Article
Immunology
Scott R. Curry, Michelle T. Hecker, Justin O'Hagan, Preeta K. Kutty, Heba Alhmidi, Yilen K. Ng-Wong, Jennifer L. Cadnum, Annette L. Jencson, Melany Gonzalez-Orta, Carlos Saldana, Brigid M. Wilson, Curtis J. Donskey
Summary: This study investigated the natural history of Clostridioides difficile colonization and infection in healthcare settings. The results showed that 9.9% of patients acquired asymptomatic carriage of C. difficile, and 13.4% were subsequently diagnosed with C. difficile infection (CDI). Most carriers had transient rather than persistent carriage, and most patients developing CDI did not have prior detection of carriage.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Aaron C. Miller, Alan T. Arakkal, Daniel K. Sewell, Alberto M. Segre, Sriram Pemmaraju, Philip M. Polgreen
Summary: This study evaluated whether hospitalized patients without diagnosed Clostridioides difficile infection (CDI) increased the risk for CDI among their family members after discharge. The study found that CDI incidence among insurance enrollees exposed to a recently hospitalized family member was 73% greater than enrollees not exposed. Additionally, there was a dose-response relationship between total days of within-household hospitalization and CDI incidence rate ratio.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Environmental Sciences
Nagham Khanafer, Philippe Vanhems, Sabrina Bennia, Geraldine Martin-Gaujard, Laurent Juillard, Thomas Rimmele, Laurent Argaud, Olivier Martin, Laetitia Huriaux, Guillaume Marcotte, Romain Hernu, Bernard Floccard, Pierre Cassier, Study Group
Summary: Clostridioides (Clostridium) difficile infection is the most common cause of hospital-acquired infectious diarrhea in the developed world, with increasing incidence and severity. This study aims to investigate and evaluate factors associated with both infection and colonization of Clostridioides difficile.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Immunology
Javier A. Villafuerte Galvez, Nira R. Pollock, Carolyn D. Alonso, Xinhua Chen, Hua Xu, Lamei Wang, Nicole White, Alice Banz, Mark Miller, Kaitlyn Daugherty, Anne J. Gonzalez-Luna, Caitlin Barrett, Rebecca Sprague, Kevin W. Garey, Ciaran P. Kelly
Summary: Clostridioides difficile diagnostics cannot reliably distinguish infection from colonization. Stool IL-1 beta, a proinflammatory cytokine, can accurately differentiate CDI from asymptomatic carriage and non-CDI diarrhea, making it a promising biomarker for CDI diagnosis. Significant positive correlations exist between stool toxins and stool IL-1 beta in CDI but not in asymptomatic carriers.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Sarah Jolivet, Jeanne Couturier, Patrick Grohs, Aurelie Vilfaillot, Jean-Ralph Zahar, Pierre Frange, Anne Casetta, Veronique Moulin, Christine Lawrence, Patricia Baune, Cleo Bourgeois, Axel Bouffier, Claudine Laussucq, Lydia Sienzonit, Simon Picard, Isabelle Podglajen, Najiby Kassis-Chikhani, Frederic Barbut
Summary: This study conducted a point prevalence analysis on patients >3 years old in 11 healthcare facilities in the Paris urban area and found a 7.7% C. difficile carriage rate, with 3.9% being toxigenic strains. Multidrug-resistant organisms co-carriage and previous CDI were positively associated with toxigenic C. difficile carriage in patients >3 years old, while consumption of raw milk products was associated with a reduced risk of colonization.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Han Eum Choi, Jae Hyun Lee, Young-Joo Sim, Ho Joong Jeong, Ghi Chan Kim
Summary: The study investigated factors affecting the duration of VRE colonization in stroke patients. It found that oral feeding, use of antibiotics, and duration of ICU care were independent factors influencing the duration of VRE colonization. Attention should be given to these factors, especially in hemorrhagic stroke patients, for intensive rehabilitation at the appropriate time.
