Article
Clinical Neurology
Humberto Parada, Jaclyn Bergstrom, Katherine J. Bangen, Emilie T. Reas
Summary: This study found that prolonged elevated pulse pressure (PP) predicts microstructural abnormalities in the brain, which may contribute to impaired executive function. APOE epsilon 4 carriers are more vulnerable to the adverse effects of high PP on brain microstructure.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, General & Internal
Yanjun Ma, Rong Hua, Zhenchun Yang, Baoliang Zhong, Li Yan, Wuxiang Xie
Summary: A comparison of cognitive decline trajectories between individuals with borderline hypertension and normal blood pressure showed no significant difference in decline rate, while those with high blood pressure exhibited significantly faster cognitive decline. Individuals with borderline hypertension may not need to start antihypertensive therapy considering cognitive decline.
Article
Health Care Sciences & Services
Linlin Ding, Xinhong Zhu, Zhenfang Xiong, Fen Yang, Xiaona Zhang
Summary: This study investigated the association between age at diagnosis of hypertension and decline in cognitive performance. The study found that hypertension diagnosed in mid-life is associated with worse cognition compared to late life, and longer duration of hypertension is associated with worse memory. Blood pressure control is critical for the preservation of cognitive function.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Health Care Sciences & Services
C. Barrett Bowling, Richard Sloane, Carl Pieper, Alison Luciano, Barry R. Davis, Lara M. Simpson, Paula T. Einhorn, Suzanne Oparil, Paul Muntner
Summary: Sustained systolic blood pressure control is associated with a lower risk of developing high-cost multimorbidity dyads and triads among Medicare beneficiaries in the ALLHAT study.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Peripheral Vascular Disease
Xi Li
Summary: The study shows a positive association between blood pressure and age in China, with nearly three-fold variation across different sociodemographic subgroups, indicating differences in biology, behavior, or exposures. Antihypertensive medication significantly diminishes the association between age and blood pressure, reducing the variation.
JOURNAL OF HYPERTENSION
(2021)
Review
Cell Biology
Leonardo Bencivenga, Philipe De Souto Barreto, Yves Rolland, Olivier Hanon, Jean-Sebastien Vidal, Philippe Cestac, Bruno Vellas, Laure Rouch
Summary: Aging is associated with increased Blood Pressure Variability (BPV), which is linked to organ damage and various health outcomes. Aging and altered BPV share the same molecular mechanisms, including subclinical inflammation, altered endothelial function, and increased production of ROS. Arterial stiffness and autonomic dysfunction are also associated with impaired BPV in elderly patients. Furthermore, molecular changes in cardiovascular aging and altered BPV are related to the hallmarks of aging. The interplay between BPV and the pathophysiology of aging suggests that BPV may serve as a new marker of aging.
AGEING RESEARCH REVIEWS
(2022)
Article
Peripheral Vascular Disease
Sae Young Jae, Kyung Hyun Lee, Hyun Jeong Kim, Setor K. Kunutsor, Kevin S. Heffernan, Rachel E. Climie, Kanokwan Bunsawat, Mira Kang
Summary: This study found that healthy vascular aging (HVA) and cardiorespiratory fitness (CRF) are both associated with a lower risk of subclinical atherosclerosis in men. Higher CRF is associated with a higher prevalence of HVA and may modify the association between HVA and subclinical atherosclerosis.
Article
Peripheral Vascular Disease
Carlos A. Valencia-Hernandez, Joni Lindbohm, Martin J. Shipley, Ian B. Wilkinson, Carmel M. McEniery, Sara Ahmadi-Abhari, Archana Singh-Manoux, Mika Kivimaki, Eric J. Brunner
Summary: Aortic pulse wave velocity can predict the risk of major adverse cardiovascular events in elderly individuals and improve the performance of commonly used cardiovascular disease risk assessment tools.
