Article
Biophysics
Yi-Jyun Chen, Ying-Pei Hsu, You-Lin Tain, Nan-Si Li, Hao-Han Pang, Shiao-Wei Kuo, Hung-Wei Yang
Summary: Chronic kidney disease is a neglected chronic disease affecting over 750 million people worldwide. During the COVID-19 pandemic, many patients with other chronic diseases struggle to receive treatment or examination, increasing the risk of death. This study developed a method to rapidly detect chronic kidney disease using the naked eye in skin fluid, aiming to reduce the impact on an individual's quality of life and life expectancy.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Biochemistry & Molecular Biology
Sebastian Spencer, Robert Desborough, Sunil Bhandari
Summary: Assessing kidney function is vital for diagnosing and managing kidney diseases. The widely used indicator, glomerular filtration rate (GFR), has challenges in direct measurement. Serum creatinine, a commonly used marker, has limitations in accuracy. Cystatin C, unaffected by muscle mass, shows stronger associations with cardiovascular disease and mortality. Equations have been developed combining creatinine and cystatin C to estimate GFR, improving accuracy. Cystatin C-based estimates outperform creatinine-based estimates in predicting outcomes, especially in elderly and non-white ethnic groups, aiding in early detection of kidney disease and guiding decision-making.
Article
Transplantation
Daniel Christiadi, Charles Simpson, Kate O'brien, Kylie Taylor, Grant Luxton, Monica Rossleigh, Jonathan Erlich, Zoltan H. Endre
Summary: Plasma cystatin C after oral protein loading can effectively assess kidney functional reserve in patients with Stage 3 and 4 chronic kidney disease. It can predict disease progression and prognosis.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Jeong Ah Hwang, Younghoon Song, Jaeun Shin, Eunjung Cho, Shin Young Ahn, Gang Jee Ko, Young Joo Kwon, Ji Eun Kim
Summary: This study found a U-shaped relationship between mortality and CCR levels in normal renal function, as well as an increased risk of mortality in CKD patients with elevated CCR.
FRONTIERS IN MEDICINE
(2022)
Article
Nutrition & Dietetics
Young Youl Hyun, Kyu-Beck Lee, Hyoungnae Kim, Yaeni Kim, Wookyung Chung, Hayne Cho Park, Seung Hyeok Han, Yun Kyu Oh, Sue Kyung Park, Kook-Hwan Oh
Summary: This study found that a higher serum creatinine/cystatin C ratio is associated with a lower risk of adverse outcomes, especially all-cause mortality, in non-dialysis chronic kidney disease (CKD) patients, even after adjusting for estimated glomerular filtration rate (eGFR). Therefore, the serum creatinine/cystatin C ratio can be considered a useful prognostic marker in CKD patients.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, General & Internal
Bjorn Kaijun Betzler, Rehena Sultana, Feng He, Yih Chung Tham, Cynthia Ciwei Lim, Ya Xing Wang, Vinay Nangia, E. Shyong Tai, Tyler Hyungtaek Rim, Mukharram M. M. Bikbov, Jost B. B. Jonas, Se Woong Kang, Kyu Hyung Park, Ching-Yu Cheng, Charumathi Sabanayagam
Summary: This study evaluated the impact of a new equation for estimated glomerular filtration rate (eGFR) on the prevalence of chronic kidney disease (CKD) in multiple Asian cohorts. The results showed that the new equation reduced the prevalence of CKD and provided higher estimations of GFR among Asian populations. Reclassifying patients to lower-risk GFR categories could potentially reduce inappropriate care and its adverse effects.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Eryk Latoch, Katarzyna Kononczuk, Anna Jander, Elzbieta Trembecka-Dubel, Anna Wasilewska, Katarzyna Taranta-Janusz
Summary: This study found that children with cSFK have lower levels of Gal-3 compared to healthy subjects, but patients with reduced eGFR had significantly higher levels of Gal-3 and Cys C. The study suggests that Gal-3 may play a role in kidney damage in children with cSFK, but further research is needed to confirm its applicability as an early biomarker for kidney injury and progression to CKD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Masaru Samura, Keisuke Takada, Risako Yamamoto, Hayato Ito, Fumio Nagumo, Masaki Uchida, Takenori Kurata, Sakura Koshioka, Yuki Enoki, Kazuaki Taguchi, Ryuji Higashita, Norifumi Kunika, Koji Tanikawa, Kazuaki Matsumoto
Summary: This study evaluated the population pharmacokinetics of daptomycin in nonobese elderly patients with hypoalbuminemia and CKD. The optimal dose was found to depend on eGFRcys and age, with standard dose potentially insufficient for some patients. The study highlights the importance of individualized dosing in this patient population.
PHARMACEUTICAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Xueping Chen, Yan Huang, Ting Bao, Fu Jia, Ruwei Ou, Qianqian Wei, Yongping Chen, Jiao Liu, Jing Yang, Huifang Shang
Summary: This study aimed to examine the correlations between serum Cystatin C levels and cognitive performance in Chinese AD patients. The results showed that AD patients had higher levels of serum Cystatin C and there was a correlation between serum Cystatin C levels and cognitive scores. Higher serum Cystatin C levels may be associated with worse cognitive performance.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Wei-Ching Fang, Hsing-Yu Chen, Shao-Chi Chu, Po-Hsi Wang, Chin-Chan Lee, I-Wen Wu, Chiao-Yin Sun, Heng-Jung Hsu, Chun-Yu Chen, Yung-Chang Chen, Vin-Cent Wu, Heng-Chih Pan
Summary: This study evaluated the predictive performance of biomarkers in determining the likelihood of developing rapid kidney function decline (RKFD) in a healthy population. It found that serum cystatin C level could predict the possibility of RKFD, and suggested that a low cystatin C level should be considered as a risk factor for RKFD in healthy subjects.
Article
Medicine, General & Internal
Marwa Zakaria, Tamer Hassan, Ali Refaat, Manar Fathy, Mustafa I. A. Hashem, Naglaa Khalifa, Ahmed A. A. Ali, Ahmed Elhewala, Ahmed Ramadan, Alaa Nafea
Summary: This study aims to explore the role of cystatin C in early prediction of acute kidney injury (AKI) following cardiac surgery in children with congenital heart disease. The results of the observational cohort study suggest that serum cystatin C level is significantly correlated with AKI at 6 hours postoperative.
Article
Nutrition & Dietetics
Yu-Li Lin, Chih-Hsien Wang, I-Chen Chang, Bang-Gee Hsu
Summary: The novel sarcopenia index based on serum creatinine and estimated glomerular filtration rate shows promise as a reliable marker for sarcopenia in patients with advanced chronic kidney disease. It has acceptable discriminative powers for predicting sarcopenia across genders and may aid in screening efforts. Further research is needed to validate and expand on these findings.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Thilini M. Wijerathna, Nicholas A. Buckley, Indika B. Gawarammana, Jacques Raubenheimer, Seyed Shahmy, Umesh Chathuranga, Chathura Palangasinghe, Fathima Shihana, Fahim Mohamed
Summary: This study investigates the epidemiology and clinical outcomes of MCPA poisoning in Sri Lanka between 2002 and 2019, and analyzes the acute kidney injury in a subset of patients. The results show that MCPA poisoning can cause renal injury, but severe injury is uncommon. Patient age and ingested dose are associated with the severity of the condition, and most patients with renal dysfunction have no pre-existing kidney diseases.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Hyoungnae Kim, Jung Tak Park, Joongyub Lee, Ji Yong Jung, Kyu-Beck Lee, Yeong-Hoon Kim, Tae-Hyun Yoo, Shin-Wook Kang, Kyu Hun Choi, Kook-Hwan Oh, Curie Ahn, Seung Hyeok Han
Summary: In this study, a large positive difference between eGFR based on creatinine and cystatin C was found to be associated with a higher risk of major adverse cardiovascular events (MACE) and accelerated coronary artery calcification (CAC) progression in patients with chronic kidney disease (CKD). Therefore, careful monitoring of cardiovascular diseases is recommended for patients with a higher eGFR difference.
