期刊
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
卷 18, 期 4, 页码 403-415出版社
OXFORD UNIV PRESS
DOI: 10.1136/amiajnl-2011-000170
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资金
- NIH [5R01LM009239-04, 3R01LM009239-03S2, U54 CA113001, N01-CO-12400]
- National Library of Medicine [SAIC/NCI 29XS154]
- National Cancer Institute [9R01CA156386-05A1]
- NCI caBIG [79077CBS10, 94995NBS23, 85983CBS43]
- NHLBI [R24 HL085343]
- NSF [CNS-0403342, CNS-0615155]
- NCI
- PHS [UL1RR025008]
- US Department of Energy [DE-AC02-06CH11357]
Objective and design The design and implementation of Image Miner, a software platform for performing comparative analysis of expression patterns in imaged microscopy specimens such as tissue microarrays (TMAs), is described. Image Miner is a federated system of services that provides a reliable set of analytical and data management capabilities for investigative research applications in pathology. It provides a library of image processing methods, including automated registration, segmentation, feature extraction, and classification, all of which have been tailored, in these studies, to support TMA analysis. The system is designed to leverage high-performance computing machines so that investigators can rapidly analyze large ensembles of imaged TMA specimens. To support deployment in collaborative, multi-institutional projects, Image Miner features grid-enabled, service-based components so that multiple instances of Image Miner can be accessed remotely and federated. Results The experimental evaluation shows that: (1) Image Miner is able to support reliable detection and feature extraction of tumor regions within imaged tissues; (2) images and analysis results managed in Image Miner can be searched for and retrieved on the basis of image-based features, classification information, and any correlated clinical data, including any metadata that have been generated to describe the specified tissue and TMA; and (3) the system is able to reduce computation time of analyses by exploiting computing clusters, which facilitates analysis of larger sets of tissue samples.
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