Article
Biochemistry & Molecular Biology
Angela L. Riffo-Campos, Javier Perez-Hernandez, Ana Ortega, Olga Martinez-Arroyo, Ana Flores-Chova, Josep Redon, Raquel Cortes
Summary: This study aims to identify a common non-coding RNA (ncRNA) signature associated with early renal damage and its related molecular pathways. Through ncRNA sequencing analysis, we found a set of 24 ncRNA molecules related to hypertension and albuminuria, with long non-coding RNAs being the most representative.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Arnold Piek, Leonie Smit, Navin Suthahar, Stephan J. L. Bakker, Rudolf A. de Boer, Herman H. W. Sillje
Summary: Plasma levels of DKK3 are associated with cardiovascular risk factors, but are generally not independently associated with prevalent and new-onset CVD and CKD, and only predicted for new-onset CKD in those subjects with the lowest UAE values.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Kang Du, Wenqi Wu, Ting Liao, Jun Yang, Xiangyang Kang
Summary: Photosynthesis plays a vital role in plant growth and is influenced by environmental signals and circadian rhythms. By analyzing the transcriptome of two poplar progenies with different photosynthesis rates, we identified genes related to circadian rhythm and photosynthesis. We found that circadian oscillators regulate photosynthesis-associated nuclear genes and carotenoid metabolism genes before dawn, while other factors affect leaf size, stomatal movement, and chlorophyll accumulation.
Article
Endocrinology & Metabolism
Peter S. Linsley, Carla J. Greenbaum, Gerald T. Nepom
Summary: The goal of personalized medicine is to match the right drugs to the right patients at the right time. However, for complex diseases like type 1 diabetes, personalized therapy should consider factors such as treatment timing, patient stratification, pharmacodynamic biomarkers, and efficacy biomarkers. Research in personalized medicine for type 1 diabetes is providing insights for achieving personalized therapies for other complex diseases.
Article
Multidisciplinary Sciences
Xinru Guo, Shuang Liang, Wenling Wang, Ying Zheng, Chun Zhang, Xiangmei Chen, Guangyan Cai
Summary: This study found that LNSBP is associated with heavy proteinuria and kidney disease outcomes in elderly CKD patients, highlighting its potential value in guiding antihypertensive treatment to improve renal prognosis.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
En Qiao, Zeping Huang, Wei Wang
Summary: This study identified potential biomarkers and pathways for CAVD through bioinformatics analysis, providing novel molecular markers for diagnosis and targeted therapy of the disease.
Article
Urology & Nephrology
Soshiro Ogata, Yuumi Akashi, Takaya Sakusabe, Shigehito Yoshizaki, Yuko Maeda, Kunihiro Nishimura, Kenji Maeda, Shigeru Nakai
Summary: This study found that there is an association between kidney function decline in patients with chronic kidney disease and sodium and potassium intake. Higher sodium intake was positively correlated, while higher potassium intake was negatively correlated with kidney function decline. Higher sodium intake but lower potassium intake was associated with more severe decline in kidney function.
KIDNEY INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Giulia Cricri, Linda Bellucci, Giovanni Montini, Federica Collino
Summary: Intercellular communication plays a vital role in multicellular interactions, with EVs acting as important mediators. EVs in urine serve as a potential source of biomarkers for kidney-related diseases, offering an alternative to traditional diagnostic techniques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Xiping Yan, Hehe Liu, Jiwei Hu, Xingfa Han, Jingjing Qi, Qingyuan Ouyang, Bo Hu, Hua He, Liang Li, Jiwen Wang, Xianyin Zeng
Summary: This study identified the neuroactive ligand-receptor interaction pathway and five key genes (VEGFC, SPARC, BMP2, THBS1, and ADAMTS15) as key signaling pathways within the HPG axis responsible for different egg production performance between ducks with high and low egg production. The results improve our understanding of HPG axis regulation in egg production and provide candidate genes for genetic selection in ducks.
