Article
Urology & Nephrology
Nicholas G. G. Larkins, Wai Lim, Carrie Goh, Anna Francis, Hugh McCarthy, Siah Kim, Germaine Wong, Jonathan C. C. Craig
Summary: This study analyzed data from the Australia and New Zealand Dialysis and Transplant Registry and found that the initiation of kidney replacement therapy (KRT) in children and young adults has been happening earlier over time. However, earlier initiation of KRT did not affect patient survival. Clinical practice variation played a significant role in determining the timing of KRT initiation.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Cell Biology
Jun Ah Lee, Jiwon Lim, Hye Young Jin, Meerim Park, Hyeon Jin Park, Jong Woong Park, June Hyuk Kim, Hyun Guy Kang, Young-Joo Won
Summary: The study compared the clinical features and survival rates of osteosarcoma in adolescents and young adults (AYA) with other age groups. It found that AYA had the highest male-to-female ratio, with most tumors located in extremities. The treatment mainly consisted of local treatment and systemic chemotherapy, and the 5-year overall survival rate of AYA was closer to that of children.
Review
Oncology
Atsushi Makimoto
Summary: Due to their rarity, there is limited understanding of rhabdomyosarcomas (RMS) in adolescents and young adults (AYA), resulting in poor treatment outcomes. This review aims to integrate new developments with existing evidence to explore factors and potential solutions in RMS in AYA.
Article
Oncology
A. Trama, D. Stark, I. Bozovic-Spasojevic, N. Gaspar, F. Peccatori, A. Toss, A. Bernasconi, P. Quarello, K. Scheinemann, S. Jezdic, A. Blondeel, G. Mountzios, S. Bielack, E. Saloustros, A. Ferrari
Summary: The incidence and mortality rates of cancers in adolescents and young adults (AYAs) in Europe and EU member states vary widely, with the highest mortality seen in Eastern EU countries. Breast, thyroid, and testicular cancers are the most common types across countries, followed by melanoma of skin and cervical cancer. Differences in cancer incidence rates may be due to various risk factors, screening implementation or uptake, and overdiagnosis. Disparities in AYA cancer mortality might be attributed to differences in early-stage diagnoses, public education and awareness of cancer symptoms, and access to treatment. It is crucial to establish AYA-specialised services and preventive initiatives to address the future healthcare needs and mitigate the increasing burden.
Article
Hematology
Alexandra Schifferli, Gautier Le Gavrian, Nathalie Aladjidi, Guillaume Moulis, Bertrand Godeau, Thomas Kuhne
Summary: Defining immune thrombocytopenia (ITP) in two age groups, children and adults, does not consider the specific clinical features and needs of adolescents and young adults (AYAS). This study reveals that refractory ITP is uncommon in AYAS, but AYAS with refractory ITP display a high disease burden at all time points.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Mohamed Abdelaal, Pamela J. Mosher, Abha Gupta, Breffni Hannon, Christine Cameron, Malka Berman, Rahim Moineddin, Jonathan Avery, Laura Mitchell, Madeline Li, Camilla Zimmermann, Ahmed Al-Awamer
Summary: Adolescents and young adults with cancer often experience high levels of distress and lack effective palliative care services. Establishing a specialized integrated palliative care and psychiatry clinic has shown promising results in improving symptom scores and end-of-life planning.
Article
Clinical Neurology
Laura Ramos Socarras, Jeremie Potvin, Genevieve Forest
Summary: The study revealed that during the COVID-19 pandemic, adolescents experienced significant changes in sleep patterns, with a tendency to sleep later and increase sleep duration. In contrast, young adults reported increased sleep difficulties, especially with sleep onset, nocturnal awakenings, and nightmares.
