Article
Computer Science, Information Systems
Kin Wah Fung, Julia Xu, Shannon McConnell-Lamptey, Donna Pickett, Olivier Bodenreider
Summary: The study found that the ICD-11 can fully represent approximately 23.5% of the most frequently used ICD-10-CM codes without postcoordination, and with postcoordination support, it can fully represent about 35.2% of the codes. Most conflicts resulted from differences in granularity and default coding assumptions between the ICD-11 and ICD-10-CM.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Public, Environmental & Occupational Health
Anna Schuh-Renner, Matthew C. Inscore, Veronique D. Hauschild, Bruce H. Jones, Michelle Canham-Chervak
Summary: The transition from ICD-9-CM to ICD-10-CM affected U.S. military injury surveillance, resulting in increased injury rates among soldiers, especially in cumulative microtraumatic injuries.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Stephanie A. A. Leonard, Danielle M. M. Panelli, Jeffrey B. B. Gould, Alison Gemmill, Elliott K. K. Main
Summary: This study assessed the validity of diagnosis codes for week of gestation in the International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) among live births. The results showed high concordance and accuracy of these codes when compared with the best obstetric estimate on the birth certificate.
Article
Obstetrics & Gynecology
Amy Metcalfe, Manal Sheikh, Erin Hetherington
Summary: This study evaluated the impact of transition from the International Classification of Diseases, Ninth Revision, to the Tenth Revision coding systems on severe maternal morbidity incidence in US hospital discharge data. The results showed a significant decrease in severe maternal morbidity incidence following the transition, indicating a sudden and clinically meaningful change associated with the coding shift.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Computer Science, Information Systems
Gregory E. Simon, Susan M. Shortreed, Jennifer M. Boggs, Gregory N. Clarke, Rebecca C. Rossom, Julie E. Richards, Arne Beck, Brian K. Ahmedani, Karen J. Coleman, Bhumi Bhakta, Christine C. Stewart, Stacy Sterling, Michael Schoenbaum, R. Yates Coley, Marc Stone, Andrew D. Mosholder, Zimri S. Yaseen
Summary: This study aims to assess the accuracy of ICD-10-CM coding for self-harm injuries and poisonings. The results indicate that nearly 90% of patients with self-harm codes for injuries and poisonings have documentation of self-harm intent.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2022)
Article
Public, Environmental & Occupational Health
Meng-Chen Hsu, Chi-Chuan Wang, Ling-Ya Huang, Chih-Ying Lin, Fang-Ju Lin, Sengwee Toh
Summary: The study evaluated the effect of diagnostic coding system transition on the identification of common conditions recorded in Taiwan's national claims database. Results showed that less than half of the 32 conditions studied had a smooth transition between the ICD-9-CM and ICD-10-CM coding systems, researchers should be aware of inconsistencies in coding definitions.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2021)
Article
Biochemical Research Methods
Michael J. Kane, Casey King, Denise Esserman, Nancy K. Latham, Erich J. Greene, David A. Ganz
Summary: This paper presents a novel dataset of numerical representations for ICD-10-CM codes generated using a language model and autoencoder. These datasets can enable more advanced analyses in the biomedical domain and have the potential to significantly improve the utility of ICD-10-CM codes.
BMC BIOINFORMATICS
(2023)
Article
Computer Science, Information Systems
A. Ram, Clair A. Kronk, Jacob R. Eleazer, Joseph L. Goulet, Cynthia A. Brandt, Karen H. Wang
Summary: Transgender individuals often face harassment and harm in healthcare settings, with gender-related terminology in electronic health records potentially exacerbating harm and failing to accommodate nonbinary patients.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Geriatrics & Gerontology
David Cheng, Clark DuMontier, Cenk Yildirim, Brian Charest, Chelsea E. Hawley, Min Zhuo, Julie M. Paik, Enzo Yaksic, J. Michael Gaziano, Nhan Do, Mary Brophy, Kelly Cho, Dae H. Kim, Jane A. Driver, Nathanael R. Fillmore, Ariela R. Orkaby
Summary: The Veterans Affairs Frailty Index (VA-FI) was updated to ICD-10, showing stability and predictive validity in measuring frailty in a contemporary cohort of Veterans aged 65 and older. The updated VA-FI-10 included 6422 codes representing 31 health deficits and maintained strong associations with mortality. Patients classified as frail consistently had a hazard of death more than 2 times higher than nonfrail patients.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Ming-Jen Tsai, Cheng-Han Tsai, Ru-Chiou Pan, Chi-Feng Hsu, Sheng-Feng Sung
Summary: This study developed and validated case definition algorithms for out-of-hospital cardiac arrest (OHCA) based on ICD diagnostic codes and billing codes for NHI reimbursement, providing an important reference for future OHCA studies using the Taiwan NHI database.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Health Care Sciences & Services
Michael Korvink, Laura H. Gunn, German Molina, Tracy Hayes, Esther Selves, Michael Duan, John Martin
Summary: The objective of this study is to risk-adjust the Potential Inpatient Complication (PIC) measure set and propose a method to identify large deviations between observed and expected PIC counts. Patient-level risk factors and PIC occurrences were used to estimate PIC-specific probabilities of occurrence through multivariate logistic regression models. The proposed method provides a consistent quality metric that adjusts for the population's case mix and identifies potential areas for quality improvements.
