Article
Geriatrics & Gerontology
H. Zhang, M. Sun, Z. Hu, Y. Cao, M. Hao, Y. Li, L. Jin, X. Sun, X. Wang, X. Jiang
Summary: This study aimed to investigate the association between arterial stiffness and the risk of functional disability and mobility limitation in older adults. The results showed that arterial stiffness was significantly associated with an increased risk of functional disability and mobility limitation, and the association was nearly linear. These findings suggest that arterial stiffness may serve as an important indicator of declining physical function in older adults.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Public, Environmental & Occupational Health
Daniel Semenza, Ian Silver, Richard Stansfield, Courtney Boen
Summary: This study examines the relationship between neighbourhood disadvantage and functional disability in the USA. The results show that there are variations in this association across age and sex groups. Neighbourhood disadvantage is most consistently associated with increased functional disability among certain age and sex groups.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Geriatrics & Gerontology
Lizhi Guo, Li An, Fengping Luo, Bin Yu
Summary: This longitudinal study in China found a significant association between social isolation and functional disability over 4 years among women, but not men. Loneliness did not show a significant association with disability. This expands our understanding of the link between social relationships and functional status in non-Western populations.
Article
Geriatrics & Gerontology
Jing Guo, Nicole Schupf, Emily Cruz, Yaakov Stern, Richard P. Mayeux, Yian Gu
Summary: The study found an association between Mediterranean diet intake and activities of daily living in older adults. Higher Mediterranean diet scores were associated with a decreased risk of ADL disability.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Clinical Neurology
Hongting Ning, Yan Du, Yinan Zhao, Qingcai Liu, Xiaoyang Li, Hongyu Zhang, Dian Jiang, Hui Feng
Summary: The study found that baseline depressive symptoms were significantly associated with both ADL and IADL disabilities, while metabolic syndrome significantly predicted ADL disability. In addition, some indications showed that the effect in those with both conditions was greater than the sum of the effects separately.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Rehabilitation
Carolina Colomer, Roberto Llorens, Clara Sanchez, Patricia Ugart, Belen Moliner, Maria D. Navarro, Enrique Noe, Joan Ferri
Summary: This study assessed the psychometric properties of the Spanish adaptation of the FIM+FAM Scale and found that it showed excellent reliability and validity. The Spanish-adapted version of the FIM+FAM Scale can be used to evaluate functional independence after stroke.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2023)
Article
Rehabilitation
Quentin Hanot, Valerie Wieczorek, Marion Wypych, Francois Machuron, Andre Thevenon
Summary: The study assessed the test-retest reliability, sensitivity to change, and criterion validity of the Functional Evaluation in Thoracic Outlet Syndrome self-questionnaire. Results showed that the questionnaire had good reliability and sensitivity to change, making it a quick, simple tool for evaluating the impact of thoracic outlet syndrome on daily activities.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Cardiac & Cardiovascular Systems
Matthias Bosman, Dustin Kruger, Charles Van Assche, Hanne Boen, Cedric Neutel, Kasper Favere, Constantijn Franssen, Wim Martinet, Lynn Roth, Guido R. Y. De Meyer, Berta Cillero-Pastor, Leen Delrue, Ward Heggermont, Emeline M. Van Craenenbroeck, Pieter-Jan Guns
Summary: Apart from cardiotoxicity, the chemotherapeutic doxorubicin (DOX) induces vascular toxicity, represented by arterial stiffness and endothelial dysfunction. DOX-induced arterial stiffness precedes reduced left ventricular ejection fraction (LVEF), while vascular dysfunction restores after DOX therapy cessation. THBS1 and SERPINA3 are promising biomarkers of DOX-induced cardiovascular toxicity and elevated in anthracycline-induced cardiotoxicity patients.
CARDIOVASCULAR RESEARCH
(2023)
Article
Neurosciences
Vaisakh Puthusseryppady, Allan Bregola, Julieta Camino, Tamara Backhouse, Eneida Mioshi
Summary: This study found that cognitive changes are the main factor contributing to the long-term decline in activities of daily living (ADL) performance for people living with dementia (PLwD). The management styles of caregivers were associated with current ADL performance but not with the longitudinal decline in ADL.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Satoko Fujihara, Yasuhiro Miyaguni, Taishi Tsuji, Katsunori Kondo
Summary: This study examines the contextual association between types of community-level social participation and functional disability. The results show that community-level sports and hobby group participation have a beneficial effect on preventing functional disability among older adults. Particularly, females benefit more from community-level social participation. Promoting sports and hobby groups in a community may help prevent functional disability among older adults.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Editorial Material
Clinical Neurology
Mark J. Edwards
Summary: Patients with medically unexplained or functional symptoms, often avoided by health professionals, may hold the key to a more successful, meaningful, and just system of medical practice. They prompt us to consider the human and participatory aspect of illness, which is often neglected in medical training and practice. There is room for improvement in addressing this aspect in healthcare.
