Article
Clinical Neurology
Nelsan Pourhadi, Janet Janbek, Christina Jensen-Dahm, Christiane Gasse, Thomas Munk Laursen, Gunhild Waldemar
Summary: The use of proton pump inhibitors (PPIs) may increase the risk of dementia in individuals aged 60 to 75 years, with a potential correlation to age.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Tung-Min Yu, Ya-Wen Chuang, Shih-Ting Huang, Jin-An Huang, Cheng-Hsu Chen, Mu-Chi Chung, Chun-Yi Wu, Pi-Yi Chang, Chih-Cheng Hsu, Ming-Ju Wu
Summary: Exposure to contrast media is significantly associated with the risk of dementia, with a particularly high risk of Alzheimer's disease in younger patients without underlying comorbidities.
Article
Ophthalmology
Do Young Park, Mina Kim, Yoonjong Bae, Hyemin Jang, Dong Hui Lim
Summary: A nationwide cohort study discovered that newly diagnosed glaucoma patients have a higher risk of developing dementia, especially among older individuals. This study used authorized data provided by the Korean National Health Insurance Service (NHIS) to conduct a population-based retrospective cohort analysis. Analysis of the collected data revealed that glaucoma patients are at a greater risk of developing dementia, particularly among older individuals.
Article
Clinical Neurology
Ilaria Ippoliti, Antonio Ancidoni, Roberto Da Cas, Andrea Pierantozzi, Nicola Vanacore, Francesco Trotta
Summary: This nationwide study aims to characterize dementia drug utilization in Italy from 2018 to 2020. The study found that Acetylcholinesterase inhibitors (AChEIs) and memantine are the only approved anti-dementia drugs (ADDs) for treating Alzheimer's disease (AD) in Italy. The consumption of AChEIs and memantine remained stable throughout the study period, with AChEI consumption being over 5 DDD/1000 inhabitants per day and memantine consumption representing 40% of ADD consumption.
NEUROLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Jiazhen Zheng, Can Ni, Yingchai Zhang, Jinghan Huang, Daniel Nyarko Hukportie, Buwen Liang, Shaojun Tang
Summary: Using large-scale observational and Mendelian randomization analyses, the study finds evidence of potential causal associations between glucosamine use and lower risk for dementia. However, further validation through randomized controlled trials is needed.
Article
Medicine, General & Internal
Huanquan Liao, Dong Pan, Zhenhong Deng, Jingru Jiang, Jinhua Cai, Ying Liu, Baixuan He, Ming Lei, Honghong Li, Yi Li, Yongteng Xu, Yamei Tang
Summary: This study found that shift work is associated with an increased risk of dementia, but night shift work is not significantly associated with dementia risk. The increased incidence of dementia in shift workers does not differ between participants with different genetic susceptibility to dementia.
Article
Clinical Neurology
Dan-Dan Zhang, Ya-Nan Ou, Liu Yang, Ya-Hui Ma, Lan Tan, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: This study used data from the UK Biobank to investigate the association between cancer status and the risk of dementia. The results showed that cancer patients had a lower risk of dementia, especially in those with cancers in the male genital system. Non-melanoma skin cancer and prostate cancer were also associated with a reduced risk of dementia.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Kevin Kuo, Ya-Ru Zhang, Shi-Dong Chen, Xiao-Yu He, Shu-Yi Huang, Bang-Sheng Wu, Yue-Ting Deng, Liu Yang, Ya-Nan Ou, Yu Guo, Rui-Qi Zhang, Yi Zhang, Lan Tan, Qiang Dong, Wei Cheng, Jin-Tai Yu
Summary: This study analyzed data from the UK Biobank and found that a 5 kg increment in grip strength was associated with lower risks of all types of dementia, while a slow walking pace was associated with increased risks of all types of dementia. These findings highlight the importance of grip strength and walking pace in estimating the risks of dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Yongqian Wang, Chenglong Li, Jie Liang, Darui Gao, Yang Pan, Wenya Zhang, Yang Zhang, Fanfan Zheng, Wuxiang Xie
Summary: This study aimed to investigate the relationship between age at diabetes diagnosis and the incidence of dementia. The results showed that an earlier onset of diabetes was significantly associated with a higher risk of dementia.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Oscar Hou In Chou, Jiandong Zhou, Lifang Li, Jeffrey Shi Kai Chan, Danish Iltaf Satti, Vanessa Hou Cheng Chou, Wing Tak Wong, Sharen Lee, Bernard Man Yung Cheung, Gary Tse, Carlin Chang, Tong Liu