Article
Medicine, General & Internal
Ashley H. Hirai, Pamela L. Owens, Lawrence D. Reid, Catherine J. Vladutiu, Elliott K. Main
Summary: Overall SMM rates in the US increased from 2012 to 2019, but were not significantly associated with the transition to ICD-10-CM/PCS. Efforts are needed to understand increases in specific indicators and state variations.
Article
Medicine, General & Internal
Yan-Hua Wang, Tian-Bing Wang, Zi-Xiao Zhang, Hui-Xin Liu, Ting-Min Xu, Chu Wang, Bao-Guo Jiang
Summary: The study developed a new mortality prediction model for trauma in China based on the ICD-10-CM lexicon, incorporating key predictors such as sex, age, new region-severity codes, comorbidities, traumatic shock, and coma. The model showed good discrimination, calibration, and internal validation, with high area under the curve and low Brier score. External verification is recommended for further validation.
CHINESE MEDICAL JOURNAL
(2021)
Article
Rheumatology
Anthony Dolomisiewicz, Hanifah Ali, Punyasha Roul, Yangyuna Yang, Grant W. Cannon, Brian Sauer, Joshua F. Baker, Ted R. Mikuls, Kaleb Michaud, Bryant R. England
Summary: The study aims to update and validate the Rheumatic Disease Comorbidity Index (RDCI) using International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes. The study demonstrates that the proposed ICD-10-CM codes can generate comparable RDCI scores to those derived from ICD-9-CM codes, and are highly predictive of functional status and death.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Hannah Yang, Emilia Pasalic, Peter Rock, James W. Davis, Sarah Nechuta, Ying Zhang
Summary: This study examined the impact of coding transition from ICD-9-CM to ICD-10-CM on drug overdose surveillance data. It was found that most states observed increased capture of drug overdose cases in ICD-10-CM coded hospital discharge data. More inclusive ICD-9-CM indicator definitions reduced the magnitude of significant level changes, but the effect of the transition was not eliminated.
Article
Biochemistry & Molecular Biology
Fabrice P. A. David, Maria Litovchenko, Bart Deplancke, Vincent Gardeux
NUCLEIC ACIDS RESEARCH
(2020)
Article
Health Care Sciences & Services
Andrew Dallas Boyd, Chioma Iheanyi Ndukwe, Anandu Dileep, Olivia Frances Everin, Yingwei Yao, Betty Welland, Jerry Field, Matt Baumann, Jose D. Flores, Adhir Shroff, Vicki Groo, Carolyn Dickens, Rami Doukky, Regeena Francis, Geraldine Peacock, Diana J. Wilkie
JMIR MHEALTH AND UHEALTH
(2020)
Editorial Material
Ethics
Carol G. Gu, Elizabeth Lerner Papautsky, Andrew D. Boyd, John Zulueta
AMERICAN JOURNAL OF BIOETHICS
(2021)
Article
Biochemical Research Methods
Dillon Aberasturi, Nima Pouladi, Samir Rachid Zaim, Colleen Kenost, Joanne Berghout, Walter W. Piegorsch, Yves A. Lussier
Summary: The study proposes a new method, Inter-N-of-1, to identify meaningful differences between very small cohorts by using the effect size of 'single-subject-study'-derived responsive biological mechanisms. In both simulations and a clinical proof-of-concept dataset, Inter-N-of-1 showed high precision and recall in cohorts of 3 versus 3 distinct subjects, outperforming conventional methods at smaller sample sizes but being outperformed at larger sample sizes.
