Review
Biochemistry & Molecular Biology
Alex Cleber Improta-Caria, Marcela Gordilho Aras, Luca Nascimento, Ricardo Augusto Leoni De Sousa, Roque Aras-Junior, Bruno Solano de Freitas Souza
Summary: MicroRNAs are small non-coding RNAs that regulate gene and protein expression, playing important roles in various cellular processes. In diseases such as hypertension, microRNAs are involved in regulating physiological processes, but the specific mechanisms need further study.
Article
Cardiac & Cardiovascular Systems
Kieran F. Docherty, Ross T. Campbell, Katriona J. M. Brooksbank, John G. Dreisbach, Paul Forsyth, Rosemary L. Godeseth, Tracey Hopkins, Alice M. Jackson, Matthew M. Y. Lee, Alex McConnachie, Giles Roditi, Iain B. Squire, Bethany Stanley, Paul Welsh, Pardeep S. Jhund, Mark C. Petrie, John J. V. McMurray
Summary: In patients with asymptomatic LV systolic dysfunction late after myocardial infarction, treatment with sacubitril/valsartan did not have a significant reverse remodeling effect compared with valsartan.
Article
Biochemistry & Molecular Biology
Fedor Simko, Tomas Baka, Peter Stanko, Kristina Repova, Kristina Krajcirovicova, Silvia Aziriova, Oliver Domenig, Stefan Zorad, Michaela Adamcova, Ludovit Paulis
Summary: This study investigated whether sacubitril/valsartan and ivabradine can prevent left ventricular fibrotic remodelling and dysfunction in a rat model of hypertension, and found that the protective effects of sacubitril/valsartan may be associated with RAAS alterations, while the benefits of ivabradine were not related to RAAS modulation.
Article
Medicine, General & Internal
Ahsan Alam, Emilie Cornec-Le Gall, Ronald D. Perrone
Summary: This article describes autosomal dominant polycystic kidney disease, its signs and symptoms, diagnosis, and treatment options.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Urology & Nephrology
Abdulmecit Yildiz, Saim Sag, Cuma Bulent Gul, Sumeyye Gullulu, Fatma Ezgi Can, Omer Bedir, Mehmet Fethullah Aydin, Aysegul Oruc, Sadettin Demirel, Suat Akgur, Mustafa Gullulu, Alparslan Ersoy
Summary: This study investigated the association between MBPS and LVH in ADPKD patients with preserved renal functions. The results suggest that there may be a connection between MBPS and LVH in these patients.
Letter
Endocrinology & Metabolism
Decio Armanini, Chiara Sabbadin, Luigi De Marco, Luciana Bordin
Summary: A recent study found that women with polycystic ovary syndrome (PCOS) have a 52% increased risk of COVID-19 infection, with nearly twice the incidence compared to women without PCOS. A survey of 200 unvaccinated women with PCOS who had been treated with spironolactone for more than 4 months revealed only four infected patients, with mild or minimal symptoms. Further research is needed to confirm these findings and evaluate the use of spironolactone in both PCOS and the general population for COVID-19.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Susanne Rysz, Jonathan Al-Saadi, Anna Sjostrom, Maria Farm, Francesca Campoccia Jalde, Michael Platten, Helen Eriksson, Margareta Klein, Roberto Vargas-Paris, Sven Nyren, Goran Abdula, Russell Ouellette, Tobias Granberg, Malin Jonsson Fagerlund, Johan Lundberg
Summary: Studies suggest that RAAS imbalance worsens the prognosis in COVID-19 patients, and experiments in pigs show that over-activation of ACE2 and RAAS can lead to a disease state similar to COVID-19 in humans. Imbalanced RAAS state in animals can be ameliorated by angiotensin receptor blockers and low-molecular-weight heparin.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Sukka Santosh Reddy, Heena Agarwal, Anant Jaiswal, Kumaravelu Jagavelu, Madhu Dikshit, Manoj Kumar Barthwal
Summary: The study found that macrophage p47phox plays a role in hypertensive cardiac remodeling, with its deficiency potentially leading to worsened cardiac dysfunction, hypertrophy, and increased interstitial fibrosis. Further experiments revealed elevated expression of M2 macrophage markers in KO mice, suggesting a restrictive role of p47phox in anti-inflammatory signaling during cardiac remodeling.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Quenia Janaina Tomaz de Castro, Carolina Morais Araujo, Patricia Yoshie Watai, Samara Stefani de Castro e Silva, Wanderson Geraldo de Lima, Lenice Kappes Becker, Jamille Locatelli, Homero Nogueira Guimaraes, Andrea Grabe-Guimaraes
