Article
Endocrinology & Metabolism
Jiannong Liu, Andrew Laster, Xiaoqing Xu, Haifeng Guo, Mary Oates, Shravanthi R. Gandra
Summary: This study analyzed real-world prescribing data of postmenopausal women using teriparatide, revealing patterns and trends in usage while also highlighting shortcomings in persistence and treatment sequence.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hussein Sakr, Zenat Khired, Marzieh Moghadas
Summary: This study examined the effect of a wheat grain diet on bone turnover markers in rats. The results showed that rats fed whole or refined grains had lower bone density and mineral content compared to the control group. Additionally, levels of bone turnover indicators in the blood were altered, indicating a decrease in bone turnover and mass with a grain diet.
Article
Nutrition & Dietetics
Nasser M. Al-Daghri, Syed Danish Hussain, Abdullah M. Alnaami, Naji Aljohani, Shaun Sabico
Summary: Osteoporosis is a significant public health concern in Saudi Arabia, particularly among the aging population. This study examined the association between dietary calcium intake and osteoporosis risk in Saudi adults. Results showed that the overall mean calcium intake was very low and that certain dietary factors, such as tea intake and consumption of fish and eggs, were associated with a lower risk of osteoporosis.
Article
Biochemistry & Molecular Biology
Ewa Jowko, Barbara Dlugolecka, Igor Cieslinski, Jadwiga Kotowska
Summary: The aim of this study was to identify relevant factors that affect bone mineral content (BMC) and bone mineral density (BMD) in young, healthy men reaching peak bone mass. The results showed that age, BMI, engaging in combat and team sports at a competitive level, and certain genetic polymorphisms were significant predictors of BMD/BMC at different skeletal sites. Specifically, the SOD2 AG genotype was associated with lower BMC values, while the VDR FokI GG genotype was associated with lower BMD. However, the CALCR AG genotype was linked to higher arm BMD. These findings suggest that sports training may mitigate the negative impact of genetic factors on bone tissue and reduce the risk of osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Elham Kazemian, Ali Pourali, Fatemeh Sedaghat, Mehrdad Karimi, Vahid Basirat, Zohreh Sajadi Hezaveh, Sayed Hossein Davoodi, Michael F. Holick
Summary: A systematic review and meta-analysis evaluated the effects of vitamin D-3 supplementation on bone health in adults. The results showed a protective effect of vitamin D-3 supplementation on bone mineral density (BMD) at the lumbar spine, femoral neck, and total hip. Dose-response analysis revealed a linear relationship between vitamin D-3 supplementation doses and BMD. However, no significant effect of vitamin D-3 supplementation on whole-body or total hip BMD was found. The relationship between vitamin D-3 supplement doses and markers of bone turnover was nonlinear.
Review
Biochemistry & Molecular Biology
Kathryn Frost, Amy J. Naylor, Helen M. McGettrick
Summary: Bone remodelling is a dynamically regulated process involving osteoblasts, osteoclasts, and their progenitors. Dysregulation of bone remodelling can lead to disorders like osteoporosis and Paget's disease. The sphingosine-1-phosphate (S1P) signaling pathway has been identified as an important regulator of bone remodelling and inflammatory responses. This review discusses the role of S1P in bone homeostasis and disease, highlighting its potential as a biomarker and therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Alicia R. Jones, Koen Simons, Susan Harvey, Vivian Grill