Article
Veterinary Sciences
Yunna Li, Hua Yang, Jing Guo, Yonglin Yang, Qian Yu, Yuanyuan Guo, Chaoxin Zhang, Zhipeng Wang, Peng Zuo
Summary: This study conducted a genome-wide association study (GWAS) using a high-density SNP chip to map loci related to weaning weight and yearling weight in sheep. The results identified significant associations of various SNPs with these weight traits and revealed potential candidate genes involved in regulating body weight. The findings highlight the value of multi-omic analysis in identifying genetic factors influencing body weight.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Plant Sciences
Shengze Wang, Haibin Han, Bo Zhang, Le Wang, Jie Wu, Zhengqiang Chen, Kejian Lin, Jianjun Hao, Ruifang Jia, Yuanyuan Zhang
Summary: This study observed the infection process of Fusarium root rot in alfalfa and compared the physiological and biochemical activities of resistant and susceptible varieties. Transcriptome sequencing and gene enrichment analysis revealed differentially expressed genes related to plant growth and disease resistance. These findings provide valuable data for gene function verification and reference for further exploration of the plant-pathogen interaction.
Article
Agriculture, Dairy & Animal Science
Zhen Zhang, Yu Yang, Liming Huang, Ligen Chen, Guixin Zhang, Ping Gong, Shengqiang Ye, Yanping Feng
Summary: The neuroactive ligand-receptor interaction pathway was identified as a potential biological pathway regulating reproductive performance in male ducks. Six genes, including HAPLN2 and EGR4, were identified as candidate genes affecting reproductive capacity. These findings are important for improving the reproductive performance in poultry.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Cell Biology
Xinhui Li, Jian Zhou, Mingming Xiao, Lingyu Zhao, Yan Zhao, Shuoshuo Wang, Shuangshu Gao, Yuan Zhuang, Yi Niu, Shijun Li, Xiaobo Li, Yuanyuan Zhu, Minghui Zhang, Jing Tang
Summary: This study utilized multiomics analysis to investigate the molecular characteristics of different breast cancer subtypes, revealing subtype-specific gene expression changes, mutations and copy number variations of driver genes, altered genes in different signaling pathways, as well as differences in immune cell infiltration levels among subtypes. The study also explored factors affecting immune infiltration and cytolytic activity in different breast cancer subtypes, providing potential markers and targets for clinical diagnosis and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Sanbao Chai, Shanshan Wu, Sixu Xin, Ning Yuan, Jianbin Sun, Xiaomei Zhang, Linong Ji
Summary: This study found a close relationship between TIR values and the severity of UAER in patients with T2DM, indicating that patients with lower TIR values are more likely to have microalbuminuria and macroalbuminuria.
CHINESE MEDICAL JOURNAL
(2022)
Article
Nutrition & Dietetics
Fang Fan, Yinghua Li, Li Li, Xueqiong Nie, Puhong Zhang, Yuan Li, Rong Luo, Gang Zhang, Lanlan Wang, Feng J. He
Summary: Salt intake in China is high and increases the risk of hypertension and cardiovascular disease. A study found that salt-related knowledge, attitudes, and behaviors are inversely associated with 24-hour urinary sodium excretion. The results suggest the need for large-scale health education, particularly targeting rural areas, individuals with low education levels, and older people, to reduce salt intake.
