Article
Chemistry, Medicinal
Na Yang, Chunpeng Zou, Wu Luo, Diyun Xu, Mengyang Wang, Yi Wang, Gaojun Wu, Peiren Shan, Guang Liang
Summary: This study demonstrates the potential use of sclareol in preventing hypertensive heart failure by inhibiting the MAPK-mediated inflammation induced by Ang II.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Yue-Tong Guo, Yuan-Yuan Lu, Xiao Lu, Shun He, Shi-Jin Li, Shuai Shao, Han-Dan Zhou, Rui-Qi Wang, Xiao-Dong Li, Ping-Jin Gao
Summary: IL-11 plays a crucial role in hypertension-associated vascular remodeling, IL-11 neutralizing antibody can alleviate adventitial fibrosis and inflammatory response, Krüppel-like factor 15 negatively regulates Ang II-induced IL-11 expression in adventitial fibroblasts.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Orthopedics
Meiling Quan, Won-Ha Hwang, Jae-Hoon Kim, Young-Yul Kim
Summary: In this study using a rat spinal surgery model, it was found that repeated surgeries may lead to an increase in dural thickness and the expression of phosphorylated ERK and p38 in the spinal dorsal horn. This suggests a potential link between epidural fibrosis, phosphorylated ERK and p38, and neuropathic pain, with pain likely intensifying as the number of surgeries increase.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Yun Liu, Jing Hu, Weiwei Wang, Qian Wang
Summary: This study explored the effect of miR-145 on cardiac fibrosis in heart failure mice and its target gene MAP3K3. The levels of miR-145 were decreased in heart failure mice and Ang II-treated cardiac fibroblasts. Upregulation of miR-145 improved cardiac dysfunction and inhibited fibrosis by suppressing MAP3K3 expression. Blocking MAP3K3 or upregulating miR-145 can be potential treatments for heart failure and cardiac fibrosis.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Agronomy
Tingzhen Wang, Mingjia Liu, Yufeng Tian, Yingyan Han, Chaojie Liu, Jinghong Hao, Shuangxi Fan
Summary: This study investigates the important role of mitogen-activated protein kinase 6 (MAPK6) in high temperature bolting of lettuce. The researchers amplified the full-length coding sequence of the LsMAPK6 gene and analyzed its expression using real-time polymerase chain reaction. The results demonstrate that LsMAPK6 is mainly expressed in the stem, stem apex, and taproot, and its expression is significantly promoted by high temperatures.
Article
Oncology
Yafei Zhou, Ying Xie, Tao Li, Peng Zhang, Tangting Chen, Zhongcai Fan, Xiaoqiu Tan
Summary: This study demonstrates that PAK1 is involved in AngII-induced proliferation, migration and transdifferentiation of cardiac fibroblasts through the JNK/c-Jun pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Matias Estaras, Manuel R. Gonzalez-Portillo, Miguel Fernandez-Bermejo, Jose M. Mateos, Daniel Vara, Gerardo Blanco-Fernandez, Diego Lopez-Guerra, Vicente Roncero, Gines M. Salido, Antonio Gonzalez
Summary: The study demonstrates that melatonin at pharmacological concentrations can diminish the proliferation of pancreatic stellate cells subjected to hypoxia by modulating the cell cycle, apoptosis, and the activation of crucial MAPKs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Benno Traub, Aileen Roth, Marko Kornmann, Uwe Knippschild, Joachim Bischof
Summary: Pancreatic cancer is a devastating disease with poor survival rates, prompting the need for new therapeutic approaches. Protein kinases play crucial roles in development and pathogenesis, making them potential targets for precision medicine in patients with deregulated kinase pathways.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Plant Sciences
Xi Zhu, Ning Zhang, Xue Liu, Shigui Li, Jiangwei Yang, Xusheng Hong, Fangfang Wang, Huaijun Si
Summary: The study demonstrates that overexpression of StMAPK11 can promote potato growth, physiological activities, and photosynthesis under drought conditions, indicating its crucial role in enhancing potato drought resistance. The up-regulation of StMAPK11 intensifies drought resistance by elevating antioxidant activities and photosynthesis, providing new insights into its function in drought response.
PLANT CELL REPORTS
(2021)
Article
Microbiology
Wuyun Lv, Yu Xiao, Zhe Xu, Hong Jiang, Qi Tong, Zhengyi Wang
Summary: The role of paxillin in signal pathways in phytopathogenic fungi is not well understood. This study reveals that MoPax1 activates MAP kinase signaling pathways and autophagy through its interaction with MoMka1, and plays an important role in appressorium-mediated plant infection by the rice blast fungus.
Article
Food Science & Technology
Jeong-Won Kim, Jin-Hwa Kim, Chang-Yeop Kim, Ji-Soo Jeong, Je-Oh Lim, Jong-Choon Kim, Je-Won Ko, Tae-Won Kim
Summary: In this study, the protective effects of DADS against 1,3-DCP-induced hepatotoxicity and oxidative damage were investigated. The results showed that DADS treatment inhibited the increase in serum aminotransferase levels and reduced histopathological alterations in the liver induced by 1,3-DCP. Additionally, DADS treatment reduced 1,3-DCP-induced apoptotic changes in the liver and inhibited phosphorylation of MAPKs. These protective effects may be related to the inhibition of CYP2E1 expression, enhancement of antioxidant enzyme activity, and reduction of apoptotic activity.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chaojun Kong, Longfei Jia, Jianping Jia
Summary: This study demonstrated that gamma-mangostin can attenuate oxidative stress and inflammation caused by Aβ42 oligomers, while protecting neurons from toxic medium-induced injury, suggesting its potential protective effect in Alzheimer's disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Qiaofeng Qian, Fengjiao Hu, Wenjun Yu, Dewen Leng, Yang Li, Hongjie Shi, Dawei Deng, Kehan Ding, Chuan Liang, Jinping Liu
Summary: This study found that SWAP70 inhibits pathological cardiac hypertrophy by suppressing the TAK1-dependent signaling pathway, thereby slowing down the progression of hypertrophy. The study also revealed the involvement of lysosomes in the regulation of SWAP70 expression level.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Feng-Yen Lin, Kuo-Feng Huang, Jui-Chieh Chen, Meng-Fu Lai, Kuo-Hsing Ma, Chun-Chang Yeh
Summary: Although PRF treatment is considered a safe alternative in refractory pain conditions, unexpected damage to normal nerves remains a possible complication. PRF stimulation may induce nerve inflammation, leading to inflammatory pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Jingwen Zhou, Xiaolong Zhang, Lingfeng Wan, Jun Yu, Tianci Li, Ziyu Lu, Nanyuan Fang, Lixia Sun, Fang Ye
Summary: The Zi Qi decoction inhibits liver fibrosis by suppressing the TLR4-related NF-κB and MAPK signaling pathways and preventing activation of HSCs, as indicated by both in vivo and in vitro experiments.
MEDICAL SCIENCE MONITOR
(2021)