Article
Cell Biology
Tianli Zhang, Chunyan Wang, Kun Wang, Ying Liang, Ting Liu, Liping Feng, Xingsheng Yang
Summary: RacGAP1 is overexpressed in cervical cancer and is associated with poor prognosis. Downregulation of RacGAP1 inhibits proliferation, migration, and invasion of cervical cancer cells, while miR-192 is identified as a downstream target of RacGAP1 and plays a tumor suppressor role.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Songbo Fu, Chengxu Ma, Xulei Tang, Xiaoni Ma, Gaojing Jing, Nan Zhao, Junta Ran
Summary: The study found that miR-192-5p is significantly decreased in PTC tissues and cells. Overexpression of miR-192-5p suppressed proliferation, migration, invasion, and EMT in TPC-1 cells, while inducing apoptosis. MiR-192-5p negatively modulates SH3RF3 expression by binding to its 3'UTR.
BIOSCIENCE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Zhirong Jia, Kaiwei Wang, Yameng Zhang, Yalei Duan, Kang Xiao, Shuo Liu, Xuansheng Ding
Summary: Icariin alleviates tubulointerstitial fibrosis by restoring autophagy through the miR-192-5p/GLP-1R pathway, offering a novel therapeutic option for diabetic fibrosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Stepan Gambaryan, Sanika Mohagaonkar, Viacheslav O. Nikolaev
Summary: The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in blood volume and blood pressure regulation, and its dysfunction is associated with cardiovascular and renal diseases. Cyclic nucleotides and phosphodiesterases are the main regulators of this system, controlling the expression and activity of renin and aldosterone. This review summarizes the known mechanisms by which cyclic nucleotides and phosphodiesterases regulate the expression of renin gene, secretion of renin granules, and production of aldosterone, as well as highlighting some unanswered questions for future research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pharmacology & Pharmacy
Fu-jia Ren, Yao Yao, Xiao-yu Cai, Guo-ying Fang
Summary: miR-192-5p plays a significant role in various human diseases, especially in cancers of the lung, liver, and breast. Levels of this miRNA in circulation can assist in the diagnosis and prognosis of diseases such as chronic hepatitis B.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Ji-Ung Jung, Melanie H. Cobb
Summary: The protein kinase WNK1 influences the trafficking and actin polymerization of membrane proteins. This study discovered a connection between WNK1 and TRIM27, which regulates endosomal actin polymerization. Depletion of WNK1 disrupted WASH ubiquitination and endosomal actin polymerization, affecting endosomal trafficking. Depletion of WNK1 or TRIM27 increased the degradation of EGFR in cancer cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Medicine, Research & Experimental
Samah S. Abbas, Mona F. Schaalan, Sahar M. Gebril, Fatma E. Hassan, Maha O. Mahmoud, Soha O. Hassanin
Summary: This research investigates the protective effect of LCZ696 on cyclophosphamide-induced nephrotoxicity. LCZ696 significantly reduced serum creatinine and urea levels, decreased oxidative stress and inflammation in the kidney, and altered the expression of specific genes and proteins related to kidney injury. The prophylactic effect of LCZ696 was superior to that of valsartan.
Article
Biology
Tongfei Wang, Wei Li, Haitao Li, Weina Li
Summary: The study revealed significant differences in the expression levels of miR-194 and miR-192 in serum samples and bronchial wash samples of NSCLC participants, which were associated with tumor staging, metastasis, and pathological grade.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Qian Li, Yanzi Zang, Zhanwei Sun, Wenqi Zhang, Hongjian Liu
Summary: This study aimed to investigate the function and mechanism of lncRNA Gm44593 in age-related hearing loss. The results showed that overexpression of lncRNA Gm44593 in HEI-OC1 cells reduced cell death rates and improved ATP content, mtDNA content, and mitochondrial membrane potential. We also discovered that miR-29b is a direct target of lncRNA Gm44593, and WNK1 is a direct target of miR-29b.