Article
Transplantation
Christian Ott, Felix Mahfoud, Giuseppe Mancia, Krzysztof Narkiewicz, Luis M. Ruilope, Martin Fahy, Markus P. Schlaich, Michael Bohm, Roland E. Schmieder
Summary: The blood pressure lowering effects of renal denervation (RDN) were compared between hypertensive patients with or without chronic kidney disease (CKD). The results showed that the reduction in 24-hour systolic and diastolic blood pressure was similar in both groups after RDN, but the reduction in office systolic blood pressure was less in patients with CKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Mateusz Siedlinski, Lorenzo Carnevale, Xiaoguang Xu, Daniela Carnevale, Evangelos Evangelou, Mark J. Caulfield, Pasquale Maffia, Joanna Wardlaw, Nilesh J. Samani, Maciej Tomaszewski, Giuseppe Lembo, Michael Holmes, Tomasz J. Guzik
Summary: Observational and genetic data were used to study the relationship between blood pressure and cognitive function. The study identified brain structures associated with blood pressure and found that higher systolic blood pressure may have an adverse effect on cognitive function. These findings contribute to our understanding of the negative impact of hypertension on cognitive performance.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jiafu Yan, Keyang Zheng, Aoya Liu, Wenli Cheng
Summary: Intensive blood pressure control may not reduce the risk of stroke, composite cardiovascular outcomes, and all-cause mortality in patients with lower cognitive function. However, it can significantly reduce the risk of stroke, composite cardiovascular outcomes, and all-cause mortality in patients with higher cognitive function. Intensive blood pressure control may also lead to adverse effects such as hypotension, electrolyte abnormality, and acute kidney injury in patients with both lower and higher cognitive function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Nur Fazidah Asmuje, Sumaiyah Mat, Choon Hian Goh, Phyo Kyaw Myint, Maw Pin Tan
Summary: This study found a relationship between beat-to-beat blood pressure variability and cognitive function, with different frequencies of BPV impacting cognitive function.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Clinical Neurology
Nicholas M. Pajewski, Fanny M. Elahi, Manjula Kurella Tamura, Jason D. Hinman, Ilya M. Nasrallah, Joachim H. Ix, Lindsay M. Miller, Lenore J. Launer, Clinton B. Wright, Mark A. Supiano, Alan J. Lerner, Tiffany L. Sudduth, Anthony A. Killeen, Alfred K. Cheung, David M. Reboussin, Donna M. Wilcock, Jeff D. Williamson
Summary: Intensive blood pressure treatment was associated with changes in NfL, which were correlated with changes in kidney function associated with intensive treatment.
ALZHEIMERS & DEMENTIA
(2022)
Review
Neurosciences
Jose Miguel Sanchez-Nieto, Uriel Dagoberto Rivera-Sanchez, Victor Manuel Mendoza-Nunez
Summary: The study found a relationship between arterial hypertension and cognitive performance in the elderly, with individuals with hypertension performing poorer in processing speed, working memory, short-term memory, learning, and delayed recall. Only one study suggested that higher blood pressure may be associated with better memory performance.
Article
Clinical Neurology
Chenglong Li, Yanjun Ma, Rong Hua, Zhenchun Yang, Baoliang Zhong, Hongyu Wang, Wuxiang Xie
Summary: The study found a significant association between higher long-term blood pressure variability and accelerated cognitive decline, with a nonlinear dose-response relationship. Further randomized controlled trials are needed to assess the potential benefits of strategies aimed at reducing blood pressure variability for cognitive health.
Article
Clinical Neurology
David S. Knopman, Emily S. Lundt, Terry M. Therneau, Sabrina M. Albertson, Jeffrey L. Gunter, Matthew L. Senjem, Christopher G. Schwarz, Michelle M. Mielke, Mary M. Machulda, Bradley F. Boeve, David T. Jones, Jon Graff-Radford, Prashanthi Vemuri, Kejal Kantarci, Val J. Lowe, Ronald C. Petersen, Clifford R. Jack
Summary: This study investigated the association between beta-amyloid in positron emission tomography and subsequent tau accumulation in cognitively unimpaired individuals. The findings showed that individuals with higher levels of beta-amyloid had greater accumulation of tau on subsequent PET scans. This suggests that recruiting individuals with high beta-amyloid levels for clinical trials using tau PET as an outcome measure may be beneficial.