Article
Oncology
Rebecca S. Parker, Justin Le, Andrew Doan, Paibel Aguayo-Hiraldo, Pia S. Pannaraj, Teresa Rushing, Jemily Malvar, Maurice R. O'Gorman, Jennifer Dien Bard, Chintan Parekh
Summary: Pediatric oncology patients are at higher risk for hospitalization with COVID-19, but the majority can undergo chemotherapy without delays in treatment. Viral load may be a potential predictor for the outcome of COVID-19 in pediatric cancer patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Public, Environmental & Occupational Health
Aditi Dhir, Narendranath Epperla, Luciano J. Costa, Ana C. Xavier
Summary: The impact of nonbiological factors on survival of adolescents and young adults with lymphoma in the US is significant. Factors such as insurance status, race, and income level play a role in mortality risk. Improving access and quality of healthcare services can increase survival chances for these patients.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Nutrition & Dietetics
K. Goueslard, F. Jollant, J. M. Petit, C. Quantin
Summary: This study found that adolescents/young adults who underwent bariatric surgery in France had a higher rate of hospitalization for self-harm during the three-year follow-up period compared to control groups. Hospitalization for self-harm was associated with prior psychiatric disorders and self-harm, but not directly with bariatric surgery.
CLINICAL NUTRITION
(2022)
Review
Oncology
Enrica Teresa Tanda, Elena Croce, Francesco Spagnolo, Lodovica Zullo, Stefano Spinaci, Carlo Genova, Giovanni Rossi
Summary: Immunotherapy has revolutionized the treatment of various cancers, leading to long-term survival for many patients with metastatic disease. However, the impact of these therapies on young cancer patients remains poorly understood, with questions surrounding fertility and pregnancy interactions still unanswered.
FRONTIERS IN ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Naoko Sasamoto, Long Ngo, Allison F. Vitonis, Simon T. Dillon, Stacey A. Missmer, Towia A. Libermann, Kathryn L. Terry
Summary: The study investigated systemic molecular profiles of endometriosis in adolescents and young adults, identifying significant enrichment of proteins related to angiogenesis and cell migration pathways in endometriosis cases. Increased activation of these pathways was observed in endometriosis cases compared to controls. Results suggest the need for further validation and mechanistic studies to better understand the pathophysiological characteristics of this understudied patient population.
HUMAN REPRODUCTION
(2022)
Article
Audiology & Speech-Language Pathology
Teresa Girolamo, Mabel L. Rice
Summary: This study aimed to explore the language abilities of autistic adolescents and young adults with language impairment. The results showed that all participants met the criteria for language impairment, with overall language abilities remaining in the impaired range, while other abilities varied. These findings contribute to our understanding of the linguistic strengths and variability in language skills of autistic young adults.
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
(2022)
Article
Urology & Nephrology
Lesley A. Inker, Silvia Titan
Summary: Assessment of GFR is crucial for clinical practice, public health, and research, as it helps in diagnosing and managing chronic kidney disease. While GFR estimates based on creatinine levels are commonly used and reasonably accurate, confirmatory tests may be needed for more precise evaluation. Various confirmatory tests, such as cystatin C-based equations or urinary clearance of exogenous markers, are available for a more accurate assessment of GFR.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Multidisciplinary Sciences
Holly C. Cooper, Jin Long, Tandy Aye
Summary: This study assessed the utilization of fertility preservation among transgender adolescents and found a low utilization rate. It also discovered that non-binary adolescents and their families are interested in fertility preservation and should be offered referrals.
