期刊
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
卷 21, 期 8, 页码 1423-1431出版社
SPRINGER
DOI: 10.1016/j.jasms.2010.04.001
关键词
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资金
- National Science Foundation [NSF0848650]
- Office of Naval Research [N00014-05-1-0454]
- Thermo Fisher Scientific [1320036659]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0848650] Funding Source: National Science Foundation
Solvent optimization is an important procedure in desorption electrospray ionization (DESI) and in this study the effects of solvent surface tension are explored. Data are presented for methanol/water/surfactant solvent systems, which show increases in ion signals of more than an order of magnitude when low concentrations of surfactants are added to the standard methanol/water (1:1) spray solvent. Examples of analytes tested include food chemicals, peptides, pharmaceuticals, and drugs of abuse. The improvement in ion intensity is mainly attributed to the effect of surface tension in producing smaller spray droplets, which are shown to cover a larger surface area. Surfactant-containing spray solutions allowed extension of DESI-MS analysis to previously intractable analytes like melamine and highly hydrophobic compounds like the sudan dyes. (J Am Soc Mass Spectrom 2010, 21, 1423-1431) (C) 2010 American Society for Mass Spectrometry
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