Article
Biochemistry & Molecular Biology
Ayaka Koma, Shunichi Asai, Chikashi Minemura, Sachi Oshima, Takashi Kinoshita, Naoko Kikkawa, Keiichi Koshizuka, Shogo Moriya, Atsushi Kasamatsu, Toyoyuki Hanazawa, Katsuhiro Uzawa, Naohiko Seki
Summary: The study identified downregulated miR-139 in head and neck squamous cell carcinoma and demonstrated its role in attenuating cancer cell aggressiveness by regulating GNA12 and OLR1 expression, which are associated with patient survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Thorben Fruendt, Linda Krause, Elaine Hussey, Bettina Steinbach, Daniel Koehler, Johann von Felden, Kornelius Schulze, Ansgar W. Lohse, Henning Wege, Heidi Schwarzenbach
Summary: Exosomes carrying small non-coding RNA, particularly miR-16, miR-146a, miR-192, and miR-221, appear to be promising diagnostic and prognostic markers for hepatocellular carcinoma (HCC) and liver cirrhosis patients. MiR-146a showed potential as a diagnostic marker for distinguishing HCC patients from liver cirrhosis patients, while miR-192 independently correlated with overall survival in HCC patients.
Article
Multidisciplinary Sciences
Xiaoding Xu, Chuwei Yu, Hongxiu He, Xiangyu Pan, Aijun Hou, Jianxun Feng, Rongrong Tan, Likun Gong, Jing Chen, Jin Ren
Summary: Epigenetic regulations, particularly miR-337-3p, play a crucial role in the pathogenesis of metabolic-associated fatty liver disease (MAFLD). Overexpression of miR-337-3p can ameliorate hepatic lipid accumulation, reduce fasting blood glucose, and improve insulin resistance. Additionally, miR-337-3p may influence multiple genes involved in glycolipid metabolism, providing a potential therapeutic target for MAFLD.
Article
Oncology
Zhenghua Fei, Yanfen Wang, Yuyang Gu, Rongrong Xie, Qiongyu Hao, Yiyan Jiang
Summary: This study identified an upregulated circular RNA, circKIF5B, in liver cancer cells and demonstrated its role in regulating the proliferation, invasion, and metastasis of liver cancer cells through modulation of the miR-192 family. These findings provide mechanistic evidence and suggest circKIF5B as a potential therapeutic target for liver cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Jiahao Liu, Yinghao Wen, Zhen Liu, Shu Liu, Ping Xu, Yan Xu, Shuting Deng, Shulu Hu, Rongcheng Luo, Jingwen Jiang, Guifang Yu
Summary: The study showed that reduced VPS33B protein level was associated with poor prognosis in NSCLC, while overexpression of VPS33B reduced cell cycle transition and proliferation of NSCLC cells. miR-192-3p, induced by VPS33B, acted as a tumor suppressor in NSCLC cell growth by targeting CCNB1. The modulation of c-Myc/p53/miR-192-3p signaling pathway by VPS33B provides a novel molecular basis for its role as a tumor suppressor in NSCLC.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Peripheral Vascular Disease
Jing Liu, Yong Liu, Feng Wang, Mingyu Liang
Summary: miR-204 is a high-value microRNA that plays a critical role in regulating cardiovascular and renal physiology, exhibiting tissue-specific expression patterns and being influenced by multiple regulatory mechanisms. It attenuates pulmonary arterial hypertension and renal injury while promoting hypertension and endothelial dysfunction, potentially impacting disease processes through targeting various biological pathways. Dysregulation of miR-204 in cardiovascular and renal diseases highlights its unequivocal functional roles and clinical relevance.
