Article
Endocrinology & Metabolism
Wencong Du, Haoyu Guan, Xinglin Wan, Zheng Zhu, Hao Yu, Pengfei Luo, Lulu Chen, Jian Su, Yan Lu, Dong Hang, Ran Tao, Ming Wu, Jinyi Zhou, Xikang Fan
Summary: This study found that the levels of circulating liver function markers were nonlinearly associated with the risk of COPD. Lower levels of ALT, TBIL, ALB, and TP and higher levels of GGT and ALP were associated with elevated COPD risk. AST levels showed a U-shaped relationship with COPD risk.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Benjamin Tari, Morgane Kunzi, C. Patrick Pflanz, Vanessa Raymont, Sarah Bauermeister
Summary: Dementia is a syndrome characterized by the loss of memory and cognitive function. Educational attainment has a mediating effect on cognitive function.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Margo W. Menkes, Carolyn M. Andrews, Helen J. Burgess, Isabel Carley, David F. Marshall, Scott A. Langenecker, Melvin G. McInnis, Patricia J. Deldin, Kelly A. Ryan
Summary: Individuals with bipolar I disorder (BD-I) have poorer sleep quality and neuropsychological functioning compared to healthy controls, and poor sleep quality is associated with learning, memory, and executive functioning impairments, with similar effects across groups.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Peripheral Vascular Disease
Matthew J. Lennon, Anbupalam Thalamuthu, Ben Chun Pan Lam, John D. Crawford, Perminder S. Sachdev
Summary: This UK Biobank study found that genetic propensity for high and low blood pressure impacts midlife cognition in subtle ways, affecting cognitive domains differently. While a genetic propensity to low blood pressure may preserve nontimed tests in midlife, it may come at a trade-off with worsened attention scores and reaction time.
Article
Public, Environmental & Occupational Health
Yan Zhang, Jason Fletcher, Qiongshi Lu, Jie Song
Summary: This paper expands the size and scope of previous work on the link between fertility history and late-life cognition by analyzing cognitive function across five domains and investigating gendered patterns. The results show important gendered associations between parity and cognition, with fathers having children likely to have better cognitive function in all domains while mothers show worse cognitive function in some domains compared to childless women. The findings highlight parity as a potential protective or risk factor to parents' cognitive health and call for replicated work covering more cognitive domains to provide implications for measure selection.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Psychology, Clinical
M. J. Bosma, S. R. Cox, T. Ziermans, C. R. Buchanan, X. Shen, E. M. Tucker-Drob, M. J. Adams, H. C. Whalley, S. M. Lawrie
Summary: This study reveals that lower global white matter microstructure is associated with having PLEs in combination with distress, suggesting a direction of future research. Additionally, it replicates the finding that processing speed mediates the relationship between white matter microstructure and g-factor.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Marilyn C. Cornelis, Puja Agarwal, Thomas M. Holland, Rob M. van Dam
Summary: A study found that high adherence to the Mediterranean-Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay (MIND) was associated with better cognition and lower risk of dementia. However, the study revealed that the MIND diet was not associated with better cognitive test scores and only with lower dementia risk in women.
Article
Nutrition & Dietetics
Christina-Alexandra Schulz, Leonie Weinhold, Matthias Schmid, Markus M. Noethen, Ute Noethlings
Summary: This study aimed to investigate the influence of diet on fluid intelligence and whether this association is modified by individual genetic disposition. The results showed no significant association between diet score and fluid intelligence, even after stratification by polygenic score.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Tom Norris, Antoine Salzmann, Albert Henry, Victoria Garfield, Snehal M. Pinto Pereira
Summary: This study used bidirectional Mendelian randomization to investigate the relationship between adiposity and cognitive function. The results suggest that the link between adiposity and cognitive function is likely not causal, but there is evidence for a causal relationship between worse visual memory and lower adiposity.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Clinical Neurology
Megan E. Wadon, Eilidh Fenner, Kimberley M. Kendall, Grace A. Bailey, Cynthia Sandor, Elliott Rees, Kathryn J. Peall
Summary: This study analyzed the clinical phenotypic and genetic information of dystonia, revealing the prevalence of psychiatric symptoms, excessive pain, and sleep disturbance among dystonia patients, as well as the impact on cognitive impairment. The study also identified genetic variants linked to dystonia and determined genetically informed phenotypic axes, consistent with the heterogeneity observed in clinical practice.
