期刊
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
卷 22, 期 8, 页码 920-927出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.echo.2009.05.014
关键词
Cardiomyopathy; Diagnosis; Echocardiography; Myocardial contraction
资金
- Interuniversity Cardiology Institute of The Netherlands
- Netherlands Heart Foundation
Background: The aim of this study was to determine the accuracy of new quantitative echocardiographic strain and strain-rate imaging parameters to identify abnormal regional right ventricular (RV) deformation associated with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). Methods: A total of 34 patients with ARVD/C (confirmed by Task Force criteria) and 34 healthy controls were prospectively enrolled. Conventional echocardiography, including Doppler tissue imaging (DTI), was performed. Doppler and two-dimensional strain-derived velocity, strain, and strain rate were calculated in the apical, mid, and basal segments of the RV free wall. Results: RV dimensions were significantly increased in patients with ARVD/C(RV outflow tract 19.3 +/- 5.2 mm/m(2) vs 14.1 +/- 2.2 mm/m(2), P < .001; RV inflow tract 23.4 +/- 4.8 mm/m(2) vs 18.8 +/- 6 2.4 mm/m(2), P < .001), whereas left ventricular dimensions were not significantly different compared with controls. Strain and strain rate values were significantly lower in patients with ARVD/C in all 3 segments. All deformation parameters showed a higher accuracy to detect functional abnormalities compared with conventional echocardiographic criteria of dimensions or global systolic function. The lowest DTI strain value in any of the 3 analyzed segments showed the best receiver operating characteristics (area under the curve 0.97) with an optimal cutoff value of -18.2%. Conclusions: DTI and two-dimensional strain-derived parameters are superior to conventional echocardiographic parameters in identifying ARVD/C. This novel technique may have additional value in the diagnostic workup of patients with suspected ARVD/C. (J Am Soc Echocardiogr 2009; 22: 920-7.)
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