Article
Environmental Sciences
Tarana Arman, Katherine D. Lynch, Michael Goedken, John D. Clarke
Summary: The study showed that MCLR exposure drives the progression of NAFLD induced by HFHC diet into a more severe state, increasing renal toxicity. In addition, an HFHC diet may increase the severity of certain MCLR-elicited renal toxicities.
Article
Immunology
Titi Chen, Qi Cao, Ruifeng Wang, Guoping Zheng, Farhana Azmi, Vincent W. Lee, Yuan Ming Wang, Hongqi Li, Di Yu, Natasha M. Rogers, Stephen I. Alexander, David C. H. Harris, Yiping Wang
Summary: Previous studies have shown that cDC1s play a protective role in early stage anti-GBM disease by interacting with Tregs, but become pathogenic in late stage Adriamycin nephropathy by activating CD8+ T cells. In this study, we investigated the role and mechanisms of cDC1s at different time points in anti-GBM disease and explored the potential of repurposing Flt3 inhibitors as a treatment strategy. Our findings revealed that the number of cDC1s increased significantly in human anti-GBM disease, and their depletion in late stages attenuated kidney injury. Depleted cDC1s showed a pro-inflammatory phenotype, and their depletion also reduced the number of CD8+ T cells. The use of Flt3 inhibitors replicated these findings, indicating their potential as a novel therapy for anti-GBM disease.
CLINICAL IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Mengyue Zhu, Jingjing Wang, Weibo Le, Feng Xu, Ying Jin, Chenfeng Jiao, Haitao Zhang
Summary: This study retrospectively analyzed data from 110 patients with anti-GBM disease and found that anti-GBM antibody levels were associated with kidney outcomes, and reducing antibody levels could improve kidney outcomes.
JOURNAL OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Thi Thuy Uyen Nguyen, Hyeongwan Kim, Yoon Jung Chae, Jong Hwan Jung, Won Kim
Summary: This study indicates that serum VEGF-D may be an important biomarker in patients with diabetic CKD, associated with renal dysfunction and proteinuria.
Article
Transplantation
Paola Romagnani, A. Richard Kitching, Nelson Leung, Hans-Joachim Anders
Summary: Glomerulonephritis (GN) is a diverse group of immune-mediated disorders, which cannot be properly classified or treated based on histological patterns alone. To overcome this problem, a new classification system is proposed that considers disease category, immunological activity, and chronicity, which will guide the therapeutic approach.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Biology
Marilena Gregorini, Claudia Del Fante, Eleonora Francesca Pattonieri, Maria Antonietta Avanzini, Maria Antonietta Grignano, Irene Cassaniti, Fausto Baldanti, Giuditta Comolli, Angela Nocco, Miriam Ramondetta, Gianluca Viarengo, Vincenzo Sepe, Carmelo Libetta, Catherine Klersy, Cesare Perotti, Teresa Rampino
Summary: This study evaluated the therapeutic long-term effect of extracorporeal photopheresis (ECP) in patients with chronic antibody-mediated rejection (ABMR). ECP was found to reduce HLA antibody levels and slow down renal failure progression by modulating immune cellular and humoral responses.
Article
Transplantation
Swati Mehta, Andrea Lightle, Marc A. Judson
Summary: Renal sarcoidosis is a rare form of sarcoidosis that causes granulomatous inflammation in the kidneys. It often presents with renal insufficiency or signs of systemic inflammation. Diagnosis is confirmed through renal biopsy, and treatment primarily consists of corticosteroids. The risk of progression to end-stage renal disease is low.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Immunology
Mengyue Zhu, Jingjing Wang, Weibo Le, Feng Xu, Ying Jin, Chenfeng Jiao, Haitao Zhang
Summary: This study investigated the relationship between serum C3 levels and outcomes in patients with anti-GBM disease, and found that patients in the low C3 group had poorer kidney outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aiying Yu, Jingfu Zhao, Shiv Pratap S. Yadav, Bruce A. Molitoris, Mark C. Wagner, Yehia Mechref
Summary: Chronic kidney disease (CKD) is characterized by reduced renal function and kidney damage, with alterations in glycosylation potentially impacting the functional properties of the proximal tubule (PT). Research indicates that sialylation levels are highest in severe CKD and diabetic groups, which could aid in the discovery of glycan biomarkers.