Article
Health Care Sciences & Services
Liliana Duca, Nadinne Alexandra Roman, Aliana Miron, Andreea Teodorescu, Lorena Dima, Petru Ifteni
Summary: This study investigates the impact of depression and anxiety on patients with systemic lupus erythematosus (SLE) and the suitability of the World Health Organization-Disability Assessment Schedule (WHODAS) 2.0 for evaluating SLE patients with these symptoms. The results demonstrate a high prevalence of depression and anxiety in SLE patients, leading to increased disability and decreased quality of life. The WHODAS assessment is proven to be a valuable tool for evaluating the functioning of SLE patients.
Article
Geriatrics & Gerontology
Junko Saito, Hiroshi Murayama, Takayuki Ueno, Masashige Saito, Maho Haseda, Tami Saito, Katsunori Kondo, Naoki Kondo
Summary: This study aimed to identify distinct trajectories of disability and their associated factors among older adults in Japan. Five trajectories of functional disability were identified, and self-rated health was found to be a common predictor. Additionally, higher education was associated with a higher probability of more severe functional decline in older men.
Article
Gerontology
Joelle H. Fong, Yongjoon Youn
Summary: This study examined the stability over time of activities of daily living (ADL) items in three different countries and found that dressing and bathing were relatively more difficult for older adults in all study populations. The results support the use of ADL scales as screening tools and interventions to reduce dependency in bathing and dressing can help improve independent functioning for community-dwelling older adults.
Article
Geriatrics & Gerontology
Yun Seo Jang, Il Yun, Yu Shin Park, Eun-Cheol Park, Sung-In Jang
Summary: A long-term study in Korea found that sensory impairment, especially dual sensory impairment, has a significant impact on functional disabilities in older adults. The results indicate that early intervention for sensory impairment can help prevent functional disabilities and improve the quality of life for older individuals.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Critical Care Medicine
Jason R. Falvey, Terrence E. Murphy, Linda Leo-Summers, Thomas M. Gill, Lauren E. Ferrante
Summary: Neighborhood socioeconomic disadvantage is associated with a higher disability burden in the 12 months after a critical illness. Future studies should evaluate barriers to functional recovery for ICU survivors living in disadvantaged neighborhoods.
CRITICAL CARE MEDICINE
(2022)
Article
Geriatrics & Gerontology
Erwin Stolz, Hannes Mayerl, Wolfgang Freidl, Regina Roller-Wirnsberger, Thomas M. Gill
Summary: The study found that intrinsic capacity (IC) declines progressively in older adults and predicts negative health outcomes. Regular monitoring of IC could work as an early warning system to inform preventive efforts, reducing risks such as impaired activities of daily living, long-term nursing home stay, and mortality.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Lauren E. Ferrante, Terrence E. Murphy, Linda S. Leo-Summers, John R. O'Leary, Brent Vander Wyk, Margaret A. Pisani, Thomas M. Gill
Summary: A prediction model has been developed and validated to identify high-risk older adults who may experience persistent functional impairment in the year following an ICU hospitalization. This model, which includes factors such as age, pre-ICU disability, and comorbidities, can help healthcare providers target interventions and follow-up care for these individuals.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Clinical Neurology
Kevin N. Vanent, Audrey C. Leasure, Julian N. Acosta, Lindsey R. Kuohn, Daniel Woo, Santosh B. Murthy, Hooman Kamel, Steven R. Messe, Michael T. Mullen, Jordana B. Cohen, Debbie L. Cohen, Raymond R. Townsend, Nils H. Petersen, Lauren H. Sansing, Thomas M. Gill, Kevin N. Sheth, Guido J. Falcone
Summary: This study found an association between chronic kidney disease (CKD) and an increased risk of spontaneous intracerebral hemorrhage (ICH) through observational and genetic analyses. Mendelian randomization analyses suggest a causal relationship. Further research is needed to identify the specific biological pathways involved.
Article
Surgery
Thomas M. Gill, Brent Vander Wyk, Linda Leo-Summers, Terrence E. Murphy, Robert D. Becher
Summary: Despite the significance of geriatric surgery in public health decision-making and policies, there is a lack of contemporary nationally representative mortality data. This study aimed to calculate population-based estimates of mortality after major surgery in community-living older adults in the US and investigate the differences based on key demographic, surgical, and geriatric characteristics. The findings highlight the elevated mortality rates among frail older adults and those with probable dementia, suggesting the prognostic value of geriatric conditions after major surgery.