Summary: This retrospective population-based cohort study aimed to explore the association between neutrophil-to-lymphocyte ratio (NLR) and dementia. The results showed that patients with NLR >5.44 had an increased risk of developing Alzheimer's disease and related dementia, but not non-Alzheimer's dementia. Utilizing baseline NLR during family medicine consultation may help predict the risks of dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Health Care Sciences & Services
Young Suk Kwon, Sang-Hwa Lee, Chulho Kim, Hyunjae Yu, Jong-Hee Sohn, Jae Jun Lee, Dong-Kyu Kim
Summary: The relationship between surgery type and dementia risk is still unclear. This study found that patients who underwent musculoskeletal surgery or multiple surgeries have a higher risk of dementia. However, there was no association with the type of anesthesia administered.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Geriatrics & Gerontology
Chuan-Chi Yang, Wu-Chien Chien, Chi-Hsiang Chung, Chung-Yu Lai, Nian-Sheng Tzeng
Summary: This study found that the usage of H1RA is associated with a higher risk of developing dementia in patients aged 65 and above, especially in male patients or those with more comorbidities. However, overall, there is no significant association between H1RA usage and the risk of dementia.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Environmental Sciences
Jinjun Ran, C. Mary Schooling, Lefei Han, Shengzhi Sun, Shi Zhao, Xiaohong Zhang, King-Pan Chan, Fang Guo, Ruby Siu-Yin Lee, Yulan Qiu, Linwei Tian
Summary: Long-term exposure to PM2.5 is positively associated with a higher risk of all-cause dementia incidence, with an estimated hazard ratio of 1.06 per every 3.8 μg/m(3) increase in annual mean PM2.5 exposure. No effect modifications by age, sex, BMI, hypertension, diabetes, or heart disease were found in this study.
ENVIRONMENTAL POLLUTION
(2021)
Article
Nutrition & Dietetics
Zhenhong Deng, Dongshu Xie, Jinhua Cai, Jingru Jiang, Dong Pan, Huanquan Liao, Xingyi Liu, Yongteng Xu, Honghong Li, Qingyu Shen, Simona Lattanzi, Songhua Xiao, Yamei Tang
Summary: This study investigated the association between different types of milk consumption and the risk of dementia. The results showed that consuming soy milk was associated with a lower risk of dementia, particularly non-vascular dementia.
CLINICAL NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Raaj S. Mehta, Bharati Kochar, Zhen Zhou, Jonathan C. Broder, Paget Chung, Keming Yang, Jessica Lockery, Michelle Fravel, Joanne Ryan, Suzanne Mahady, Suzanne G. Orchard, John J. Mcneil, Anne Murray, Robyn L. Woods, Michael E. Ernst, Andrew T. Chan
Summary: This study investigated the associations of proton pump inhibitor (PPI) and histamine-2 receptor antagonist (H2RA) use with dementia and cognitive decline. The study found that long-term use of PPI and H2RA was not associated with incident dementia, cognitive impairment without dementia (CIND), or decline in cognition over time.
Article
Clinical Neurology
Michael Von Korff, Kathleen Saunders, Sascha Dublin, Rod L. Walker, Manu Thakral, Karen J. Sherman, Evette J. Ludman, Ryan N. Hansen, Michael Parchman, Susan M. Shortreed
Article
Neurosciences
Erin J. Aiello Bowles, Paul K. Crane, Rod L. Walker, Jessica Chubak, Andrea Z. LaCroix, Melissa L. Anderson, Dori Rosenberg, C. Dirk Keene, Eric B. Larson
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Letter
Geriatrics & Gerontology
Zachary A. Marcum, Rod Walker, Jennifer F. Bobb, Mo-Kyung Sin, Shelly L. Gray, James D. Bowen, Wayne McCormick, Susan M. McCurry, Paul K. Crane, Eric B. Larson
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2019)
Article
Pharmacology & Pharmacy
Laura A. Hart, Zachary A. Marcum, Shelly L. Gray, Rod L. Walker, Paul K. Crane, Eric B. Larson
Article
Geriatrics & Gerontology
Zachary A. Marcum, Rod L. Walker, Bobby L. Jones, Arvind Ramaprasan, Shelly L. Gray, Sascha Dublin, Paul K. Crane, Eric B. Larson
Article
Geriatrics & Gerontology
Deborah E. Barnes, Jing Zhou, Rod L. Walker, Eric B. Larson, Sei J. Lee, W. John Boscardin, Zachary A. Marcum, Sascha Dublin
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2020)
Article
Geriatrics & Gerontology
Shelly L. Gray, Zachary A. Marcum, Sascha Dublin, Rod Walker, Negar Golchin, Dori E. Rosenberg, Erin J. Bowles, Paul Crane, Eric B. Larson
