Article
Nutrition & Dietetics
Jerusa da Mota Santana, Marcos Pereira, Gisele Queiroz Carvalho, Djanilson Barbosa dos Santos, Ana Marlucia Oliveira
Summary: This study found that plasma levels of ω-3 and ω-6 fatty acids during pregnancy are associated with weight gain. Women with higher ARA/LA ratio (ω-6) and lower levels of α-linolenic acid, docosahexaenoic acid, and EPA/ALA ratio (ω-3) had the greatest weight gain.
Article
Biochemistry & Molecular Biology
Kaitlyn B. Hartnett, Bradley J. Ferguson, Patrick M. Hecht, Luke E. Schuster, Joel I. Shenker, David R. Mehr, Kevin L. Fritsche, Martha A. Belury, Douglas W. Scharre, Adam J. Horwitz, Briana M. Kille, Briann E. Sutton, Paul E. Tatum, C. Michael Greenlief, David Q. Beversdorf
Summary: This pilot study aimed to explore the relationship between stress exposure and dietary omega-3 fatty acid intake in relation to the risk of Alzheimer's disease (AD). The results showed that among individuals with high stress exposure, healthy controls had significantly higher omega-3 fatty acid intake compared to AD patients. No difference was observed among those with low stress exposure. These preliminary findings suggest that omega-3 fatty acids may mitigate AD risk in the setting of greater stress exposure.
Review
Food Science & Technology
Vahideh Behrouz, Zahra Yari
Summary: The quality and quantity of dietary fatty acids play a significant role in weight, appetite, and energy expenditure. Saturated fatty acids have a greater impact on appetite control, while mono-unsaturated fats have stimulatory effects on energy expenditure and can be beneficial in long-term weight control. Poly unsaturated fats, including n-3 and n-6, have similar effects on increasing energy expenditure but act differently in controlling weight and appetite.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Immunology
Pan-Yen Lin, Chin Cheng, Senthil Kumaran Satyanarayanan, Lu-Ting Chiu, Yu-Chuan Chien, Chih-Pin Chuu, Tsuo-Hung Lan, Kuan-Pin Su
Summary: The study found that n-3 PUFAs supplements did not significantly reduce cognitive, functional, and depressive symptoms outcomes in Alzheimer's disease patients, but showed improvements in spoken language ability and constructional praxis scores. Attention to clinical heterogeneity in dementia is crucial, and CCL4 may be a better indicator for EPA treatment response compared to other inflammatory cytokines.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Agriculture, Dairy & Animal Science
Julia Fabjanowska, Edyta Kowalczuk-Vasilev, Renata Klebaniuk, Szymon Milewski, Hidir Guemues
Summary: This paper focuses on the role of n-3 fatty acids in the reproductive and immune systems of cattle. The importance of n-3 fatty acids in ruminant nutrition and their effects on reproductive performance and immunity of calves are discussed. The results confirm the beneficial impact of n-3 fatty acids on ruminant organisms. However, the supplementation of fatty acids in the diet of cows during pregnancy should be balanced to avoid negative effects on offspring development. Additionally, the presence of n-3 fatty acids in calves' ration affects their performance, immune response, antioxidant status, and overall metabolism.
Article
Ecology
Mika Volov, Nitzan Cohen, Levona Bodner, Shahar Dubiner, Abraham Hefetz, Sofia Bouchebti, Eran Levin
Summary: The specific lipid composition of hornet bodies is highly regulated and deficient in essential PUFA, even under different climates or high Omega-3 or Omega-6 PUFA diets. The study found that environmental temperature affects hornet colonies' thermal environments, but the hornets do maintain their colony temperature within a narrow range. Different caste of hornets showed differences in unsaturation levels of body lipids, with gynes and males containing less unsaturated lipids than workers.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2021)
Article
Chemistry, Medicinal
Fabian Sandgruber, Annekathrin Gielsdorf, Benjamin Schenz, Sandra Marie Mueller, Tanja Schwerdtle, Stefan Lorkowski, Carola Griehl, Christine Dawczynski
Summary: This study screened and analyzed the nutritional profile and value for human health of 15 rarely researched microalgae from two kingdoms. It was found that Chrysotila carterae has great potential for human nutrition due to its high nutrient contents.
