Article
Veterinary Sciences
Matthias Flor, Bernd-Alois Tenhagen, Annemarie Kasbohrer
Summary: The German Antibiotics Minimization Concept defines a benchmarking process based on treatment frequencies for different animal populations. The study shows that using metrics based on used daily dose (UDD) is more accurate for monitoring antimicrobial use at the treatment and farm level compared to metrics based on defined daily doses for animals (DDDvet).
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Patricia Helena Castro Nunes, Jessica Pronestino de Lima Moreira, Alessandra de Figueiredo Thompson, Thalita Lyrio da Silveira Machado, Jose Cerbino-Neto, Fernando Augusto Bozza
Summary: This study investigated the prevalence of antibiotic consumption and the deviation of prescribed daily dose (PDD) from defined daily dose (DDD) in Brazilian ICUs. The study found a high prevalence of antibiotic use, predominantly in empirical regimens and antibiotics belonging to the WHO Watch classification. The most prescribed antibiotics exhibited high variability of doses and large deviations of PDD from DDD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Elena Montecatine-Alonso, Marta Mejias-Trueba, Walter Alfredo Goycochea-Valdivia, Estibaliz Chavarri-Gil, Cecilia M. Fernandez-Llamazares, Elisenda Dolz, Jose Maria Gutierrez-Urbon, Carmen Gallego-Fernandez, Jesus Llorente-Gutierrez, Maria Victoria Gil-Navarro
Summary: The study aimed to establish appropriate DDD values for the pediatric population to assess the effectiveness of antimicrobial stewardship programs (ASPs). Antimicrobial prescriptions were collected from pediatric wards of seven Spanish tertiary hospitals for 2 years. Pediatric DDDs for 30 different antimicrobials were obtained, providing a globally applicable indicator for analyzing the use and efficacy of ASPs in different hospitals.
Article
Infectious Diseases
Cristina Villanueva-Bueno, Elena Montecatine-Alonso, Francisco Jimenez-Parrilla, Maria Gonzalez-Lopez, Silvia Manrique-Rodriguez, Francisco Moreno-Ramos, Carme Canete-Ramirez, Elisenda Dolz, Ana Garcia-Robles, Jose Manuel Caro-Teller, Maria Teresa Moral-Pumarega, Elena Bergon-Sendin, Maria Teresa Gomez-Trevecedo Calvo, Carmen Gallego-Fernandez, Concepcion Alvarez del Vayo-Benito, Marta Mejias-Trueba, Maria Victoria Gil-Navarro
Summary: The aim of this study is to validate the neonatal Defined Daily Doses (DDD) as a new standardized form of antibiotic consumption in the neonatal population. Through an observational study of antibiotic prescriptions in neonatal and intensive care units of nine Spanish hospitals, the majority of intravenously administered antibiotics used in clinical practice in neonates have been validated using DDD. This will provide a global indicator for estimating antibiotic consumption in the neonatal population and confirm its usefulness and applicability.
Article
Infectious Diseases
Matthias Karer, Teresa Haider, Manuel Kussmann, Markus Obermueller, Claas Tiehen, Heinz Burgmann, Heimo Lagler, Ludwig Traby
Summary: This study investigated the efficacy of a single intravenous dose of azithromycin for the treatment of pulmonary legionellosis. The results showed that single-dose azithromycin treatment was equally effective as conventional treatment regimens and had the advantage of shorter hospital stay and antibiotic treatment duration.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Public, Environmental & Occupational Health
Naila Jabeen, Waseem Ullah, Javeria Khalid, Zia Samad
Summary: This study evaluated the five-year inpatient antibiotic use in a tertiary care hospital in Islamabad and found that the antibiotic consumption rate was higher than the WHO standard. The study also highlighted the fluctuation in antibiotic consumption trends and the lack of adherence to the hospital antibiotic policy.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Multidisciplinary Sciences
Eko Setiawan, Mohd-Hafiz Abdul-Aziz, Menino Osbert Cotta, Susaniwati Susaniwati, Heru Cahjono, Ika Yunita Sari, Tjipto Wibowo, Ferdy Royland Marpaung, Jason A. Roberts
Summary: This study developed a population pharmacokinetic model of levofloxacin for adult hospitalized patients and suggested a daily dose of 1000 mg to maximize the likelihood of efficacy.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Cristina Villanueva-Bueno, Elena Montecatine-Alonso, Francisco Jimenez-Parrilla, Cecilia M. Fernandez-Llamazares, Silvia Manrique-Rodriguez, Elena Zamora-Flores, Elisenda Dolz, Aurora Fernandez-Polo, Felix Catillo-Salinas, Juanjo Comunas, Carmen Gallego-Fernandez, Maria Gonzalez-Lopez, Maria-Teresa Gomez-Trevecedo Calvo, Rocio Gazquez-Perez, Concepcion Alvarez del Vayo-Benito, Maria-Victoria Gil-Navarro
Summary: This study proposed an alternative approach for antimicrobial defined daily dose design in neonates, including variables such as weight and gestational age. The standardized DDD values for representative antimicrobials were calculated based on recommended doses for common infectious indications, providing a useful tool for monitoring antimicrobial consumption in neonatology.