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Obstetrics & Gynecology
Lu Chen, Susan M. Shortreed, Thomas Easterling, T. Craig Cheetham, Kristi Reynolds, Lyndsay A. Avalos, Aruna Kamineni, Victoria Holt, Romain Neugebauer, Mary Akosile, Nerissa Nance, Zoe Bider-Canfield, Rod L. Walker, Sylvia E. Badon, Sascha Dublin
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2020)
Article
Public, Environmental & Occupational Health
Dori Rosenberg, Rod Walker, Mikael Anne Greenwood-Hickman, John Bellettiere, Yunhua Xiang, KatieRose Richmire, Michael Higgins, David Wing, Eric B. Larson, Paul K. Crane, Andrea Z. LaCroix
Article
Geriatrics & Gerontology
Oleg Zaslavsky, Onchee Yu, Rod L. Walker, Paul K. Crane, Shelly L. Gray, Tatiana Sadak, Soo Borson, Eric B. Larson
Summary: The study found that incident dementia is associated with an increased rate of potentially preventable hospitalizations (PPHs) in individuals with diabetes, especially PPHs due to diabetes, urinary tract infections (UTIs), and dehydration. Additionally, HbA1c levels above 8% are associated with higher rates of overall PPHs and PPHs related to UTIs and dehydration.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Melinda C. Power, Alia E. Murphy, Kan Z. Gianattasio, Yi Zhang, Rod L. Walker, Paul K. Crane, Eric B. Larson, Laura E. Gibbons, Raj G. Kumar, Kristen Dams-O'Connor
Summary: This study, using data from the Adult Changes in Thought (ACT) cohort study, found no association between military employment and cognitive decline or dementia risk in late life.
Article
Ophthalmology
Cecilia S. Lee, Chloe Krakauer, Yu-Ru Su, Rod L. Walker, Marian Blazes, Susan M. McCurry, James D. Bowen, Wayne C. McCormick, Aaron Y. Lee, Edward J. Boyko, Ann M. O'Hare, Eric B. Larson, Paul K. Crane
Summary: This study indicates that the association between diabetic retinopathy (DR) and dementia and Alzheimer's disease (AD) remains significant even after controlling for several measures of diabetes severity.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Psychology, Clinical
Laura A. Rabin, Sietske A. M. Sikkes, Douglas Tommet, Richard N. Jones, Paul K. Crane, Milushka M. Elbulok-Charcape, Mark A. Dubbelman, Rebecca Koscik, Rebecca E. Amariglio, Rachel F. Buckley, Merce Boada, Gael Chetelat, Bruno Dubois, Kathryn A. Ellis, Katherine A. Gifford, Angela L. Jefferson, Frank Jessen, Sterling Johnson, Mindy J. Katz, Richard B. Lipton, Tobias Luck, Eleni Margioti, Paul Maruff, Jose Luis Molinuevo, Audrey Perrotin, Ronald C. Petersen, Lorena Rami, Barry Reisberg, Dorene M. Rentz, Steffi G. Riedel-Heller, Shannon L. Risacher, Octavio Rodriguez-Gomez, Perminder S. Sachdev, Andrew J. Saykin, Nikolaos Scarmeas, Colette Smart, Beth E. Snitz, Reisa A. Sperling, Vanessa Taler, Wiesje M. van der Flier, Argonde C. van Harten, Michael Wagner, Steffen Wolfsgruber
Summary: This study aimed to link self-perceived cognitive functioning data from international aging studies using item response theory. The results demonstrated that a single-factor structure was reasonable for the latent trait, and identified top items that made the greatest contribution to measurement precision. This allows for joint or pooled analyses across international studies and may lead to the development of new self-perceived cognitive functioning questionnaires.
Article
Psychology, Clinical
Paul K. Crane, Seo-Eun Choi, Michael Lee, Phoebe Scollard, R. Elizabeth Sanders, Brandon Klinedinst, Connie Nakano, Emily H. Trittschuh, Jesse Mez, Andrew J. Saykin, Laura E. Gibbons, Chun Wang, Dan Mungas, Ruoyi Zhu, Nancy S. Foldi, Melissa Lamar, Roos Jutten, Sietske A. M. Sikkes, Evan Grandoit, Laura A. Rabin, Richard N. Jones, Doug Tommet, Shubhabrata Mukherjee
Summary: Objective of this study is to demonstrate measurement precision of cognitive domains in the Alzheimer's Disease Neuroimaging Initiative (ADNI) data set. The study used data from participants with normal cognition (NC), mild cognitive impairment (MCI), and Alzheimer's disease (AD) to calibrate scores for memory, executive function, language, and visuospatial functioning. The results showed variations in measurement precision across cognitive domains in ADNI, with memory having the highest standard error of measurement and visuospatial having the lowest.
Article
Clinical Neurology
Oleg Zaslavsky, Rod L. Walker, Paul K. Crane, Shelly L. Gray, Eric B. Larson
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2020)