☆ 4.6 Letter

CAN COGNITIVE ENHANCERS REDUCE THE RISK OF FALLS IN PEOPLE WITH DEMENTIA? AN OPEN-LABEL STUDY WITH CONTROLS

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2009)

期刊

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

卷 57, 期 2, 页码 359-360

出版社

WILEY

DOI: 10.1111/j.1532-5415.2009.02085.x

关键词

-

类别

Geriatrics & Gerontology Gerontology

资金

CIHR [102491-1] Funding Source: Medline

向作者/读者索取更多资源

Protocol

Reagent

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Review Geriatrics & Gerontology

Therapeutic dilemmas: cognitive enhancers and risk of falling in older adults-a clinical review

Gabbie E. Portlock, Matthew D. Smith, Eveline P. van Poelgeest, Tomas James Welsh

Summary: This article summarizes the falls-related risks of cognitive enhancing medications used to treat neurodegenerative conditions and explores the factors that should be considered when reviewing the ongoing use of these medications. Cognitive enhancer use is associated with multiple fall-related side effects, particularly in the initial weeks of administration and up-titration. Acetylcholinesterase inhibitors and memantine differ in their fall-related side effect profiles.

EUROPEAN GERIATRIC MEDICINE (2023)

添加到收藏夹

Review Cell Biology

Risk factors for falls in older people with cognitive impairment living in the community: Systematic review and meta-analysis

Thanwarat Chantanachai, Daina L. Sturnieks, Stephen R. Lord, Narelle Payne, Lyndell Webster, Morag E. Taylor

Summary: This systematic review identified risk factors for prospectively ascertained falls in older people with cognitive impairment living in the community. Balance deficits, poor mobility, slow gait speed, and depressive symptoms were found to be associated with fallers. Global cognition was not significantly associated with falls, suggesting interventions should focus on improving balance impairment. More high-quality research is needed to support these findings.

AGEING RESEARCH REVIEWS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Imaginary pills and open-label placebos can reduce test anxiety by means of placebo mechanisms

Sarah Buergler, Dilan Sezer, Niels Bagge, Irving Kirsch, Cosima Locher, Claudia Carvalho, Jens Gaab

Summary: This study evaluated placebo effects without the use of a physical placebo by imagining taking a pill. The results showed that both open-label placebos and imaginary pills reduced test anxiety. This finding provides a novel and ethical method to harness placebo effects.

SCIENTIFIC REPORTS (2023)

添加到收藏夹

Article Geriatrics & Gerontology

Modified STEADI Fall Risk Categories Predict Incident Cognitive Impairment

Rebecca S. Crow, Christian Haudenschild, Matthew C. Lohman, Robert M. Roth, Meredith Roderka, Travis Masterson, John Brand, Tyler Gooding, Todd A. Mackenzie, John A. Batsis

Summary: The study indicates that older adults with high fall risk but without cognitive impairment have nearly twice the risk of cognitive decline after an 8-year follow-up period.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Longitudinal associations between falls and future risk of cognitive decline, the Motoric Cognitive Risk syndrome and dementia: the Einstein Ageing Study

Oshadi Jayakody, Helena M. Blumen, Monique Breslin, Emmeline Ayers, Richard B. Lipton, Joe Verghese, Michele L. Callisaya

Summary: Multiple falls may be an important marker to identify older people at greater risk of future cognitive decline and incident MCR.

AGE AND AGEING (2022)

添加到收藏夹

Editorial Material Neurosciences

Exercise for Preventing Falls in People with Dementia: Time to Work Together

Mathieu Maltais

Summary: Over the past two decades, systematic reviews and meta-analyses have yielded conflicting results regarding the impact of exercise on fall reduction in individuals with dementia. A recent systematic review published in the Journal of Alzheimer's Disease identified positive outcomes in only two studies, suggesting insufficient data to support the effectiveness of exercise interventions in reducing falls. This commentary highlights the importance of interdisciplinary approaches in reducing falls among this vulnerable population.