Review
Geriatrics & Gerontology
Masatsugu Okamura, Masaaki Konishi, Javed Butler, Kamyar Kalantar-Zadeh, Stephan von Haehling, Stefan D. Anker
Summary: This review discusses the impact of cachexia and muscle wasting on patients with chronic kidney disease, and summarizes the prevalence of these conditions and indicators for evaluating kidney function. However, there is limited understanding of cachexia in patients with chronic kidney disease, and its effects on kidney function and patient outcomes are not clear. Future studies should focus on the effects of cachexia and muscle wasting on chronic kidney disease and use cystatin C to accurately estimate kidney function.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Endocrinology & Metabolism
Carolyn D. Seib, Calyani Ganesan, Katherine D. Arnow, Alan C. Pao, John T. Leppert, Nicolas B. Barreto, Electron Kebebew, Manjula Kurella Tamura
Summary: A longitudinal cohort study found that patients with primary hyperparathyroidism (PHPT) who underwent parathyroidectomy were at a higher risk of kidney stone events in the immediate years after treatment compared to those managed nonoperatively, although the adjusted risk declined over time.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Urology & Nephrology
Benjamin Lidgard, Nisha Bansal, Leila R. Zelnick, Andrew Hoofnagle, Jing Chen, Derek Colaizzo, Mirela Dobre, Katherine T. Mills, Anna C. Porter, Sylvia E. Rosas, Mark J. Sarnak, Stephen Seliger, James Sondheimer, Manjula Kurella Tamura, Kristine Yaffe, Bryan Kestenbaum
Summary: Lower kidney clearances of secreted solutes are associated with incident global cognitive decline in a prospective study of CKD, independent of eGFR. However, serum concentrations of the solutes were not associated with cognitive decline. Further research is needed to determine the specific domains of cognition affected by decreased secretory clearance and the underlying mechanisms of these associations.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Nwamaka D. Eneanya, Joshua R. Lakin, Michael K. Paasche-Orlow, Charlotta Lindvall, Edward T. Moseley, Lori Henault, Amresh D. Hanchate, Ernest Mandel, Susan P. Y. Wong, Sophia N. Zupanc, Aretha Delight Davis, Areej El-Jawahri, Lisa M. Quintiliani, Yuchiao Chang, Sushrut S. Waikar, Amar D. Bansal, Jane O. Schell, Andrew L. Lundquist, Manjula Kurella Tamura, Margaret K. Yu, Mark L. Unruh, Christos Argyropoulos, Michael J. Germain, Angelo Volandes
Summary: This study aims to test the effectiveness of a video intervention on advance care planning, treatment preferences, and other patient-reported outcomes in older patients with advanced chronic kidney disease.
Article
Clinical Neurology
Sudipto Dolui, John A. Detre, Sarah A. Gaussoin, Jennifer S. Herrick, Danny J. J. Wang, Manjula Kurella Tamura, Monique E. Cho, William E. Haley, Lenore J. Launer, Henry A. Punzi, Anjay Rastogi, Carolyn H. Still, Daniel E. Weiner, Jackson T. Wright, Jeff D. Williamson, Clinton B. Wright, R. Nick Bryan, Adam P. Bress, Nicholas M. Pajewski, Ilya M. Nasrallah
Summary: Intensive antihypertensive treatment is associated with increased cerebral perfusion, particularly in patients with a history of cardiovascular disease.
Editorial Material
Medicine, General & Internal
Christine K. Liu, Manjula Kurella Tamura
Article
Nutrition & Dietetics
M. Kyla Shea, Jifan Wang, Kathryn Barger, Daniel E. Weiner, Sarah L. Booth, Stephen L. Seliger, Amanda H. Anderson, Rajat Deo, Harold Feldman, Alan S. Go, Jiang He, Ana C. Ricardo, Manjula Kurella Tamura
Summary: This study found an association between vitamin K status and cognitive performance in individuals with chronic kidney disease. Participants with lower levels of plasma (dp)ucMGP, indicating higher vitamin K status, had better cognitive performance. Plasma phylloquinone levels were not significantly associated with cognitive performance. These findings suggest that vitamin K may play an important role in cognitive function in individuals with chronic kidney disease.