Article
Cardiac & Cardiovascular Systems
Jeffrey W. Olin, Antonio F. Di Narzo, Valentina d'Escamard, Daniella Kadian-Dodov, Haoxiang Cheng, Adrien Georges, Annette King, Allison Thomas, Temo Barwari, Katherine C. Michelis, Rihab Bouchareb, Emir Bander, Anelechi Anyanwu, Paul Stelzer, Farzan Filsoufi, Sander Florman, Mete Civelek, Stephanie Debette, Xavier Jeunemaitre, Johan L. M. Bjorkegren, Manuel Mayr, Nabila Bouatia-Naji, Ke Hao, Jason C. Kovacic
CARDIOVASCULAR RESEARCH
(2020)
Article
Genetics & Heredity
Salma Adham, Sophie Dupuis-Girod, Etienne Charpentier, Jean-Michael Mazzella, Xavier Jeunemaitre, Anne Legrand
Article
Cardiac & Cardiovascular Systems
Nicolas Ledieu, Louis Larnier, Vincent Auffret, Coralie Marie, Dominique Fargeau, Erwan Donal, Mariana Mirabel, Xavier Jeunemaitre, Tania Puscas, Eloi Marijon, Amelie Reynaud, Philippe Ritter, Stephane Lafitte, Philippe Mabo, Patricia Reant, Claude Daubert, Albert A. Hagege
Article
Genetics & Heredity
Jean-Michael Mazzella, Salma Adham, Michael Frank, Anne Legrand, Khadija Lahlou-Laforet, Xavier Jeunemaitre
JOURNAL OF GENETIC COUNSELING
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Piotr Zieminski, Jessie Risse, Anne Legrand, Virginie Dufrost, Laurence Bal, Nicla Settembre, Serguei Malikov, Xavier Jeunemaitre, Denis Wahl, Stephane Zuily
Review
Medicine, General & Internal
J. Albuisson, A. Legrand, C. Billon, J-M Mazzella, M. Frank, S. Adham, X. Jeunemaitre
BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE
(2020)
Article
Cardiac & Cardiovascular Systems
Adrien Georges, Juliette Albuisson, Takiy Berrandou, Delia Dupre, Aurelien Lorthioir, Valentina D'Escamard, Antonio F. Di Narzo, Daniella Kadian-Dodov, Jeffrey W. Olin, Ewa Warchol-Celinska, Aleksander Prejbisz, Andrzej Januszewicz, Patrick Bruneval, Anna A. Baranowska, Tom R. Webb, Stephen E. Hamby, Nilesh J. Samani, David Adlam, Natalia Fendrikova-Mahlay, Stanley Hazen, Yu Wang, Min-Lee Yang, Kristina Hunker, Nicolas Combaret, Pascal Motreff, Antoine Chedid, Beatrice Fiquet, Pierre-Francois Plouin, Elie Mousseaux, Arshid Azarine, Laurence Amar, Michel Azizi, Heather L. Gornik, Santhi K. Ganesh, Jason C. Kovacic, Xavier Jeunemaitre, Nabila Bouatia-Naji
Summary: This study identified rare genetic mutations in the prostaglandin 12 receptor gene (PTGIR) that are enriched among FMD patients and found in SCAD patients, suggesting a role for prostacyclin signaling in non-atherosclerotic arterial stenosis and dissection. The biological effects of these mutations on human prostacyclin receptor (hIP) function were characterized, showing severe impairments in vitro.