JOURNAL OF NEUROLOGY
(2022)
Article
Respiratory System
Laura J. Horsfall, Ian P. Hall, Irwin Nazareth
Summary: The study found associations between serum urate and lung cancer incidence and lung function, but could not confirm a causal relationship, nor prove serum urate as a modifiable risk factor for respiratory health or lung cancer.
RESPIRATORY RESEARCH
(2021)
Review
Behavioral Sciences
Kristin Stedal, Catherine Broomfield, Phillipa Hay, Stephen Touyz, Ronny Scherer
Summary: Several studies have found that individuals with anorexia nervosa show significant underperformance in overall neuropsychological functioning, especially in executive function, memory, and visuospatial abilities. Factors like age and BMI also have significant moderator effects on these impairments. This comprehensive review highlights the potential neuropsychological dysfunction in adult patients diagnosed with AN.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Stephen L. Aita, Victor A. Del Bene, Dario A. Marotta, Jasmin H. Pizer, Nanako A. Hawley, Lindsay Niccolai, Harrison C. Walker, Adam Gerstenecker, Roy C. Martin, Olivio J. Clay, Michael Crowe, Kristen L. Triebel, Benjamin D. Hill
Summary: This meta-analysis study found that patients with primary dystonia showed poorer cognitive performance in neuropsychological tests across multiple domains. The results suggest that cognitive slowing may occur in dystonia patients beyond the effects of motor symptoms.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Neal S. Parikh, Hooman Kamel, Cenai Zhang, Ajay Gupta, David E. Cohen, Mony J. de Leon, Rebecca F. Gottesman, Costantino Iadecola
Summary: This study found that liver fibrosis is associated with worse cognitive performance, lower hippocampal and total brain volumes, but not memory impairment.
ALZHEIMERS & DEMENTIA
(2023)
Article
Genetics & Heredity
Nasa Sinnott-Armstrong, Yosuke Tanigawa, David Amar, Nina Mars, Christian Benner, Matthew Aguirre, Guhan Ram Venkataraman, Michael Wainberg, Hanna M. Ollila, Tuomo Kiiskinen, Aki S. Havulinna, James P. Pirruccello, Junyang Qian, Anna Shcherbina, Fatima Rodriguez, Themistocles L. Assimes, Vineeta Agarwala, Robert Tibshirani, Trevor Hastie, Samuli Ripatti, Jonathan K. Pritchard, Mark J. Daly, Manuel A. Rivas
Summary: The study evaluated the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank, identifying 1,857 loci associated with at least one trait. Through Mendelian randomization analysis, 51 causal relationships were discovered, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, by developing polygenic risk scores and building 'multi-PRS' models, genetic risk stratification for common diseases was improved.
Review
Geriatrics & Gerontology
Iris Linden, Maud Hevink, Claire Wolfs, Marieke Perry, Carmen Dirksen, Rudolf Ponds
Summary: This study explores the preferences of people with memory complaints and their significant others regarding starting a diagnostic trajectory for dementia. The findings highlight the variety of considerations in the decision-making process and emphasize the need to explore individual preferences to facilitate timely dementia diagnosis.
AGING & MENTAL HEALTH
(2023)
Article
Medicine, General & Internal
Anouk W. Vaes, Yvonne M. J. Goertz, Maarten van Herck, Rosanne J. H. C. G. Beijers, Martijn van Beers, Chris Burtin, Daisy J. A. Janssen, Annemie M. W. J. Schols, Martijn A. Spruit
Summary: The study found that both physical and mental fatigue are frequently experienced simultaneously in people with non-communicable chronic diseases, but can also occur separately. There is a lack of discussion and treatment for fatigue among healthcare professionals, highlighting the need for increased awareness.
