Article
Cell Biology
Paulina Roux-Biejat, Marco Coazzoli, Pasquale Marrazzo, Silvia Zecchini, Ilaria Di Renzo, Cecilia Prata, Alessandra Napoli, Claudia Moscheni, Matteo Giovarelli, Maria Cristina Barbalace, Elisabetta Catalani, Maria Teresa Bassi, Clara De Palma, Davide Cervia, Marco Malaguti, Silvana Hrelia, Emilio Clementi, Cristiana Perrotta
Summary: The acid sphingomyelinase (ASMase) plays a crucial role in skeletal muscle regeneration by regulating the balance between M1 and M2 macrophages in the injured muscles, reducing inflammation and accelerating the early phases of muscle regeneration. This study reveals a novel function of ASMase in modulating the immune response during muscle repair and suggests ASMase as a potential therapeutic target to improve muscle recovery in conditions with excessive inflammation.
Article
Pediatrics
Jeanne Frisby-Zedan, Matthew F. Barhight, Mahima Keswani, Jennifer Arzu, Delphine Nelson
Summary: This retrospective cohort study analyzed the risk of chronic kidney disease (CKD) in critically ill pediatric patients who received continuous kidney replacement therapy (CKRT). The study found that approximately one-fourth of the patients had evidence of CKD after discharge, and there was sub-optimal follow-up with pediatric nephrologists for high-risk patients.
PEDIATRIC NEPHROLOGY
(2023)
Article
Multidisciplinary Sciences
Changwei Wu, Yun Zhang, Sheng Nie, Daqing Hong, Jiajing Zhu, Zhi Chen, Bicheng Liu, Huafeng Liu, Qiongqiong Yang, Hua Li, Gang Xu, Jianping Weng, Yaozhong Kong, Qijun Wan, Yan Zha, Chunbo Chen, Hong Xu, Ying Hu, Yongjun Shi, Yilun Zhou, Guobin Su, Ying Tang, Mengchun Gong, Li Wang, Fanfan Hou, Yongguo Liu, Guisen Li
Summary: This study developed a deep learning model to predict the risk of in-hospital death and dialysis for patients with acute kidney injury (AKI) during hospitalization. The model showed consistent predictive performance in both internal and external validation cohorts.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Shuo-Ming Ou, Kuo-Hua Lee, Ming-Tsun Tsai, Wei-Cheng Tseng, Yuan-Chia Chu, Der-Cherng Tarng
Summary: The study revealed that patients with chronic kidney disease discharged from hospitalization for sepsis are at higher risks of subsequent renal adverse events compared to non-sepsis group.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Alex Yashchenko, Sarah J. Bland, Cheng J. Song, Ummey Khalecha Bintha Ahmed, Rachel Sharp, Isabella G. Darby, Audrey M. Cordova, Morgan E. Smith, Jeremie M. Lever, Zhang Li, Ernald J. Aloria, Shuja Khan, Bibi Maryam, Shanrun Liu, Michael R. Crowley, Kenneth L. Jones, Lauren A. Zenewicz, James F. George, Michal Mrug, David K. Crossman, Katharina Hopp, Stavros Stavrakis, Mary B. Humphrey, Florent Ginhoux, Kurt A. Zimmerman
Summary: Kidney macrophages in healthy mice exhibit cellular heterogeneity, with four major subsets of monocytes and two major subsets of kidney resident macrophages. The expression of Ccr2 in kidney resident macrophages is not solely derived from Ly6c(hi) monocytes, and Ccr2 expression reflects their spatial distribution in the kidney cortex. The gene Cx3cr1 regulates the heterogeneity of kidney resident macrophages and plays a role in niche-specific disease progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Jia H. Ng, Jamie S. Hirsch, Azzour Hazzan, Rimda Wanchoo, Hitesh H. Shah, Deepa A. Malieckal, Daniel W. Ross, Purva Sharma, Vipulbhai Sakhiya, Steven Fishbane, Kenar D. Jhaveri
Summary: The study found that COVID-19 patients with AKI had a higher risk of death, but good kidney function recovery among survivors. However, some patients still needed dialysis at discharge.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Cell Biology
Jiabei Yang, Xuewei Zhang, Jiaqing Chen, Boon Chin Heng, Yangzi Jiang, Xiaoyu Hu, Zigang Ge
Summary: The study highlights the important role of macrophages in cartilage regeneration, showing that they promote regeneration by modulating proliferation and apoptosis. Exogeneous macrophages have therapeutic potential in promoting cartilage regeneration by regulating stem cells. Only M2c macrophages are able to promote regeneration of both cartilage tissues and subchondral bone.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Critical Care Medicine
Peerapat Thanapongsatorn, Kamolthip Chaikomon, Nuttha Lumlertgul, Khanitha Yimsangyad, Akarathep Leewongworasingh, Win Kulvichit, Phatadon Sirivongrangson, Sadudee Peerapornratana, Weerachai Chaijamorn, Yingyos Avihingsanon, Nattachai Srisawat
Summary: The study showed that implementing comprehensive care by an MDCT can improve outcomes for severe AKI survivors, including better feasibility outcomes such as dietary records, drug reconciliation, and drug alerts, as well as reduced urine albumin levels and improved blood pressure control.
