期刊
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
卷 62, 期 2, 页码 222-229出版社
WILEY
DOI: 10.1111/jgs.12644
关键词
telomere length; vitamin C; lutein zeaxanthin; aging; antioxidants; oxidative stress
资金
- PhD Program Neurosciences of the Medical University of Graz
- Oesterreichische Nationalbank (Anniversary Fund) [15435]
- Austrian Science Fund [P20545-B05, P22976-B18, P13180]
- Intramural Research Program, National Institute on Aging, National Institutes of Health
- Austrian Science Fund (FWF) [P 20545] Funding Source: researchfish
- Austrian Science Fund (FWF) [P20545] Funding Source: Austrian Science Fund (FWF)
ObjectivesTo examine the association between plasma concentrations of antioxidative micronutrients and leukocyte telomere length (LTL) in elderly adults. DesignCross-sectional cohort study. SettingAustrian Stroke Prevention Study, a population-based cohort study on brain aging. ParticipantsIndividuals with a mean age of 667 (n=786; 58% female). MeasurementsConcentrations of vitamin C, lutein, zeaxanthin, -cryptoxanthin, canthaxanthin, lycopene, - and -tocopherol, - and -carotene, and retinol in plasma, advanced oxidation protein products as a measure of oxidative stress in serum, and LTL were measured. Vitamins and carotenoids were measured using high-performance liquid chromatography, advanced oxidation protein products using spectrophotometry, and telomere length using quantitative real-time polymerase chain reaction. ResultsMultiple linear regression analyses with adjustment for age and sex demonstrated that higher lutein, zeaxanthin, and vitamin C concentrations were strongly associated with longer telomere length. The associations were independent of body mass index, maximum oxygen uptake, and vascular risk factors and were not mediated by advanced oxidation protein products content. ConclusionThis study provides first evidence that higher lutein, zeaxanthin, and vitamin C concentrations in plasma are associated with longer LTL in normal elderly persons and suggest a protective role of these vitamins in telomere maintenance.
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