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2022)
Article
Microbiology
Yeliz Tanriverdi Cayci, Kubra HaciemInoglu Ulker, Gulsah Karacan Temur, Doga Beliz Guney, Mustafa Ertokatli, Asuman Birinci
Summary: This study investigated the prevalence of the O25b-ST131 clone and the presence of carbapenem and fosfomycin resistance genes in fluoroquinolone-resistant E.coli isolates. The results showed that the prevalence of E.coli O25b-ST131 isolates was 51.2%, with a carbapenem resistance rate of 3.41% and a fosfomycin resistance rate of 3.41% in fluoroquinolone-resistant E.coli isolates. This study is important for understanding resistance patterns and guiding treatment strategies.
MIKROBIYOLOJI BULTENI
(2023)
Article
Multidisciplinary Sciences
Kanitha Tiankanon, Stephen J. Kerr, Siriwan Thongthip, Suwasin Udomkarnjananun, Pimpayao Sodsai, Athaya Vorasittha, Kamol Panumatrassamee, Kullaya Takkavatakarn, Kriang Tungsanga, Somchai Eiam-Ong, Kearkiat Praditpornsilpa, Yingyos Avihingsanon, Natavudh Townamchai
Summary: Converting from BID TAC to OD TAC provided similar AUC(0-24) regardless of CYP3A5 genotypic polymorphism, but the C-trough was lower in the CYP3A5 expressor group.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Lillian Min, Jin-Kyung Ha, Carole E. Aubert, Timothy P. Hofer, Jeremy B. Sussman, Kenneth M. Langa, Mary Tinetti, Hyungjin Myra Kim, Matthew L. Maciejewski, Leah Gillon, Angela Larkin, Chiao-Li Chan, Eve A. Kerr, Dawn Bravata, William C. Cushman
Summary: This study developed and validated a method to precisely quantify dose intensity of hypertension treatment using only health system administrative pharmacy fill data. Results suggest that health system pharmacy data can accurately quantify hypertension regimen dose intensity, which can be utilized in future research or quality improvement efforts related to hypertension treatment in older adults.
Article
Oncology
Jason N. Barreto, Kristen T. Peterson, Erin F. Barreto, Kristin C. Mara, Ross A. Dierkhising, Nelson Leung, Thomas E. Witzig, Carrie A. Thompson
Summary: This retrospective study followed lymphoma patients receiving high-dose methotrexate (HDMTX) to investigate the effects of high-dose leucovorin (HDLV) rescue. Results showed that HDLV rescue was associated with higher incidence of elevated MTX levels and AKI. Further investigation is warranted for optimal supportive care strategy following HDMTX administration.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Chemistry, Medicinal
Joao Pedro Pais, Margarida Policarpo, David Pires, Ana Paula Francisco, Ana Margarida Madureira, Bernard Testa, Elsa Anes, Luis Constantino
Summary: Tuberculosis is a leading cause of death and the rise in multidrug-resistant cases poses a threat to public health. This study developed esters as prodrugs of fluoroquinolones and found that they exhibit bioactivity against other drug-resistant bacteria, suggesting potential for new compounds to combat resistance.
Article
Pharmacology & Pharmacy
Catarina Abrantes, Fernanda S. Tonin, Joana Reis-Pardal, Margarida Castel-Branco, Claudia Furtado, Isabel V. Figueiredo, Fernando Fernandez-Llimos
Summary: The study found that changes in DDD in 2009 led to decreases in the consumption of certain statins using the DDDYEAR approach, while gradual changes in overall statin consumption were indicated using the DDDLAST and PDDYEAR approaches in Portugal. Before 2009, the utilization of certain statins was greatly overestimated using the DDDYEAR/1000 inhabitants/day method.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)