Summary: Individuals with primary hyperparathyroidism have reduced cortical bone mineral density, but relatively preserved trabecular bone density. However, their fracture risk is still increased. Trabecular bone score may provide a more accurate assessment of bone quality and fracture risk. This study compared the effectiveness of bone mineral density and trabecular bone score in describing bone quality in patients with primary hyperparathyroidism, and also evaluated changes in trabecular bone score following parathyroidectomy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Kazuyoshi Shigehara, Kouji Izumi, Yoshifumi Kadono, Atsushi Mizokami
Summary: Bone fracture due to osteoporosis is a significant issue for elderly men, and testosterone replacement therapy has shown benefits in improving bone mineral density in symptomatic hypogonadal men with osteopenia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Geriatrics & Gerontology
Xiaowen Zhang, Warrington W. Q. Hsu, Chor-Wing Sing, Gloria H. Y. Li, Kathryn C. B. Tan, Annie W. C. Kung, Janus S. H. Wong, Ian Chi-Kei Wong, Ching-Lung Cheung
Summary: This study investigated the relationship between bone mineral density (BMD) and the risk of incident dementia, and found that higher BMD was associated with a reduced risk of dementia, particularly in women. Further research is needed to evaluate the clinical usefulness of BMD in predicting and managing dementia.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Marta Galvez-Fernandez, Maria Grau-Perez, Tamara Garcia-Barrera, Sara Ramirez-Acosta, Jose L. Gomez-Ariza, Beatriz Perez-Gomez, Inaki Galan-Labaca, Ana Navas-Acien, Josep Redon, Laisa S. Briongos-Figuero, Antonio Duenas-Laita, Jose Luis Perez-Castrillon, Maria Tellez-Plaza, Juan Carlos Martin-Escudero
Summary: The study evaluated the association between arsenic, cadmium, and selenium biomarkers with bone mineral density. Results showed that selenium was associated with BMD-related disease, while arsenic and cadmium were not. The non-linear association of selenium with BMD-related disease included a strong positive association with osteoporosis-related bone fractures risk at higher selenium exposure levels.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Endocrinology & Metabolism
Chin-Hao Hsu, Sheng-Feng Sung, Hsin-Yi Yang, Wan-Ting Huang, Cheng-Yang Hsieh
Summary: Despite being at higher risk, stroke survivors are less likely to receive bone mineral density testing and osteoporosis treatment compared to non-stroke patients. Factors such as female sex, osteoporosis, prior BMD testing, and low-trauma fractures after stroke increase the likelihood of receiving these measures, while greater stroke severity reduces the likelihood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Ming Qin, Yue Gao, Meichen Zhang, Junhua Wu, Yang Liu, Yuting Jiang, Xiaodi Zhang, Xin Wang, Yanmei Yang, Yanhui Gao
Summary: This study investigates the effects of fluorine and ADAMTS14_rs4747096 on bone mineral density (BMD). The findings suggest that fluoride exposure and mutation G allele in ADAMTS14_rs4747096 may be risk factors for decreased BMD, and there is an interaction between the two influencing factors.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Endocrinology & Metabolism
Y. Zhang, Z. Tian, S. Ye, Q. Mu, X. Wang, S. Ren, X. Hou, W. Yu, J. Guo
Summary: The study found that individuals with Down syndrome have significantly lower bone mineral density in total body and different regions (hip, lumbar spine, and femoral neck) compared to controls. It also showed a decreasing trend in lumbar spine volumetric bone mineral density and an elevated femoral neck volumetric bone mineral density in Down syndrome individuals versus controls.