CURRENT DEVELOPMENTS IN NUTRITION
(2022)
Article
Surgery
Carolyn D. Seib, Tong Meng, Robin M. Cisco, Insoo Suh, Dana T. Lin, Alex H. S. Harris, Amber W. Trickey, Manjula K. Tamura, Electron Kebebew
Summary: This study compared the incidence of adverse cardiovascular events in older adults with primary hyperparathyroidism treated with parathyroidectomy versus nonoperative management. The results showed that parathyroidectomy was associated with a lower incidence of cardiovascular events compared to nonoperative management, which is relevant for patients with a long life expectancy.
Article
Health Care Sciences & Services
Fahad Saeed, Susan Ladwig, Rebecca Jane Allen, Nwamaka D. Eneanya, Manjula Kurella Tamura, Kevin A. Fiscella
Summary: This study investigated racial disparities in prognostic discussions, beliefs about future health, and completion of advance care planning (ACP)-related documents among Black and White patients receiving maintenance dialysis. The results showed that there were differences in health expectations and completion of ACP-related documents between Black and White patients. Therefore, systemic efforts are needed to investigate differences in health beliefs and address racial disparities in the completion of ACP-related documents.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Endocrinology & Metabolism
Carolyn Dacey Seib, Tong Meng, Robin M. Cisco, Dana T. Lin, Elizabeth A. McAninch, Julie Chen, Manjula Kurella Tamura, Amber W. Trickey, Electron Kebebew
Summary: The objective of this study was to determine the incidence of permanent hypoparathyroidism requiring calcitriol therapy among older adults undergoing total thyroidectomy for Graves' disease in the United States. The study found that the risk of permanent hypoparathyroidism was low and should not deter surgical management for Graves' disease in older adults.
Article
Medicine, General & Internal
Carolyn D. Seib, Calyani Ganesan, Adam Furst, Alan C. Pao, Glenn M. Chertow, John T. Leppert, Insoo Suh, Maria E. Montez-Rath, Alex H. S. Harris, Amber W. Trickey, Electron Kebebew, Manjula Kurella Tamura
Summary: The effect of parathyroidectomy on long-term kidney function in patients with primary hyperparathyroidism (PHPT) and reduced eGFR was investigated. The study found that parathyroidectomy did not have a significant impact on long-term kidney function in older adults with PHPT.
ANNALS OF INTERNAL MEDICINE
(2023)
Letter
Health Care Sciences & Services
Fahad Saeed, Amaka Eneanya, Rebecca J. Allen, Manjula K. Tamura, Kevin A. Fiscella
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Medicine, General & Internal
Susan P. Y. Wong, David K. Prince, Manjula Kurella Tamura, Yoshio N. Hall, Catherine R. Butler, Ruth A. Engelberg, Elizabeth K. Vig, J. Randall Curtis, Ann M. O'Hare
Summary: This study examines the relationship between patients' health care values and their engagement in advance care planning and end-of-life care. The findings suggest a discrepancy between patients' expressed values and their actual involvement in advance care planning and end-of-life care.
JAMA INTERNAL MEDICINE
(2023)
Editorial Material
Urology & Nephrology
Vivek Charu, Lu Tian, Manjula Kurella Tamura, Maria E. Montez-Rath
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Clinical Neurology
C. Shah, D. Srinivasan, G. Erus, M. Kurella Tamura, M. Habes, J. A. Detre, W. E. Haley, A. J. Lerner, C. B. Wright, J. T. Wright Jr, S. Oparil, S. B. Kritchevsky, H. A. Punzi, A. Rastogi, R. Malhotra, C. H. Still, J. D. Williamson, R. N. Bryan, Y. Fan, I. M. Nasrallah
Summary: The study demonstrates that intensive treatment for hypertension can slow the progression of cerebral white matter hyperintensities and is associated with changes in functional brain connectivity. Specifically, the auditory-salience-language network showed a significant decline in connectivity score in the standard treatment group compared to the intensive treatment group. Additionally, changes in the mean connectivity score of the default mode network correlated significantly with changes in white matter hyperintensities.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Meeting Abstract
Health Care Sciences & Services
Jessica Ma, Ariadna Garcia, Anne C. Black, Karleen Giannitrapani, Derek Boothroyd, Manjula K. Tamura, I-Chun Thomas, Amanda Midboe, Lara K. Troszak, Shiqi Zhang, Selen Bozkurt, Devon Check, Jessica S. Merlin, Barrett Bowling, William Becker, Lorenz Karl
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