Article
Immunology
Wenjing Wu, Wenbiao Wang, Liying Liang, Junzhe Chen, Sifan Sun, Biao Wei, Yu Zhong, Xiao-Ru Huang, Jian Liu, Xiaoqin Wang, Xueqing Yu, Hui-Yao Lan
Summary: Cytokine storm in critically ill COVID-19 patients is triggered by SARS-CoV-2 N protein-induced tubular death and release of HMGB1, resulting in M1 proinflammatory macrophage activation and cytokine production through Mincle-Syk/NF-kappa B-dependent mechanism. Treatment with quercetin inhibits this pathway and improves SARS-CoV-2 N protein-induced AKI by suppressing HMGB1 release and activating reparative M2 macrophages.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Surgery
Ashish R. Chowdary, Tristan Maerz, Dominic Henn, Kurt D. Hankenson, Chase A. Pagani, Simone Marini, Katherine Gallagher, Carlos A. Aguilar, Robert J. Tower, Benjamin Levi
Summary: The objective of this study was to identify macrophage subpopulations and gene signatures associated with different types of musculoskeletal injury. Through single-cell RNA sequencing data analysis, distinct subpopulations of macrophages were identified in regenerative and fibrotic healing, and it was found that the transcriptional profiles of these subpopulations had similarities in cell composition. Macrophage polarization state was not correlated with healing outcomes, but the analysis of receptor/ligand interaction between macrophages and mesenchymal progenitor cells showed potential therapeutic targets for predicting fibrotic responses and promoting regenerative conditions.
Article
Urology & Nephrology
Soraya Arzhan, Maria-Eleni Roumelioti, Igor Litvinovich, Cristian G. Bologa, Mark L. Unruh
Summary: Hospital-acquired hypernatremia is associated with in-hospital mortality and discharge to hospice or to nursing facilities in all stages of CKD.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Basil T. Darras, Riccardo Masson, Maria Mazurkiewicz-Beldzinska, Kristy Rose, Hui Xiong, Edmar Zanoteli, Giovanni Baranello, Claudio Bruno, Dmitry Vlodavets, Yi Wang, Muna El-Khairi, Marianne Gerber, Ksenija Gorni, Omar Khwaja, Heidemarie Kletzl, Renata S. Scalco, Paulo Fontoura, Laurent Servais
Summary: In this study involving infants with type 1 SMA, treatment with risdiplam resulted in higher percentages of infants who achieved motor milestones and showed improvements in motor function compared to historical controls. Longer and larger trials are needed to confirm the long-term safety and efficacy of risdiplam in infants with type 1 SMA.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cell Biology
Chengxiao Hu, Yangyang Zuo, Qian Ren, Xiaoli Sun, Shan Zhou, Jinlin Liao, Xue Hong, Jinhua Miao, Lili Zhou, Youhua Liu
Summary: MMP-10 plays a protective role in AKI by enhancing EGFR signaling, leading to promotion of tubular cell survival and proliferation after injury.
CELL DEATH & DISEASE
(2021)
Article
Critical Care Medicine
Nuttha Lumlertgul, Leah Pirondini, Enya Cooney, Waisun Kok, John Gregson, Luigi Camporota, Katie Lane, Richard Leach, Marlies Ostermann
Summary: This retrospective study investigated acute kidney injury (AKI) in critically ill patients with COVID-19 in ICU, finding that AKI was highly prevalent in these patients with a portion progressing to severe stages requiring kidney replacement therapy. Steroid therapy may have a protective effect in reducing AKI progression.