Article
Biochemistry & Molecular Biology
Arianna Miles-Jay, Evan S. Snitkin, Michael Y. Lin, Teppei Shimasaki, Michael Schoeny, Christine Fukuda, Thelma Dangana, Nicholas Moore, Sarah E. Sansom, Rachel D. Yelin, Pamela Bell, Krishna Rao, Micah Keidan, Alexandra Standke, Christine Bassis, Mary K. Hayden, Vincent B. Young
Summary: Despite enhanced infection prevention efforts, Clostridioides difficile remains the leading cause of healthcare-associated infections in the United States. Understanding the contribution of asymptomatic carriers to C. difficile spread is crucial. Current prevention strategies can prevent cross-transmission, but interventions targeting the transition from asymptomatic carriage to infection are needed to further decrease C. difficile infections.
Article
Critical Care Medicine
Chiara Abbruzzese, Amedeo Guzzardella, Dario Consonni, Gloria Turconi, Claudia Bonetti, Matteo Brioni, Mauro Panigada, Giacomo Grasselli
Summary: CRTs are common in ICU population but rarely symptomatic. Obesity and ECMO were identified as protective factors, while pulmonary artery catheter, internal jugular vein, and left-side positioning were risk factors for CRT.
ANNALS OF INTENSIVE CARE
(2023)
Article
Surgery
Sarah E. Ibitoye, Philip Braude, Ben Carter, Frances Rickard, Helen Deakin, Rebecca Martin, Julian Thompson, Benjamin Walton, David Shipway
Summary: Geriatrician review can reduce 1-year mortality in older adults admitted with trauma.
Article
Critical Care Medicine
Julien Cobert, Sun Young Jeon, John Boscardin, Allyson C. Chapman, Lauren E. Ferrante, Sei Lee, Alexander K. Smith
Summary: The rates of pre-existing disability, frailty, and multimorbidity in older adults admitted to ICUs have increased over time, while the rate of dementia has not significantly changed.
Article
Geriatrics & Gerontology
Lorene Zerah, Edouard Baudouin, Marion Pepin, Morgane Mary, Sebastien Krypciak, Celine Bianco, Swasti Roux, Ariane Gross, Charlotte Tomeo, Nadege Lemarie, Antoine Dureau, Sophie Bastiani, Flora Ketz, Clemence Boully, Cedric de Villelongue, Mouna Romdhani, Marie-Astrid Desoutter, Emmanuelle Duron, Jean-Philippe David, Caroline Thomas, Elena Paillaud, Pauline de Malglaive, Eric Bouvard, Mathilde Lacrampe, Elise Mercadier, Alexandra Monti, Olivier Hanon, Virginie Fossey-Diaz, Lauriane Bourdonnec, Bruno Riou, Helene Vallet, Jacques Boddaert
Summary: This study investigated 821 patients aged 70 and older with confirmed COVID-19 in 13 acute geriatric wards in the Paris area. Common symptoms at COVID-19 onset included asthenia, fever, dyspnea, dry cough, and delirium. Risk factors for severe illness included male gender, low ADL score, asthenia, high quick Sequential Organ Failure Assessment score, and specific COVID-19 anomalies on chest CT.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Infectious Diseases
Helen S. Lee, Kamryn Plechot, Shruti Gohil, Jennifer Le
Summary: Clostridium difficile infection (CDI) is a significant healthcare-associated infection with varying diagnostic methods. Overdiagnosis from highly sensitive tests may lead to unnecessary treatment and adverse outcomes. It is important to optimize the sensitivity and specificity of laboratory tests to differentiate clinical CDI from colonization.