Review
Nutrition & Dietetics
Alexandra Podpeskar, Roman Crazzolara, Gabriele Kropshofer, Benjamin Hetzer, Bernhard Meister, Thomas Mueller, Christina Salvador
Summary: The review highlights the significance of adequate nutrition and the role of n-3 polyunsaturated fatty acids in childhood cancer, emphasizing the need for further research and clinical trials to confirm their anti-cancer effects.
Article
Agriculture, Dairy & Animal Science
Sabrina de Freitas Vieira, Sandra Gesteira Coelho, Hilton do Carmo Diniz Neto, Hemily Cristina Menezes de Sa, Barbara Pironi Pereira, Bianca Souza Ferreira Albuquerque, Fernanda Samarini Machado, Luiz Gustavo Ribeiro Pereira, Thierry Ribeiro Tomich, Isis Rodrigues Toledo Renhe, Mariana Magalhaes Campos
Summary: The study found that feeding waste milk and pasteurized waste milk did not have significant negative effects on the intake, ruminal parameters, blood parameters, health, or performance of dairy calves.
Article
Nutrition & Dietetics
Xuefei Li, Zhengjie Lu, Yongjian Qi, Biao Chen, Bin Li
Summary: This study used the Mendelian randomization approach to explore the potential causal relationships between polyunsaturated fatty acids (PUFAs) and osteoarthritis (OA), and found that higher levels of omega-6 fatty acids may reduce the risk of knee OA and hip OA. These results highlight the importance of maintaining optimal levels of PUFAs, especially omega-6 fatty acids, in individuals with a genetic predisposition to OA.
Review
Biochemistry & Molecular Biology
Domenico Sergi, Enrico Zauli, Veronica Tisato, Paola Secchiero, Giorgio Zauli, Carlo Cervellati
Summary: Cerebrovascular diseases and brain hypoperfusion form the basis of vascular dementia. Dyslipidemia, characterized by an increase in triglycerides and LDL-cholesterol levels and a decrease in HDL-cholesterol, promotes atherosclerosis in cardiovascular and cerebrovascular diseases. The quality and functionality of HDL-cholesterol play a significant role in cardiovascular health and cognitive function, and ceramides embedded in lipoproteins are proposed as a novel risk factor for atherosclerosis. This review discusses the role of HDL lipoprotein and ceramides in cerebrovascular diseases and their impact on vascular dementia, as well as the influence of saturated and omega-3 fatty acids on HDL levels and ceramide metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Carolina B. Castro, Cintia B. Dias, Heidi Hillebrandt, Hamid R. Sohrabi, Pratishtha Chatterjee, Tejal M. Shah, Stephanie J. Fuller, Manohar L. Garg, Ralph N. Martins
Summary: This systematic review and meta-analysis examined the effects of medium-chain fatty acid (MCFA) supplementation on circulating ketone bodies and cognition in individuals with cognitive decline and Alzheimer's disease. The results showed that MCFA supplementation increases blood ketone levels and enhances brain energy metabolism. However, the effects on cognition varied and further research is needed to determine if MCFA-mediated increase in brain energy metabolism can improve cognition.
Article
Nutrition & Dietetics
Eric T. Guardino, Yanping Li, Xuan-Mai Nguyen, Peter W. F. Wilson, J. Michael Gaziano, Kelly Cho, Emelia J. Benjamin, Luc Djousse
Summary: Contrary to the hypothesis, dietary intake of EPA/DHA/DPA was not associated with an increased risk of atrial fibrillation (AF), but instead showed a nonlinear inverse relationship with AF risk.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Ghaith Mohsen, Annika Stroemer, Andreas Mayr, Andrea Kunsorg, Christian Stoppe, Maria Wittmann, Markus Velten
Summary: Initial evidence suggests that preoperative administration of omega-3 fatty acids can reduce postoperative inflammatory reaction. However, the effects of immunonutrition with omega-3 fatty acids on inflammatory response in abdominal surgery patients are still unclear. This study found no significant difference in inflammatory markers or postoperative length of hospital stay between the preoperative omega-3 fatty acids group and the control group.