Article
Clinical Neurology
Brian W. Kunkle, Michael Schmidt, Hans-Ulrich Klein, Adam C. Naj, Kara L. Hamilton-Nelson, Eric B. Larson, Denis A. Evans, Phil L. De Jager, Paul K. Crane, Joe D. Buxbaum, Nilufer Ertekin-Taner, Lisa L. Barnes, M. Daniele Fallin, Jennifer J. Manly, Rodney C. P. Go, Thomas O. Obisesan, M. Ilyas Kamboh, David A. Bennett, Kathleen S. Hall, Alison M. Goate, Tatiana M. Foroud, Eden R. Martin, Li-Sao Wang, Goldie S. Byrd, Lindsay A. Farrer, Jonathan L. Haines, Gerard D. Schellenberg, Richard Mayeux, Margaret A. Pericak-Vance, Christiane Reitz
Summary: This study identified additional Alzheimer disease risk loci in African American individuals, indicating that the disease risk in this population differs from other ethnic groups.
Article
Biochemistry & Molecular Biology
Jacob W. Vogel, Alexandra L. Young, Neil P. Oxtoby, Ruben Smith, Rik Ossenkoppele, Olof T. Strandberg, Renaud La Joie, Leon M. Aksman, Michel J. Grothe, Yasser Iturria-Medina, Michael J. Pontecorvo, Michael D. Devous, Gil D. Rabinovici, Daniel C. Alexander, Chul Hyoung Lyoo, Alan C. Evans, Oskar Hansson
Summary: By using an unbiased subtyping algorithm, the study systematically characterized longitudinal tau variability in human Alzheimer's disease, identifying four trajectories of tau deposition with distinct clinical features. The results suggest that variation in tau pathology is common and systematic, potentially necessitating a re-examination of the notion of 'typical AD' and a revisiting of tau pathological staging.
Article
Geriatrics & Gerontology
Fikru B. Bedada, Oyonumo E. Ntekim, Evaristus O. Nwulia, Thomas V. Fungwe, Sheeba Raaj Nadarajah, Thomas O. Obisesan
Summary: The study investigated the impact of UPS and FOXOs on mild cognitive impairment in African Americans and the effects of exercise on these components. The results showed that exercise can increase the expression levels of FBXO32 and FOXO1 in different genders, which may have a positive effect on enhancing the cellular clearance system in neurodegenerative diseases.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Correction
Multidisciplinary Sciences
Jacob W. Vogel, Yasser Iturria-Medina, Olof T. Strandberg, Ruben Smith, Elizabeth Levitis, Alan C. Evans, Oskar Hansson
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Julia Neitzel, Nicolai Franzmeier, Anna Rubinski, Martin Dichgans, Matthias Brendel, Rainer Malik, Michael Ewers
Summary: The Klotho-VS haplotype is associated with reduced risk of Alzheimer's disease and dementia. This study demonstrates an association between the KL-VS haplotype and amyloid-dependent tau accumulation using PET data. KL-VShet carriers show lower levels of tau-PET per unit increase in amyloid-PET, suggesting a protective role against amyloid-related tau pathology and memory impairments in elderly individuals at risk of AD dementia.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
William T. Hu, Tugba Ozturk, Alexander Kollhoff, Whitney Wharton, J. Christina Howell
Summary: Neuroinflammation is observed in Alzheimer's disease. Here the authors show that 15 proteins related to inflammation found in CSF can potentially be used as a prognostic biomarker, providing predictive information independent of established Alzheimer's markers.
