Article
Geriatrics & Gerontology
Jessica Orth, Yue Li, Adam Simning, Sheryl Zimmerman, Helena Temkin-Greener
Summary: Decedents with ADRD in nonprofit NHs, Alzheimer's units, higher licensed nurse staffing, and more competitive markets had better EOL care/outcomes. State Medicaid NH payments modifications may promote better EOL care/outcomes. Future research on NH care practices associated with Alzheimer's units is needed to identify mechanisms for promoting higher-quality EOL care.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Geriatrics & Gerontology
Alirameen Akram, Francesca Nicosia, Jennifer Lee, Maria Lee, Lynn Martin, Steven Martinez, Cherry Ordonez, Michele Woo, Deborah E. Barnes
Summary: The study evaluated the implementation of the PLIe program at a VA nursing home and found that participants experienced significant improvements in physical, psychological, social, and cognitive domains, with high satisfaction rates. Participants reported positive effects on themselves and others, especially in terms of physical abilities, mental well-being, social relationships, and cognitive functioning.
Article
Geriatrics & Gerontology
Meghan Hendricksen, Daniel Habtemariam, Erika M. C. D'Agata, Susan L. Mitchell
Summary: Around 13.7% of nursing home residents with advanced dementia received antimicrobials in the 2 months prior to the study. Facility-level characteristics, such as having a full time nurse practitioner/physician assistant and fewer existing infectious disease practices, were significantly associated with antimicrobial use, while resident characteristics were not independently associated.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Geriatrics & Gerontology
Lihui Pu, Christian Bakker, Britt Appelhof, Sandra A. Zwijsen, Steven Teerenstra, Martin Smalbrugge, Frans R. J. Verhey, Marjolein E. de Vugt, Sytse U. Zuidema, Raymond T. C. M. Koopmans
Summary: The study found that while overall QoL in YOD patients in nursing homes remained relatively stable over 18 months, there were multidirectional changes in QoL subscales, with some scores increasing and some decreasing. Patients with higher levels of QoL and more advanced dementia were more likely to experience a decline in QoL over time.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Geriatrics & Gerontology
Tadeja Gracner, Patricia W. Stone, Mansi Agarwal, Mark Sorbero, Susan L. Mitchell, Andrew W. Dick
Summary: This study compared mortality risk factors and survival between nursing home residents with advanced Alzheimer's disease and Alzheimer's disease related dementia, revealing distinct patterns of survival and mortality between the two groups.
Article
Geriatrics & Gerontology
Deborah S. Lee, Andrew R. Zullo, Yoojin Lee, Lori A. Daiello, Dae Hyun Kim, Douglas P. Kiel, Sarah D. Berry
Summary: Beta-blockers are commonly prescribed to nursing home residents in their last year of life, but discontinuation occurs earlier in those where clinicians perceive limited life expectancy or poor prognosis, indicating potential for reducing polypharmacy towards end of life.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Public, Environmental & Occupational Health
Laura Bavelaar, Maria Nicula, Sophie Morris, Sharon Kaasalainen, Wilco P. Achterberg, Martin Loucka, Karolina Vlckova, Genevieve Thompson, Nicola Cornally, Irene Hartigan, Andrew Harding, Nancy Preston, Catherine Walshe, Emily Cousins, Karen Harrison Dening, Kay De Vries, Kevin Brazil, Jenny T. van der Steen
Summary: This study aimed to develop question prompt lists (QPLs) for family caregivers of nursing home residents with advanced dementia and explore cross-national differences. The findings revealed that family caregivers have many questions about dementia palliative care, but the local context may influence the specific questions asked.
PATIENT EDUCATION AND COUNSELING
(2022)
Article
Economics
Robert J. Brent
Summary: This study identifies and evaluates four categories of benefits associated with not living in a nursing home (NH), focusing on the Quality Adjusted Life Year (QALY) outcome effect. The results show that NHs have direct and indirect effects on the quality of life and life expectancy through increased dementia symptoms. The valuation of QALY effects is based on literature regarding the value of a statistical life year. Additionally, the study considers the savings from not incurring expenses for a NH as a fifth category of foregone benefits. The total losses incurred amount to $1.93 trillion.
