Article
Oncology
Olga Laura Sena Almeida, Eduardo Ferriolli, Roberta Cristina Cintra Taveira, Meire Gallo Rosenburg, Daniela Dalpubel Campanari, Natalia Maira da Cruz Alves, Karina Pfrimer, Liane Rapatoni, Fernanda Maris Peria, Nereida K. C. Lima
Summary: This study compared the effectiveness of mirtazapine and megestrol in managing cancer-related anorexia-cachexia syndrome. It was a randomized, double-blind, controlled clinical trial involving patients with advanced cancer and anorexia-cachexia syndrome. Participants received either mirtazapine 30 mg/day or megestrol 320 mg/day for eight weeks. The results showed that megestrol was more effective in promoting weight gain and improving appetite compared to mirtazapine. However, there may be a difference in the therapeutic response between sexes.
Article
Biotechnology & Applied Microbiology
Vinay G. Joshi, Kantaraja Chindera, Manish Bais, Basavaraj Sajjanar, Ashok K. Tiwari, Satish Kumar
Summary: PNA is a chimeric molecule with advantages over natural antisense nucleic acid molecules, but faces challenges in cellular delivery due to its charge-neutral nature. The proposed novel RATH-2 peptide-based non-covalent PNA delivery mechanism showed promising results in cellular delivery and therapeutic application in antiviral intervention.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Maurizio Muscaritoli, Giovanni Imbimbo, Harriet Jager-Wittenaar, Tommy Cederholm, Elisabet Rothenberg, Filippo Giorgio di Girolamo, Maria Ida Amabile, Martine Sealy, Stephana Schneider, Rocco Barazzoni, Gianni Biolo, Alessio Molfino
Summary: In 2010, the European Society for Clinical Nutrition and Metabolism (ESPEN) developed the definition of cachexia, which is considered a synonym of disease-related malnutrition with inflammation. The ESPEN guidelines on clinical nutrition provided the basis for this definition. Through meetings conducted from 2020 to 2022, the ESPEN Special Interest Group on Cachexia-anorexia in chronic wasting diseases discussed the similarities and differences between cachexia and disease-related malnutrition, the role of inflammation, and potential assessment methods. The report also identified novel perspectives in the field of disease-related malnutrition and cachexia.
CLINICAL NUTRITION
(2023)
Article
Oncology
Galina Proshkina, Elena Shramova, Anastasiya Ryabova, Liat Katrivas, Clelia Giannini, Daniele Malpicci, Yael Levi-Kalisman, Sergey Deyev, Alexander Kotlyar
Summary: This study demonstrates a methodology to enhance the solubility of peptide nucleic acid (PNA) and delivers it specifically to cancer cells using designed ankyrin repeat protein (DARPin)-functionalized small multilamellar vesicles (SMVs). The positively charged PNA molecules bind electrostatically to the negatively charged phospholipid membranes, encapsulating the PNA in the vesicles. The DARPin-functionalized SMVs can enter HER2-overexpressing cells and cause cell death by interfering with normal cell functioning.
Article
Oncology
Ayelet Shai, Evleen Galouk, Reem Miari, Hala Tareef, Marei Sammar, Mouhammad Zeidan, Anwar Rayan, Mizied Falah
Summary: KRAS mutations play a crucial role in lethal pancreatic adenocarcinomas. In this study, the use of PNAs to target the mutated KRAS gene resulted in inhibition of cancer cell growth and induction of apoptosis. This therapeutic approach shows promise as a novel drug for targeting KRAS-driven cancers.
Article
Biophysics
Xiaotong Meng, Danny O'Hare, Sylvain Ladame
Summary: With the increasing demand for a new generation of nucleic acid tests, easily miniaturized electrochemical sensors show the greatest promise as they can be cost-effective, highly sensitive, and specific. These sensors rely on the immobilization of sequence-specific hybridization probes onto conductive materials or electrodes. This review covers various strategies for immobilizing nucleic acid probes onto different solid electrode materials, including both physical and chemical immobilization techniques.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Acoustics
Alessandra Del Bene, Antonia D'Aniello, Stefano Tomassi, Francesco Merlino, Vincenzo Mazzarella, Rosita Russo, Angela Chambery, Sandro Cosconati, Salvatore Di Maro, Anna Messere
Summary: We developed an innovative and easily accessible solid-phase synthetic protocol for PNA oligomers by investigating the ultrasonication effects. This approach improved the crude product purities and the isolated yields of different types of PNA.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Oncology
Maurizio Muscaritoli, Alessandra Modena, Matteo Valerio, Paolo Marchetti, Roberto Magarotto, Silvia Quadrini, Filomena Narducci, Giuseppe Tonini, Teresa Grassani, Luigi Cavanna, Camilla Di Nunzio, Chiara Citterio, Marcella Occelli, Antonia Strippoli, Bruno Chiurazzi, Antonio Frassoldati, Giuseppe Altavilla, Antonio Lucenti, Fabrizio Nicolis, Stefania Gori
Summary: Malnutrition and cachexia in cancer patients have a negative impact on treatment, outcomes, quality of life, and survival. However, the risk of malnutrition and cachexia is still overlooked in cancer patients. A study revealed that 51% of patients already had nutritional deficiencies at their first oncology visit. These findings emphasize the importance of proactive, early management of malnutrition in cancer patients.