NATURE COMMUNICATIONS
(2021)
Article
Psychiatry
Shi-Dong Chen, Jia-Ying Lu, Hong-Qi Li, Yu-Xiang Yang, Jie-Hui Jiang, Mei Cui, Chuan-Tao Zuo, Lan Tan, Qiang Dong, Jin-Tai Yu
Summary: NIA-AA proposed a biological research framework to define Alzheimer's disease with dichotomized biomarker measurement, but it cannot characterize the hierarchical spreading pattern of tau pathology. A refined topographic F-18-AV-1451 tau PET staging scheme was constructed to reflect in vivo tau progression, showing potential in early diagnosis and disease mechanism study. Highly accumulated tau in temporal regions independently led to cognitive deterioration, indicating the importance of studying tau spreading pattern in Alzheimer's disease.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Sandhitsu R. Das, Xueying Lyu, Michael Tran Duong, Long Xie, Lauren McCollum, Robin Flores, Michael DiCalogero, David J. Irwin, Bradford C. Dickerson, Ilya M. Nasrallah, Paul A. Yushkevich, David A. Wolk
Summary: The study aimed to investigate the impact of Tau neurofibrillary tangles on neurodegeneration, and identified age and burden of white matter hyperintensity lesions as related modulatory factors. Data analysis showed that grouping individuals based on the relationship between Tau neurofibrillary tangles and neurodegeneration may help identify potential contributors to neurodegeneration.
ANNALS OF NEUROLOGY
(2021)
Article
Psychiatry
Xue-Ning Shen, Yu-Yuan Huang, Shi-Dong Chen, Yu Guo, Lan Tan, Qiang Dong, Jin-Tai Yu
Summary: Plasma phosphorylated-tau181 (p-tau181) shows potential as a marker for Alzheimer's pathology in the brain, correlating significantly with amyloid, tau, and FDG PET biomarkers. Combining plasma p-tau181 with clinical information improves diagnostic accuracy. Abnormal plasma p-tau181 levels at baseline are associated with a higher risk of pathological progression in brain amyloid and FDG PET status. Plasma p-tau181 may serve as a sensitive screening test and predictive biomarker for Alzheimer's pathophysiology.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Julius S. Ngwa, Evaristus Nwulia, Oyonumo Ntekim, Fikru B. Bedada, Bernard Kwabi-Addo, Sheeba Nadarajah, Steven Johnson, William M. Southerland, John Kwagyan, Thomas O. Obisesan
Summary: This study investigates the effects of aerobic exercise on DNA methylation in older African American individuals with mild cognitive impairment. The results show that aerobic exercise training is associated with changes in global methylation levels and identifies specific genes related to amyloid biology, protein trafficking, and lipoprotein regulation that are affected by exercise-induced methylation changes.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Michael Tran Duong, Sandhitsu R. Das, Xueying Lyu, Long Xie, Hayley Richardson, Sharon X. Xie, Paul A. Yushkevich, David A. Wolk, Ilya M. Nasrallah
Summary: Through machine learning, heterogeneity in F-18-flortaucipir and F-18-fluorodeoxyglucose PET scans was assessed in 289 symptomatic AD patients, revealing distinct imaging signatures with pathobiological and prognostic implications for AD.
NATURE COMMUNICATIONS
(2022)
Article
Geriatrics & Gerontology
Johannes Tobias Neumann, Le T. P. Thao, Anne M. Murray, Emily Callander, Prudence R. Carr, Mark R. Nelson, Rory Wolfe, Robyn L. Woods, Christopher M. Reid, Raj C. Shah, Anne B. Newman, Jeff D. Williamson, Andrew M. Tonkin, John J. McNeil
Summary: This study analyzed data from ASPREE and found that age, cognitive function, and gait speed were the strongest predictors of disability-free survival in healthy older people. Other factors, such as body mass index and smoking status, were also associated with a worse prognosis.
Correction
Multidisciplinary Sciences
Tingxiang Yan, Jingjing Liang, Ju Gao, Luwen Wang, Hisashi Fujioka, Xiaofeng Zhu, Xinglong Wang
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Narayan Rai, Maria Mananita Hipolito, John W. VanMeter, Riya Seth, Ayokunnumi Adenuga, Myeshia Shelby, Magdalena Misiak-Christian, Charles Nwaokobia, Kebreten F. Manaye, Thomas O. Obisesan, Evaristus Nwulia
Summary: This study found that odor identification tasks may be more potent than memory tasks in engaging specific olfactory and memory regions in older populations, and repetitive odor identification significantly activated the hippocampus - a region relevant to Alzheimer's disease - more significantly than the odor memory task.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)