Review
Biology
Jibran A. Wali, Samantha M. Solon-Biet, Therese Freire, Amanda E. Brandon
Summary: Obesity and overweight are widespread issues linked to insulin resistance and various diseases; nutrition plays a key role in metabolic health, but effective dietary interventions for long-term compliance are lacking.
Article
Physiology
Klinsmann Carolo Dos Santos, Camilla Olofsson, Joao Paulo M. C. M. Cunha, Fiona Roberts, Sergiu-Bogdan Catrina, Malin Fex, Neda Rajamand Ekberg, Peter Spegel
Summary: The study found that insulin and glucagon secretion depended on glycemic status and meal composition, while IGR depended on meal composition. Consuming a low carbohydrate diet may be beneficial for weight loss, especially in obese individuals.
Article
Endocrinology & Metabolism
Guanhong Miao, Ying Zhang, Zhiguang Huo, Wenjie Zeng, Jianhui Zhu, Jason G. Umans, Gert Wohlgemuth, Diego Pedrosa, Brian DeFelice, Shelley A. Cole, Amanda M. Fretts, Elisa T. Lee, Barbara V. Howard, Oliver Fiehn, Jinying Zhao
Summary: The study found that alterations in plasma molecular lipids are closely associated with the risk of type 2 diabetes (T2D) in American Indians, with various lipid species showing significant impact on T2D risk both at baseline and over time. Aberrant lipid profiles were observed in prediabetes, and longitudinal changes in lipidome were significantly linked to changes in continuous measures of T2D. The findings suggest that lipid dysregulation occurs many years before the onset of T2D and may provide new therapeutic targets for early intervention tailored to American Indians.
Article
Psychology, Developmental
Frank M. Biro, Suzanne S. Summer, Bin Huang, Chen Chen, Janie Benoit, Susan M. Pinney
Summary: This study examines the relationship between dietary fiber and protein intake and estrogen and sex hormone-binding globulin (SHBG) concentrations at the onset of puberty. The findings suggest that higher protein intake, especially from animal sources, is associated with increased estrogen concentrations and decreased SHBG levels, leading to higher levels of bioavailable estrogen. These results indicate that modest reduction in animal protein intake may be beneficial in reducing the risk of breast cancer.
JOURNAL OF ADOLESCENT HEALTH
(2022)
Article
Nutrition & Dietetics
Hyerim Park, Anthony Kityo, Yeonjin Kim, Sang-Ah Lee
Summary: This study found that Korean adults diagnosed with MetS had high consumption of plant-source macronutrients and low consumption of animal-source macronutrients, especially with females having higher intake of carbohydrates and proteins from plant sources, while lower intake of total energy and fat.
Article
Peripheral Vascular Disease
Mingjing Chen, Guanhong Miao, Ying Zhang, Jason G. Umans, Elisa T. Lee, Barbara V. Howard, Oliver Fiehn, Jinying Zhao
Summary: This study used liquid chromatography-mass spectrometry to measure 1542 lipid species in a large population and found multiple lipid species associated with the development of hypertension. These findings contribute to a better understanding of the role of dyslipidemia in hypertension and may provide potential opportunities for risk stratification and early prediction of hypertension.
Article
Nutrition & Dietetics
Chien-Hsien Wu, Ting-Yu Chang, Yen-Chu Chen, Rwei-Fen S. Huang
Summary: The PEMT rs7946 polymorphism has sex-specific effects on choline requirement and hepatic steatosis (HS) risk in humans. This study explored the interaction effect of the PEMT rs7946 polymorphism and sex on the impact of adequate choline intake on HS risk. The findings suggest that elevated levels of the PEMT rs7946 A allele are associated with decreased HS risk and body mass index in both men and women.
Article
Nutrition & Dietetics
Ramatu Wuni, Nagarajan Lakshmipriya, Kuzhandaivelu Abirami, Eduard Flores Ventura, Ranjit Mohan Anjana, Vasudevan Sudha, Shanmugam Shobana, Ranjit Unnikrishnan, Kamala Krishnaswamy, Karani Santhanakrishnan Vimaleswaran, Viswanathan Mohan
Summary: The study found that increased consumption of dairy products is associated with a lower risk of metabolic syndrome and cardiometabolic risk factors.