OSTEOPOROSIS INTERNATIONAL
(2022)
Review
Endocrinology & Metabolism
Panagiotis Anagnostis, Kalliopi Lampropoulou-Adamidou, Julia K. Bosdou, Georgios Trovas, Petros Galanis, Efstathios Chronopoulos, Dimitrios G. Goulis, Symeon Tournis
Summary: The optimal management of pregnancy and lactation-associated osteoporosis (PLO) has not been determined. Existing studies have found that calcium/vitamin D, bisphosphonates, and teriparatide can improve bone mineral density, with teriparatide showing better efficacy. However, due to heterogeneity and lack of robust comparative data, safe conclusions cannot be drawn regarding the optimal therapeutic intervention in women with PLO.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Orthopedics
Jiemei Gu, Hao Zhang, Qingyun Xue, Li Wang, Zhifeng Cheng, Yawei Zhang, Qifu Li, Lingqing Yuan, Yukun Li, Jin Dong, Yanan Huo, Xin Tang, Ling Hu, Xinjia Wang, Fei Hua, Lin Shen, Jinluo Cheng, Huimin Zhou, Youjia Xu, Tao Yang, Chuansuo Wang, Jin Xu, Jie Shen, Ying Zhang, Xiaomei Zhang, Dun Hong, Xiaoling Guan, Xinhua Xiao, Guang Wang, Yonghua Liu, Liujun Fu, Jianting Chen, Xigao Cheng, Yue Ding, Lijun Liu, Qi Yao, Xinchao Zhang, Lixin Li, Panjun Zhang, Chunying Deng, Chengyan Jiang, Li You, Kai Wang, Shimin Zhang, Jianzhong Xiao, Wei Liu, Xiaohong Du, Xianwen Shang, Tianrong Pan, Chen Lei, Shuren Guo, Zhenlin Zhang
Summary: This study assessed the efficacy, safety, pharmacokinetics, and immunogenicity of a denosumab biosimilar (LY06006) in Chinese postmenopausal women with osteoporosis. The results showed that LY06006 significantly increased bone mineral density and reduced bone resorption. The safety and tolerability of LY06006 were comparable to the reference drug Prolia(R).
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Letter
Allergy
Christine R. F. Rukasin, Susanne Henderlight, Terry Bosen, Scott D. Nelson, Elizabeth J. Phillips
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2020)
Article
Computer Science, Information Systems
Xiangyang Ye, Qing T. Zeng, Julio C. Facelli, Diana Brixner, Mike Conway, Bruce E. Bray
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2020)
Article
Computer Science, Information Systems
Patrick Wu, Scott D. Nelson, Juan Zhao, Cosby A. Stone, QiPing Feng, Qingxia Chen, Eric A. Larson, Bingshan Li, Nancy J. Cox, C. Michael Stein, Elizabeth J. Phillips, Dan M. Roden, Joshua C. Denny, Wei-Qi Wei
Summary: The study developed the DDIWAS method to detect potential drug-drug interactions using data from EHR allergy lists. It showed a positive predictive value of 85% to 86% for rediscovering known DDIs and discovering novel interactions. A software package is available for detecting and validating DDI signals across institutions.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Anesthesiology
Amanda L. Stone, Dima Qu'd, Twila Luckett, Scott D. Nelson, Erin E. Quinn, Amy L. Potts, Stephen W. Patrick, Stephen Bruehl, Andrew D. Franklin
Summary: Despite Tennessee's policy aimed at reducing leftover opioids, a significant proportion of prescribed opioids were left over following pediatric ambulatory surgeries. A majority of parents did not engage in safe opioid disposal practices, posing safety risks.
ANESTHESIA AND ANALGESIA
(2022)
Review
Medical Informatics
Liang Yan, Thomas Reese, Scott D. Nelson
Summary: Clinical pharmacists using Clinical Decision Support (CDS) tools have shown significant improvements in medication use quality, patient safety, and quality of care, supporting their expanded roles and establishing them as leaders in safe and effective pharmacotherapy.
APPLIED CLINICAL INFORMATICS
(2021)
Editorial Material
Medicine, General & Internal
Scott D. Nelson, Yaa Kumah-Crystal
JAMA INTERNAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Austin R. Brown, Allison B. McCoy, Adam Wright, Scott D. Nelson
Summary: The study evaluated the state of problem list maintenance at an academic medical center, highlighting issues such as problem duplicates, SNOMED CT code duplications, contradicting disease stages, and inconsistencies. The results indicate the need for further research and improvements in problem list maintenance.
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2022)
Article
Anesthesiology
Scott D. Nelson, Allison B. McCoy, Hayley Rector, Andrew J. Teare, Tyler W. Barrett, Elizabeth A. Sigworth, Qingxia Chen, David A. Edwards, David E. Marcovitz, Adam Wright
Summary: A targeted clinical decision support alert significantly increased the rate of naloxone coprescribing for patients at risk for opioid overdose.