Article
Pediatrics
Tiago Sacchet Dumcke, Alais Benedetti, Luciano da Silva Selistre, Ana Maria Paim Camardelo, Emerson Rodrigues da Silva
JORNAL DE PEDIATRIA
(2020)
Article
Medical Laboratory Technology
Laurence Dubourg, Sandrine Lemoine, Brune Joannard, Laurence Chardon, Vandrea de Souza, Pierre Cochat, Jean Iwaz, Muriel Rabilloud, Luciano Selistre
Summary: The studied formulas showed equivalent precision and accuracy in calculating plasma iohexol clearance, with Ng-Schwartz-Munoz formula demonstrating improved accuracy at higher levels of in-GFR.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Medicine, General & Internal
Hans Pottel, Jonas Bjork, Marie Courbebaisse, Lionel Couzi, Natalie Ebert, Bjorn O. Eriksen, R. Neil Dalton, Laurence Dubourg, Francois Gaillard, Cyril Garrouste, Anders Grubb, Lola Jacquemont, Magnus Hansson, Nassim Kamar, Edmund J. Lamb, Christophe Legendre, Karin Littmann, Christophe Mariat, Toralf Melsom, Lionel Rostaing, Andrew D. Rule, Elke Schaeffner, Per-Ola Sundin, Stephen Turner, Arend Bokenkamp, Ulla Berg, Kajsa Asling-Monemi, Luciano Selistre, Anna Akesson, Anders Larsson, Ulf Nyman, Pierre Delanaye
Summary: A new SCr-based equation, combining design features of the FAS and CKD-EPI equations, has been developed and validated to estimate glomerular filtration rate more accurately, especially during the transition from adolescence to adulthood. The equation shows low bias and fewer estimation errors across the full age spectrum.
ANNALS OF INTERNAL MEDICINE
(2021)
Review
Geriatrics & Gerontology
Lucas Goldmann Bigarella, Vinicius Remus Ballotin, Lucas Ferrazza Mazurkiewicz, Ana Carolina Ballardin, Dener Lizot Rech, Roberto Luis Bigarella, Luciano da Silva Selistre
Summary: Exercise has a significant impact in improving depression and depressive symptoms in older adults, suggesting that physical activity should be recommended for this population.
AGING & MENTAL HEALTH
(2022)
Article
Multidisciplinary Sciences
Rosa Maria Rahmi, Priscila de Oliveira, Luciano Selistre, Paulo Cury Rezende, Gabriela Neuvald Pezzella, Pamela Antoniazzi dos Santos, Daiane de Oliveira Pereira Vergani, Sonia Regina Cabral Madi, Jose Mauro Madi
Summary: The study aimed to compare 24-hour glycemic levels between obese pregnant women with normal glucose tolerance and non-obese pregnant women. The results showed that obesity in pregnancy was associated with higher glycemic levels even in the presence of normal glucose tolerance test findings. Obese pregnant women had significantly higher blood sugar levels at various time points compared to non-obese pregnant women.
Article
Pharmacology & Pharmacy
Pierre Delanaye, Jonas Bjork, Marie Courbebaisse, Lionel Couzi, Natalie Ebert, Bjorn O. Eriksen, R. Neil Dalton, Laurence Dubourg, Francois Gaillard, Cyril Garrouste, Anders Grubb, Lola Jacquemont, Magnus Hansson, Nassim Kamar, Edmund J. Lamb, Christophe Legendre, Karin Littmann, Christophe Mariat, Toralf Melsom, Lionel Rostaing, Andrew D. Rule, Elke Schaeffner, Per-Ola Sundin, Ulla B. Berg, Kajsa Asling-Monemi, Luciano Selistre, Anna Akesson, Anders Larsson, Arend Bokenkamp, Hans Pottel, Ulf Nyman
Summary: The Cockcroft-Gault creatinine-based equation is still commonly used for estimating glomerular filtration rate for drug dosage adjustment, but it has been found to perform worse than more recent equations in terms of bias, imprecision and accuracy. Specifically, the CG equation showed poor ability to estimate GFR overall and in analyses stratified for mGFR, age, and BMI, as well as inferior classification of patients in mGFR staging compared to newer equations.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pediatrics
Luciano da Silva Selistre, Cecile Renard, Justine Bacchetta, Marie-Pierre Goutagny, Julie Hu, Vandrea Carla de Souza, Yves Bertrand, Laurence Dubourg, Carine Domenech
Summary: In this study, the long-term renal outcomes of children and adolescents who underwent aHSCT for malignant hemopathies were retrospectively assessed. The study found that CKD was a significant long-term consequence, either with glomerular dysfunction or with the more insidious tubular dysfunction, and emphasized the importance of specialized long-term nephrology follow-up for these patients.
