-linked PI aerogel membranes with low dielectric constant and high moisture resistance were prepared by co-polymerization and scraping coating technology. The incorporation of fluorinated blocks and benzimidazole ring structures resulted in novel PI aerogel membranes with fascinating dielectric properties and outstanding moisture resistance.
Article
Polymer Science
Zhaoyang Chu, Qing Zhang, Haihua Luo, Han Zhou, Fapei Zhang, Wei Chen, Wenhua Zhang
Summary: Multi-physical fields solution processing strategy is a universal and facile method for preparing various conjugated polymer films and high-performance devices. In this study, we employed a combined microfluidic flow and ultrasonication strategy (FU) for processing CP solutions, and found a pronounced synergetic effect in promoting the pre-ordering of chains in solution. The conformation order and anisotropy of the solution were revealed through various characterizations. A non-classical nucleation model for polymer crystallization in non-equilibrium solution processing was confirmed. The roles of microfluidic flow and ultrasonication in chain aggregation and crystallization were addressed through multi-physical simulations. Compared to pristine solutions, the FU strategy showed improved solution anisotropy and crystallization kinetics, resulting in higher crystallinity in films and increased mobilities in OFET devices. The FU processing strategy provides a universal approach for regulating chain conformation and aggregation in conjugated polymer solutions.