ANNALS OF INTENSIVE CARE
(2021)
Article
Medical Laboratory Technology
Annemarie Albert, Sebastian Radtke, Louisa Blume, Rinaldo Bellomo, Michael Haase, Philipp Stieger, Ulrich Paul Hinkel, Ruediger C. Braun-Dullaeus, Christian Albert
Summary: This study investigated the impact of neutrophil gelatinase-associated lipocalin (NGAL) cutoff value selection and the acute kidney injury (AKI) classification system on the allocation of clinical AKI phenotypes and associated outcomes.
ANNALS OF LABORATORY MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Tathambika Tejeswini Sen, Ajinath Kale, Maciej Lech, Hans-Joachim Anders, Anil Bhanudas Gaikwad
Summary: Globally, there are approximately 850 million people diagnosed with kidney disease, but the available treatment options are still limited. Preclinical studies propose several potential therapeutic targets for chronic kidney disease and acute kidney injury, including intermedin, periostin, sirtuin, the cannabinoid receptor, Klotho, Apelin, Elabela, growth differentiation factor-15, Fyn kinase, and uromodulin. The selection of target for clinical development should consider redundancy with existing treatments, potential synergistic effects, and additional effects on the cardiovascular system, which is a common comorbidity in patients with kidney disease.
DRUG DISCOVERY TODAY
(2023)
Article
Biochemistry & Molecular Biology
Chao Han, Pengxuan Ren, Medina Mamtimin, Linus Kruk, Edita Sarukhanyan, Chenyu Li, Hans-Joachim Anders, Thomas Dandekar, Irena Krueger, Margitta Elvers, Silvia Goebel, Kristin Adler, Goetz Muench, Thomas Gudermann, Attila Braun, Elmina Mammadova-Bach
Summary: This study analyzed the collagen- and CRP-binding surfaces of GPVI monomers and dimers using computational modeling and bioinformatics, and compared them with other mammalian GPVI isoforms. Experimental results show that the EA-20 antibody inhibits platelet adhesion and aggregation in response to collagen and CRP, but not to fibrin, and prevents thrombus formation in whole blood. Therefore, the blockade of this minimal collagen-binding epitope of GPVI with the EA-20 antibody could represent a new anti-thrombotic approach.
Review
Oncology
Ajinath Kale, Maciej Lech, Hans-Joachim Anders, Anil Bhanudas Gaikwad
Summary: Lupus nephritis is a severe complication of systemic lupus erythematosus, mainly affecting women of childbearing age. Current treatment options for lupus nephritis have limited effectiveness, but recent drug approvals and clinical trials on novel medications offer hope for improved outcomes. These medications aim to modulate the activity of systemic lupus erythematosus, target non-immune mechanisms of disease progression, or have dual immunosuppressive and antiproteinuric effects, thereby providing more personalized treatment options.
Article
Biochemistry & Molecular Biology
Andrea Ribeiro, Feiyue Liu, Matthias Srebrzynski, Simone Rother, Karina Adamowicz, Marta Wadowska, Stefanie Steiger, Hans-Joachim Anders, Christoph Schmaderer, Joanna Koziel, Maciej Lech
Summary: In this study, the impact of uremic toxin indoxyl sulfate on macrophages and tubular epithelial cells and its role in modulating the response to lipopolysaccharide (LPS) were investigated. Indoxyl sulfate, which accumulates in the blood of patients with chronic kidney disease (CKD), was found to induce low-grade inflammation and modulate macrophage function. Additionally, it was shown to enhance the inflammatory response associated with LPS and contribute to the senescence of tubular epithelial cells during injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Transplantation
Paola Romagnani, A. Richard Kitching, Nelson Leung, Hans-Joachim Anders
Summary: Glomerulonephritis (GN) is a diverse group of immune-mediated disorders, which cannot be properly classified or treated based on histological patterns alone. To overcome this problem, a new classification system is proposed that considers disease category, immunological activity, and chronicity, which will guide the therapeutic approach.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Hans-Joachim Anders, Gema M. Fernandez-Juarez, Augusto Vaglio, Paola Romagnani, Juergen Floege
Summary: The management of immune-mediated kidney diseases focuses on controlling the underlying immune disease process and the non-immune mechanisms of chronic kidney disease (CKD) progression. Non-pharmacological interventions, such as reducing salt intake and regular physical activity, along with approved drug interventions, can help attenuate CKD progression.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Transplantation
Hans-Joachim Anders
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Oncology
Linus Kruk, Medina Mamtimin, Attila Braun, Hans-Joachim Anders, Joachim Andrassy, Thomas Gudermann, Elmina Mammadova-Bach
Summary: Inflammation plays a crucial role in the progression and metastasis of renal cell carcinoma by regulating the interaction between tumor cells and the tumor microenvironment. This review summarizes recent research on the role of inflammation in RCC tumors and discusses potential inflammatory pathways as therapeutic targets.