Article
Immunology
Ping-Tao Tseng, Bing-Syuan Zeng, Mein-Woei Suen, Yi-Cheng Wu, Christoph U. Correll, Bing-Yan Zeng, John S. Kuo, Yen-Wen Chen, Tien-Yu Chen, Yu-Kang Tu, Pao-Yen Lin, Andre F. Carvalho, Brendon Stubbs, Dian-Jeng Li, Chih-Sung Liang, Chih-Wei Hsu, Cheuk-Kwan Sun, Yu-Shian Cheng, Pin-Yang Yeh, Ming-Kung Wu, Yow-Ling Shiue, Kuan-Pin Su
Summary: This network meta-analysis suggests that high-dose EPA-dominant omega-3 PUFAs may have potential benefits in improving cognitive function in patients with Alzheimer's dementia. Omega-3 PUFAs have similar acceptability and safety profiles compared to placebo. Future large-scale RCTs should investigate different dosages of EPA-dominant omega-3 PUFAs in AD patients with varying levels of inflammation and psychopathology to further explore its therapeutic effects on cognitive decline.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Clinical Neurology
Olin Janssen, Willemijn J. Jansen, Stephanie J. B. Vos, Merce Boada, Lucilla Parnetti, Tomasz Gabryelewicz, Tormod Fladby, Jose Luis Molinuevo, Sylvia Villeneuve, Jakub Hort, Stephane Epelbaum, Alberto Lleo, Sebastiaan Engelborghs, Wiesje M. van der Flier, Susan Landau, Julius Popp, Anders Wallin, Philip Scheltens, Marcel Olde Rikkert, Peter J. Snyder, Chris Rowe, Gael Chetelat, Agustin Ruiz, Marta Marquie, Elena Chipi, Steffen Wolfsgruber, Michael Heneka, Henning Boecker, Oliver Peters, Jonas Jarholm, Lorena Rami, Adria Tort-Merino, Alexa Pichet Binette, Judes Poirier, Pedro Rosa-Neto, Jiri Cerman, Bruno Dubois, Marc Teichmann, Daniel Alcolea, Juan Fortea, M. Belen Sanchez-Saudinos, Jarith Ebenau, Cornelia Pocnet, Marie Eckerstrom, Louisa Thompson, Victor Villemagne, Rachel Buckley, Samantha Burnham, Marion Delarue, Yvonne Freund-Levi, Asa K. Wallin, Inez Ramakers, Magda Tsolaki, Hilkka Soininen, Harald Hampel, Luiza Spiru, Betty Tijms, Rik Ossenkoppele, Frans R. J. Verhey, Frank Jessen, Pieter Jelle Visser
Summary: In addition to age, setting, and APOE ε4 carriership, specific characteristics of subjective cognitive decline may aid in identifying individuals with amyloid positivity.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Juraj Secnik, Hong Xu, Emilia Schwertner, Niklas Hammar, Michael Alvarsson, Bengt Winblad, Maria Eriksdotter, Sara Garcia-Ptacek, Dorota Religa
Summary: This study analyzed the all-cause mortality among users of six glucose-lowering drugs in patients with and without dementia. The results showed that insulin and sulfonylurea were associated with higher mortality risk among dementia patients, while GLP-1a and SGLT-2i were associated with lower risk.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jacob Holmer, Maria Eriksdotter, Henrike Habel, Ida Hed Myrberg, Anton Jonsson, Pirkko J. Pussinen, Sara Garcia-Ptacek, Leif Jansson, Gunilla Sandborgh-Englund, Kare Buhlin
Summary: The incidence of dementia was compared between individuals with deep probing pocket depths (DPPD) and those without DPPD, and no association was found.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Cell Biology
Khanh Do, Erik Hjorth, Ying Wang, Bokkyoo Jun, Marie-Audrey Kautzmann, Makiko Ohshima, Maria Eriksdotter, Marianne Schultzberg, Nicolas G. Bazan
Summary: This study analyzed lipid mediators in cerebrospinal fluid (CSF) of patients with cognitive impairment and found a shift from pro-resolving to pro-inflammatory lipid mediators in the progression to Alzheimer's disease (AD). These findings suggest that these lipid mediators may serve as biomarkers for diagnosis and should be confirmed by replication studies.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Emilia Schwertner, Joana B. Pereira, Hong Xu, Juraj Secnik, Bengt Winblad, Maria Eriksdotter, Katarina Nagga, Dorota Religa