Article
Geriatrics & Gerontology
Brienne Miner, Margaret Doyle, Melissa Knauert, Henry Klar Yaggi, Katie L. Stone, Sonia Ancoli-Israel, Jane A. Cauley, Susan Redline, Terri Blackwell, Thomas M. Gill
Summary: ISSD, characterized by insomnia or poor sleep quality with short sleep duration, is common among older adults and is associated with various factors. Future research should focus on determining causal relationships and whether these factors are modifiable risk factors.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Natalia Festa, John Hsu, James K. K. Hammitt, Thomas M. M. Gill
Summary: Although environmental pollution and societal aging are concurrent public health challenges, the relationship between the two is rarely considered. The current approach to valuing public health benefits of environmental policy may not be suitable for aging populations. We describe the limitations of the age-invariant approach used by the US EPA for estimating public health benefits of environmental regulation. We offer an empirical framework that could address these limitations and improve the calibration of environmental regulatory analysis to the changing age distribution of the US population.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Clinical Neurology
Julian N. Acosta, Cameron P. Both, Zachariah S. Demarais, Carolyn J. Conlon, Audrey C. Leasure, Victor M. Torres-Lopez, Adam de Havenon, Nils H. Petersen, Thomas M. Gill, Lauren H. Sansing, Kevin N. Sheth, Guido J. Falcone
Summary: This study examines the relationship between genetic susceptibility to hypertension and blood pressure control in stroke survivors. The results show that stroke survivors with higher genetic susceptibility tend to have worse blood pressure control, with a higher prevalence of uncontrolled and resistant hypertension.
Article
Medicine, General & Internal
Natalia Festa, Kaitlin F. Throgmorton, Nora Heaphy, Maureen Canavan, Thomas M. Gill
Summary: This study examined the preparedness of US nursing homes in coastal areas for hurricane-related inundation and found regional variations in emergency preparedness. Some areas showed deficiencies in emergency preparedness, while there were opportunities to reduce regional heterogeneity and improve nursing home preparedness.
Article
Medicine, General & Internal
Xingqi Cao, Zhenqing Yang, Xueqin Li, Chen Chen, Emiel O. Hoogendijk, Jingyun Zhang, Nengliang Aaron Yao, Lina Ma, Yawei Zhang, Yong Zhu, Xuehong Zhang, Yuxian Du, Xiaofeng Wang, Xifeng Wu, Thomas M. Gill, Zuyun Liu
Summary: Using two widely used frailty indicators, this study found that frailty, even in the very early stage, was positively associated with the incidence risk of cardiovascular disease and type 2 diabetes mellitus among long-term cancer survivors.
Article
Geriatrics & Gerontology
Thomas M. M. Gill, Ling Han, Terrence E. E. Murphy, Shelli L. L. Feder, Evelyne A. A. Gahbauer, Linda Leo-Summers, Robert D. D. Becher
Summary: Little is known about how distressing symptoms change among older persons after major surgery. This study found that the occurrence and number of distressing symptoms increased substantially after major surgery, especially in nonelective procedures. Men had a greater increase in symptoms compared to women. Reducing symptom burden can improve quality of life and functional outcomes after major surgery.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Julie A. A. Womack, Terrence E. E. Murphy, Linda Leo-Summers, Jonathan Bates, Samah Jarad, Thomas M. M. Gill, Evelyn Hsieh, Maria C. C. Rodriguez-Barradas, Phyllis C. C. Tien, Michael T. T. Yin, Cynthia A. A. Brandt, Amy C. C. Justice
Summary: Among older individuals living with HIV, risk factors commonly associated with serious falls and fragility fractures in the general population also play a significant role.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Review
Geriatrics & Gerontology
Emily J. Smail, Jordan M. Alpert, Mamoun T. Mardini, Christopher N. Kaufmann, Chen Bai, Thomas M. Gill, Roger B. Fillingim, Erta Cenko, Ruben Zapata, Yashaswi Karnati, Michael Marsiske, Sanjay Ranka, Todd M. Manini
Summary: This study introduces a Real-time Online Assessment and Mobility Monitor (ROAMM) smartwatch application that captures daily fluctuations in mobility in ecological settings. The usability and feasibility of ROAMM were assessed using a sample of 31 participants, showing high satisfaction and engagement. Some features of the smartwatch were correlated with traditional measurements, indicating its potential contribution to mobility measurement and risk factors for mobility decline.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Erwin Stolz, Hannes Mayerl, Graciela Muniz-Terrera, Thomas M. Gill
Summary: This study reveals that there is a terminal decline in physical function among older adults, which is comparable to the established terminal decline phenomenon in cognition and may be associated with impending death.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
Daniela Renedo, Julian N. Acosta, Andrew B. Koo, Cyprien Rivier, Nanthiya Sujijantarat, Adam de Havenon, Richa Sharma, Thomas M. Gill, Kevin N. Sheth, Guido J. Falcone, Charles C. Matouk
Summary: This study aims to investigate the relationship between the hospital frailty risk score (HFRS) and the risk of stroke, as well as to determine whether there is a significant association between genetically determined frailty and stroke. The results showed that frailty status is positively associated with the risk of stroke, and genetically determined frailty is independently associated with the risk of stroke.