CARDIOVASCULAR RESEARCH
(2021)
Letter
Peripheral Vascular Disease
Ewa Warchol-Celinska, Takiy Berrandou, Aleksander Prejbisz, Adrien Georges, Delia Dupre, Magdalena Januszewicz, Elzbieta Florczak, Katarzyna Jozwik-Plebanek, Piotr Dobrowolski, Witold Smigielski, Wojciech Drygas, Jacek Kadziela, Adam Witkowski, Marek Kabat, Malgorzata Szczerbo-Trojanowska, Marco Pappaccogli, Alexandre Persu, Xavier Jeunemaitre, Andrzej Januszewicz, Nabila Bouatia-Naji
Article
Peripheral Vascular Disease
Andrea V. Haas, Rene Baudrand, Rebecca M. Easly, Gillian R. Murray, Rhian M. Touyz, Luminita H. Pojoga, Xavier Jeunemaitre, Paul N. Hopkins, Bernard Rosner, Jonathan S. Williams, Gordon H. Williams, Gail K. Adler
Article
Medicine, Research & Experimental
Helene Louis-Dit-Picard, Ilektra Kouranti, Chloe Rafael, Irmine Loisel-Ferreira, Maria Chavez-Canales, Waed Abdel-Khalek, Eduardo R. Argaiz, Stephanie Baron, Sarah Vacle, Tiffany Migeon, Richard Coleman, Marcio Do Cruzeiro, Marguerite Hureaux, Nirubiah Thurairajasingam, Stephane Decramer, Xavier Girerd, Kevin O'Shaugnessy, Paolo Mulatero, Gwenaelle Roussey, Ivan Tack, Robert Unwin, Rosa Vargas-Poussou, Olivier Staub, Richard Grimm, Paul A. Welling, Gerardo Gamba, Eric Clauser, Juliette Hadchouel, Xavier Jeunemaitre
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Samia Boussouar, Amira Benattia, Jean. -Baptiste Escudie, Laure Gibault, Frederique Capron, Anne Legrand, Pierre-Yves Brillet, Xavier Jeunemaitre, Philippe A. Grenier, Elie Mousseaux, Michael Frank, Olivier Sanchez
Summary: This study describes the CT features of lung involvement in patients with vEDS, with around 57.3% of patients showing abnormalities in lung parenchyma, most commonly emphysema. Surgical samples histologically revealed lung issues often correlated with arterial abnormalities.
EUROPEAN RADIOLOGY
(2021)
Article
Medicine, General & Internal
A. Legrand, C. Pujol, C. M. Durand, A. Mesnil, I. Rubera, C. Duranton, S. Zuily, A. B. Sousa, M. Renaud, J. L. Boucher, N. Pietrancosta, S. Adham, C. Orssaud, C. Marelli, C. Casali, L. Ziccardi, N. Villain, C. Ewenczyk, A. Durr, C. Mignot, G. Stevanin, C. Billon, M. Hureaux, X. Jeunemaitre, C. Goizet, J. Albuisson
Summary: A study identified CYP2U1 pathogenic variants in PXE patients with neurological symptoms who were unresolved by ABCC6 genetic screening, expanding the phenotype of SPG56 and highlighting its overlap with PXE. The pathophysiology of ABCC6 and CYP2U1 should be explored further to understand their respective roles and potential interaction in ectopic mineralization.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jeremie Bazin, Emilie Elvira-Matelot, Thomas Blein, Vincent Jauvion, Nathalie Bouteiller, Jun Cao, Martin D. Crespi, Herve Vaucheret
Summary: In addition to regulating splicing, the spliceosome components SmD1 and PRP39 also promote posttranscriptional gene silencing in Arabidopsis thaliana. However, their actions are distinct in both splicing and gene silencing. The double mutant analysis suggests that PRP39 and SmD1 work together to limit degradation of transgene-derived aberrant RNAs, thus promoting the initiation of posttranscriptional gene silencing in the cytoplasm.
Meeting Abstract
Respiratory System
Amira Benattia, Samia Boussouar, Jean-Baptiste Escudie, Laure Gibault, Frederique Capron, Pierre-Yves Brillet, Philippe Grenier, Xavier Jeunemaitre, Elie Mousseaux, Michael Frank, Olivier Sanchez
EUROPEAN RESPIRATORY JOURNAL
(2020)
Meeting Abstract
Clinical Neurology
Charlotte Arnaud, Marion Boulanger, Aurelien Lorthioir, Laurence Amar, Arshid Azarine, Michel Azizi, Louis Boyer, Gilles Chatelllier, Xavier Jeunemaitre, Elie Mousseaux, Catherine Oppenheim, Frederic Thony, Pierre-Francois Plouin, Alexandre Persu, Jeffrey Olin, Emmanuel Touze