Summary: This study characterizes the behavioral and psychological symptoms of dementia (BPSD) in different types of dementia in long-term care facilities. The results show that there are variations in symptom risks between different types of dementia, but aberrant motor behavior, agitation, and irritability are common symptoms among all types of dementia patients.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Mandy Roheger, Hong Xu, Minh Tuan Hoang, Maria Eriksdotter, Sara Garcia-Ptacek
Summary: This study presents a reliable and simple method for converting MMSE scores to MoCA scores (and vice versa) in patients with different types of dementia. By establishing a conversion table, the scores of the two assessment tools can be easily compared, facilitating research and clinical practice.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Clinical Neurology
Aurore Delvenne, Johan Gobom, Betty Tijms, Isabelle Bos, Lianne M. Reus, Valerija Dobricic, Mara Ten Kate, Frans Verhey, Inez Ramakers, Philip Scheltens, Charlotte E. Teunissen, Rik Vandenberghe, Jolien Schaeverbeke, Silvy Gabel, Julius Popp, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Magda Tsolaki, Yvonne Freund-Levi, Simon Lovestone, Johannes Streffer, Frederik Barkhof, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Pieter Jelle Visser, Stephanie J. B. Vos
Summary: The pathophysiology of MCI-SNAP is distinct from that of MCI-AD, highlighting the need for different treatment approaches.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Anders Wimo, Ron Handels, Riitta Antikainen, Maria Eriksdotter, Linus Jonsson, Martin Knapp, Jenni Kulmala, Tiina Laatikainen, Jenni Lehtisalo, Markku Peltonen, Anders Skoldunger, Hilkka Soininen, Alina Solomon, Timo Strandberg, Jaakko Tuomilehto, Tiia Ngandu, Miia Kivipelto
Summary: This study estimated the potential cost-effectiveness of the FINGER program in Finland. The results showed that the FINGER program could save costs and improve quality-adjusted life years, supporting its effectiveness in preventing cognitive impairment and disability.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Milan Nemy, Martin Dyrba, Frederic Brosseron, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Wenzel Glanz, Doreen Goerss, Michael T. Heneka, Stefan Hetzer, Enise I. Incesoy, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Franziska Maier, Matthias H. Munk, Robert Perneczky, Oliver Peters, Lukas Preis, Josef Priller, Boris-Stephan Rauchmann, Sandra Roeske, Nina Roy, Klaus Scheffler, Anja Schneider, Bjorn H. Schott, Annika Spottke, Eike J. Spruth, Michael Wagner, Jens Wiltfang, Renat Yakupov, Maria Eriksdotter, Eric Westman, Olga Stepankova, Lenka Vyslouzilova, Emrah Duezel, Frank Jessen, Stefan J. Teipel, Daniel Ferreira
Summary: Nemy et al. investigate cholinergic white matter projections along the Alzheimer's disease continuum, finding that alterations in these pathways are present in individuals with subjective cognitive decline. These alterations precede the more widespread changes seen in mild cognitive impairment and Alzheimer's disease dementia. The study highlights the potential of using cholinergic white matter pathways as markers for the early stages of Alzheimer's disease.