Article
Geriatrics & Gerontology
Helena Temkin-Greener, Di Yan, Sijiu Wang, Shubing Cai
Summary: This study explores racial disparities in end-of-life hospitalizations for residents with ADRD within and across nursing homes. The results show higher risk of hospitalizations for black decedents compared to whites, even among those with severe cognitive impairment. Disparities exist both within and across facilities, indicating systemic differences in care quality based on residents' race.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Geriatrics & Gerontology
Matthias Hoben, Emily Dymchuk, Kyle Corbett, Rashmi Devkota, Shovana Shrestha, Jenny Lam, Sube Banerjee, Stephanie A. Chamberlain, Greta G. Cummings, Malcolm B. Doupe, Yinfei Duan, Janice Keefe, Hannah M. O'Rourke, Seyedehtanaz Saeidzadeh, Yuting Song, Carole A. Estabrooks
Summary: This study examined the association between COVID-19 outbreaks, access to geriatric professionals, care aide burnout, and the quality of life (QoL) of nursing home residents. The results showed that recent COVID-19 outbreaks, high levels of emotionally exhausted care aides, and lack of access to geriatric professionals were significantly associated with poorer QoL among nursing home residents.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Nursing
Melanie van der Velde-van Buuringen, Wilco P. Achterberg, Monique A. A. Caljouw
Summary: This study aimed to evaluate the process of daily going outside in a nursing home garden and explore the effect of garden use on quality of life and neuropsychiatric symptoms in persons with dementia. Results showed that caregivers experienced and observed benefits of going outside for themselves, in residents and relatives. Incorporating daily garden use does not imply an additional task, but rather rearranging priorities and doing the usual activities outside a part of the time.
Article
Geriatrics & Gerontology
Ellen M. McCreedy, Xiaofei Yang, Susan L. Mitchell, Roee Gutman, Joan Teno, Lacey Loomer, Patience Moyo, Angelo Volandes, Pedro L. Gozalo, Emmanuelle Belanger, Jessica Ogarek, Vincent Mor
Summary: The purpose of the study was to evaluate the impact of an ACP Video Program on documented DNH orders among nursing home residents with advanced illness. The results showed that compared to usual care, the ACP Video Program intervention increased the proportion of residents with new DNH orders, but did not significantly reduce hospitalizations.
Article
Geriatrics & Gerontology
Victoria Shepard, Lin-Na Chou, Yong-Fang Kuo, Mukaila Raji
Summary: This study investigated factors associated with feeding tube (FT) placement in advanced dementia among nursing home residents in Texas. It found that age, race, provider type, and regional differences played a role in the prevalence of FT placement. Regional, racial, and ethnic variations suggest opportunities to improve the quality of end-of-life care for minorities living in border towns.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Geriatrics & Gerontology
Meghan Hendricksen, Susan L. Mitchell, Ruth Palan Lopez, Ashley Roach, Anita Hendrix Rogers, Harriet Akunor, Ellen P. McCarthy
Summary: This study explored the experiences of nursing home staff and proxies during the COVID-19 pandemic. Staff faced difficulties implementing infection control policies for advanced dementia residents, while proxies emphasized the challenges of being separated from their loved ones. Additionally, the majority of proxies expressed deep appreciation for the care provided by nursing home staff.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Shekinah A. Fashaw-Walters, Ellen McCreedy, Julie P. W. Bynum, Kali S. Thomas, Theresa Shireman
Summary: The research demonstrated an increase in schizophrenia diagnoses among nursing home residents, especially for those with Alzheimer's and related dementia. After the partnership, there was a significant increase in schizophrenia diagnoses for Black residents with ADRD.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Psychology, Clinical
Gretha J. Boersma, Yada Treesukosol, Zachary A. Cordner, Anneke Kastelein, Pique Choi, Timothy H. Moran, Kellie L. Tamashiro
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2016)
Article
Psychiatry
Z. A. Cordner, K. L. K. Tamashiro
TRANSLATIONAL PSYCHIATRY
(2016)
Article
Genetics & Heredity