ANNALS OF MEDICINE
(2022)
Review
Public, Environmental & Occupational Health
Anouk J. L. Muijsenberg, Sarah Houben-Wilke, Yuqin Zeng, Martijn A. Spruit, Daisy J. A. Janssen
Summary: In order to develop learner-centered education, it is important to understand the learning styles and factors that affect the ability to learn in patients and their significant others. This scoping review aimed to identify the current evidence on the assessment of learning styles in health education and the factors affecting learning in adult patients and their significant others. The results showed that learning style can be assessed through multiple methods and health literacy, anxiety, and illness condition were the most reported factors affecting learning.
PATIENT EDUCATION AND COUNSELING
(2023)
Review
Medicine, General & Internal
Ianthe Piscaer, Rob Janssen, Frits M. E. Franssen, Leon J. Schurgers, Emiel F. M. Wouters
Summary: Patients with chronic obstructive pulmonary disease (COPD) often have multiple co-occurring conditions and systemic manifestations. Vitamin A, vitamin D, and vitamin K are all potentially involved in COPD pathogenesis. In this review, the potential role of vitamin K in the systemic manifestations of COPD is discussed, including its effects on prevalent co-occurring chronic conditions such as cardiovascular disorders, chronic kidney disease, osteoporosis, and sarcopenia. Recommendations for future clinical studies are also provided.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Environmental Sciences
Yuqin Zeng, Martijn A. Spruit, Qichen Deng, Frits M. E. Franssen, Ping Chen
Summary: This study aimed to measure the differences between male and female patients with COPD in terms of risk factors, symptoms, quality of life, and drug prescriptions. The results showed that female patients with COPD had lower educational levels and were less likely to be married. Compared to male patients, female patients had more complaints of cough, breathlessness, decreased activity, decreased confidence, sleep problems, and lack of energy. In addition, more women were prescribed triple therapy.
Article
Respiratory System
Kiki Waeijen-Smit, Sarah Houben-Wilke, Rein Posthuma, Fenne de Jong, Daisy J. A. Janssen, Nicole P. H. van Loon, Bita Hajian, Sami O. Simons, Martijn A. Spruit, Frits M. E. Franssen
Summary: Inpatient pulmonary rehabilitation (PR) during the COVID-19 pandemic did not show a significant reduction in the occurrence of acute exacerbations of COPD (AECOPDs) compared to previous years. This suggests that patient avoidance of healthcare may be a key factor in the observed decrease in AECOPD-related hospitalizations during the pandemic.
CHRONIC OBSTRUCTIVE PULMONARY DISEASES-JOURNAL OF THE COPD FOUNDATION
(2023)
Letter
Respiratory System
Diana H. Ferreira, Magnus Ekstrom, Cornelia Verberkt, Daisy J. A. Janssen, David C. Currow
Article
Geriatrics & Gerontology
Chandni Khemai, Judith M. Meijers, Sascha R. Bolt, Sabine Pieters, Daisy J. A. Janssen, Jos M. G. A. Schols
Summary: This study aimed to explore the experiences of persons with dementia regarding collaboration with healthcare professionals (HCPs) and their perceptions of a possible future move to the nursing home (NH) in palliative dementia care. The findings showed that most persons with dementia find it difficult to perceive collaboration among HCPs, but they could describe their perceived continuity of care. Their core needs in collaboration with HCPs included receiving information, support from informal caregivers, personal attention, and tailored care. Regarding a possible future move to the NH, persons with dementia cope with their current and future decline and express preferences for social life and activities in their future NH.
