Review
Endocrinology & Metabolism
Yu-Peng Han, Li-Juan Liu, Jia-Lin Yan, Meng-Yuan Chen, Xiang-Fei Meng, Xin-Ru Zhou, Ling-Bo Qian
Summary: Diabetic nephropathy (DN) is a major complication of diabetes with limited treatment options. Autophagy, a process that maintains cellular homeostasis by degrading damaged proteins and organelles, plays a critical role in the development of DN. Autophagy is regulated by nutrient-sensing pathways and cellular stress signaling pathways. Dysregulation of autophagy due to abnormal nutrient status and cellular stresses caused by diabetes-related metabolic disorders leads to cellular dysfunction and the progression of DN.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Anqi Tang, Yu Zhang, Ling Wu, Yong Lin, Lizeyu Lv, Liangbin Zhao, Bojun Xu, Youqun Huang, Mingquan Li
Summary: Diabetic nephropathy (DN) is a major cause of end-stage renal disease worldwide, and alpha-klotho (klotho) has shown potential as a therapeutic agent for DN by impacting various pathways. This article explores the reduction in klotho levels observed in type 2 diabetes and its complications DN, and its involvement in multiple pathological mechanisms contributing to DN. It also discusses the potential of targeting klotho for the prevention and treatment of both DN and diabetic retinopathy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Jing Ji, Pengyu Tao, Qian Wang, Lingxing Li, Yuzhen Xu
Summary: SIRT1 plays a protective role in the pathogenesis of diabetic nephropathy by attenuating proteinuria and kidney injury through deacetylation of transcription factors involved in the disease process.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2021)
Article
Endocrinology & Metabolism
Hongyan Yao, Zijing Li
Summary: This study analyzed retinal vessel density and thickness characteristics in patients with diabetic nephropathy (DN) and preclinical diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA). The findings suggest that DN individuals have more severe microvascular and microstructural impairment compared to individuals without DN. Additionally, estimated glomerular filtration rate (eGFR) may serve as an indicator for retinal microvascular impairment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ming Yang, Xi Wang, Yachun Han, Chenrui Li, Ling Wei, Jinfei Yang, Wei Chen, Xuejing Zhu, Lin Sun
Summary: Diabetic nephropathy is one of the most common complications of diabetes and the inflammatory response plays a key role in its pathological process. Abnormal activation of the NLRP3 inflammasome accelerates the progression of diabetic nephropathy, presenting a potential therapeutic target.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Filipe A. Moura, David D. Berg, Andrea Bellavia, Jamie P. Dwyer, Ofri Mosenzon, Benjamin M. Scirica, Stephen D. Wiviott, Deepak L. Bhatt, Itamar Raz, Mark W. Feinberg, Eugene Braunwald, David A. Morrow, Marc S. Sabatine
Summary: A risk assessment tool has been developed to identify T2D patients at higher risk for kidney disease progression and who may benefit more from SGLT2 inhibition.
Review
Transplantation
Claudia Seikrit, Thomas Rauen, Eleni Stamellou, Jurgen Floege
Summary: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide with complex pathophysiology and clinical presentations. Early identification and individualized therapies are crucial for predicting disease progression.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Ecology
Samuel Jacquiod, Ayme Spor, Shaodong Wei, Victoria Munkager, David Bru, Soren J. Sorensen, Christophe Salon, Laurent Philippot, Manuel Blouin
Summary: This study demonstrates the correlation between variability in plant traits and selected microbiota structures, revealing two distinct sub-communities associated with high or low leaf greenness. The stabilisation of microbiota structure is crucial for the success of artificial microbiota selection.
Article
Chemistry, Medicinal
Xiaoyuan Guo, You Wu, Chengfei Zhang, Lili Wu, Lingling Qin, Tonghua Liu
Summary: This study investigated the pharmacological mechanisms of ZiShenWan (ZSW) in treating diabetic nephropathy using a network pharmacology approach. Results showed that ZSW achieved renoprotective effects by regulating multiple targets and signaling pathways, particularly by alleviating inflammation. Experimental validation in db/db mice confirmed the regulatory effects of ZSW on core targets and signaling pathways associated with inflammation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Immunology
Kuipeng Yu, Dengren Li, Fuping Xu, Hao Guo, Feng Feng, Yu Ding, Xiang Wan, Nan Sun, Yang Zhang, Jiahui Fan, Lei Liu, Huimin Yang, Xiangdong Yang
Summary: In this study, IDO1 was identified as a key immune gene in diabetic nephropathy (DN), with its expression correlated with specific immune cell types. It serves as a diagnostic and prognostic biomarker for DN, playing a vital role in immune cell infiltration in DN as determined using microarray data and CIBERSORTx for the first time.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuanpei Lian, Maomao Zhu, Juan Chen, Bing Yang, Qinglin Lv, Long Wang, Shuchen Guo, Xiaobin Tan, Chang Li, Weiquan Bu, Wenbo Ding, Xiaobin Jia, Liang Feng
Summary: This study identified a new heteropolysaccharide (MC-Pa) from Moutan Cortex with protective effects on diabetic nephropathy (DN), showing antioxidant activity and ability to alleviate histopathological changes. MC-Pa also regulates inflammatory factors and has a positive therapeutic effect on DN patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Urology & Nephrology
Jean-Sebastien Rachoin, Yanika Wolfe, Sharad Patel, Elizabeth Cerceo
Summary: Intravenous contrast media is commonly used in clinical practice to enhance CT imaging, but the risk of contrast-induced nephropathy has been a concern. Recent studies have challenged the previous paradigm, making the true risk of intravenous contrast media for CIN occurrence debatable.
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Endocrinology & Metabolism
Dong-Yuan Chang, Meng-Rui Li, Xiao-Juan Yu, Su-Xia Wang, Min Chen, Ming-Hui Zhao
Summary: In this study, it was found that compared to proteinuric DN patients, nonproteinuric DN patients had lower frequency of diabetic retinopathy (DR) and better renal outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Georgia Samakidou, Ioanna Eleftheriadou, Anastasios Tentolouris, Nikolaos Papanas, Nikolaos Tentolouris
Summary: The prevalence of diabetes mellitus is increasing at an epidemic level, resulting in a rise in chronic complications including neuropathy. Diabetic neuropathy presents in various forms, with common types being distal symmetrical polyneuropathy and autonomic neuropathy. Clinicians should be aware of less common forms of neuropathy in diabetic patients and recognize their symptoms.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)