JOURNAL OF ALZHEIMERS DISEASE (2023)

添加到收藏夹

Review Clinical Neurology

Edible Bird's Nest as a Potential Cognitive Enhancer

Su-Peng Loh, Shi-Hui Cheng, Wael Mohamed

Summary: This article introduces the potential therapeutic effects of edible bird's nest in improving cognitive function, including its effectiveness in enhancing brain development in mammals. It also discusses the impact of edible bird's nest on learning and memory control, as well as its potential as a cognitive enhancer drug.

FRONTIERS IN NEUROLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial

Md. Habibur Rahman, Johny Bajgai, Subham Sharma, Eun-Sook Jeong, Seong Hoon Goh, Yeon-Gyu Jang, Cheol-Su Kim, Kyu-Jae Lee

Summary: This study investigated the effects of 4 weeks of hydrogen gas inhalation on community-dwelling adults of various ages. The results showed that hydrogen gas inhalation did not adversely affect white blood cell counts, and oxidative stress markers and dementia-related biomarkers improved. Therefore, hydrogen gas inhalation may be a good treatment option for cognitive dysfunction and improvement of Alzheimer's disease.

ANTIOXIDANTS (2023)

添加到收藏夹

Article Health Care Sciences & Services

Understanding Cognitive Deficits in People with High Blood Pressure

Weixi Kang, Sonia Pineda Hernandez

Summary: This study found that individuals with high blood pressure exhibited impaired performance in domains such as immediate and delayed word recall, animal naming, number series, and numeracy tasks. Clinicians should incorporate these tasks into the neuropsychological assessment of individuals with high blood pressure and explore strategies to improve their cognitive performance.

JOURNAL OF PERSONALIZED MEDICINE (2023)

添加到收藏夹

Article Clinical Neurology

Cognitive frailty and falls in Chinese elderly people: a population-based longitudinal study

Y. Ma, X. Li, Y. Pan, R. Zhao, X. Wang, X. Jiang, S. Li

Summary: Cognitive frailty was found to be associated with falls in older people in a population-based longitudinal study. It may serve as a risk factor for falls, and early screening might be beneficial in fall prevention.

EUROPEAN JOURNAL OF NEUROLOGY (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Exercise program to reduce the risk of cognitive decline and physical frailty in older adults: study protocol for an open label double-arm clinical trial

Moeko Noguchi-Shinohara, Kunihiko Yokoyama, Junji Komatsu, Kazumi Masuda, Mitsunobu Kouno, Mitsuhiro Yoshita, Kenjiro Ono

Summary: This study aims to prevent cognitive decline and improve physical function in older adults through a exercise program and nutritional lectures. The study includes physical exercise training once a week, nutritional lectures once a month for 5 months, and follow-up for at least 1 year. The primary endpoint is the effectiveness of the program in preventing cognitive decline, while secondary endpoints include the incidence of MCI and dementia, physical testing, and frailty proportion.

FRONTIERS IN AGING NEUROSCIENCE (2023)

添加到收藏夹

Article Medicine, General & Internal

Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial

Isla S. Mackenzie, Amy Rogers, Neil R. Poulter, Bryan Williams, Morris J. Brown, David J. Webb, Ian Ford, David A. Rorie, Greg Guthrie, J. W. Kerr Grieve, Filippo Pigazzani, Peter M. Rothwell, Robin Young, Alex McConnachie, Allan D. Struthers, Chim C. Lang, Thomas M. MacDonald

Summary: The TIME study aimed to investigate whether evening dosing of antihypertensive medication improves cardiovascular outcomes compared with morning dosing. The results showed that there was no difference in major cardiovascular outcomes between evening dosing and morning dosing, and patients can choose a convenient time to take their medications.

