Article
Multidisciplinary Sciences
Manon Doue, Anais Okwieka, Alexandre Berquand, Laetitia Gorisse, Pascal Maurice, Frederic Velard, Christine Terryn, Michael Molinari, Laurent Duca, Christine Pietrement, Philippe Gillery, Stephane Jaisson
Summary: The study found that vascular elastic fibers can undergo carbamylation, leading to an increase in stiffness that may affect the mechanical properties of the vascular wall, thereby being associated with aortic stiffness and the development of cardiovascular diseases.
SCIENTIFIC REPORTS
(2021)
Article
Transplantation
Sahir Kalim, Anders H. Berg, Subbian Ananth Karumanchi, Ravi Thadhani, Andrew S. Allegretti, Sagar Nigwekar, Sophia Zhao, Anand Srivastava, Dominic Raj, Rajat Deo, Anne Frydrych, Jing Chen, James Sondheimer, Tariq Shafi, Matthew Weir, James P. Lash
Summary: The study suggests that protein carbamylation is a predictor of CKD progression beyond traditional risk factors like eGFR and proteinuria. However, the association of carbamylation with mortality was weaker in this limited sample size.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Biochemistry & Molecular Biology
Nataliya Mushenkova, Evgeny E. Bezsonov, Varvara A. Orekhova, Tatyana Popkova, Antonina Starodubova, Alexander N. Orekhov
Summary: Atherosclerosis is a chronic disease with inflammatory components, now recognized as an active autoimmune process involving both innate and adaptive immune pathways. One of the key factors driving this process is the presence of modified LDL, which leads to the formation of oxidation-specific epitopes recognized by immune cells. Macrophage response to these epitopes is crucial for initiating and promoting inflammation in the arteries.
Review
Pharmacology & Pharmacy
Ali Ahmadi, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: This review examines the role of polyphenols in reducing oxidized low-density lipoprotein (oxLDL) and their potential impact on atherosclerosis. While polyphenols show promise as antioxidants, further high-quality studies are needed to fill the gaps in our knowledge.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Aurelie Lenglet, Mohamad Ali Rahali, Francois-Ludovic Sauvage, Sophie Liabeuf, Gabriel Choukroun, Marie Essig, Souleiman El Balkhi, Ziad A. Massy
Summary: In end-stage kidney disease patients, carbamylated albumin is present with carbamylation extending beyond LRVP residues. Treatment with sevelamer or nicotinamide for 24 weeks did not decrease levels of albumin carbamylation, and the proportion of carbamylated serum albumin was not correlated with vascular calcification scores in this population. Therapeutic strategies to lower carbamylation load should focus on direct anti-carbamylation processes and potentially anti-inflammatory therapies.
Article
Biochemistry & Molecular Biology
Bhupesh Singla, Hui-Ping Lin, WonMo Ahn, Joseph White, Gabor Csanyi
Summary: This study reveals that oxidized LDL (oxLDL) inhibits lymphangiogenesis via CD36-mediated regulation of the AKT/eNOS pathway and cell cycle, which can be promoted by therapeutic blockade of the CD36 in LEC, leading to a reduction in atherosclerosis by increasing arterial lymphangiogenesis and cholesterol removal.
Article
Medicine, Research & Experimental
Donghai Wen, Zihe Zheng, Aditya Surapaneni, Bing Yu, Linda Zhou, Wen Zhou, Dawei Xie, Haochang Shou, Julian Avila-Pacheco, Sahir Kalim, Jiang He, Chi-Yuan Hsu, Afshin Parsa, Panduranga Rao, James Sondheimer, Raymond Townsend, Sushrut S. Waikar, Casey M. Rebholz, Michelle R. Denburg, Paul L. Kimmel, Ramachandran S. Vasan, Clary B. Clish, Josef Coresh, Harold I. Feldman, Morgan E. Grams, Eugene P. Rhee
Summary: This study demonstrates the application of metabolomics in identifying potential biomarkers and causal pathways in the progression of chronic kidney disease (CKD).