Article
Immunology
Xueling Hu, Chanjuan Shen, Ting Meng, Joshua D. Ooi, Peter J. Eggenhuizen, Ya-ou Zhou, Hui Luo, Jin-biao Chen, Wei Lin, Yizi Gong, Qi Xiong, Jia Xu, Ning Liu, Xiangcheng Xiao, Rong Tang, Yong Zhong
Summary: The study found that DPPs tended to involve multi-organ damage rather than being limited to the kidney, compared to anti-GBM disease. The clinical and pathological characteristics of DPPs differed from those of MPO-AAV and anti-GBM disease patients. DPPs had a worse prognosis compared to MPO-AAV and anti-GBM disease patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aiying Yu, Jingfu Zhao, Jieqiang Zhong, Junyao Wang, Shiv Pratap S. Yadav, Bruce A. Molitoris, Mark C. Wagner, Yehia Mechref
Summary: Chronic kidney disease (CKD) is characterized by reduced renal function and proteinuria, with proteinuria increasing with age and potentially caused by alterations in glycoproteins in the proximal tubule. Glycomic analysis revealed differential O-glycan expressions in various stages of CKD, with higher fucosylation levels observed in CKD and diabetic groups, potentially contributing to tubular dysfunction.
Article
Urology & Nephrology
Meryl Waldman, Maria Jose Soler, Clara Garcia-Carro, Liz Lightstone, Tabitha Turner-Stokes, Megan Griffith, Joan Torras, Laura Martinez Valenzuela, Oriol Bestard, Colin Geddes, Oliver Flossmann, Kelly L. Budge, Chiara Cantarelli, Enrico Fiaccadori, Marco Delsante, Enrique Morales, Eduardo Gutierrez, Jose A. Nino-Cruz, Armando J. Martinez-Rueda, Giorgia Comai, Claudia Bini, Gaetano La Manna, Maria F. Slon, Joaquin Manrique, Irene Agraz, Ninet Sinaii, Paolo Cravedi
Summary: Patients with immune-mediated glomerulonephritis infected with SARS-CoV-2 had higher mortality and acute kidney injury rates compared to the general population without glomerulonephritis. Different etiologies of glomerulonephritis did not significantly affect outcomes, but factors such as lower serum albumin levels and shorter duration of glomerular disease were associated with increased risk of acute kidney injury in this population.
KIDNEY INTERNATIONAL
(2021)
Article
Environmental Sciences
Kai-Fan Tsai, Fu-Jen Cheng, Wan-Ting Huang, Chia-Te Kung, Chien-Te Lee, Ben-Chung Cheng, Jin-Bor Chen, Shau-Hsuan Li, Chin-Chou Wang, Liang-Jen Wang, Yu-Che Ou, Wen-Chin Lee
Summary: This study found that there is universal exposure to OPFRs in the CKD population, with high urinary detection rate. The urinary concentration of BCEP was independently correlated with lower eGFR, and the concentration of BBOEP was independently correlated with overt proteinuria in CKD patients. Additionally, lifestyle factors such as seafood consumption and age were associated with urinary concentrations of OPFR compounds.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Urology & Nephrology
Lida Rodas, Esther Barnadas, Arturo Pereira, Natalia Castrejon, Anna Saurina, Jordi Calls, Yolanda Calzada, Alvaro Madrid, Miguel Blasco, Esteban Poch, Adriana Garcia-Herrera, Luis F. Quintana
Summary: The density of lymphatic vessels may serve as a prognostic indicator for predicting the risk of progression to end-stage kidney disease (ESKD) in patients with IgA nephropathy (IgAN) and has implications for the evaluation of new targeted therapies.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Peripheral Vascular Disease
Janis M. Dionne, Shuai Jiang, Derek K. Ng, Joseph T. Flynn, Mark M. Mitsnefes, Susan L. Furth, Bradley A. Warady, Joshua A. Samuels
Summary: In children with moderate CKD, the association between MAP percentile and disease progression risk was not significant until after 4 years of follow-up for those with nonglomerular CKD. On the other hand, in those with glomerular CKD, the differential risk for progression was observed from baseline with the highest risk in those with MAP >90th percentile. These relationships remained significant even after adjustment for proteinuria levels.