Article
Genetics & Heredity
Karl W. Broman, Daniel M. Gatti, Petr Simecek, Nicholas A. Furlotte, Pjotr Prins, Saunak Sen, Brian S. Yandell, Gary A. Churchill
Article
Anesthesiology
Jill M. Recla, Jason A. Bubiera, Daniel M. Gatti, Jennifer L. Ryan, Katie H. Long, Raymond F. Robledo, Nicole C. Glidden, Guodiang Hou, Gary A. Churchill, Richard S. Maser, Zhong-wei Zhang, Erin E. Young, Elissa J. Chesler, Carol J. Bult
Article
Genetics & Heredity
Karl W. Broman, Daniel M. Gatti, Karen L. Svenson, Saunak Sen, Gary A. Churchill
G3-GENES GENOMES GENETICS
(2019)
Article
Genetics & Heredity
Vishal Kumar Sarsani, Narayanan Raghupathy, Ian T. Fiddes, Joel Armstrong, Francoise Thibaud-Nissen, Oraya Zinder, Mohan Bolisetty, Kerstin Howe, Doug Hinerfeld, Xiaoan Ruan, Lucy Rowe, Mary Barter, Guruprasad Ananda, Benedict Paten, George M. Weinstock, Gary A. Churchill, Michael V. Wiles, Valerie A. Schneider, Anuj Srivastava, Laura G. Reinholdt
G3-GENES GENOMES GENETICS
(2019)
Article
Genetics & Heredity
Larry D. Mesner, Gina M. Calabrese, Basel Al-Barghouthi, Daniel M. Gatti, John P. Sundberg, Gary A. Churchill, Dana. A. Godfrey, Cheryl L. Ackert-Bicknell, Charles R. Farber
Article
Genetics & Heredity
Caroline J. Zeiss, Daniel M. Gatti, Olga Toro-Salazar, Crystal Davis, Cathleen M. Lutz, Francis Spinale, Timothy Stearns, Milena B. Furtado, Gary A. Churchill
G3-GENES GENOMES GENETICS
(2019)
Article
Medicine, Research & Experimental
Mark P. Keller, Mary E. Rabaglia, Kathryn L. Schueler, Donnie S. Stapleton, Daniel M. Gatti, Matthew Vincent, Kelly A. Mitok, Ziyue Wang, Takanao Ishimura, Shane P. Simonett, Christopher H. Emfinger, Rahul Das, Tim Beck, Christina Kendziorski, Karl W. Broman, Brian S. Yandell, Gary A. Churchill, Alan D. Attie
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Genetics & Heredity
Ulia H. Kemis, Vanessa Linke, Kelsey L. Barrett, Frederick J. Boehm, Lindsay L. Traeger, Mark P. Keller, Mary E. Rabaglia, Kathryn L. Schueler, Donald S. Stapleton, Daniel M. Gatti, Gary A. Churchill, Daniel Amador-Noguez, Jason D. Russell, Brian S. Yandell, Karl W. Broman, Joshua J. Coon, Alan D. Attie, Federico E. Rey
Article
Multidisciplinary Sciences
Kwangbom Choi, Narayanan Raghupathy, Gary A. Churchill
NATURE COMMUNICATIONS
(2019)
Article
Clinical Neurology
Brendan T. Keenan, Raymond J. Galante, Jie Lian, Petr Simecek, Daniel M. Gatti, Lin Zhang, Diane C. Lim, Karen L. Svenson, Gary A. Churchill, Allan Pack
Article
Biochemical Research Methods
Susan McClatchy, Kristin M. Bass, Daniel M. Gatti, Adam Moylan, Gary Churchill
PLOS COMPUTATIONAL BIOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Tian Zhang, Gregory R. Keele, Isabela Gerdes Gyuricza, Matthew Vincent, Catherine Brunton, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Steven C. Munger, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Joao A. Paulo, Steven P. Gygi, Gary A. Churchill
Summary: This study quantified phosphopeptides, proteins, and transcripts in mouse tissue samples and identified key regulators of protein phosphorylation, including kinases, phosphatases, cytokines, and genes. The integrative multi-omics analysis provided a powerful tool for identifying regulators of protein phosphorylation.
Article
Biotechnology & Applied Microbiology
Kwangbom Choi, Yang Chen, Daniel A. Skelly, Gary A. Churchill
Meeting Abstract
Endocrinology & Metabolism
Basel Al-Barghouthi, Gina Calabrese, Larry Mesner, Kevin Nguyen, Mary Bouxsein, Daniel Brooks, Mark Horowitz, Clifford Rosen, Steve Tommasini, Petr Simecek, Gary Churchill, Cheryl Ackert-Bicknell, Daniel Pomp, Charles Farber
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Meeting Abstract
Clinical Neurology
B. Keenan, R. Galante, J. Lian, P. Simecek, D. Gatti, L. Zhang, D. Lim, K. Svenson, G. Churchill, A. Pack
JOURNAL OF SLEEP RESEARCH
(2018)