Passerini Multicomponent Reaction of Indane-1,2,3-Trione: an Efficient Route for the One-Pot Synthesis of Sterically Congested 2,2-Disubstituted Indane-1,3-Dione Derivatives

The Passerini reaction of indane-1,2,3-trione, isocyanides and benzoic acid derivatives proceed at room temperature and sterically congested 2,2-disubstituted indane-1,3-dione derivatives are synthesized in excellent yields. The reaction proceeds smoothly and cleanly under mild conditions and no side reactions are observed.