LANCET (2022)

添加到收藏夹

Article Geriatrics & Gerontology

Tailored Exercise and Home Hazard Reduction Program for Fall Prevention in Older People With Cognitive Impairment: The i-FOCIS Randomized Controlled Trial

Morag E. Taylor, Jacqueline Wesson, Catherine Sherrington, Keith D. Hill, Susan Kurrle, Stephen R. Lord, Henry Brodaty, Kirsten Howard, Sandra D. O'Rourke, Lindy Clemson, Narelle Payne, Barbara Toson, Lyndell Webster, Roslyn Savage, Genevieve Zelma, Cecelia Koch, Beatrice John, Keri Lockwood, Jacqueline C. T. Close

Summary: The intervention aimed at preventing falls in older people with cognitive impairment did not significantly reduce the overall fall rate, but did show a significant reduction in participants with better baseline physical function.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Poor Cognitive Agility Conservation in Obese Aging People

Teresa Pardo-Moreno, Himan Mohamed-Mohamed, Antonio Rivas-Dominguez, Victoria Garcia-Morales, Ruben A. Garcia-Lara, Sami Suleiman-Martos, Beatriz Bermudez-Pulgarin, Juan Jose Ramos-Rodriguez

Summary: Life expectancy has increased but age-associated diseases, especially dementia, have become more prevalent. The development of dementia is influenced by various risk factors, including metabolic pathologies such as obesity and diabetes. However, a high level of education and moderate physical activity are protective factors against cognitive impairment and dementia. In this study, we assessed the metabolic composition of mentally healthy individuals aged 60-90 with high academic degrees. The results indicated that excess body fat was associated with poorer cognitive maintenance, while higher muscle mass percentage was associated with better cognitive abilities.

BIOMEDICINES (2023)

添加到收藏夹

Article Health Care Sciences & Services

Can clinician champions reduce potentially inappropriate medications in people living with dementia? Study protocol for a cluster randomized trial

Michael L. Parchman, Jennifer Perloff, Grant Ritter

Summary: This study protocol outlines a 24-month clinical trial to assess the effectiveness of a clinician champion intervention on de-implementing potentially inappropriate medications in people with dementia. The trial will also examine the impact of the intervention on reducing emergency department visits and hospitalizations attributed to falls, as well as the implementation outcomes of appropriateness, feasibility, fidelity, penetration, and equity.

IMPLEMENTATION SCIENCE (2022)

添加到收藏夹

Article Geriatrics & Gerontology

Cognitive and neuroimaging profiles of older adults with dual decline in memory and gait speed

Qu Tian, Stephanie A. Studenski, Manuel Montero-Odasso, Christos Davatzikos, Susan M. Resnick, Luigi Ferrucci

Summary: The study found that individuals experiencing dual decline in memory and gait speed showed steeper declines in multiple cognitive domains and greater brain volume loss in areas related to cognition, sensorimotor function, and locomotion compared to others. Impaired sensorimotor integration and locomotion were identified as underlying features of dual decline, suggesting a potential connection to the increased risk of dementia.

NEUROBIOLOGY OF AGING (2021)

添加到收藏夹

Review Cell Biology

Potentially modifiable risk factors for slow gait in community-dwelling older adults: A systematic review

Erica Figgins, Frederico Pieruccini-Faria, Mark Speechley, Manuel Montero-Odasso

Summary: This systematic review aimed to identify potentially modifiable risk factors associated with slow gait speed and clinically meaningful gait speed decline in older community-dwelling adults. The results suggest that physical activity, education level, body mass index-obesity, pain, and depression/depressive symptoms are commonly investigated risk factors showing significant associations with slow gait and/or meaningful gait speed decline. The findings support the idea that there are modifiable targets for maintaining gait speed that can be targeted for potential treatment.

AGEING RESEARCH REVIEWS (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Motor Imagery Deficits in High-Functioning Older Adults and Its Impact on Fear of Falling and Falls

Ryota Sakurai, Manuel Montero-Odasso, Hiroyuki Suzuki, Susumu Ogawa, Yoshinori Fujiwara

Summary: This study found that cognitive differences in imagery and execution of actions in older adults are associated with the onset of FoF and future falls. Overestimating physical capabilities may increase the risk of daily activity hazards.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

添加到收藏夹

Review Cell Biology

The role of physical exercise in modulating peripheral inflammatory and neurotrophic biomarkers in older adults: A systematic review and meta-analysis