Article
Chemistry, Multidisciplinary
Andrea Mosseri, Maria Sancho-Albero, Marilisa Leone, Donatella Nava, Francesco Secundo, Daniela Maggioni, Luisa De Cola, Alessandra Romanelli
Summary: This study reports the formation of homogeneous chiral fibers through self-assembly of peptide nucleic acids. Nucleobases play a key role in determining the morphology and chirality of the fibers. By spectroscopic characterization and microscopy studies, a structural model consistent with the experimental evidence was obtained.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Oncology
Yolanda Escobar, Avinash Ramchandani, Mercedes Salgado, Alfredo Castillo-Trujillo, Eva Martinez de Castro, Isabela Diaz de Corcuera, Ruth Vera, Alejandra Lacalle, Irene Torres, Pedro Perez Segura, Cinta Hierro, Diego Soto de Prado, Almudena Cotes, Gema Marin Zafra, Raquel Marse Fabregat, Juan Virizuela, Jose Carlos Villa, Pablo Borrega, Paula Jimenez-Fonseca
Summary: The Quasar_SEOM study conducted by the Spanish Oncology Society (SEOM) investigates the current impact of Anorexia-Cachexia Syndrome (ACS) through questionnaires and the Delphi method. The study reveals deficiencies in knowledge and protocol implementation among oncologists, as well as concerns from patients regarding lack of attention to malnutrition-related issues. There is a need to improve education and follow-up for cancer patients with anorexia-cachexia.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Siqi Gao, Ranfeng Wu, Qiang Zhang
Summary: This article introduces a controllable DNA cross circuit based on a new control method and realizes a programmable DNA tile self-assembly strategy by integrating a DNA cross circuit and DNA tile self-assembly. The design of this system provides a new idea for generating dynamic and controllable trigger elements and broadens the programmable range of stimuli-responsive self-assembly.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Xiushuang Yuan, Shi-Zhong Luo, Long Chen
Summary: The designed branched amphiphilic peptides (BAPs) showed potential as vectors for DNA/RNA delivery, with increased amphiphilicity improving nucleic acid transfection efficiency.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Xiushuang Yuan, Shi-Zhong Luo, Long Chen
Summary: This study designed a series of branched amphiphilic peptides (BAPs) as nucleic acids delivery vectors. The results showed that increasing amphiphilicity improved the transfection efficiency of the vectors. These BAPs effectively compacted and delivered nucleic acids into cells with low cytotoxicity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Physical
Yu Wang, Tianhao Yan, Kainan Mei, Depeng Rao, Wenjie Wu, Ye Chen, Yongpei Peng, Jianye Wang, Shangquan Wu, Qingchuan Zhang
Summary: This study developed an ultrasensitive nanomechanical method based on peptide nucleic acid for the detection of SARS-CoV-2 RNA. The method has a low detection limit and can accurately diagnose COVID-19 patients, making it an important tool for early diagnosis and broad detection.
Article
Chemistry, Multidisciplinary
Carlo Diaferia, Concetta Avitabile, Marilisa Leone, Enrico Gallo, Michele Saviano, Antonella Accardo, Alessandra Romanelli
Summary: Peptides and nucleic acids can self-assemble to form supramolecular structures with different applications, and hydrogen bonds or aromatic interactions typically stabilize these structures; Watson-Crick pairing drives self-assembly in nucleic acids, while backbone hydrogen bonds and interactions between aromatic side chains trigger the formation of structures in peptides. Molecules containing aromatic peptides and nucleic acids can potentially utilize different forces for self-assembly.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Oncology
Andrea Feldstain, Neil MacDonald, Ravi Bhargava, Martin Chasen
SUPPORTIVE CARE IN CANCER
(2017)
Review
Medicine, General & Internal
Martin Chasen, Ravi Bhargava, Neil MacDonald
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2014)
Article
Oncology
Josee Lemoignan, Martin Chasen, Ravi Bhargava
SUPPORTIVE CARE IN CANCER
(2010)
Review
Oncology
Martin R. Chasen, Ravi Bhargava
SUPPORTIVE CARE IN CANCER
(2009)
Article
Oncology
Martin Robert Chasen, Ravi Bhargava
SUPPORTIVE CARE IN CANCER
(2010)
Article
Oncology
Martin Chasen, Ravi Bhargava
SUPPORTIVE CARE IN CANCER
(2012)
Article
Oncology
Martin Chasen, Ravi Bhargava, Catherine Dalzell, Jose Luis Pereira
SUPPORTIVE CARE IN CANCER
(2015)
Review
Health Care Sciences & Services
Martin Chasen, Ravi Bhargava, Shalom Hirschman
CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE
(2014)
Article
Oncology
Anish Jammu, Martin Chasen, Rardi van Heest, Sean Hollingshead, Deepanjali Kaushik, Harprit Gill, Ravi Bhargava
SUPPORTIVE CARE IN CANCER
(2020)