Article
Urology & Nephrology
Wenjie Zeng, Habtamu B. Beyene, Mikko Kuokkanen, Guanhong Miao, Dianna J. Magliano, Jason G. Umans, Nora Franceschini, Shelley A. Cole, George Michailidis, Elisa T. Lee, Barbara V. Howard, Oliver Fiehn, Joanne E. Curran, John Blangero, Peter J. Meikle, Jinying Zhao
Summary: Dyslipidemia is associated with and usually precedes the onset of chronic kidney disease (CKD). This study identified multiple lipid species, including glycerophospholipids, glycerolipids and sphingolipids, as being significantly associated with increased risk of CKD. The longitudinal change in plasma lipidome was also found to be significantly associated with change in kidney function. Network analysis identified distinct lipidomic signatures differentiating high from low-risk groups.
KIDNEY INTERNATIONAL
(2022)
Article
Microbiology
Zubaidah Hasain, Raja Affendi Raja Ali, Shairah Abdul Razak, Kamalrul Azlan Azizan, Emad El-Omar, Nurul Huda Razalli, Norfilza Mohd Mokhtar
Summary: The study found that dietary intake is an important predictor of gut microbiota dysbiosis in post-GDM women, and is associated with obesity, low-grade inflammation, and poor glycemic control. Hence, modifying dietary intake to reshape gut microbiota composition is a promising strategy for preventing T2DM in post-GDM women.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Evan L. Reynolds, Gulcin Akinci, Mousumi Banerjee, Helen C. Looker, Adam Patterson, Robert G. Nelson, Eva L. Feldman, Brian C. Callaghan
Summary: In participants with longstanding diabetes, neuropathy and kidney disease worsened during follow-up, despite stable to improving MetS components. Early metabolic intervention is necessary to prevent complications in such patients. The number of MetS components was associated with an increased rate of neuropathy progression, and SBP was associated with each complication.
Article
Oncology
Arce Domingo-Relloso, Angela L. Riffo-Campos, Martha Powers, Maria Tellez-Plaza, Karin Haack, Robert H. Brown, Jason G. Umans, M. Daniele Fallin, Shelley A. Cole, Ana Navas-Acien, Tiffany R. Sanchez
Summary: This study investigated the association between lung disease and DNA methylation, finding multiple differentially methylated CpG sites associated with chronic lung disease. These findings contribute to a better understanding of the molecular mechanisms involved in lung disease and may have diagnostic implications.
CLINICAL EPIGENETICS
(2022)
Article
Environmental Sciences
Christian K. Dye, Arce Domingo-Relloso, Allison Kupsco, Naomi E. Tinkelman, Miranda J. Spratlen, Anne K. Bozack, Maria Tellez-Plaza, Walter Goessler, Karin Haack, Jason G. Umans, Andrea A. Baccarelli, Shelley A. Cole, Ana Navas-Acien
Summary: Exposure to low to moderate arsenic (As) levels has been associated with type 2 diabetes (T2D) and other chronic diseases in American Indian communities. Prenatal exposure to As may also increase the risk for T2D in adulthood, and maternal As has been associated with adult offspring metabolic health measurements. This study evaluated the association of maternal DNA methylation with incident T2D and insulin resistance in adult offspring.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Clinical Neurology
Astrid M. Suchy-Dicey, Kyra Oziel, Charles Sawyer, Yunusa Olufadi, Tauqeer Ali, Amanda M. Fretts, Jason G. Umans, Dean K. Shibata, W. T. Longstreth Jr, Kristoffer Rhoads, Dedra S. Buchwald, Thomas J. Grabowski
Summary: This study provides the first data on cognitive and imaging changes in American Indians and reports Alzheimer disease-related features for the first time. The standardized cognitive tests may not perform well in this population, calling for test validation and score adjustment. Years of education were not a good proxy for premorbid function, suggesting the need for new methods of cognitive score contextualization.