Josh Titus, Nick W. Bray, Nellie Kamkar, Richard Camicioli, Lindsay S. Nagamatsu, Mark Speechley, Manuel Montero-Odasso

Summary: Different exercise modalities have diverse effects on blood biomarker concentrations in older adults. Aerobic training may increase or not significantly change BDNF, while resistance training can increase or not significantly change IGF-1. The results also show that multimodal training significantly increased or did not change BDNF concentrations.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

添加到收藏夹

Review Cell Biology

The effect of physical exercise on functional brain network connectivity in older adults with and without cognitive impairment. A systematic review

Nick W. Bray, Frederico Pieruccini-Faria, Robert Bartha, Timothy J. Doherty, Lindsay S. Nagamatsu, Manuel Montero-Odasso

Summary: The study found that physical exercise increases functional brain network connectivity (FBNC) in older adults, leading to significant improvements in cognitive and physical performance. However, careful consideration must be given to various factors when assessing the association between FBNC and physical and cognitive functioning.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

添加到收藏夹

Review Rehabilitation

The effect of dual-task testing on the balance and gait of people with lower limb amputations: A systematic review

Humberto Omana, Edward Madou, Manuel Montero-Odasso, Michael W. Payne, Ricardo Viana, Susan W. Hunter

Summary: This study systematically reviewed the literature on the effect of dual-task testing on the balance and gait of people with lower limb amputations, and found that individuals with lower limb amputations demonstrated greater instability and abnormal gait during dual-task testing. Further research is needed to understand how specific factors related to lower limb amputations influence dual-task performance.

PM&R (2023)

添加到收藏夹

Article Clinical Neurology

The apathy, gait impairment, and executive dysfunction (AGED) triad vascular variant

Vladimir Hachinski, Elizabeth Finger, Frederico Pieruccini-Faria, Manuel Montero-Odasso

Summary: Apathy, gait disturbances, and executive dysfunction (AGED) often occur together, and the presence of one might indicate the presence of another. Vascular etiology is the most common, treatable, and preventable cause, and we need methods for determining optimal individual blood pressures.

ALZHEIMERS & DEMENTIA (2022)

添加到收藏夹

Editorial Material Clinical Neurology

Multidomain trials to prevent dementia: addressing methodological challenges

Manuel Montero-Odasso, G. Y. Zou, Nellie Kamkar, Howard H. Feldman, Sylvie Belleville, Howard Chertkow, Haakon B. Nygaard, Surim Son, Mark Speechley

Summary: Designing and evaluating multidomain interventions to reduce dementia risk is methodologically challenging but important. This article discusses the challenges and considerations in using a standardly tailored design and proposes sensitivity and exploratory analyses to support causal inferences.

ALZHEIMERS RESEARCH & THERAPY (2022)

添加到收藏夹

Review Geriatrics & Gerontology

Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis

Lotta J. Seppala, Nellie Kamkar, Eveline P. van Poelgeest, Katja Thomsen, Joost G. Daams, Jesper Ryg, Tahir Masud, Manuel Montero-Odasso, Sirpa Hartikainen, Mirko Petrovic, Nathalie van der Velde

Summary: The effectiveness of medication review and deprescribing interventions as a single intervention in falls prevention is assessed in this study. The heterogeneity of the interventions prevents an accurate estimation of the exact effect. These interventions should be included in multimodal strategies rather than implemented as stand-alone strategies in falls prevention.

AGE AND AGEING (2022)

添加到收藏夹

Editorial Material Geriatrics & Gerontology

Are falls a manifestation of brain failure? Revisited 40 years later

Manuel Montero-Odasso

AGE AND AGEING (2023)

添加到收藏夹

Article Geriatrics & Gerontology

Brain Structural Correlates of Obstacle Negotiation in Mild Cognitive Impairment: Results from The Gait and Brain Study

Frederico Pieruccini-Faria, Seyyed Mohammad Hassan, Nickolas W. Bray, Yanina Sarquis-Adamson, Robert Bartha, Manuel Montero-Odasso

Summary: Mild Cognitive Impairment (MCI) affects obstacle negotiation capabilities, potentially increasing the risk of falls in older adults. However, it is unclear whether smaller brain volumes typically observed in older individuals with MCI are related to the observed hazardous obstacle negotiation in this population.

