Article
Multidisciplinary Sciences
Florian Siegerist, Tim Lange, Anna Iervolino, Thor Magnus Koppe, Weibin Zhou, Giovambattista Capasso, Karlhans Endlich, Nicole Endlich
Summary: Most kidney diseases are caused by podocyte loss and morphological changes, with microRNAs playing a key role in their pathogenesis. Larval zebrafish are a popular vertebrate model for studying kidney diseases. The study identified dre-miR-92b-3p as a suitable endogenous reference gene for miRNA expression studies in zebrafish.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, Research & Experimental
Xiandeng Li, Ying Zhang, Xiaodong Xing, Mi Li, Yan Liu, Ajing Xu, Jian Zhang
Summary: Diabetic nephropathy is a severe complication of diabetes mellitus, and understanding the underlying mechanisms of podocyte injury is key to developing effective therapeutic interventions. This review summarizes the factors contributing to podocyte injury in DN, including lipotoxicity, hemodynamic abnormalities, oxidative stress, mitochondrial dysfunction, and impaired autophagy. The findings presented in this review provide potential therapeutic targets and strategies for the management of DN associated with podocyte injury.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Xu He, Lingling Yang, Meiqiu Wang, Pei Zhang, Ren Wang, Daxi Ji, Chunlin Gao, Zhengkun Xia
Summary: This study found that reduced expression of GPX4 is associated with focal segmental glomerulosclerosis (FSGS) and targeting ferroptosis could be a promising therapeutic option for FSGS patients. Treatment with the ferroptosis inhibitor Fer1 reduced proteinuria, prevented glomerulosclerosis, and attenuated podocyte injury in an FSGS mouse model.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Qing Hou, Weibo Le, Shuyan Kan, Jinsong Shi, Yue Lang, Zhihong Liu, Zhaohong Chen
Summary: NRIP2 acts as a stabilizer of beta-catenin activation in podocyte injury, regulating beta-catenin degradation through the ubiquitin proteasomal pathway. Its role in podocyte injury influences the occurrence of proteinuria.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chunhong Wang, Jiafeng Liu, Xiaoyao Zhang, Qiyan Chen, Xiaoyan Bai, Xue Hong, Lili Zhou, Youhua Liu
Summary: miR-671-5p plays a crucial role in mediating beta-catenin-triggered podocyte injury by targeting Wilms tumor 1 (WT1). This study highlights the significance of miR-671-5p in proteinuric kidney disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Xu He, Tao Sun, Pei Zhang, Zhengkun Xia, Chunlin Gao, Hongqi Ren, Daxi Ji
Summary: Inhibition of HDAC IIa improves podocyte injury and proteinuria, suggesting the potential use of MC1568 in the treatment of nephrotic syndrome.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yan Zeng, Yun-ming Li, Yue Cheng, Xiao-shan Zeng, Tao Wang, Fan Zhang, Yao-lei Zhang
Summary: This study found that podocyte injury may be involved in proteinuria after rapid ascent to high altitude. The study also found that hypoxia-inducible factor (HIF)-1 alpha is involved in the adaptive regulation of proteinuria. By upregulating local HIF-1 alpha expression, podocyte injury and proteinuria can be alleviated.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Xuejing Zhu, Dan Gao, Vittorio Albertazzi, Jianyong Zhong, Li-Jun Ma, Liping Du, Yu Shyr, Valentina Kon, Hai-Chun Yang, Agnes B. Fogo
Summary: The study found that long-term treatment with high-dose angiotensin receptor blocker (ARB) and nonspecific antihypertensive therapy can ameliorate the progression of glomerulosclerosis. Among them, ARB treatment showed superior preservation of podocyte integrity, decreased proteinuria and aldosterone levels, and higher survival rate in uremic rats compared to other treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Teruhiko Mizumoto, Yutaka Kakizoe, Terumasa Nakagawa, Yasunobu Iwata, Yoshikazu Miyasato, Kohei Uchimura, Masataka Adachi, Qinyuan Deng, Manabu Hayata, Jun Morinaga, Taku Miyoshi, Yuichiro Izumi, Takashige Kuwabara, Yoshiki Sakai, Kimio Tomita, Kenichiro Kitamura, Masashi Mukoyama
Summary: The study demonstrated that camostat mesilate (CM) could exert renoprotective effects in MetS model rats, along with inhibiting podocyte apoptosis. These findings suggest that serine protease inhibition may become a new therapeutic strategy against MetS-related hypertension and renal injuries.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Review
Oncology
Ai Qi Lee, Yan Li, Zhiyuan Gong
Summary: Primary liver cancer is a major global health issue with increasing incidence and poor treatment response. Using transgenic zebrafish models, researchers have been able to study liver cancer biology, tumor initiation, drug screening, and environmental factors, providing valuable insights for the development of new therapies and treatment approaches. The findings demonstrate the utility and convenience of zebrafish models in advancing cancer research and therapeutic discovery.
Article
Medicine, General & Internal
Qi Ren, Shengyou Yu, Huasong Zeng, Huimin Xia
Summary: Podocytes' specialized role in maintaining the filtration barrier is regulated, in part, by the phosphatase and tensin homolog (PTEN). This study investigated the role of PTEN in podocyte injury induced by puromycin aminonucleoside (PAN) and the potential protective effects of dexamethasone (DEX) through the PTEN/PI3K/Akt signaling pathway. The findings suggest that targeting PTEN could be a promising therapeutic strategy against podocyte injury.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Transplantation
Paola Romagnani, A. Richard Kitching, Nelson Leung, Hans-Joachim Anders
Summary: Glomerulonephritis (GN) is a diverse group of immune-mediated disorders, which cannot be properly classified or treated based on histological patterns alone. To overcome this problem, a new classification system is proposed that considers disease category, immunological activity, and chronicity, which will guide the therapeutic approach.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Pharmacology & Pharmacy
Yipeng Fang, Yunfei Zhang, Chenxi Jia, Chunhong Ren, Xutao Zhao, Xin Zhang
Summary: The purpose of this study was to investigate the pharmacological mechanisms of Niaoduqing granules on treating podocyte injury in diabetic nephropathy (DN) using network pharmacology and experimental validation. The results showed that Niaoduqing may protect against podocyte injury by regulating the activity of AGE/RAGE pathway and expression of multiple genes.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Shih-Chen Chang, Chien-Yi Hsu, Li-Kuo Liu, Ya-Wen Lu, Yi-Lin Tsai, Ruey-Hsing Chou, Po-Hsun Huang, Liang-Kung Chen, Shing-Jong Lin
Summary: The study found an association between high activin A levels and a higher incidence of albuminuria, with the concentration significantly correlated with patients' urine albumin levels. Activin A levels were also associated with multiple risk factors.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Baris Afsar, Rengin Elsurer Afsar, Atalay Demiray, Adrian Covic, Mehmet Kanbay
Summary: Despite increasing awareness and therapeutic options for chronic kidney disease (CKD), glomerular diseases still constitute a significant percentage of CKD. Proteinuria/albuminuria plays a direct pathogenic role in CKD progression and there is a need for more efficient and less toxic therapeutic options to treat glomerular diseases. In recent years, modifying dietary intake has gained attention as a potential treatment for podocyte function and structure.
PHARMACOLOGICAL RESEARCH
(2021)