ANESTHESIA AND ANALGESIA
(2022)
Article
Pharmacology & Pharmacy
Mark A. Munger, Scott D. Nelson, Chia-Chen Teng, Alfred K. Cheung, Brian C. Sauer
Summary: The concomitant use of NSAID plus misoprostol is associated with a reduced risk of NSAID-induced cardiovascular, cerebrovascular, and renal adverse events.
Article
Pharmacology & Pharmacy
Eugene Jeong, Scott D. Nelson, Yu Su, Bradley Malin, Lang Li, You Chen
Summary: This study conducted a data analysis on COVID-19 patients from the FDA Adverse Event Reporting System (FAERS) to identify potential drug-drug interactions (DDIs) and associated adverse events (AEs). The results revealed some significant associations that were not found in existing databases, indicating the need for further research.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Computer Science, Information Systems
Adam Wright, Scott Nelson, David Rubins, Richard Schreiber, Dean F. Sittig
Summary: This study aims to identify common causes of clinical decision support malfunctions related to medication routes and to provide best practices for avoiding these malfunctions. The results revealed that value set errors related to medication routes are widespread and can impact the accuracy of CDS interventions.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2022)
Article
Computer Science, Information Systems
Siru Liu, Aileen P. Wright, Barron L. Patterson, Jonathan P. Wanderer, Robert W. Turer, Scott D. Nelson, Allison B. McCoy, Dean F. Sittig, Adam Wright
Summary: This study used ChatGPT to generate suggestions for improving clinical decision support (CDS) logic and compared them to human-generated suggestions. The results showed that ChatGPT-generated suggestions offered unique perspectives and were highly understandable and relevant, but had moderate usefulness and lower acceptance, bias, inversion, and redundancy.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Article
Gastroenterology & Hepatology
Ashley Spann, Kristy M. Bishop, Asli O. Weitkamp, Shane P. Stenner, Scott D. Nelson, Manhal Izzy
Summary: This study evaluated the ability of an electronic health record-embedded clinical decision support system to risk stratify and identify care gaps in patients with NAFLD. The results showed that NAFLD patients often lacked annual screening labs in primary care settings, and only a small percentage of patients received further evaluation and treatment.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Computer Science, Information Systems
Allison B. McCoy, Elise M. Russo, Kevin B. Johnson, Bobby Addison, Neal Patel, Jonathan P. Wanderer, Dara E. Mize, Jon G. Jackson, Thomas J. Reese, SyLinda Littlejohn, Lorraine Patterson, Tina French, Debbie Preston, Audra Rosenbury, Charlie Valdez, Scott D. Nelson, Chetan Aher, Mhd Wael Alrifai, Jennifer Andrews, Cheryl Cobb, Sara N. Horst, David P. Johnson, Lindsey A. Knake, Adam A. Lewis, Laura Parks, Sharidan K. Parr, Pratik Patel, Barron L. Patterson, Christine M. Smith, Krystle D. Suszter, Robert W. Turer, Lyndy J. Wilcox, Aileen P. Wright, Adam Wright
Summary: The Clickbusters initiative at VUMC successfully optimized clinical decision support alerts by reducing alert firings and clicks, increasing user engagement, and fostering a culture of continuous evaluation and improvement of clinical content in the electronic health record.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2022)
Article
Health Care Sciences & Services
Thomas J. Reese, Guilherme Del Fiol, Keaton Morgan, Jason T. Hurwitz, Kensaku Kawamoto, Ainhoa Gomez-Lumbreras, Mary L. Brown, Henrik Thiess, Sara R. Vazquez, Scott D. Nelson, Richard Boyce, Daniel Malone
Summary: This study designed a tool to support shared decision-making between patients and clinicians for the drug-drug interaction between warfarin and nonsteroidal anti-inflammatory drugs. Both patients and clinicians participated in the usability study, with patients showing a preference for pain treatments with less risk of gastrointestinal bleeding. Clinicians successfully completed tasks using the tool and rated the usability of DDInteract positively.
JMIR HUMAN FACTORS
(2021)