Article
Peripheral Vascular Disease
Timon Kuchler, Roman Guenthner, Andrea Ribeiro, Renate Hausinger, Lukas Streese, Anna Woehnl, Veronika Kesseler, Johanna Negele, Tarek Assali, Javier Carbajo-Lozoya, Maciej Lech, Heike Schneider, Kristina Adorjan, Hans Christian Stubbe, Henner Hanssen, Konstantin Kotilar, Bernhard Haller, Uwe Heemann, Christoph Schmaderer
Summary: This study analyzed the retinal microcirculation in patients with Post-COVID-19 syndrome (PCS) and found that persistent endothelial dysfunction is a hallmark of PCS, and impairments of the microcirculation seem to explain ongoing symptoms in patients. The study suggests that retinal vessel analysis parameters may become relevant as clinical biomarkers for diagnosis and therapy management of PCS.
Review
Pharmacology & Pharmacy
Shubhangi Saxena, Neha Dagar, Vishwadeep Shelke, Maciej Lech, Pragyanshu Khare, Anil Bhanudas Gaikwad
Summary: The kidney undergoes metabolic reprogramming in various disease states, and understanding the involved bioenergetic pathways and developing targeted interventions are crucial for addressing the high number of kidney disease cases worldwide. Reprogramming of metabolic pathways has been observed in kidney disease, and therapies targeting these pathways have shown promising results in retarding disease progression. This review focuses on potential pharmacological interventions targeting metabolic reprogramming that have advanced through clinical trials and preclinical studies, with the aim of managing kidney disease effectively in the future.
DRUG DISCOVERY TODAY
(2023)
Review
Pharmacology & Pharmacy
Tahib Habshi, Vishwadeep Shelke, Ajinath Kale, Maciej Lech, Anil Bhanudas Gaikwad
Summary: The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) is a slow but continuous progression towards end-stage kidney disease. Previous research shows that Hippo components, such as YAP and TAZ, play a role in regulating inflammation and fibrogenesis during this transition. However, the roles and mechanisms of Hippo components differ during AKI, AKI-to-CKD transition, and CKD, highlighting the importance of understanding these roles in detail. This review explores the potential of Hippo regulators or components as future therapeutic targets for halting the AKI-to-CKD transition.
DRUG DISCOVERY TODAY
(2023)
Editorial Material
Pharmacology & Pharmacy
Baohui Zhu, Ryota Ouda, Paul de Figueiredo, Koichi S. Kobayashi
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Review
Biochemistry & Molecular Biology
Chongxu Shi, Elmina Mammadova-Bach, Cong Li, Dong Liu, Hans-Joachim Anders
Summary: Cholesterol crystal (CC) embolism is a complication of advanced atherosclerotic plaques primarily induced by interventional and surgical procedures. Prophylaxis through plaque stabilization and avoiding unnecessary catheter interventions is the main approach to CC embolism. Platelet inhibitors and anticoagulants may reduce the risk of vascular occlusions and tissue ischemia in case CC embolism occurs. Given the unmet medical need, effective treatment strategies for CC embolism are urgently needed.
Review
Cell Biology
Ajinath Kale, Vishwadeep Shelke, Yutian Lei, Anil Bhanudas Gaikwad, Hans-Joachim Anders
Summary: This article reviews the unique chemistry, pharmacology, and toxicity profile of the novel calcineurin inhibitor (CNI) Voclosporin and summarizes its efficacy and safety data in the treatment of active lupus nephritis. The article also discusses possible options for implementing Voclosporin in the management of lupus nephritis, including patient stratification, combination therapy, sequential therapy, and alternative options.
Review
Immunology
Hans-Joachim Anders, A. Richard Kitching, Nelson Leung, Paola Romagnani
Summary: 'Glomerulonephritis' (GN) refers to a group of immune-mediated disorders characterized by inflammation of the kidney's filtration units. Current classification is based on histopathological lesion patterns, but these patterns do not align well with the diverse pathological mechanisms and do not guide optimal therapy. Instead, a proposed immunopathogenesis-based classification groups GN disorders into five categories, allowing for more targeted and effective treatments.
NATURE REVIEWS IMMUNOLOGY
(2023)