AGING & MENTAL HEALTH
(2023)
Article
Respiratory System
Daisy J. A. Janssen, Sabrina Bajwah, Michele Hilton Boon, Courtney Coleman, David C. Currow, Albert Devillers, Chantal Vandendungen, Magnus Ekstrom, Ron Flewett, Sarah Greenley, Mai -Britt Guldin, Cristina Jacome, Miriam J. Johnson, Geana Paula Kurita, Matthew Maddocks, Alda Marques, Hilary Pinnock, Steffen T. Simon, Thomy Tonia, Kristoffer Marsaa
Summary: This study provides recommendations for the initiation and integration of palliative care in the respiratory care of patients with COPD or ILD, including considering palliative care during holistic needs assessment, providing palliative care interventions based on identified needs, offering advance care planning, and integrating palliative care into routine care for COPD and ILD.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Geriatrics & Gerontology
Maud Hevink, Claire Wolfs, Rudolf Ponds, Shelley Doucet, Carrie McAiney, Isabelle Vedel, Maria Mackowiak, Joanna Rymaszewska, Greta Rait, Louise Robinson, Marie Poole, Meredith Gresham, Yun-Hee Jeon, Lyn Phillipson, Lee-Fay Low, Henry Brodaty, Marjolein de Vugt, Frans Verhey
Summary: This study aims to describe the experiences of people with dementia and informal caregivers in receiving support after diagnosis, and compare these experiences. The study finds that there are differences in support experiences between satisfied and dissatisfied individuals.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Ada E. M. Bloem, Sarah Houben-Wilke, Remy L. M. Mostard, Naomi Stoot, Daisy J. A. Janssen, Frits M. E. Franssen, Jan W. H. Custers, Martijn A. Spruit
Summary: In addition to dyspnoea and cough, patients with idiopathic pulmonary fibrosis (IPF) or sarcoidosis may experience distressing non-respiratory symptoms such as fatigue or muscle weakness. This study aimed to analyze the respiratory and non-respiratory burden of symptoms in patients with IPF or sarcoidosis and compare it with individuals without respiratory disease.
Review
Cardiac & Cardiovascular Systems
Alexander Mueller, Tobias Mraz, Emiel FM. Wouters, Sander MJ. van Kuijk, Andre FS. Amaral, Robab Breyer-Kohansal, Marie-Kathrin Breyer, Sylvia Hartl, Daisy JA. Janssen
Summary: This review aims to estimate the prevalence of dyspnea in general adult populations, identify associated factors, and explore the methods used for dyspnea assessment. Based on 20 original articles from high-income countries, the pooled prevalence of dyspnea was found to be 10%, with increasing age, female sex, higher BMI, and respiratory or cardiac disease being the most frequently reported risk factors. The MRC or modified MRC scale was commonly used for dyspnea assessment in general populations.
RESPIRATORY MEDICINE
(2023)
Article
Nursing
Fran B. A. L. Peerboom, Jolanda H. H. M. Friesen-Storms, Benedicte J. E. G. Coenegracht, Sabine Pieters, Jenny T. van der Steen, Daisy J. A. Janssen, Judith M. M. Meijers
Summary: This review explores the fundamentals of end-of-life communication performed by nursing staff, including building a relationship, assessing readiness, timing and methods to start the conversation, communication based on information needs, attention to family relationships, a professional attitude, improving communication skills, listening and non-verbal observation skills, and verbal communication skills.
Article
Multidisciplinary Sciences
Yvonne M. J. H. Goertz, Martijn Spruit, Maarten Van Herck, Nicole Dukers-Muijrers, Carla J. H. van der Kallen, Chris Burtin, Daisy J. A. Janssen, Lifelines Corona Res Initiative
Summary: This study evaluates the presence of symptoms before, during, and after a positive SARS-CoV-2 PCR test and compares the symptom burden with those who tested negative. Participants from the Dutch Lifelines COVID-19 Cohort Study were surveyed about demographics, COVID-19 diagnosis, severity, QoL, and symptoms. The results show that most symptoms were more common after a positive test compared to before (p < 0.05), except fever. Symptoms were also common in those who tested negative. Quality of life decreased around the test for both positive and negative individuals, with a greater deterioration for positives.
SCIENTIFIC REPORTS
(2023)
Article
Psychology, Clinical
E. P. J. Janssen, P. J. J. Spauwen, S. J. M. Rijnen, R. W. H. M. Ponds
Summary: EMDR is a feasible, well tolerated, and potentially effective treatment for PTSD in ABI patients. It can significantly reduce PTSD symptoms and affective distress, with a high rate of clinically relevant change in symptoms. EMDR should be considered as a treatment option for ABI patients with PTSD.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2023)
