期刊
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
卷 106, 期 493, 页码 260-274出版社
AMER STATISTICAL ASSOC
DOI: 10.1198/jasa.2011.tm10284
关键词
Gene-set test; Large p, small n; U-statistics
资金
- NSF [SES-0518904, DMS-0604563, DMS-0714978]
We propose simultaneous tests for coefficients in high-dimensional linear regression models with factorial designs. The proposed tests are designed for the large p, small n situations where the conventional F-test is no longer applicable. We derive the asymptotic distribution of the proposed test statistic under the high-dimensional null hypothesis and various scenarios of the alternatives, which allow power evaluations. We also evaluate the power of the F-test for models of moderate dimension. The proposed tests are employed to analyze a microarray data on Yorkshire Gilts to find significant gene ontology terms which are significantly associated with the thyroid hormone after accounting for the designs of the experiment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据