Article
Nanoscience & Nanotechnology
Chao Wang, Yiyu Cai, Wei Zhou, Peng Chen, Li Xu, Tao Han, Yulin Hu, Xuhui Xu, Bitao Liu, Xue Yu
Summary: This study developed a wearable respiration sensor based on CeO2@PANI nanocomposites that underwent a hydrogen plasma treatment, which showed significantly enhanced response to NH3 and the potential for detecting trace levels of NH3 in human breathing. Clinical tests suggested its potential applications in clinical monitoring for CKD.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Cell Biology
Wen-Chin Lee, Chien-Hua Chiu, Tian-Huei Chu, Yu-Shu Chien
Summary: This review discusses the correlation between HIF-PHIs and cancer development in treating anemia in CKD patients, and proposes monitoring strategies and WT1 inhibition to reduce the risk of cancer progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Solmaz Maleki Dizaj, Aziz Eftekhari, Shakar Mammadova, Elham Ahmadian, Mohammadreza Ardalan, Soodabeh Davaran, Aygun Nasibova, Rovshan Khalilov, Mahbuba Valiyeva, Sevil Mehraliyeva, Ebrahim Mostafavi
Summary: This review focuses on current research and clinical applications of nanoparticles in the diagnosis of chronic kidney disease (CKD) and other renal diseases that may lead to CKD.
APPLIED SCIENCES-BASEL
(2021)
Editorial Material
Urology & Nephrology
David S. Weisman, Sumeska Thavarajah, Bernard G. Jaar
Summary: Chronic kidney disease is a global public health burden, with significant impact on the quality of life and mortality of patients. Most patients with CKD are managed by primary care practitioners, and this educational series aims to improve understanding and care delivery for this high-risk patient population.
Article
Urology & Nephrology
Inga Steinbrenner, Zhi Yu, Jin Jin, Ulla T. Schultheiss, Fruzsina Kotsis, Morgan E. Grams, Josef Coresh, Matthias Wuttke, Florian Kronenberg, Kai-Uwe Eckardt, Nilanjan Chatterjee, Peggy Sekula, Anna Koettgen
Summary: Chronic kidney disease (CKD) is a global health burden affecting over 10% of the adult population. This study aims to investigate the association between a polygenic predisposition to lower eGFR and adverse outcomes in CKD patients, and determine whether it provides additional predictive information beyond established risk factors.
KIDNEY INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Satyesh K. Sinha, Michael Mellody, Maria Beatriz Carpio, Robert Damoiseaux, Susanne B. Nicholas
Summary: Osteopontin (OPN) is a protein with various physiological functions and has been implicated in the pathogenesis of chronic kidney disease (CKD). OPN may serve as a biomarker in CKD and targeting OPN could be a potential treatment strategy.
Review
Cardiac & Cardiovascular Systems
Ashton C. Lai, Solomon W. Bienstock, Raman Sharma, Karl Skorecki, Frans Beerkens, Rajeev Samtani, Andrew Coyle, Tonia Kim, Usman Baber, Anton Camaj, David Power, Valentin Fuster, Martin E. Goldman
Summary: Cardiovascular disease is the leading cause of death in end-stage renal disease patients, exacerbated by dialysis treatment. Multimodality imaging may offer additional prognostication and risk stratification for these patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pedro Caetano Pinto, Cindy Roennau, Martin Burchardt, Ingmar Wolff
Summary: Kidney cancer and chronic kidney disease have different clinical management strategies, but share closely related cellular and molecular mechanisms, both involving the kidney's response to hypoxia. Fibrosis is a common factor in deteriorating renal function in both conditions.
Editorial Material
Biochemistry & Molecular Biology
Francisco Herrera-Gomez, F. Javier Alvarez
Summary: The current healthcare concept promotes personalized treatment through biomarkers for chronic kidney disease patients. Prognostic markers based on real-world evidence aim to identify high-risk patients for better decision-making.
Article
Urology & Nephrology
Carla Santos-Araujo, Luis Mendonca, Daniel Seabra Carvalho, Filipa Bernardo, Marisa Pardal, Joao Couceiro, Hugo Martinho, Cristina Gavina, Tiago Taveira-Gomes, Ricardo Jorge Dinis-Oliveira
Summary: This study provides the first real-world based estimation of the prevalence of chronic kidney disease (CKD) in a large, unselected Portuguese population. The overall estimated prevalence of CKD was 9.8% and was higher in females than males. This study may help healthcare providers in formulating policies and strategies focused on preventing CKD and improving cardiovascular outcomes.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Infectious Diseases
Lisa Pilgram, Lukas Eberwein, Kai Wille, Felix C. Koehler, Melanie Stecher, Siegbert Rieg, Jan T. Kielstein, Carolin E. M. Jakob, Maria Ruthrich, Volker Burst, Fabian Prasser, Stefan Borgmann, Roman-Ulrich Mueller, Julia Lanznaster, Nora Isberner, Lukas Tometten, Sebastian Dolff
Summary: In CKD patients with SARS-CoV-2 infection, age, lactate dehydrogenase levels, platelet count, anemia, and C-reactive protein levels were identified as important predictive factors for mortality, while renal replacement therapy was not associated with mortality.
Article
Medicine, General & Internal
Massini A. Merzkani, Aleksandar Denic, Ramya Narasimhan, Camden L. Lopez, Joseph J. Larson, Walter K. Kremers, Harini A. Chakkera, Walter D. Park, Sandra J. Taler, Mark D. Stegall, Manam P. Alexander, Naim Issa, Andrew D. Rule
Summary: Microstructural features such as low nephron number for age and larger glomeruli were found to be important predictors for long-term risk of chronic kidney disease after living kidney donation. Incident hypertension, on the other hand, was not predicted by any microstructural features in the study.
MAYO CLINIC PROCEEDINGS
(2021)
Review
Medicine, General & Internal
Mehmet Kanbay, Sidar Copur, Atalay Demiray, Alan A. Sag, Adrian Covic, Alberto Ortiz, Kathherine R. Tuttle
Summary: This article reviews the latest literature on fatty kidney and provides perspectives on future research, diagnosis, and treatment of this increasingly prevalent disease in the contemporary world. The study suggests that oxidative stress and inflammation, Klotho deficiency, endoplasmic reticulum stress, mitochondrial dysfunction, and disruption of cellular energy balance are the main pathophysiological mechanisms leading to tissue damage in fatty kidney.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, General & Internal
Lukasz Kuzma, Anna Tomaszuk-Kazberuk, Anna Kurasz, Malgorzata Zalewska-Adamiec, Hanna Bachorzewska-Gajewska, Slawomir Dobrzycki, Marlena Kwiatkowska, Jolanta Malyszko
Summary: Patients with atrial fibrillation (AF) scheduled for coronary angiography are at higher risk of post-contrast acute kidney injury (PC-AKI), especially those with chronic kidney disease (CKD). This study found that kidney impairment was twice as common in AF patients undergoing coronary angiography, highlighting the need for extra caution in these cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Jun Wu, QianLing Ye, LanLan Fang, LiJun Deng, Tao Liao, Bo Liu, XiaoJie Lv, Jie Zhang, JinHui Tao, DongQing Ye
Summary: This study found associations between air pollution and low temperature with hospital visits related to chronic kidney disease (CKD). Low temperature enhanced the association between air pollution and CKD-related hospital visits. Mitigation strategies for air pollution and improved understanding of the temperature variance effect on air pollution may help reduce the burden of CKD on healthcare systems in the context of climate change.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)