Article
Multidisciplinary Sciences
Chao-Wen Cheng, Wen-Fang Fang, Kam-Tsun Tang, Jiunn-Diann Lin
Summary: This study suggests a potential link between sex hormones, specifically estrogen, and B-cell activating factor (BAFF) in autoimmune thyroid disease. The results showed higher serum BAFF levels in women with Graves' disease and female mice in a murine model of autoimmune thyroiditis. Estrogen may play a role in modulating BAFF expression, possibly contributing to the higher incidence of autoimmune thyroid disease in women.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Faisal Nabi, Mahwash Kassi, Kamil Muhyieddeen, Su Mm Chang, Jiaqiong Xu, Leif E. Peterson, Nelda P. Wray, Beverly A. Shirkey, Carol M. Ashton, John J. Mahmarian
JOURNAL OF NUCLEAR MEDICINE
(2016)
Article
Oncology
Haijun Zhou, Roxanne R. Mody, Eric Luna, Donna Armylagos, Jiaqiong Xu, Mary R. Schwartz, Dina R. Mody, Yimin Ge
CANCER CYTOPATHOLOGY
(2016)
Article
Geriatrics & Gerontology
Kathryn S. Agarwal, Rabia Kazim, Jiaqiong Xu, Soo Borson, George E. Taffet
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2016)
Article
Cardiac & Cardiovascular Systems
Oyvind S. Andersen, Otto A. Smiseth, Hisham Dokainish, Muaz M. Abudiab, Robert C. Schutt, Arnav Kumar, Kimi Sato, Serge Harb, Einar Gude, Espen W. Remme, Arne K. Andreassen, Jong-Won Ha, Jiaqiong Xu, Allan L. Klein, Sherif F. Nagueh
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Robert A. Phillips, Jiaqiong Xu, Leif E. Peterson, Ryan M. Arnold, Joseph A. Diamond, Adam E. Schussheim
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Razvan T. Dadu, Jiaqiong Xu, Hasan Rehman, Moritz Wyler von Ballmoos, Colin M. Barker, Manuel Reyes, Mahesh Ramchandani, Ross M. Reul, Michael J. Reardon, Neal S. Kleiman
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2019)
Letter
Cardiac & Cardiovascular Systems
Robert A. Phillips, Ryan M. Arnold, Jiaqiong Xu, Joseph A. Diamond, Leif E. Peterson
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Danai Kitkungvan, Faisal Nabi, Raymond J. Kim, Robert O. Bonow, Mohammad A. Khan, Jiaqiong Xu, Stephen H. Little, Miguel A. Quinones, Gerald M. Lawrie, William A. Zoghbi, Dipan J. Shah
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2018)
Article
Clinical Neurology
B. Pascual, S. T. de Bot, M. R. Daniels, M. C. Franca, C. Toro, M. Riverol, P. Hedera, M. T. Bassi, N. Bresolin, B. P. van de Warrenburg, B. Kremer, J. Nicolai, P. Charles, J. Xu, S. Singh, N. J. Patronas, S. H. Fung, M. D. Gregory, J. C. Masdeu
AMERICAN JOURNAL OF NEURORADIOLOGY
(2019)
Article
Oncology
Yimin Ge, Paul Christensen, Eric Luna, Donna Armylagos, Jiaqiong Xu, Mary R. Schwartz, Dina R. Mody
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2019)
Article
Obstetrics & Gynecology
Justine R. Johnson, Rachel A. High, Olivia Dziadek, Adriana Ocon, Tristi W. Muir, Jiaqiong Xu, Danielle D. Antosh
FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY
(2020)
Article
Medicine, General & Internal
Hina Faisal, Syeda T. Ali, Jiaqiong Xu, Tariq Nisar, Mahmoud Sabawi, Eric Salazar, Faisal N. Masud
Summary: Carboxyhemoglobinemia in COVID-19 patients may be due to sepsis, hemolysis, and cytokine storm triggered by the virus, rather than directly from the virulence of novel coronavirus. The study found a high incidence of carboxyhemoglobinemia in critically ill COVID-19 patients, suggesting routine monitoring of COHb levels for more effective treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Yimin Ge, Paul Christensen, Eric Luna, Donna Armylagos, Jiaqiong Xu, Mary R. Schwartz, Dina R. Mody
JOURNAL OF LOWER GENITAL TRACT DISEASE
(2018)
Article
Endocrinology & Metabolism
Jawairia Shakil, Mohammed Z. Ansari, Jett Brady, Jiaqiong Xu, Richard J. Robbins
ENDOCRINE PRACTICE
(2017)
Article
Cardiac & Cardiovascular Systems
Sherif F. Nagueh, Theodore P. Abraham, Gerard P. Aurigemma, Jeroen J. Bax, Carmen Beladan, Alyssa Browning, Mohammed A. Chamsi-Pasha, Victoria Delgado, Genevieve Derumeaux, Giulia Dolci, Erwan Donal, Thor Edvardsen, Kinan Carlos El Tallawi, Laura Ernande, Roberta Esposito, Frank A. Flachskampf, Maurizio Galderisi, James Gentry, Steven A. Goldstein, Serge C. Harb, Arnaud Hubert, Judy Hung, Allan L. Klein, Patrizio Lancellotti, Redah Z. Mahmood, Paolo Marino, Bogdan A. Popescu, Martina Previato, Saket R. Sanghai, Otto A. Smiseth, Jiaqiong Xu
CIRCULATION-CARDIOVASCULAR IMAGING
(2019)