Article
Biochemical Research Methods
Johannes Bues, Marjan Biocanin, Joern Pezoldt, Riccardo Dainese, Antonius Chrisnandy, Saba Rezakhani, Wouter Saelens, Vincent Gardeux, Revant Gupta, Rita Sarkis, Julie Russeil, Yvan Saeys, Esther Amstad, Manfred Claassen, Matthias P. Lutolf, Bart Deplancke
Summary: DisCo is a deterministic droplet microfluidics tool that enables high-resolution snapshots of cellular heterogeneity in small, individual tissues, revealing important cell types and subtypes.
Article
Biotechnology & Applied Microbiology
Ayokunle Olagoke, Rachel Caskey, Brenikki Floyd, Jennifer Hebert-Beirne, Andrew Boyd, Yamile Molina
Summary: Psychosocial factors such as perceived self-efficacy and perceived response efficacy are positively associated with HPV vaccination intention. Attitudes toward HPV vaccination mediate the relationship between self-efficacy/response efficacy and vaccination intention, suggesting that attitude-focused interventions may help overcome religious barriers to vaccination.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Hongjie Li, Jasper Janssens, Maxime De Waegeneer, Sai Saroja Kolluru, Kristofer Davie, Vincent Gardeux, Wouter Saelens, Fabrice David, Maria Brbic, Jure Leskovec, Colleen N. McLaughlin, Qijing Xie, Robert C. Jones, Katja Brueckner, Jiwon Shim, Sudhir Gopal Tattikota, Frank Schnorrer, Katja Rust, Todd G. Nystul, Zita Carvalho-Santos, Carlos Ribeiro, Soumitra Pal, Sharvani Mahadevaraju, Teresa M. Przytycka, Aaron M. Allen, Stephen F. Goodwin, Cameron W. Berry, Margaret T. Fuller, Helen White-Cooper, Erika L. Matunis, Stephen DiNardo, Anthony Galenza, Lucy Erin O'Brien, Julian A. T. Dow, Heinrich Jasper, Brian Oliver, Norbert Perrimon, Bart Deplancke, Stephen R. Quake, Liqun Luo, Stein Aerts
Summary: This study presents a single-cell atlas of the fruit fly Drosophila melanogaster, including 580,000 nuclei and annotations of over 250 distinct cell types. It serves as a valuable resource for the Drosophila community and provides a reference for studying genetic perturbations and disease models at single-cell resolution.
Article
Multidisciplinary Sciences
Gerard Llimos, Vincent Gardeux, Ute Koch, Judith F. Kribelbauer, Antonina Hafner, Daniel Alpern, Joern Pezoldt, Maria Litovchenko, Julie Russeil, Riccardo Dainese, Riccardo Moia, Abdurraouf Mokhtar Mahmoud, Davide Rossi, Gianluca Gaidano, Christoph Plass, Pavlo Lutsik, Clarissa Gerhauser, Sebastian M. Waszak, Alistair Boettiger, Freddy Radtke, Bart Deplancke
Summary: This study reveals that a non-coding variant induces transcription factor nucleation through chromatin compaction, leading to up-regulation of the AXIN2 gene and is associated with better prognosis in chronic lymphocytic leukemia.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Wanze Chen, Orane Guillaume-Gentil, Pernille Yde Rainer, Christoph G. Gaebelein, Wouter Saelens, Vincent Gardeux, Amanda Klaeger, Riccardo Dainese, Magda Zachara, Tomaso Zambelli, Julia A. Vorholt, Bart Deplancke
Summary: Live-seq is a novel single-cell transcriptomic profiling approach that preserves cell viability during RNA extraction, allowing for the correlation analysis between a cell's ground-state transcriptome and its downstream molecular or phenotypic behavior. It accurately stratifies diverse cell types and states without major cellular perturbations, and can be used to map a cell's trajectory and evaluate gene effects on cell phenotypes.