Review
Cardiac & Cardiovascular Systems
Anastasia V. Poznyak, Vasily N. Sukhorukov, Raisa Surkova, Nikolay A. Orekhov, Alexander N. Orekhov
Summary: Atherosclerosis is a complex disease influenced by many factors. Understanding the pathological mechanisms underlying atherogenesis is crucial for developing effective therapeutic strategies. This review focuses on low density lipoproteins and their atherogenic properties, particularly the role of glycated LDL in atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Anastasia V. Poznyak, Dmitry A. Kashirskikh, Vasily N. Sukhorukov, Vladislav Kalmykov, Andrey V. Omelchenko, Alexander N. Orekhov
Summary: Atherosclerosis is a major cause of serious cardiovascular disorders, and its pathogenesis involves multiple processes. Reverse transport of cholesterol is a mechanism that plays a protective role against atherosclerosis. Disordered cholesterol metabolism can result in dyslipidemia and early atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Alessandra Puddu, Fabrizio Montecucco, Davide Maggi
Summary: Caveolae are cell surface plasma membrane invaginations observed in terminally differentiated cells, characterized by the presence of caveolin-1. They play a central role in regulating atherosclerosis and can have both pro-atherogenic and anti-atherogenic functions depending on the cell type examined. This study focuses on the role of caveolin-1 in regulating the fate of LDLs in endothelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Petri Kresanov, Juha Mykkanen, Markku Ahotupa, Mika Ala-Korpela, Markus Juonala, Jari Kaikkonen, Mika Kahonen, Terho Lehtimaki, Tommi Vasankari, Jorma Viikari, Olli T. Raitakari
Summary: The study found that oxidized HDL lipids were not significantly associated with lipoprotein subclass lipid concentrations and composition after adjusting for certain factors, while oxidized LDL lipids were associated with multiple markers of lipoprotein subclass lipid concentrations and composition. Additionally, HDL and LDL subclass measures, such as phospholipid and triglyceride composition, were directly associated with oxidized LDL lipids, while cholesterol ester and free cholesterol composition in HDL and LDL were inversely associated. These results suggest that LDL oxidation may play a role in atherogenesis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Nuria Puig, Pol Camps-Renom, Arnau Sole, Ana Aguilera-Simon, Elena Jimenez-Xarrie, Alejandro Fernandez-Leon, Mercedes Camacho, Marina Guasch-Jimenez, Rebeca Marin, Joan Marti-Fabregas, Alejandro Martinez-Domeno, Luis Prats-Sanchez, Francesca Casoni, Belen Perez, Francesc Jimenez-Altayo, Jose Luis Sanchez-Quesada, Sonia Benitez
Summary: This study aimed to identify modified LDLs and antioxidant enzymes associated with plaque vulnerability in patients with ischemic stroke and carotid atherosclerosis. Patients showed lower levels of cholesterol and apolipoproteins, as well as lower enzymatic activities of PAF-AH and PON-1 in HDL and higher levels of oxidized LDL and electronegative LDL. The proportion of LDL(-) was independently associated with carotid stenosis, hypoechoic plaque presence, and diffuse neovessels.
Article
Biochemical Research Methods
Pascal Schlosser, Morgan E. Grams, Eugene P. Rhee
Summary: Current proteomic tools allow for high-throughput analysis of the blood proteome in large cohorts, identifying proteins associated with kidney function and CKD progression. However, determining the causal role of these proteins in kidney disease pathogenesis remains a challenge, given the strong impact of kidney function on blood protein levels. Leveraging genotyping methods in epidemiologic cohorts can provide evidence for causal inference, and integrating urine and tissue proteomics with blood proteome analysis is an important future direction. These approaches aim to translate proteomic profiling into improved diagnostic tools and therapeutic target identification in kidney disease.
MOLECULAR & CELLULAR PROTEOMICS
(2023)
Article
Cardiac & Cardiovascular Systems
Prakriti Gaba, Michelle L. O'Donoghue, Jeong-Gun Park, Stephen D. Wiviott, Dan Atar, Julia F. Kuder, KyungAh Im, Sabina A. Murphy, Gaetano M. De Ferrari, Zbigniew A. Gaciong, Kalman Toth, Ioanna Gouni-Berthold, Jose Lopez-Miranda, Francois Schiele, Francois Mach, Jose H. Flores-Arredondo, J. Antonio G. Lopez, Mary Elliott-Davey, Bei Wang, Maria Laura Monsalvo, Siddique Abbasi, Robert P. Giugliano, Marc S. Sabatine
Summary: This study found that long-term achievement of lower LDL-C levels (below 20 mg/dL) in patients with atherosclerotic cardiovascular disease was associated with a lower risk of cardiovascular events without significant safety concerns.
Article
Biochemistry & Molecular Biology
Nurjannatul Naim Kamaruddin, Nor Azwin Hajri, Yosie Andriani, Aina Farahiyah Abdul Manan, Tengku Sifzizul Tengku Muhammad, Habsah Mohamad
Summary: Atherosclerosis, caused by elevated plasma cholesterols, is a major factor in global cardiovascular disease mortality. While statins are commonly used to lower cholesterol levels, they may have adverse effects, prompting the search for new treatments. Research on the marine invertebrate Acanthaster planci suggests its potential in reducing cholesterol levels without causing harm to the liver.