GERONTOLOGY (2023)

添加到收藏夹

Article Geriatrics & Gerontology

World guidelines for falls prevention and management for older adults: a global initiative

Manuel Montero-Odasso, Nathalie van der Velde, Finbarr C. Martin, Mirko Petrovic, Maw Pin Tan, Jesper Ryg, Sara Aguilar-Navarro, Neil B. Alexander, Clemens Becker, Hubert Blain, Robbie Bourke, Ian D. Cameron, Richard Camicioli, Lindy Clemson, Jacqueline Close, Kim Delbaere, Leilei Duan, Gustavo Duque, Suzanne M. Dyer, Ellen Freiberger, David A. Ganz, Fernando Gomez, Jeffrey M. Hausdorff, David B. Hogan, Susan M. W. Hunter, Jose R. Jauregui, Nellie Kamkar, Rose-Anne Kenny, Sarah E. Lamb, Nancy K. Latham, Lewis A. Lipsitz, Teresa Liu-Ambrose, Pip Logan, Stephen R. Lord, Louise Mallet, David Marsh, Koen Milisen, Rogelio Moctezuma-Gallegos, Meg E. Morris, Alice Nieuwboer, Monica R. Perracini, Frederico Pieruccini-Faria, Alison Pighills, Catherine Said, Ervin Sejdic, Catherine Sherrington, Dawn A. Skelton, Sabestina Dsouza, Mark Speechley, Susan Stark, Chris Todd, Bruce R. Troen, Tischa van der Cammen, Joe Verghese, Ellen Vlaeyen, Jennifer A. Watt, Tahir Masud

Summary: This article introduces the common occurrence and negative effects of falls and fall-related injuries in older adults, which impact their functional independence and quality of life, as well as increase morbidity, mortality, and health-related costs. Current guidelines are inconsistent and not globally applicable. Therefore, the objective of this study is to create evidence- and expert consensus-based falls prevention and management recommendations for older adults. These recommendations consider a person-centered approach, the perspectives of older adults, caregivers, and stakeholders, recent developments in e-health, and implementation in resource-limited locations.

AGE AND AGEING (2022)

添加到收藏夹

Article Geriatrics & Gerontology

Sustainable fall prevention across Europe: challenges and opportunities

Nathalie van der Velde, Lotta Seppala, Mirko Petrovic, Jesper Ryg, Maw Pin Tan, Manuel Montero-Odasso, Finbarr C. Martin, Tahir Masud

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2022)

添加到收藏夹

Article Geriatrics & Gerontology

Geriatric co-management and interdisciplinary transitional care reduced hospital readmissions in frail older patients in Argentina: results from a randomized controlled trial

Marcelo Schapira, Maria Belen Outumuro, Fabiana Giber, Claudia Pino, Mercedes Mattiussi, Manuel Montero-Odasso, Bruno Boietti, Javier Saimovici, Cristian Gallo, Lucila Hornstein, Javier Pollan, Leonardo Garfi, Abdelhady Osman, Gaston Perman

Summary: The study successfully reduced the 30-day hospital readmission rate and emergency room visits within 6 months after discharge for frail older patients in a tertiary hospital in Argentina through geriatric co-management and interdisciplinary transitional care intervention.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2022)

添加到收藏夹

Review Engineering, Biomedical

Acceleration Gait Measures as Proxies for Motor Skill of Walking: A Narrative Review

Pritika Dasgupta, Jessie VanSwearingen, Alan Godfrey, Mark Redfern, Manuel Montero-Odasso, Ervin Sejdic

Summary: This article discusses the importance of declines in walking-related motor skill in adults 65 years or older and how accelerometers can be used to assess and predict these declines. Accelerometer measurements play a crucial role in measuring walking and motor performance.

IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING (2021)

添加到收藏夹

暂无数据

© Peeref 2019-2024. All rights reserved.