Weiyi Mu, Zachary A. Cordner, Kevin Yuqi Wang, Kate Reed, Gina Robinson, Sally Mitchell, Doris Lin
GENETICS IN MEDICINE
(2018)
Article
Endocrinology & Metabolism
Lin Song, Bo Sun, Gretha J. Boersma, Zachary A. Cordner, Jianqun Yan, Timothy H. Moran, Kellie L. K. Tamashiro
Article
Psychology, Biological
Anjali Chawla, Zachary A. Cordner, Gretha Boersma, Timothy H. Moran
PHYSIOLOGY & BEHAVIOR
(2017)
Article
Multidisciplinary Sciences
Shanshan Zhu, Zachary A. Cordner, Jiali Xiong, Chi-Tso Chiu, Arabiye Artola, Yanning Zuo, Andrew D. Nelson, Tae-Yeon Kim, Natalya Zaika, Brian M. Woolums, Evan J. Hess, Xiaofang Wang, De-Maw Chuang, Mikhail M. Pletnikov, Paul M. Jenkins, Kellie L. Tamashiro, Christopher A. Ross
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
Yan Yang, Pique P. Choi, Wanli W. Smith, Weijie Xu, Delin Ma, Zachary A. Cordner, Nu-Chu Liang, Timothy H. Moran
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Benjamin Hing, Patricia Braun, Zachary A. Cordner, Erin R. Ewald, Laura Moody, Melissa McKane, Virginia L. Willour, Kellie L. Tamashiro, James B. Potash
Article
Biochemistry & Molecular Biology
Seva G. Khambadkone, Zachary A. Cordner, Faith Dickerson, Emily G. Severance, Emese Prandovszky, Mikhail Pletnikov, Jianchun Xiao, Ye Li, Gretha J. Boersma, C. Conover Talbot, Wayne W. Campbell, Christian S. Wright, C. Evan Siple, Timothy H. Moran, Kellie L. Tamashiro, Robert H. Yolken
MOLECULAR PSYCHIATRY
(2020)
Article
Neurosciences
Zachary A. Cordner, Seva G. Khambadkone, Gretha J. Boersma, Lin Song, Tyler N. Summers, Timothy H. Moran, Kellie L. K. Tamashiro
EXPERIMENTAL NEUROLOGY
(2019)
Review
Endocrinology & Metabolism
Seva G. Khambadkone, Zachary A. Cordner, Kellie L. K. Tamashiro
FRONTIERS IN NEUROENDOCRINOLOGY
(2020)
Article
Medicine, Research & Experimental
Zachary A. Cordner, Qian Li, Liansheng Liu, Kellie L. Tamashiro, Aditi Bhargava, Timothy H. Moran, Pankaj Jay Pasricha
Summary: Functional dyspepsia (FD) is associated with abnormal gastric signals affecting the vagus nerve, which leads to changes in affective and pain behavior in key brain regions. FD rats exhibit increased vagal activity in response to gastric distention, as well as gastric mast cell hyperplasia and alterations in Crh signaling in the amygdala. Subdiaphragmatic vagotomy reverses these changes and restores behavior, suggesting a bottom-up pathway involving the gut-brain axis in the pathogenesis of FD symptoms.
Article
Neurosciences
Zachary A. Cordner, Isaiah Marshall-Thomas, Gretha J. Boersma, Richard S. Lee, James B. Potash, Kellie L. K. Tamashiro
Summary: The study found that social defeat stress has long-term effects on behavior and gene expression. Fluoxetine and environmental enrichment have similar behavioral recovery effects on social defeat-induced depression and anxiety-like phenotypes, but have divergent effects on gene expression in the amygdala.
NEUROBIOLOGY OF STRESS
(2021)
Review
Psychiatry
Kate Levenberg, Zachary A. Cordner
Summary: Bipolar depression (BD-D) is a common and challenging condition to treat. There are relatively few approved treatment options for BD-D, with most of them being second-generation antipsychotics. Long-term use of antipsychotics carries a significant risk of adverse effects, and the decision to use them must be weighed against the risk of relapse when patients are off medications. This article reviews commonly used treatments for BD-D, discusses the controversial topic of antidepressant use, and summarizes emerging treatment options and ongoing clinical trials.
GENERAL PSYCHIATRY
(2022)
Review
Pharmacology & Pharmacy
Chad A. Bousman, Susanne A. Bengesser, Katherine J. Aitchison, Azmeraw T. Amare, Harald Aschauer, Bernhard T. Baune, Bahareh Behroozi Asl, Jeffrey R. Bishop, Margit Burmeister, Boris Chaumette, Li-Shiun Chen, Zachary A. Cordner, Juergen Deckert, Franziska Degenhardt, Lynn E. DeLisi, Lasse Folkersen, James L. Kennedy, Teri E. Klein, Joseph L. McClay, Francis J. McMahon, Richard Musil, Nancy L. Saccone, Katrin Sangkuhl, Robert M. Stowe, Ene-Choo Tan, Arun K. Tiwari, Clement C. Zai, Gwyneth Zai, Jianping Zhang, Andrea Gaedigk, Daniel J. Mueller
Summary: The implementation of pharmacogenomic testing in psychiatry is limited, but specific genes have been identified to guide the selection and dosing of certain antidepressant and antipsychotic medications.
PHARMACOPSYCHIATRY
(2021)