Article
Urology & Nephrology
Hong Xu, Sara Garcia-Ptacek, Annette Bruchfeld, Edouard L. Fu, Taher Darreh Shori, Bengt Lindholm, Maria Eriksdotter, Juan Jesus Carrero
Summary: Preclinical evidence suggests that the use of Cholinesterase inhibitors (ChEIs) may have beneficial effects on the kidney. This study examined the risk of chronic kidney disease (CKD) progression among newly diagnosed Alzheimer's disease (AD) patients who either used or did not use ChEIs. The results showed that ChEI use was associated with a lower risk of CKD progression.
KIDNEY INTERNATIONAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Anton Jonsson, Jacob Holmer, Leif Kullman, Maria Eriksdotter, Jan Ahlqvist, Eva Levring Jaeghagen, Kare Buhlin
Summary: In this middle-aged and older Swedish population, CCAA was found to be common (40%). There were no differences in the prevalence of CCAA between cases with cognitive impairment and controls without cognitive impairment.
ACTA ODONTOLOGICA SCANDINAVICA
(2023)
Article
Geriatrics & Gerontology
Jonathan K. L. Mak, Maria Eriksdotter, Martin Annetorp, Ralf Kuja-Halkola, Laura Kananen, Anne-Marie Bostrom, Miia Kivipelto, Carina Metzner, Viktoria Back Jerlardtz, Malin Engstrom, Peter Johnson, Lars Goran Lundberg, Elisabet Akesson, Carina Suhl Oberg, Maria Olsson, Tommy Cederholm, Sara Hagg, Dorota Religa, Juulia Jylhava
Summary: This retrospective cohort study used electronic health records to investigate the association between frailty and outcomes in older COVID-19 patients. The results showed that a medical record-based electronic frailty index (eFI) was effective for risk stratification in hospitalized COVID-19 patients. Frailty was significantly associated with higher mortality, readmission, and longer hospital stays, and the eFI had the best predictive accuracy among all measures.
Article
Clinical Neurology
Juraj Secnik, Maria Eriksdotter, Hong Xu, Martin Annetorp, Aleksander Rytarowski, Kristina Johnell, Sara Haegg, Dorota Religa
Summary: This study investigates the associations between dementia, medication use, and mortality in patients with COVID-19. The study finds that dementia is independently associated with higher in-hospital and overall mortality among COVID-19 patients. Furthermore, the use of antipsychotic medication is associated with an increased risk of mortality.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Microbiology
Nele Fogelholm, Jaakko Leskela, Muhammed Manzoor, Jacob Holmer, Susanna Paju, Kaija Hiltunen, Hanna-Maria Roitto, Riitta Kt Saarela, Kaisu Pitkala, Maria Eriksdotter, Kare Buhlin, Pirkko J. Pussinen, Paivi Mantyla
Summary: Oral health and declining cognition may have a bi-directional association. The composition of the subgingival microbiota was analyzed in subjects with normal cognition to severe cognitive decline. The study found that certain taxa of oral bacteria were associated with the MMSE score, and Lachnospiraceae [XIV] increased with decreasing MMSE. Impaired cognition is accompanied by changes in the composition of the oral microbiota, highlighting the importance of oral health-care practices among older adults.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Article
Clinical Neurology
Kirsten E. J. Wesenhagen, Johan Gobom, Isabelle Bos, Stephanie J. B. Vos, Pablo Martinez-Lage, Julius Popp, Magda Tsolaki, Rik Vandenberghe, Yvonne Freund-Levi, Frans Verhey, Simon Lovestone, Johannes Streffer, Valerija Dobricic, Lars Bertram, Kaj Blennow, Maria Pikkarainen, Merja Hallikainen, Johanna Kuusisto, Markku Laakso, Hilkka Soininen, Philip Scheltens, Henrik Zetterberg, Charlotte E. Teunissen, Pieter Jelle Visser, Betty M. Tijms
Summary: This study aimed to understand the changes in cerebrospinal fluid proteomics with aging and their associations with Alzheimer's disease risk. The results showed that while some proteins decreased with age in individuals with amyloid abnormalities, others increased independently of amyloid status, and were associated with immune and signaling processes.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2022)