INFECTIOUS DISEASES AND THERAPY
(2021)
Article
Immunology
Jay Worley, Mary L. Delaney, Christopher K. Cummins, Andrea DuBois, Michael Klompas, Lynn Bry
Summary: This study found that 7.4% of ICU patients asymptomatically carried C. difficile, with 69% of isolates carrying an intact toxin locus. Rates of CDI in asymptomatic carriers of toxin-encoding strains were 5.3%, significantly higher than the 0.57% in noncarriers. The relative risk for CDI with asymptomatic carriage of a toxin-encoding strain was 9.32.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Health Care Sciences & Services
Ryuichi Ohta, Yoshinori Ryu, Chiaki Sano
Summary: White nails are associated with higher in-hospital mortality, along with male sex and caregiver dependence. Detection of white nails can predict patient deterioration and aid in providing better care for elderly patients.
Article
Medicine, General & Internal
Petros Ioannou, Symeon Panagiotakis, Emmanouela Tsagkaraki, Constantinos Tsioutis, Konstantinos Fragkiadakis, Achilleas Gikas, Theodosios D. Filippatos
Summary: Hyponatremia is a common electrolyte disorder that often affects older hospitalized individuals and can have an impact on mortality. The main cause is hypovolemia, with a significant proportion of patients not meeting the criteria for SIAD at admission. Re-admission rates and mortality are higher in patients with hyponatremia at admission.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Deborah Steensels, Ariane Deplano, Olivier Denis, Anne Simon, Alexia Verroken
ACTA CLINICA BELGICA
(2017)
Article
Microbiology
A. Noel, A. Verroken, L. Belkhir, H. Rodriguez-Villalobos
Article
Medicine, General & Internal
Elodie Degroote, Halil Yildiz, Frederic Lecouvet, Alexia Verroken, Leila Belkhir
ACTA CLINICA BELGICA
(2018)
Article
Infectious Diseases
A. Verroken, C. Bauraing, A. Deplano, P. Bogaerts, D. Huang, G. Wauters, Y. Glupczynski
CLINICAL MICROBIOLOGY AND INFECTION
(2014)
Article
Infectious Diseases
M. Gizzi, B. Delaere, B. Weynand, J. Clement, P. Maes, V. Vergote, L. Laenen, B. Hjelle, A. Verroken, A. Dive, I. Michaux, P. Evrard, D. Creytens, P. Bulpa
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2013)
Article
Infectious Diseases
A. Verroken, L. Defourny, L. Lechgar, A. Magnette, M. Delmee, Y. Glupczynski
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2015)
Article
Microbiology
A. Verroken, M. Janssens, C. Berhin, P. Bogaerts, T. -D. Huang, G. Wauters, Y. Glupczynski
JOURNAL OF CLINICAL MICROBIOLOGY
(2010)
Article
Infectious Diseases
Didier Schoevaerdts, Alexia Verroken, Te-Din Huang, Malorie Frennet, Catherine Berhin, Jacques Jamart, Pierre Bogaerts, Christian Swine, Youri Glupczynski
JOURNAL OF INFECTION
(2012)
Letter
Infectious Diseases
Pierre Bogaerts, Alexia Verroken, Beatrice Jans, Olivier Denis, Youri Glupczynski
LANCET INFECTIOUS DISEASES
(2010)
Article
Multidisciplinary Sciences
Alexia Verroken, Lydwine Defourny, Olivier le Polain de Waroux, Leila Belkhir, Pierre-Francois Laterre, Michel Delmee, Youri Glupczynski
Article
Multidisciplinary Sciences
Alexia Verroken, Noemie Despas, Hector Rodriguez-Villalobos, Pierre-Francois Laterre
Article
Infectious Diseases
Lidvine Boland, Corentin Streel, Helene De Wolf, Hector Rodriguez, Alexia Verroken
BMC INFECTIOUS DISEASES
(2019)
Letter
Critical Care Medicine
Alexia Verroken, Anais Scohy, Ludovic Gerard, Xavier Wittebole, Christine Collienne, Pierre-Francois Laterre
Article
Medicine, General & Internal
N. Ausselet, M. Bourgeois, V Gerard, A. Verroken, D. Tuerlinckx, E. Marchand, T-D Huang, I Michaux, Y. Glupczynski, B. Delaere
ACTA CLINICA BELGICA
(2012)