Summary: The study showed that the combination of physical exercise with RAAS blockers could effectively lower blood pressure, improve cardiac parameters, and potentially benefit hypertensive LVH treatment.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Review
Chemistry, Multidisciplinary
Antonietta Gigante, Adolfo Marco Perrotta, Francesca Tinti, Eleonora Assanto, Maurizio Muscaritoli, Silvia Lai, Rosario Cianci
Summary: Autosomal dominant polycystic kidney disease (ADPKD) is an inherited kidney disease that leads to progressive kidney failure. 5-10% of patients requiring renal replacement therapy are affected by ADPKD. Cardiovascular diseases are the main causes of morbidity and mortality in these patients, with arterial hypertension being an early symptom. A systematic review was conducted to evaluate the evidence on different imaging techniques for grading the cardiovascular risk in the early stage of ADPKD.
APPLIED SCIENCES-BASEL
(2023)
Review
Urology & Nephrology
Julie Xia Zhou, Vicente E. Torres
Summary: Autosomal dominant polycystic kidney disease is a progressive condition that leads to kidney failure due to the formation of kidney cysts. The only approved drug, tolvaptan, for treating this disease is limited by its reduced tolerability and potential hepatotoxicity. Therefore, there is an urgent need to find more effective drugs through drug repurposing, which is a cost-efficient and time-efficient strategy. This review focuses on repurposing approaches to identify suitable drug candidates and prioritize those with a high probability of success for treating autosomal dominant polycystic kidney disease.
KIDNEY INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Dagmar Jarkovska, Matus Miklovic, Jitka Sviglerova, Ludek Cervenka, Petra Skaroupkova, Vojtech Melenovsky, Milan Stengl
Summary: Chronic volume overload leads to various cardiac remodeling processes, with eccentric cardiac hypertrophy and heart failure as final outcomes. Trandolapril, an ACE inhibitor, was found to have different effects on remodeling processes, showing significant reduction in proarrhythmic electrical remodeling and mortality in rats with aortocaval fistula, while having less impact on cardiac hypertrophy. This suggests that the therapeutic effects of trandolapril in volume overload heart failure may be dissociated from its antihypertrophic effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Piotr Jedrusik, Bartosz Symonides, Jacek Lewandowski, Zbigniew Gaciong
Summary: Primary aldosteronism (PA) is a potentially curable form of secondary hypertension that requires measuring renin and aldosterone, followed by confirmatory tests. Various antihypertensive drug classes interfere with PA evaluation, with calcium antagonists and alpha-blockers being the least interfering drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
D. Marshall Brinkley, Li Wang, Chang Yu, E. Wilson Grandin, Michael S. Kiernan
Summary: In LVAD patients, treatment with ACEI/ARB but not MRA was independently associated with lower mortality. ACEI/ARB therapy was also associated with decreased risk of cardiovascular death, gastrointestinal bleeding, and creatinine level, while MRA therapy was associated with lower risk of gastrointestinal bleeding but higher risk of hemolysis.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Urology & Nephrology
Kyongtae T. Bae, Cheng Tao, Robert Feldman, Alan S. L. Yu, Vicente E. Torres, Ronald D. Perrone, Arlene B. Chapman, Godela Brosnahan, Theodore I. Steinman, William E. Braun, Michal Mrug, William M. Bennett, Peter C. Harris, Avantika Srivastava, Douglas P. Landsittel, Kaleab Z. Abebe
Summary: This study aimed to evaluate the associations of polycystic liver progression with other disease progression variables and classify liver progression on the basis of patient's age, height-adjusted liver cystic volume, and height-adjusted liver volume. The use of height-adjusted liver cystic volume showed greater separations in volumetric progression of polycystic liver disease.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)