PEDIATRIC NEPHROLOGY
(2022)
Article
Urology & Nephrology
Gisela da Silva da Fonseca, Vandrea Carla de Souza, Sarah Assoni Bilibio, Vanessa Carobin, Ligia Facin, Ketelly Koch, Morgana Machado, Laurence Dubourg, Luciano da Silva Selistre
Summary: In this study, it was found that local CKD-EPI and FAS equations performed better than MDRD and CKD-EPI when compared to ClCr. Especially in the group with ClCr < 60 mL/min/1.73 m(2), local CKD-EPI and FAS equations showed lower variability and better P-30 results.
JORNAL BRASILEIRO DE NEFROLOGIA
(2022)
Article
Biochemistry & Molecular Biology
Ariane Zaloszyc, Philippe Choquet, Amira Sayeh, Maria Bartosova, Betti Schaefer, Ulrike Huegel, Gaelle Aubertin-Kirch, Christopher Healy, Francois Severac, Sebastien Rizzo, Georges Boivin, Franz Schaefer, Michel Fischbach, Justine Bacchetta, Seiamak Bahram, Claus Peter Schmitt
Summary: Chronic kidney disease often leads to bone disorders and cardiovascular mortality, and the G alpha(q/11)/PKC pathway in osteoblasts plays an important role in CKD-MBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Transplantation
Pierre Delanaye, Emmanuelle Vidal-Petiot, Jonas Bjork, Natalie Ebert, Bjorn O. Eriksen, Laurence Dubourg, Anders Grubb, Magnus Hansson, Karin Littmann, Christophe Mariat, Toralf Melsom, Elke Schaeffner, Per-Ola Sundin, Arend Bokenkamp, Ulla B. Berg, Kajsa Asling-Monemi, Anna Akesson, Anders Larsson, Etienne Cavalier, R. Neil Dalton, Marie Courbebaisse, Lionel Couzi, Francois Gaillard, Cyril Garrouste, Lola Jacquemont, Nassim Kamar, Christophe Legendre, Lionel Rostaing, Thomas Stehle, Jean-Philippe Haymann, Luciano da Silva Selistre, Jorge P. Strogoff-de-Matos, Justine B. Bukabau, Ernest K. Sumaili, Eric Yayo, Dagui Monnet, Ulf Nyman, Hans Pottel, Martin Flamant
Summary: This study compared and validated the performance of the new Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPIAS) with the European Kidney Function Consortium (EKFC) and Lund-Malmo Revised (LMREV) equations in European and African cohorts. The results showed that the EKFC equation had the best performance in both European and African populations, while CKD-EPIAS had suboptimal performance.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Luciano Selistre, Vandrea de Souza, Carla Nicola, Laurent Juillard, Sandrine Lemoine, Laurence Derain-Dubourg
Summary: A study compared the performance of mCl(UN-cr) with CKD-EPI equations in estimating eGFR and found that mCl(UN-cr) performed similarly to CKD-EPI equations and had better performance at mGFR <60 mL/min/1.73 m(2).
CLINICAL KIDNEY JOURNAL
(2023)
Article
Endocrinology & Metabolism
Marcia Ines Boff, Cristiane Kopacek, Vandrea Carla de Souza, Sabliny Carreiro Ribeiro, Edmundo Kreisner, Paula Regla Vargas, Livia Silveira Mastella, Jose Mauro Madi, Simone Martins de Castro, Rosa Maria Rahmi
Summary: Objective: To determine the incidence of congenital hypothyroidism (CH) over a 10-year period at the Reference Service in Neonatal Screening of the state of Rio Grande do Sul (RSNS-RS). The overall incidence of CH was 42.1 per 100,000 newborns screened, with a sensitivity of 97% and specificity of 11% for the neonatal TSH cutoff value of 9 mIU/L.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