Article
Medicine, Research & Experimental
Ardith Z. Doorenbos, Judith M. Schlaeger, Victoria A. deMartelly, Larisa A. Burke, Andrew D. Boyd, Mitchell R. Knisely, Jonathan W. Leigh, Hongjin Li, Molly W. Mandernach, Robert E. Molokie, Crystal L. Patil, Alana D. Steffen, Nirmish Shah, Miriam O. Ezenwa
Summary: The GRACE study aims to evaluate the effectiveness of guided relaxation and acupuncture therapy in alleviating pain associated with sickle cell disease, as well as the implementation processes within healthcare systems. A total of 366 participants will be recruited and randomized into different groups, and assessments will be conducted at 6 weeks, 12 weeks, and 24 weeks. The results of this study will be critical in improving pain management for patients with sickle cell disease.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2023)
Article
Health Care Sciences & Services
Heather Coats, Nadia Shive, Bonnie Adrian, Andrew Boyd, Ardith Z. Doorenbos, Sarah J. Schmiege
Summary: This study aims to evaluate the feasibility, usability, and effects of delivering a person-centered narrative intervention (PCNI) via electronic means in an outpatient setting. The study used a mixed method design and lasted for approximately 3 to 4 weeks. The results showed that a total of 20 patient participants and 7 clinician participants were enrolled. The findings from this study have the potential to influence clinical practices and policies and provide innovative avenues for more person-centered care.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Computer Science, Information Systems
Andrew D. Boyd, Rosa Gonzalez-Guarda, Katharine Lawrence, Crystal L. Patil, Miriam O. Ezenwa, Emily C. O'Brien, Hyung Paek, Jordan M. Braciszewski, Oluwaseun Adeyemi, Allison M. Cuthel, Juanita E. Darby, Christina K. Zigler, P. Michael Ho, Keturah R. Faurot, Karen L. Staman, Jonathan W. Leigh, Dana L. Dailey, Andrea Cheville, Guilherme Del Fiol, Mitchell R. Knisely, Corita R. Grudzen, Keith Marsolo, Rachel L. Richesson, Judith M. Schlaeger
Summary: Embedded pragmatic clinical trials (ePCTs) play a vital role in addressing population health problems by utilizing electronic health record (EHR) systems to increase the speed and volume of relevant research. However, the growing number of ePCTs using EHR-derived data increases the risk of biases due to differences in data capture and access to care, perpetuating health inequalities. This article identifies 3 challenges - incomplete data on social determinants of health, lack of representation of vulnerable populations, and data loss due to variable technology use - that exacerbate bias when working with EHR data and provides recommendations and examples to actively mitigate bias.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Article
Computer Science, Information Systems
Vera C. Kaelin, Andrew D. Boyd, Martha M. Werler, Natalie Parde, Mary A. Khetani
Summary: This research aimed to develop and identify a predictive model for classifying caregiver strategies into participation-related constructs, using natural language processing. The best performing model was found to be a support vector machine (SVM) using term frequency-inverse document frequency (TF-IDF).
JOURNAL OF HEALTHCARE INFORMATICS RESEARCH
(2023)
Article
Health Care Sciences & Services
Haiquan Li, Edwin Baldwin, Xiang Zhang, Colleen Kenost, Wenting Luo, Elizabeth A. Calhoun, Lingling An, Charles L. Bennett, Yves A. Lussier
Summary: This study analyzed the risk of fatality for cancer patients with COVID-19, controlling for covariates such as age, sex, metastasis status, and cancer type. Results showed an overall HR of fatality of 7.76, with varying levels of risk among different cancer types. The study emphasizes the importance of prompt vaccination for uninfected cancer patients, especially for those most affected by COVID-19.
BMJ HEALTH & CARE INFORMATICS
(2021)
Article
Multidisciplinary Sciences
Maria Litovchenko, Antonio C. A. Meireles-Filho, Michael Frochaux, Roel P. J. Bevers, Alessio Prunotto, Ane Martin Anduaga, Brian Hollis, Vincent Gardeux, Virginie S. Braman, Julie M. C. Russeil, Sebastian Kadener, Matteo dal Peraro, Bart Deplancke
Summary: Natural genetic variation plays a role in affecting circadian rhythms in fruit flies, leading to widespread tissue-specific circadian expression variation. Through analysis of a line with extreme deviation in circadian expression, a novel cry mutation was identified, providing further evidence for the importance of light-driven regulatory mechanisms.